Cell differentiation and aging accompanied by depletion of the ACE2 proteinResearch Paper Published on 2020-11-302022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, SARS, [키워드] accompanied ACE2 ACE2 protein Brain caused Cell cell differentiation cell types cells changed COVID-19 disease decrease differentiation downregulated downregulation Embryo embryonic heart enterocytes female human kidney embryonic cells kidneys lowest lung cancer cells Lungs males mice nucleus observation Older olfactory bulb pathophysiology Protein Renin renin-angiotensin system surface receptor the SARS-CoV-2 virus tissue upregulated upregulation [DOI] 10.18632/aging.202221 PMC 바로가기 [Article Type] Research Paper
Coevolution, Dynamics and Allostery Conspire in Shaping Cooperative Binding and Signal Transmission of the SARS-CoV-2 Spike Protein with Human Angiotensin-Converting Enzyme 2Article Published on 2020-11-042022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 ACE2 protein adaptive Alanine alanine scanning allosteric interactions Analysis angiotensin-converting enzyme 2 association binding binding energy binding free energy binding interaction binding mechanism biochemical carrier change coevolution complexes computational studies conformational Consensus Cooperative coronavirus SARS-CoV-2 Critical cumulative determinant Drug discovery Dynamics highlight host receptor hotspot Human Infection transmission inhibiting initial Interaction Interface residues molecular molecular dynamics Molecular simulation network analysis performed preference receptor Receptor binding domain residue responsible SARS-CoV SARS-CoV spike protein SARS-CoV-2 SARS-CoV-2 spike protein Sequence analysis shaping signal signal transmission spike Spike protein target cell the SARS-CoV-2 Transmission virus entry virus transmission [DOI] 10.3390/ijms21218268 PMC 바로가기 [Article Type] Article
Could urinary ACE2 protein level help identify individuals susceptible to SARS-CoV-2 infection and complication?소변 ACE2 단백질 수치가 SARS-CoV-2 감염 및 합병증에 취약한 개인을 식별하는 데 도움이 될 수 있습니까?Article Published on 2020-11-012022-09-11 Journal: Science China. Life sciences [Category] SARS, 바이오마커, [키워드] ACE2 protein help identify individual SARS-COV-2 infection susceptible [DOI] 10.1007/s11427-020-1759-4 PMC 바로가기 [Article Type] Article
Autoimmunity to ACE2 as a possible cause of tissue inflammation in Covid-19Covid-19에서 조직 염증의 가능한 원인으로서 ACE2에 대한 자가면역Article Published on 2020-11-012022-09-12 Journal: Medical Hypotheses [Category] 진단, [키워드] ACE2 ACE2 protein amplifying APCS autoantibody Autoimmune response caused complex complexes CoV disease for inclusion HLA Hypothesis inflammatory phase likelihood lung lung damage Lung disease Patient positive predict SARS-COV-2 infection spike T cell tested the spike protein tissue inflammation Vaccines [DOI] 10.1016/j.mehy.2020.110043 PMC 바로가기 [Article Type] Article
Molecular docking study of potential phytochemicals and their effects on the complex of SARS-CoV2 spike protein and human ACE2Article Published on 2020-10-192022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 치료제, [키워드] ACE2 ACE2 protein affected Analysis analyzed angiotensin converting enzyme antiviral activity binding binding energy binding site cause Chinese competent complex Compound Computational chemistry conformational change coronavirus COVID-19 Effect effective emodin FIVE human ACE2 in silico indicate Infection medication modulate molecular molecular docking Molecular docking study natural Novel coronavirus patients plants Protein receptor receptor ACE2 Safe SARS-CoV2 selected small molecule Spike protein three-dimensional structure transmembrane protein treat Trial Virtual drug screening [DOI] 10.1038/s41598-020-74715-4 PMC 바로가기 [Article Type] Article
A Hydrophobic‐Interaction‐Based Mechanism Triggers Docking between the SARS‐CoV‐2 Spike and Angiotensin‐Converting Enzyme 2Full Paper Published on 2020-10-152022-10-31 Journal: Global Challenges [Category] COVID-19, [키워드] ACE2 ACE2 protein acute respiratory syndrome angiotensin‐converting enzyme 2 antibody blockers cellular receptor chain structure coronavirus coronavirus disease COVID‐19 COVID‐19 docking Effect enzyme greater hydrophilic hydrophobic hydrophobic interactions Interaction involved mechanism pandemic physical Protein RBD receptor‐binding domain responsible reveal SARS‐CoV‐2 SARS‐CoV‐2 spike SARS‐CoV‐2 shielding significantly Taking tension the binding affinity therapeutic Trigger understanding Vaccines water molecules [DOI] 10.1002/gch2.202000067 PMC 바로가기 [Article Type] Full Paper
Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers During the COVID-19 Pandemic: A Modeling AnalysisResearch Article Published on 2020-10-082022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 protein acute inflammatory response Angiotensin II angiotensin-converting enzyme inhibitor approach ARB binding blocker cardiovascular disease cardiovascular diseases Cell cell entry cell membrane chronic inflammation Chronic kidney disease coronavirus COVID-19 COVID-19 pandemic diabete diabetes disease disease severity dosage drug Effects enzyme epidemiological data epithelial cell Evidence exacerbated Factors heart failure help host cell host cells host’s immune response hypertension implication increase in induce Infection Inflammation inhibitor Invasion lack lethal disease Lungs mathematical medication medications Model modeling Mortality pandemic Pandemics pathogenesis of COVID-19 Patient physician predict RAS receptor renin-angiotensin system risk SARS- CoV-2 SARS-CoV SARS-CoV-2 severe COVID-19 subsequent suggested the spike protein therapy tissue damage tissues treated Treatment virus while [DOI] 10.1371/journal.pcbi.1008235 PMC 바로가기 [Article Type] Research Article
Expression of the COVID-19 receptor ACE2 in the human conjunctiva인간 결막에서 COVID-19 수용체 ACE2의 발현Article Published on 2020-10-012022-09-11 Journal: Journal of medical virology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 ANPEP assumed auxiliary Cell cell entry cofactor cofactors Conjunctiva conjunctival conjunctival congestion Coronavirus-2 COVID-19 described DPP4 eight ENPEP epithelial cell epithelial cells Evidence Express expressed expression healthy human conjunctiva. immunohistochemistry infection with SARS-CoV-2 laboratory-confirmed mediators Messenger RNA mRNA papilloma Patient patients Protein protein levels recent receptor ACE2 respiratory RNA sequencing SARS-CoV-2 SARS-CoV-2 receptor Seven severe acute respiratory syndrome Coronavirus speculation Squamous cell squamous cell carcinomas the SARS-CoV-2 TMPRSS2 transcript Transcription transmitted unlikely [DOI] 10.1002/jmv.25981 PMC 바로가기 [Article Type] Article
ACE2 in the Era of SARS-CoV-2: Controversies and Novel PerspectivesMolecular Biosciences Published on 2020-09-302022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] “cytokine storm” accumulates ACE ACE inhibitor ACE2 ACE2 expression ACE2 protein ACE2 receptor acute respiratory syndrome Administered Alter Angiotensin receptor blockers angiotensin-converting enzyme 2 antibodies appear binding biochemical Biochemistry cardioprotection cardiovascular system cellular clinical investigation competitive binding COVID-19 COVID-19 disease COVID-19 pandemic Cytokine storm determinant downregulation drugs Effect effort engage enzyme Epigenetic event Evidence exogenously forms glycosylation Host host cell membrane hypertension induce Infection initial Interaction intestine kidney knowledge limit Lung inflammation mammalian mechanism Medical conditions MicroRNAs modulation Neutralizing novel observation pathogenicity pathophysiological pathophysiology peptides Phosphorylation plasma membrane Protein reduce reduced regulated Replication respiratory tract responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 severe COVID-19 small molecule Spike protein Strategy subunits: S1 tissues transcriptional viral envelope viral genome virus virus entry [DOI] 10.3389/fmolb.2020.588618 PMC 바로가기 [Article Type] Molecular Biosciences
Highly conserved binding region of ACE2 as a receptor for SARS-CoV-2 between humans and mammalsBrief Report Published on 2020-09-292022-10-28 Journal: The Veterinary Quarterly [Category] COVID-19, MERS, SARS, [키워드] accelerate ACE2 ACE2 protein acute respiratory syndrome addition Amino acid Analysis angiotensin-converting enzyme 2 antiviral therapeutics appear binding binding region Complete conserved coronavirus COVID-19 FIVE food homologous homology Human human ACE2 humans infected with SARS-CoV-2 Infection information Interaction involved mammal Medical countermeasures mink Multiple sequence alignment Nature New York peptide Phylogenetic tree Precision Protein protein regions Quality RBD receptor Receptor binding domain reduced reported residue risk SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 Spike RBD SARS-CoV-2 transmission sequence spike glycoprotein structural homology Support the SARS-CoV-2 three-dimensional structure transmitted USA Vaccine design virus was used were infected World Health Organization [DOI] 10.1080/01652176.2020.1823522 PMC 바로가기 [Article Type] Brief Report