Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses치명적인 COVID-19 결과는 풍토성 코로나바이러스와 공유되는 에피토프를 표적으로 하는 항체 반응과 관련이 있습니다Article Published on 2022-07-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] Adaptive immunity antibody Antibody Response Antibody responses antigenic beta-coronavirus characteristic conservation coronavirus coronavirus disease Coronavirus disease 2019 correlated strongly correlation COVID-19 cross-reactive disease Disease progression domain Endemic epitope Epitopes fatal COVID-19 full-length spike protein highest ICU immune response immune responses immunology Imprinting individual Infection Infectious disease intensive care intensive care unit less magnitude not significantly different nucleocapsid outcome outcomes proportion Protective Region respiratory Respiratory Coronavirus response S2 subunit SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 spike protein severe acute respiratory coronavirus Spike protein Spike proteins subunits the antibody response the SARS-CoV-2 variable regions [DOI] 10.1172/jci.insight.156372 PMC 바로가기 [Article Type] Article
New Perspectives on Immune Involvement in Parkinson’s Disease PathogenesisReview Published on 2022-07-072024-09-04 Journal: Journal of Parkinson's Disease [Category] 대상포진, [키워드] Adaptive immunity immune Immunogenetics Parkinson’s disease T cells [DOI] 10.3233/JPD-223240 PMC 바로가기 [Article Type] Review
The prevalence of adaptive immunity to COVID-19 and reinfection after recovery – a comprehensive systematic review and meta-analysisMeta-Analysis Published on 2022-07-012023-07-07 Journal: Pathogens and global health [Category] COVID19(2023년), [키워드] Adaptive immunity antibodies COVID-19 preventive efficacy Reinfection SARS-CoV-2 [DOI] 10.1080/20477724.2022.2029301 PMC 바로가기 [Article Type] Meta-Analysis
SARS-CoV-2-Specific Memory B Cell Responses Are Maintained After Recovery from Natural Infection and PostvaccinationArticle Published on 2022-07-012023-07-10 Journal: Viral immunology [Category] COVID19(2023년), [키워드] Adaptive immunity Humoral immunity memory B cell natural infection SARS-CoV-2 vaccination [DOI] 10.1089/vim.2022.0013
Structure of a Vaccine-Induced, Germline-Encoded Human Antibody Defines a Neutralizing Epitope on the SARS-CoV-2 Spike N-Terminal Domain백신 유도 생식계열 인코딩 인간 항체의 구조는 SARS-CoV-2 스파이크 N-말단 도메인에서 중화 에피토프를 정의합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Alpha) (Beta) activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immunity Affinity maturation Alpha antibody Antigen arms race B cell B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Biliverdin bind binding Cell cognate antigen complementarity-determining region complex conserved coronavirus cryo-EM Donor electron microscopy engage epitope evolutionary arms race Genetic germ line HCDR3 heme high-resolution structure Host Human hydrophobic Infection intermolecular interaction intermolecular interactions knowledge mAb maintain metabolite monoclonal monoclonal antibodies monoclonal antibody mRNA vaccination N-terminal domain neutralize Neutralizing NTD pathogen plasmablast plasmablasts provide respiratory responses reveal SARS-CoV-2 SARS-CoV-2 spike sequence severe acute respiratory syndrome Coronavirus shown spike spike glycoprotein Structure the SARS-CoV-2 the vaccine undergo vaccination Vaccine vaccine immunogen variant variants Viral viral strain viral variant Viral variants [DOI] 10.1128/mbio.03580-21 PMC 바로가기 [Article Type] Article
Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination감염 또는 예방 접종 후 재태 연령이 일치하는 모자에서 SARS-CoV-2 변이체에 대한 중화 항체 활성Article Published on 2022-06-222022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adaptive immunity age analyzed antibody COVID-19 Delta disease during pregnancy effective elicit first trimester gestation gestational age immune response immune responses immunoglobulins individuals Infection Infectious disease less mother mRNA vaccine mRNA vaccines NAb NAbs neutralization neutralization activity Neutralizing plasma plasma sample Pregnancy pregnant Protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccination SARS-CoV-2 variant second trimester sequence Spike protein spike variants time of delivery transfer unique vaccination Vaccine variant virion was measured with infection women WT spike [DOI] 10.1172/jci.insight.157354 PMC 바로가기 [Article Type] Article
Boosting corrects a memory B cell defect in SARS-CoV-2 mRNA-vaccinated patients with inflammatory bowel disease부스팅은 염증성 장 질환이 있는 SARS-CoV-2 mRNA 백신 접종 환자의 기억 B 세포 결함을 수정합니다Article Published on 2022-06-222022-09-12 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adaptive immunity antibody antibody affinity B cell B lymphocyte bowel Cell cellular Control control group controls COVID-19 elevated generate healthy controls IBD identify immunology Inflammatory bowel disease maturation memory memory B memory B cell mRNA vaccination neutralizing antibody Patient produced Receptor binding SARS-CoV-2 SARS-CoV-2 spike serum antibody vaccination [DOI] 10.1172/jci.insight.159618 PMC 바로가기 [Article Type] Article
Antibodies from convalescent plasma promote SARS-CoV-2 clearance in individuals with and without endogenous antibody response회복기 혈장의 항체는 내인성 항체 반응이 있거나 없는 개인에서 SARS-CoV-2 제거를 촉진합니다Clinical Trial Published on 2022-06-152022-09-11 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] 95% CI absence Adaptive immunity adjusted hazard ratio adverse events affected antibody Antibody Response clearance Clinical research Comorbidity Comprehensive conducted convalescent plasma Convalescent plasma therapy Corona COVID-19 Critical demonstrated disease status Efficacy evidenced faster hazard ratio hospitalized COVID-19 patient human infection human infections Immunotherapy individual Innovation Intervention IQR Kaplan-Meier analysis laboratory parameter median interval Mortality neutralization Neutralizing neutralizing antibody onset of symptom parameter Phase I plasma plasma therapy pool principle priority Program promote recipient recipients Red respond Safe SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 clearance SARS-CoV-2 vaccines serological significantly survival therapeutic Therapeutics therapy transfusion-related adverse event transfusion-related adverse events Trial university University of Zurich Viral viral clearance Viral load Viremia Virological virus clearance [DOI] 10.1172/JCI158190 PMC 바로가기 [Article Type] Clinical Trial
Accelerated waning of immunity to SARS-CoV-2 mRNA vaccines in patients with immune-mediated inflammatory diseases면역 매개 염증성 질환 환자에서 SARS-CoV-2 mRNA 백신에 대한 면역 약화 가속화Observational Study Published on 2022-06-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, [키워드] Adaptive immunity Adult patients All participants ankylosing spondylitis anti-TNF Arthritis attrition Autoimmune diseases azathioprine COVID-19 COVID-19 vaccination declining disease donation dose Efficacy examined force greater healthy control healthy controls Immune-mediated inflammatory disease Immune-mediated inflammatory diseases Immunity immunogenicity immunology Immunosuppressant immunosuppressants immunosuppressive therapies Immunotherapy Inflammatory bowel disease Inflammatory diseases information Juan methotrexate mRNA vaccine neutralization Observational cohort study omicron Participants Patient rapid response rheumatoid arthritis SARS-CoV-2 SARS-CoV-2 variants Speck spondylitis subjects Support T cell T cell response Task Force Treatment undetectable Vaccine variants variants of concern [DOI] 10.1172/jci.insight.159721 PMC 바로가기 [Article Type] Observational Study
Vitamin D Regulation of Immune FunctionReview Published on 2022-06-012023-07-09 Journal: Current osteoporosis reports [Category] COVID19(2023년), [키워드] Adaptive immunity airway epithelia calcitriol Cathelicidin Innate immunity Pulmonary alveolar macrophage viral infection Vitamin D [DOI] 10.1007/s11914-022-00732-z PMC 바로가기 [Article Type] Review