Alanine – Page 10 – Communicable Diseases Research

Elucidating Interactions Between SARS-CoV-2 Trimeric Spike Protein and ACE2 Using Homology Modeling and Molecular Dynamics Simulations

Chemistry

Published on 2021-01-052022-10-31
Journal: Frontiers in Chemistry [Category] COVID-19,

COVID-19 Severity and Stroke: Correlation of Imaging and Laboratory Markers

COVID-19 중증도 및 뇌졸중: 영상 및 실험실 마커의 상관관계

Article

Published on 2021-01-012022-09-11
Journal: AJNR. American journal of neuroradiology [Category] MERS, 바이오마커,

[키워드] activating Alanine alanine aminotransferase anticoagulation appear Biomarkers blood counts C-reactive protein Care case sery Chain Reaction characterized clinical Clinical and laboratory data Coagulopathy collected complete blood count complete blood counts coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 symptom COVID-19 symptoms creatinine D-dimer D-dimer levels develop distribution elevated ferritin ferritin levels Health Health care hemorrhage Hemorrhagic hepatic injury Hospitalized hyperinflammation imaging independent risk factor Infarction Inflammatory Inflammatory marker inflammatory markers intracranial hemorrhage island laboratory data Lactate lactate dehydrogenase Long lymphopenia material New York City pathogenic mechanism Patient patients with COVID-19 polymerase chain polymerase chain reaction Polymerase chain reaction testing positive prothrombotic state recorded renal retrospective risk severe COVID-19 significantly higher significantly more stroke thrombosis treated
[DOI] 10.3174/ajnr.A6920 PMC 바로가기 [Article Type] Article

Observational study on off-label use of tocilizumab in patients with severe COVID-19

중증 COVID-19 환자에서 토실리주맙의 오프라벨 사용에 대한 관찰 연구

Observational Study

Published on 2021-01-012022-09-11
Journal: European Journal of Hospital Pharmacy [Category] 임상, 진단, 치료제,

[키워드] 95% CI age Alanine alanine aminotransferase aspartate Aspartate aminotransferase average respiratory rate baseline best binding C-reactive protein candidate carried caused clinical conditions clinical impact clinical medicine cohort study collected control group Course COVID-19 Critical Critical care CRP cytokine Cytokine storm cytolysis deaths diagnosed with COVID-19 Efficacy Fewer patient Fewer patients Follow-up France Gender greater decrease had more Hospital stay hyperinflammation IL-6 IL-6 receptor impairment Inclusion infected with COVID-19 Inflammatory inhibit initial interleukin interleukin 6 interleukin 6 (IL-6) Intubated laboratory parameter Laboratory parameters lack less Ligand limit lung damage mechanical ventilation Novel coronavirus Observational cohort study observational study off-label off-label use oxygen oxygen supplementation Oxygen therapy pandemic Paris Patient pharmaceutical preparations Potential treatment pulmonary impairment pulmonary medicine Randomised clinical trials required respiratory respiratory rate SARS-CoV-2 SARS-COV-2 infection severe COVID-19 significant decrease significant difference Spread symptoms of COVID-19 syndrome TCZ the cytokine storm the disease the patient therapy Tocilizumab treated treated patient treated patients two groups Virology
[DOI] 10.1136/ejhpharm-2020-002414 PMC 바로가기 [Article Type] Observational Study

Computational Prediction of Mutational Effects on SARS-CoV-2 Binding by Relative Free Energy Calculations

상대 자유 에너지 계산에 의한 SARS-CoV-2 결합에 대한 돌연변이 효과의 컴퓨터 예측

Article

Published on 2020-12-282022-09-11
Journal: Journal of Chemical Information and Modeling [Category] SARS, 변종,

Computational Determination of Potential Inhibitors of SARS-CoV-2 Main Protease

SARS-CoV-2 주요 프로테아제의 잠재적 억제제의 컴퓨터 결정

Article

Published on 2020-12-282022-09-11
Journal: Journal of Chemical Information and Modeling [Category] SARS, 신약개발, 치료제,

Beneficial effect of Indigo Naturalis on acute lung injury induced by influenza A virus

Research

Published on 2020-12-212022-11-01
Journal: Chinese Medicine [Category] COVID-19,

[키워드] Activation acute lung injury administration Alanine ALT animal Anti-inflammatory anti-inflammatory property Aspartate aminotransferase AST BALB/c mice canine Cell Chinese coronavirus disease COVID-19 cytokine Cytokines ELISA evaluated expressed expression H1N1 IAV IFN-α IFN-β IFN-γ IL-10 IL-6 in vitro Indigo Naturalis Inflammation Influenza influenza A virus influenza viruses inhibited inoculated interferon interferon γ interleukin-6 intranasally IP-10 kidney liver liver index Lung injury lung tissue MCP-1 MDA mechanism mice monocyte chemoattractant protein-1 Mortality MPO multi organ failure myeloperoxidase nitric oxide organ pandemic peritoneal macrophage Protein RANTES reduced regulated Respiratory Coronavirus Result SARS-CoV-2 secreted significantly significantly increased spleen staining suppressed survival rate T cell TCM TLR4 TNF-α toll-like receptor 4 treat treated Treatment tumor necrosis factor-α viral replication virus replication were recorded
[DOI] 10.1186/s13020-020-00415-w PMC 바로가기 [Article Type] Research

Clinical Features and Risk Factors of ICU Admission for COVID-19 Patients with Diabetes

Research Article

Published on 2020-12-112022-10-29
Journal: Journal of Diabetes Research [Category] COVID-19, MERS,

[키워드] 95% CI addition age Alanine ALT Aspartate transaminase assist AST Binary logistic regression C-reactive protein Characteristics clinical Clinical characteristics collected Comorbidity complications coronavirus disease COVID-19 COVID-19 patient CRP demographic diabete diabetes diarrhea early stage Factor General population greater groups Guangzhou ICU ICU admission identify increase in independent risk factor intensive care Laboratory results laboratory-confirmed Multiple Myoglobin Odds ratio Older Older age Patient previous study Radiographic regression analysis respiratory rate Result risk factor risk stratification TnI transfer Treatment was used
[DOI] 10.1155/2020/5237840 PMC 바로가기 [Article Type] Research Article

Diabetes and Covid-19 among hospitalized patients in Saudi Arabia: a single-centre retrospective study

Original Investigation

Published on 2020-12-052022-10-31
Journal: Cardiovascular Diabetology [Category] COVID-19, MERS,

[키워드] 95% confidence interval Admission age Alanine analyzed bilateral lung infiltrate bilateral lung infiltrates Blood city clinical Clinical characteristics congestive heart failure COVID-19 creatinine death rate deficiency Diabetes Mellitus died elevated Factor hazard Hospitalization Hospitalized hospitalized patient hyperglycemia hypertension information intensive care King median age medical record men Mortality mortality rate most prevalent comorbidity multivariate obesity outcome Patient patients positive predictor Prevalence radiological receive Regression model Result Retrospective study Saudi Arabia serological significantly significantly higher single-center smoking survival university were recorded while
[DOI] 10.1186/s12933-020-01184-4 PMC 바로가기 [Article Type] Original Investigation

Differences in Clinical Features and Laboratory Results between Adults and Children with SARS-CoV-2 Infection

SARS-CoV-2 감염 성인과 소아의 임상적 특징 및 검사 결과의 차이

Comparative Study

Published on 2020-12-012022-09-12
Journal: BioMed Research International [Category] 진단,

[키워드] absolute value accounted acute respiratory syndrome acute respiratory syndrome coronavirus Adults Alanine alanine aminotransferase analyzed aspartate Aspartate aminotransferase Asymptomatic asymptomatic infection cause causes Characteristics Chest computed tomography Chest CT chest CT examination children clinical Clinical characteristics clinical information Clinical symptoms Clustering Computed tomography coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 determine difference epidemiological Families increased risk infected with SARS-CoV-2 Infection Laboratory Liver damage lymphocyte Lymphocytes Manifestations Mild neutrophil Neutrophils not significantly different nucleic acid Patient performed Platelet platelet counts Platelets positive Prevalence proportion reduction respiratory Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleic acid severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly higher
[DOI] 10.1155/2020/6342598 PMC 바로가기 [Article Type] Comparative Study

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity

COVID-19 환자의 바이러스 에피토프 프로파일링은 교차 반응성과 심각도의 상관 관계를 보여줍니다

Research Article

Published on 2020-11-272022-09-12
Journal: Science (New York, N.y.) [Category] Fulltext, SARS, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect age Alanine Analysis antibody Antibody detection antibody epitope antibody epitopes antibody repertoire Antibody Response Antibody responses Antibody-dependent enhancement antiviral antibodies antiviral antibody Asymptomatic caused circulating clinical outcomes colds common-cold Control controls coronavirus coronavirus disease Coronavirus disease 2019 coronavirus strains Coronaviruses correlation Course covariates COVID-19 COVID-19 patient COVID-19 severity Critical cross-react cross-reactive antibody cross-reactivity cytomegalovirus death deep Demographic variables detect diagnostic diagnostics disease disease severity distress enzyme-linked immunosorbent assays epitope epitope mapping Epitopes exacerbate examination exhibited explain females Fever functional Gender generate gold herpes simplex herpes simplex virus Herpes Simplex Virus 1 Hospitalization Hospitalized hospitalized patients human coronaviruses human sera humans humoral Humoral response humoral responses hypothese hypotheses immune immunogenicity incidence individual individuals infect infected with SARS-CoV-2 Infection infections interactions Isolation knowledge machine machine-learning male mapped Mild Mutagenesis Neutralizing Neutralizing antibodies neutralizing antibody not need notable nucleoprotein ORF1 outcome outcomes Patient patient cohort peptide peptides performed predicted probe Profiling Protein proteome proteomes raise rationale required respiratory respiratory distress Respiratory system response responses reveal SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody response SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 proteome Science screened sensitivity Sequence conservation sera serological Serological assay severe acute respiratory syndrome Coronavirus severe COVID-19 severe infections severity severity of COVID-19 specificity Spike protein stratified strength suggested target targets tested the antibody response the SARS-CoV-2 the spike protein Therapeutics Therapies two groups understanding Vaccine Vaccines Viral virus
[DOI] 10.1126/science.abd4250 PMC 바로가기 [Article Type] Research Article