SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocationSARS-CoV-2 nsp12는 IRF3 핵 전위를 억제하여 I형 인터페론 생산을 약화시킵니다Article Published on 2021-02-262022-09-11 Journal: Cellular and Molecular Immunology [Category] MERS, SARS, 변종, 치료제, [키워드] (RdRp) Activation Analysis Antiviral antiviral immunity antiviral responses attenuate COVID-19 dependent on dose-dependent manner global pandemic Host host antiviral responses IFN IFN-β immune evasion impair inducer inhibited inhibiting Innate immunity IRF3 MAVS MDA5 not dependent Nsp12 nuclear translocation overexpression pathogenic Phosphorylation poly(I:C) polymerase promoter provide RdRP respiratory respiratory RNA viruses reveal RIG-I RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp Sendai virus SeV suggested suppresse suppressed triggered type I interferon Viral viral infection viral pathogenesis Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.1038/s41423-020-00619-y PMC 바로가기 [Article Type] Article
Apoptosis induced by SARS-CoV-2: can we target it?SARS-CoV-2에 의해 유도된 세포자멸사: 표적화할 수 있습니까?Article Published on 2021-02-012022-09-11 Journal: Apoptosis [Category] 치료제, [키워드] antiviral immunity Apoptosis Apoptotic cell death cell death complex COVID-19 Disease progression Evidence facilitate hallmark Host induction of apoptosis mechanism ORF3a SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 virus infection targeting these viruses tissue injury Treatment triggered Viral viral clearance virus virus infection viruses [DOI] 10.1007/s10495-021-01656-2 PMC 바로가기 [Article Type] Article
Sex differences in antiviral immunity in SARS-CoV-2 infection: Mitochondria and mitomiR come into viewSARS-CoV-2 감염에서 항바이러스 면역의 성별 차이: 미토콘드리아와 미토미R이 밝혀졌습니다Editorial Published on 2021-02-012022-09-12 Journal: Acta physiologica (Oxford, England) [Category] MERS, SARS, 진단, [키워드] antiviral immunity Mitochondria SARS-CoV-2 [DOI] 10.1111/apha.13571 PMC 바로가기 [Article Type] Editorial
Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium1차 인간 기도 상피에서 SARS-CoV-2 향성의 단일 세포 분해능, 항바이러스 반응 및 요법에 대한 감수성Research Article Published on 2021-01-282022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, 치료제, [키워드] airway epithelial cells airway epithelium Antiviral antiviral immunity antiviral responses antiviral therapies antiviral therapy array blocked Cell cell population cell type cell types cellular ciliated cell ciliated cells Ciliated epithelial cells contribute COVID-19 pathogenesis dominant element elements epithelial cell epithelial cell type epithelial cell types epithelial cells expressed Factor flow cytometry gene signatures heterogeneity heterogenous host protease host protease TMPRSS2 Human airway epithelium hyperinflammatory responses IL-6 induction infect infected cell infected cells Infection inhibited initial interferon interferon response ISG ISGs mediator outcome Pathogenesis predominant primary human airway Remdesivir required respiratory respiratory tract RNA-sequencing SARS-CoV-2 SARS-COV-2 infection secretory cell secretory cells Single Cell susceptibility susceptible therapy These cells TMPRSS2 Treatment Treatment response variety Viral viral replication viral tropism [DOI] 10.1371/journal.ppat.1009292 PMC 바로가기 [Article Type] Research Article
Protective Effects of Lactoferrin against SARS-CoV-2 Infection In Vitro시험관 내 SARS-CoV-2 감염에 대한 락토페린의 보호 효과Article Published on 2021-01-232022-09-10 Journal: Nutrients [Category] MERS, 진단, 치료제, [키워드] analyzed anti-inflammatory cytokine Anti-inflammatory effects Antiviral antiviral immune response antiviral immunity Caco-2 Caco-2 cell Caco-2 cells COVID-19 curative cytokine determined by Effect epithelial cells expression Gene Expression Genes glycoprotein IFNA1 IFNB1 immune immune response immune response gene immunomodulatory immunostaining in vitro in vitro data Infection inhibited intestinal epithelial cell intestinal epithelial cells IRF3 IRF7 lack lactoferrin MAVS moderate non-toxic Plaque assay qRT-PCR Replication SARS-CoV-2 SARS-COV-2 infection significantly Support TLR3 TLR7 treated uninfected virus was determined was performed [DOI] 10.3390/nu13020328 PMC 바로가기 [Article Type] Article
Human stem cell models to study host–virus interactions in the central nervous system Reviews Published on 2021-01-042022-10-05 Journal: Nature reviews. Immunology [Category] SARS, 신약개발, 치료제, [키워드] acute infection acute respiratory syndrome advancement Affect antiviral immunity Brain brain development caused Cell cell type Central nervous system clinical outcomes CNS complex coronavirus determine developmental disease Encephalitis Genetic herpesviruses host–virus interaction Human latency mechanisms molecular mechanism neurological neurotropic offer prenatal question restriction factor SARS-CoV-2 stages subpopulation susceptibility unique virus [DOI] 10.1038/s41577-020-00474-y [Article Type] Reviews
Hexosamine biosynthetic pathway promotes the antiviral activity of SAMHD1 by enhancing O-GlcNAc transferase-mediated protein O-GlcNAcylationResearch Paper Published on 2021-01-012023-06-03 Journal: Theranostics [Category] B형 간염, Fulltext, [키워드] antiviral immunity Hepatitis B virus hexosamine biosynthetic pathway O-linked β-N-acetylglucosamine modification sterile alpha motif and histidine/aspartic acid domain-containing protein 1 [DOI] 10.7150/thno.50230 PMC 바로가기 [Article Type] Research Paper
Mendelian randomization analysis identified genes pleiotropically associated with the risk and prognosis of COVID-19Mendelian randomization analysis는 COVID-19의 위험 및 예후와 다면적으로 관련된 유전자를 확인했습니다.Article Published on 2021-01-012022-09-11 Journal: The Journal of Infection [Category] Fulltext, SARS, 변종, 유전자 메커니즘, [키워드] Analysis antiviral immunity applied association Blood Blood coagulation caused Coagulation coronavirus coronavirus disease Coronavirus disease 2019 correction COVID-19 cytokine Cytokine storm disease effective exhibited expression Gene expression quantitative trait loci Genes Genetic variant Genome-wide association study global pandemic hospitalized COVID-19 HPS5 identify IFNAR2 Inflammation Interpretation involved leads lung mechanism mendelian randomization multiple testing outcome pleiotropic PON2 potential therapeutic target potential therapeutic targets probe probes Prognosis Quantitative respiratory risk SMR Summary Mendelian randomization. susceptibility Treatment Variation Venous Thromboembolism with COVID-19 [DOI] 10.1016/j.jinf.2020.11.031 PMC 바로가기 [Article Type] Article
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2) 막(M) 단백질은 RIG-I/MDA-5 신호전달을 표적으로 하여 I형 및 III형 인터페론 생산을 억제합니다Article Published on 2020-12-282022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료법, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition affected Antiviral antiviral immunity attenuate caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytosolic ectopic expression ENhance evade facilitate IFN Immune suppression individuals Infection Infectious diseases inhibit Innate immunity interact interferon Interpretation IRF3 M protein MAVS mechanism membrane molecular mechanism multiprotein complex nuclear translocation pathogenic pathway Phosphorylation Protein provide Replication reported respiratory RIG-I SARS-CoV-2 SeV severe acute respiratory syndrome Coronavirus Signaling Spread stimulated stomatitis suppresse suppression TBK1 the SARS-CoV-2 TRAF3 type I type I and III IFNs vesicular stomatitis vesicular stomatitis virus Viral viral replication [DOI] 10.1038/s41392-020-00438-7 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse Repertoire of Human T Cell ReceptorsSARS-CoV-2 에피토프는 인간 T 세포 수용체의 공개적이고 다양한 레퍼토리에 의해 인식됩니다Article Published on 2020-12-152022-09-12 Journal: Immunity [Category] MERS, SARS, 진단, [키워드] Activation antibody antibody secretion antiviral immunity asymptomatic infection Biomarker CD4 CD8 clonal structure. convalescent COVID-19 patient Convalescent patients COVID-19 COVID-19 pandemic Critical Donor donors examined exhibited Features group hallmark healthy donor HLA-A∗02:01 homologous Human humoral immune response MHC motif pandemic Preexisting immunity Public reactivity repertoire SARS-CoV-2 SARS-CoV-2 epitopes SARS-CoV-2-specific T cells spike T cell T cell epitopes T cell receptor T cell response TCR TCR sequencing TCRs the spike protein understanding virus [DOI] 10.1016/j.immuni.2020.11.004 PMC 바로가기 [Article Type] Article