AST – Page 10 – Communicable Diseases Research

Early prediction keys for COVID-19 cases progression: A meta-analysis

Review article

Published on 2021-05-012022-10-05
Journal: Journal of infection and public health [Category] SARS, 바이오마커,

Efficacy and safety of nelfinavir in asymptomatic and mild COVID-19 patients: a structured summary of a study protocol for a multicenter, randomized controlled trial

무증상 및 경증 COVID-19 환자에 대한 nelfinavir의 효능 및 안전성: 다기관, 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-04-282022-09-10
Journal: Trials [Category] SARS, 임상, 치료기술,

[키워드] 1:1 Administered administration adverse event adverse events age all-cause mortality ALT Analysis anticipated Antigen antiviral efficacy AST Asymptomatic asymptomatic patients blinded blinded outcome assessment Blinding blood glucose body temperature both group both groups capture caused childbearing potential clearance clinical Clinical efficacy clinical examinations Clinical symptoms clinical trial clinical trials comparator Patients condition Consent contraceptive method Controlled clinical trial cough COVID-19 creatinine creatinine clearance dataset Day defervescence diabete diabetes diarrhea discretion dissemination distribution drug element enrolled enrolment evaluate event exclusion criteria exploratory Factor female patient Fever Frequency Glucose group hazard ratio Hemophiliac Hemorrhagic history HIV infection hospital hypersensitivity incidence incidence rate Inclusion inclusion and exclusion criteria inclusion criteria Infection Informed consent initial investigator investigator-initiated investigators Japan Japanese LAMP limit log-rank test male Mild mild COVID-19 patient Mild disease mixed-effects model multicenter Nasopharyngeal swab Negative conversion Negative PCR nelfinavir null hypothesis number objective Open-label outcome oxygen Oxygen administration p value parallel group parameter participant Patient patients with asymptomatic PCR PCR test Pneumonia power Pregnancy primary endpoint Primary outcome principal investigator Probability probability distribution protocol random randomization Randomized Randomized controlled trial Registered registry reported required respiratory tract rifampicin room air safety endpoint Saliva saliva samples Sample size SARS-CoV-2 SARS-CoV-2 vaccination secondary efficacy endpoint serious complication serum creatinine severity specimen Standard status study period Study protocol supplementary material survival survival function Symptom symptomatic symptomatic COVID-19 Symptomatic treatment the log-rank test Three times daily Treatment treatment for HIV treatment period Trial Trial registration two-sided Unsuitable Viral viral dynamics Viral load virus was determined website Withdrawal withdrawal of consent
[DOI] 10.1186/s13063-021-05282-w PMC 바로가기 [Article Type] Letter

Severe COVID-19 Associated With Liver Injury in Patients Without Preexisting Liver Disease

Family/General Practice

Published on 2021-04-262022-10-31
Journal: Cureus [Category] COVID-19,

High Child-Pugh and CRUB65 scores predict mortality of decompensated cirrhosis patients with COVID-19: A 23-center, retrospective study

Research Article

Published on 2021-04-192022-10-28
Journal: Virulence [Category] COVID-19, SARS,

[키워드] activated adverse outcome age alanine aminotransferase ALT aPTT Aspartate aminotransferase AST bleeding characteristic Chinese hospitals cirrhosis collected Comorbidity Complication COVID-19 COVID-19 in patient COVID-19 patient COVID-19 severity Decompensated cirrhosis diarrhea disease enrolled health emergency Hospital admission index jaundice Logistic regression lymphocyte medical record Mortality multivariate multivariate logistic regression outcome Patient patients predict Predictive proportion provided reached receiver Result Retrospective study risk factor ROC severity shown significantly stratified total bilirubin
[DOI] 10.1080/21505594.2021.1909894 PMC 바로가기 [Article Type] Research Article

Correlation of Severity of COVID-19 Disease With Gastrointestinal Manifestations and Liver Injury – A North Brooklyn Community Hospital Experience: A Retrospective Cohort Study

Gastroenterology

Published on 2021-04-182022-10-31
Journal: Cureus [Category] COVID-19,

[키워드] 30-Day mortality 95% confidence interval ACE-2 acute respiratory syndrome Alanine ALT angiotensin-converting enzyme-2 Aspartate transaminase AST Brooklyn center Combination conducted Coronavirus-2 COVID-19 COVID-19 patients criterion Critical care diarrhea expressed Gastrointestinal Gastrointestinal symptom gastrointestinal tract hospital Hospital admission Hospital stay identify In-hospital Infection intensive care liver Liver function test liver parenchyma liver transaminase manifestation Mild Mortality nausea North Odds ratio outcome outcomes Patient patients patients with COVID-19 predict Presence Prognosis Protective receptor remained Result retrospective SARS-CoV-2 SARS-COV-2 infection Symptom Symptoms transaminases vomiting was used worsened
[DOI] 10.7759/cureus.14543 PMC 바로가기 [Article Type] Gastroenterology

Clinical characteristics of Egyptian male patients with COVID‐19 acute respiratory distress syndrome

이집트 남성 코로나19 급성호흡곤란증후군 환자의 임상적 특징

Research Article

Published on 2021-04-162022-09-10
Journal: PLoS ONE [Category] MERS, SARS, 바이오마커,

[키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alanine alanine aminotransferase ALT Analysis ARDS aspartate Aspartate aminotransferase association AST Biomarker Biomarkers blood biochemistry Blood routine C‐reactive protein can be used caused Characteristics clinical Clinical characteristics coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 severity COVID‐19 creatinine CRP D-dimer D‐dimer disease severity ferritin ferritin levels groups hemoglobin information involved Laboratory Lactate lactate dehydrogenase LDH lymphopenia male material monocyte monocyte count not significantly different objective parameter Participants Patient patients Platelet Platelet count predict RBC RBC count reported respiratory respiratory distress Result SARS-CoV-2 Serum ferritin severe acute respiratory syndrome Coronavirus Severe case severe cases severity syndrome the disease thrombotic
[DOI] 10.1371/journal.pone.0249346 PMC 바로가기 [Article Type] Research Article

Potential Predictors of Poor Prognosis among Severe COVID-19 Patients: A Single-Center Study

Research Article

Published on 2021-04-122022-10-31
Journal: The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie Médicale [Category] COVID-19,

[키워드] alanine aminotransferase ALT Aspartate aminotransferase association AST basophils Bilirubin blood cell count Blood urea nitrogen can be used changes in Comorbidity contagious coronavirus disease COVID-19 COVID-19 patient creatinine Critically ill patient D-dimer D-dimer level diagnosis and monitoring disease Disease progression early stage elevated eosinophils female patient help hemoglobin ICU increase in increased mortality Infection intensive care Intervention Laboratory test Lung disease lymphocyte management Monocytes Mortality neutrophil count outcome outcomes parameter Patient patients patients older Poor poor prognosis Potential predict profile Prognosis progression reducing mortality Result Retrospective study risk SARS-CoV-2-positive patients Serum ferritin significantly significantly higher
[DOI] 10.1155/2021/6656092 PMC 바로가기 [Article Type] Research Article

Liver injury is independently associated with adverse clinical outcomes in patients with COVID-19

간 손상은 COVID-19 환자의 불리한 임상 결과와 독립적으로 연관되어 있습니다

Article

Published on 2021-04-012022-09-11
Journal: Gut [Category] SARS, 치료제,

[키워드] 95% CI acute respiratory syndrome adjusted Admission admitted to ICU age Alanine alanine aminotransferase albumin ALT/AST aspartate Aspartate aminotransferase AST Beta Biochemistry cholestasis Clinical outcome coronavirus disease Coronavirus disease 2019 Corticosteroid Corticosteroids COVID-19 COVID-19 patient COVID-19 patients database death defined diabete diabetes Diagnosis died HCoV HCoVs Hepatitis Hong Kong human coronavirus hypertension ICU Injury intensive care intensive care unit interferon interferon beta Invasive mechanical ventilation limit liver Liver function Liver function test Liver injury Lopinavir Lopinavir-ritonavir men occurred Patient patients patients with COVID-19 primary end point retrospective cohort study ribavirin Ritonavir SARS patient SARS patients Severe acute respiratory syndrome Virological
[DOI] 10.1136/gutjnl-2020-321726 PMC 바로가기 [Article Type] Article

Sex- and age-specific clinical and immunological features of coronavirus disease 2019

Research Article

Published on 2021-03-262022-10-29
Journal: PLoS Pathogens [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome adult COVID-19 patient age age and sex alanine aminotransferase ALT Analysis analyzed assigned association AST B cell C-reactive protein (CRP CD8 cell count Concentration concentrations Control coronavirus coronavirus disease COVID-19 COVID-19 disease severity COVID-19 pathogenesis COVID-19 patient COVID-19 patients Critical CRP decrease determine disease feature female female patient females four group had more Immune profile immunological Immunological response incidence Infection Inflammatory response leukocyte limit Liver damage lymphocyte Lymphocyte count male males Multiple linear regression natural killer neutrophil count neutrophil counts NK cell Patient patients plasma positive previous study reduced resulting Retrospective study SARS-CoV-2 SARS-COV-2 infection Sex significantly higher susceptibility T cell T-cell Treatment variable Variation
[DOI] 10.1371/journal.ppat.1009420 PMC 바로가기 [Article Type] Research Article

Clinical Features and Risk Factors for In-Hospital Mortality From COVID-19 Infection at a Tertiary Care Medical Center, at the Onset of the US COVID-19 Pandemic

Original Research

Published on 2021-03-242022-10-29
Journal: Journal of Intensive Care Medicine [Category] COVID-19, MERS,

[키워드] Admission adverse outcomes age albumin AST benefit Care center clinical Clinical research clinical risk factor Cohort collected comorbid condition Comorbidity conducted congestive heart failure COVID-19 death Dementia Detroit Diagnosis died Factor fatal COVID-19 Fatality rate greater help hospital Hospital mortality hospitalized patients identify in-hospital mortality independent index Infection infections information initial Inpatient Intervention Laboratory laboratory biomarker laboratory data lymphocytopenia male malignancy management marker mitigate Mortality multivariable analysis Nasopharyngeal swab obesity observation Older Older age Onset pandemic Patient patients died patients with COVID-19 positive Primary outcome qSOFA remained retrospective cohort study risk factor RT-PCR significantly single-center Tertiary understanding vital signs WBC with COVID-19
[DOI] 10.1177/08850666211001799 PMC 바로가기 [Article Type] Original Research