Longitudinal clinico-serological analysis of anti-nucleocapsid and anti-receptor binding domain of spike protein antibodies against SARS-CoV-2SARS-CoV-2에 대한 스파이크 단백질 항체의 항-뉴클레오캡시드 및 항-수용체 결합 도메인의 종단 임상-혈청 분석Article Published on 2021-11-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, 치료법, [키워드] 240 days Analysis antibody Antibody Response Antibody responses Antibody titer Antibody titers Antigen Asymptomatic binding domain Clinical data collected correlated correlation COVID-19 patient COVID-19 patients Critical disease Disease progression Disease spectrum evaluated First wave followed by IgG IgG antibody IgG antibody response IgG response increase in longitudinal monitoring N protein NAb nAb response NAb titer NAb titers NAbs neutralizing antibody Neutralizing antibody response nucleocapsid pandemic Patient persistence POD post infection progression Protein RBD Re-infection Receptor binding domain response robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic severe disease Spike protein symptomatic symptomatic status the antibody response the disease the SARS-CoV-2 [DOI] 10.1016/j.ijid.2021.09.024 PMC 바로가기 [Article Type] Article
Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico ApproachResearch Article Published on 2021-10-262022-10-29 Journal: mBio [Category] COVID-19, MERS, SARS, [키워드] in silico prediction Alpha Amino acid amino acid change amino acid variation antigenicity association B.1.1.7 B.1.351 B.1.617 binding affinity binding domain collected Complete conformational change COVID-19 D614G dispersion E484K evade Evolution of SARS-CoV-2 genomic GISAID glycoprotein greater hACE2 Host hypothetical immune immunoinformatics immunological in silico information initiative lineages Mutation mutations N439K N501Y P.1 pandemic Positive selection positive-sense single-stranded RNA predicted prediction Protein residue S protein S protein variant SARS-CoV-2 SARS-CoV-2 variant sequence spike Surveillance the Spike Transmission Vaccines variants variants of concern Variation virus VOCs [DOI] 10.1128/mBio.02687-21 PMC 바로가기 [Article Type] Research Article
Predictors of neutralizing antibody response to BNT162b2 vaccination in allogeneic hematopoietic stem cell transplant recipientsResearch Published on 2021-10-242022-10-29 Journal: Journal of Hematology & Oncology [Category] COVID-19, [키워드] administration Adults affecting Allogeneic Analysis anti-RBD binding antibody binding domain BNT162b2 BNT162b2 mRNA vaccine CD4 Cell chronic chronic GVHD comparable correlated COVID-19 Cytometry cytometry analysis detectable Factor first vaccination Flow follicular GVHD healthy help helper T cell Hematopoietic cell transplantation identify immunization indicated marker memory B cell mRNA vaccination mRNA vaccine multivariate analyses Neutralizing Neutralizing antibody response Patient patients peripheral blood cell plasmacytoid dendritic cells postvaccination predictor RBD recipient reduced Registered response responses Result risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor significantly lower Stem cell transplantation supplementary material Switched B cells T cell T-SNE therapy vaccination Vaccine was performed were assessed wild type [DOI] 10.1186/s13045-021-01190-3 PMC 바로가기 [Article Type] Research
SARS-CoV-2 Vaccine Induced Atypical Immune Responses in Antibody Defects: Everybody Does their Best항체 결함에서 SARS-CoV-2 백신 유도 비정형 면역 반응: 모두가 최선을 다합니다Original Article Published on 2021-10-202022-09-12 Journal: Journal of Clinical Immunology [Category] MERS, SARS, 진단, [키워드] agammaglobulinemia age-matched control analyzed Anti-spike anti-Spike IgG antibody production Antibody Response Atypical B-cell B-cells binding domain BNT162b2 BNT162b2 vaccine Cohort common Common variable immune deficiencies COVID-19 CVID detectable generate Germinal center healthy heterogeneous IgA IgG immune response immune responses immunization induced infected patient infected patients infected with SARS-CoV-2 Infection memory Memory cells naïve occurred of BNT162b2 one patient Patient patients Primary antibody deficiencies raising RBD Reactions Receptor-binding-domain Reinfection response Result SARS-CoV-2 SARS-COV-2 infection second dose Seven Specific specificity Spike protein spike-specific IgG subsequent supplementary material T-cell T-cell Response T-cells undetectable vaccination Vaccine vaccine dose variable while X-linked X-linked agammaglobulinemia XLA [DOI] 10.1007/s10875-021-01133-0 PMC 바로가기 [Article Type] Original Article
An Antigenic Space Framework for Understanding Antibody Escape of SARS-CoV-2 VariantsArticle Published on 2021-10-062022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] anti-SARS-CoV-2 antibody antibody Antibody Response antigenic antigenic drift antigenic site binding domain build contribute epitope escape Evolution framework heterogeneous host immunity Human identify Immune escape Immunity Mutation N-terminal domain natural infection Neutralizing antibodies Neutralizing antibody response nine NTD overlap paratope polyclonal predict RBD Region residue risk SARS-CoV-2 Space Spike protein the RBD understanding vaccination Vaccine variant variants of concern virus VoC VOCs [DOI] 10.3390/v13102009 PMC 바로가기 [Article Type] Article
Active components in Ephedra sinica stapf disrupt the interaction between ACE2 and SARS-CoV-2 RBD: Potent COVID-19 therapeutic agentsEphedra Sinica STAPF의 활성 성분은 ACE2와 SARS-COV-2 RBD 사이의 상호 작용을 방해합니다 : 강력한 COVID-19 치료제Article Published on 2021-10-052022-08-31 Journal: Journal of ethnopharmacology [Category] MERS, SARS, 치료제, [키워드] 293T-ACE2 4-hydroxy-6-methoxyquinoline-2-carboxylic acid (PubChem CID: 22017520) 4-hydroxyquinoline-2-carboxylic acid (PubChem CID: 3845) 4,6-dihydroxyquinoline-2-carboxylic acid (PubChem CID: 440752) ACE2 ACE2-RBD activity alleviate angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Asia Asthma binding domain Calu calu-3 cells carboxylic acid carried cells Chinese Cold component Compound compounds cough COVID-19 COVID-19 therapeutic agent Deterioration disrupt disrupting docking domain effort ephedra Ephedra sinica Ethanol HPLC hydrogen Hydrogen bond hydroxy indicated inhibit inhibit SARS-CoV-2 inhibiting Inhibition assays inhibitory activity Interaction Isolation knock-out Lung diseases material mechanism molecular docking NMR observé potent potential therapeutic agent potential therapeutic agents PPI PPI inhibitor Prevent protein-protein interaction provided pseudoviruses PubChem quinoline Quinoline-2-carboxylic acid S protein SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 virus SARS-CoV-2 virus infection Spike protein SPR Structure structures suggested surface plasmon surface plasmon resonance Symptom TCM the SARS-CoV-2 therapeutic agents these compound these compounds Traditional Chinese medicine treat viropexis virus infection were used [DOI] 10.1016/j.jep.2021.114303 PMC 바로가기 [Article Type] Article
BNT162b2 Vaccination Elicits Strong Serological Immune Responses Against SARS-CoV-2 Including Variants of Concern in Elderly ConvalescentsBNT162b2 백신 접종은 노인 요양기의 우려 변종을 포함하여 SARS-CoV-2에 대한 강력한 혈청학적 면역 반응을 이끌어냅니다Observational Study Published on 2021-09-292022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 임상, 진단, [키워드] Against age analyzed anti-Spike IgG Antibody titer Antibody titers B.1.1.7 B.1.351 benefit binding domain BNT162b2 Care Comirnaty concern convalescent individual COVID-19 COVID-19-convalescent individual cross-reactive Efficacy elderly End End points Gender IgA titer IgA titers IgG titers immune response immune responses Including individual Long-term care MOST mRNA vaccine mutated neutralization capacity neutralization test Neutralizing neutralizing capacity P.1 pre-vaccination prospective observational cohort response SARS-CoV-2 SARS-CoV-2 receptor serological serum significantly higher strength Strong subject vaccination Vaccine vaccinees variants of concern VOCs [DOI] 10.3389/fimmu.2021.743422 PMC 바로가기 [Article Type] Observational Study
Association between Reactogenicity and Immunogenicity after Vaccination with BNT162b2Article Published on 2021-09-272022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome Adverse reaction Adverse reactions age Antibody Response association binding domain BNT162b2 center chose Control coronavirus COVID-19 detectable humoral humoral immune response IgG titer immune response immunogenicity information inhibitory concentration injection median men moderate neutralization activity participant provided RBD reactogenicity resulting robust SARS-CoV-2 SARS-CoV-2 RBD second vaccination severe adverse reaction Sex sick significantly higher university vaccination vaccinee women [DOI] 10.3390/vaccines9101089 PMC 바로가기 [Article Type] Article
Association of total and neutralizing SARS-CoV-2 spike -receptor binding domain antibodies with epidemiological and clinical characteristics after immunization with the 1 st and 2 nd doses of the BNT162b2 vaccineBNT162b2 백신의 1차 및 2차 접종 후 역학 및 임상 특성을 갖는 총 및 중화 SARS-CoV-2 스파이크 수용체 결합 도메인 항체의 연관성Article Published on 2021-09-242022-09-11 Journal: Vaccine [Category] SARS, 진단, 치료기술, [키워드] age antibody antibody levels association binding domain BMI BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine BNT162b2 vaccine Clinical characteristics clinical parameter Clinical parameters Cohort correlation COVID-19 COVID-19 vaccine dose elicited epidemiological females Final groups healthcare worker Immunity immunization Immunosuppressive medication immunosuppressive medications IQR median NAbs negatively affected Neutralizing Neutralizing antibodies neutralizing antibody Older age participant positive Protective Protein RBD Receptor binding domain SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein second dose significant difference smoking Spearman spike Spike protein statistical analysis statistically significant systemic adverse event systemic adverse events the vaccine vaccine dose vaccine doses was performed [DOI] 10.1016/j.vaccine.2021.07.067 PMC 바로가기 [Article Type] Article
SARS-CoV-2 mucosal antibody development and persistence and their relation to viral load and COVID-19 symptomsSARS-CoV-2 점막 항체 개발 및 지속성 및 바이러스 부하 및 COVID-19 증상과의 관계Observational Study Published on 2021-09-232022-09-12 Journal: Nature Communications [Category] SARS, 임상, 진단, 치료기술, [키워드] age analysed antibody Antibody Response binding domain correlated COVID-19 COVID-19 symptom disease symptom disease symptoms elevated Epidemiology faster household contacts index case index cases Mild mucosal mucosal immune Mucosal immunology nasal nine Older age pandemic persistence Primary infection Receptor binding domain remained Research respiratory symptoms SARS-CoV-2 SARS-COV-2 infection serological studies SEROLOGICAL STUDY serum antibody response shown Spike protein study inclusion symptom onset Symptoms systemic systemic symptoms viral infection Viral load [DOI] 10.1038/s41467-021-25949-x PMC 바로가기 [Article Type] Observational Study