SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2SARS-CoV-2 Omicron RBD는 인간 ACE2에 대해 현재 지배적인 Delta 변이체보다 약한 결합 친화력을 나타냅니다.Comment Published on 2022-01-052022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, [키워드] binding affinity Biochemistry Computational biology and bioinformatics delta variant dominant human ACE2 omicron RBD SARS-CoV-2 [DOI] 10.1038/s41392-021-00863-2 PMC 바로가기 [Article Type] Comment
An undergraduate laboratory experiment with real-world applications: Utilizing templateless polymerase chain reaction and real-time polymerase chain reaction to test for SARS-CoV-2 RNA실제 적용을 위한 학부 실험실 실험: 템플릿이 없는 중합효소 연쇄 반응과 실시간 중합효소 연쇄 반응을 활용하여 SARS-CoV-2 RNA 테스트Article Published on 2022-01-012022-09-11 Journal: Biochemistry and Molecular Biology Education [Category] SARS, 치료기술, [키워드] Biochemistry Biotechnology Chain Reaction Combination exercise experiment experimental protocols independent Laboratory laboratory exercise. Molecular biology polymerase chain polymerase chain reaction positive control primer Primers protocols Research RNA RNA extraction RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV2 [DOI] 10.1002/bmb.21593 PMC 바로가기 [Article Type] Article
Confusion and Hallucination: A Case Report of an Unusual Presentation of COVID-19Case Report Published on 2021-12-302022-10-31 Journal: Case Reports in Psychiatry [Category] COVID-19, [키워드] absence anticipated Anxiety Atypical Biochemistry Case report Confusion COVID-19 COVID-19 disease Culture described Diagnosis Fever Hallucination healthcare investigated involved less medical illness microbial outbreak pathophysiological mechanism polymerase chain positive presentation report reported respiratory symptoms SARS-CoV-2 Symptoms upper respiratory vital sign [DOI] 10.1155/2021/3794019 PMC 바로가기 [Article Type] Case Report
Designing a multi-epitope vaccine to provoke the robust immune response against influenza A H7N9Article Published on 2021-12-292023-05-31 Journal: Scientific Reports [Category] Fulltext, 조류인플루엔자, [키워드] Biochemistry Biotechnology Computational biology and bioinformatics immunology Molecular biology [DOI] 10.1038/s41598-021-03932-2 PMC 바로가기 [Article Type] Article
Liver Injury and Elevated FIB-4 Define a High-Risk Group in Patients with COVID-19Article Published on 2021-12-282022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Admission Analysis aspartate AST AST/ALT AUROC Biochemistry characteristic Computed tomography conducted consecutive patient COVID-19 disease elevated Elevation evaluate FIB-4 fibrosis Fibrosis-4 group heterogeneous hospitalized COVID-19 patients liver Liver disease liver steatosis liver test Liver tests Mortality Non-invasive outcome Patient patients with moderate Prognosis retrospective cohort study severe COVID-19 significantly higher steatosis survival susceptible threshold with COVID-19 [DOI] 10.3390/jcm11010153 PMC 바로가기 [Article Type] Article
Modulatory Effects of Physical Activity Levels on Immune Responses and General Clinical Functions in Adult Patients with Mild to Moderate SARS-CoV-2 Infections—A Protocol for an Observational Prospective Follow-Up Investigation: Fit-COVID-19 StudyProtocol Published on 2021-12-162022-10-04 Journal: International Journal of Environmental Research an [Category] SARS, 임상, [키워드] activity Adipose tissue analyzed approach baseline Biochemistry Blood blood sample body composition clinical collected conducted Control coronavirus coronavirus disease COVID-19 cytokine profile determine Effect evaluated Evidence exercise Exercise capacity explain expressed function functional healthy help homologous immune Immunity immunomodulatory in-vitro assay inactive individual Infection Inflammation Inflammatory information innate immune system knowledge Level long-COVID mechanism Mental mental health metabolic parameters metabolism Mild Moderate COVID-19 mononuclear cell obese participant Patient patients with COVID-19 PBMC PBMCs peripheral phenotypic physical physical activity physical activity level physically positive procedure Prospective prospective observational cohort provided Pulmonary function registry repeated-measures ANOVA Respiratory muscle strength respond response SARS-CoV-2 SARS-COV-2 infection Seahorse serum stimulated survival the SARS-CoV-2 virus the vaccine Trajectories treated vaccination venous viral infection virus [DOI] 10.3390/ijerph182413249 PMC 바로가기 [Article Type] Protocol
ACE and ACE2: insights from Drosophila and implications for COVID-19Review article Published on 2021-12-072022-10-05 Journal: Heliyon [Category] 변종, [키워드] accelerated ACE ACE2 Acer acute respiratory syndrome addition Ance Biochemistry Cardiovascular function catalytically cellular entry conserved coronavirus coronavirus disease COVID-19 COVID-19 pandemic Drosophila Drosophila melanogaster enzyme function functional highlight homologue homology identify implication in vivo knowledge mammalian organism orthologue pathogenicity peptides provide raise recent receptor renin-angiotensin system Research responsible SARS-CoV-2 therapeutic intervention unique utility Vaccine variants various coronaviruses Vasoactive Virus-host interaction [DOI] 10.1016/j.heliyon.2021.e08555 [Article Type] Review article
Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patientsArticle Published on 2021-12-032022-10-04 Journal: Scientific Reports [Category] 신약개발, 임상, 치료법, 치료제, [키워드] 95% CI 95% confidence interval acute respiratory distress association Biochemistry Computational biology and bioinformatics COVID-19 COVID-19 patient decrease Drug discovery Electronic health record Endocrine endocrinology Evidence hazard hazard ratio Health Hospitalization Hospitalized Kaplan–Meier survival curve metabolite metabolites Mortality mortality rate Patient patient survival patients Population Ratio retrospective cohort Risk factors severity of COVID-19 suggested Support survival syndrome were recorded [DOI] 10.1038/s41598-021-02701-5 PMC 바로가기 [Article Type] Article
Metabolites with SARS-CoV-2 Inhibitory Activity Identified from Human Microbiome CommensalsResearch Article Published on 2021-12-012022-10-30 Journal: mSphere [Category] COVID-19, SARS, [키워드] activity Anti-SARS-CoV-2 Activity Antiviral antiviral activities antiviral activity antiviral property antivirals Bacteria bacterial metabolite Bioactivity Biochemistry biological activities clinically commensal complement Compound COVID-19 COVID-19 pandemic Culture drug Evidence examined fraction functional host receptor Human Identified identify in vitro inhibit SARS-CoV-2 inhibiting inhibitory concentration Isolation ligands metabolite Microbiome Molecular biology natural antiviral phylogenetically platform prevalence of COVID-19 Prevent produced receptor reported SARS-CoV-2 SARS-COV-2 infection screened similarity small molecule Therapies Treatment variant viral infections Virology [DOI] 10.1128/mSphere.00711-21 PMC 바로가기 [Article Type] Research Article
Mechanistic principles of an ultra-long bovine CDR reveal strategies for antibody designArticle Published on 2021-11-182022-10-29 Journal: Nature Communications [Category] COVID-19, MERS, SARS, [키워드] Alpha variant antibodies antibody Antibody structure Antigen Biochemistry bovine CDR CDRs complementarity-determining region contribute Critical de novo disulfide bond Efficiency experiment feature flexible high affinity Interaction MD simulation neutralize Neutralizing organized Protein Protein design remained residue SARS-CoV-2 Spike protein stability the SARS-CoV-2 unique [DOI] 10.1038/s41467-021-27103-z PMC 바로가기 [Article Type] Article