The SARS-CoV-2 Nucleocapsid Protein and Its Role in Viral Structure, Biological Functions, and a Potential Target for Drug or Vaccine MitigationReview Published on 2021-06-102022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Biological biological function Biological functions component coronavirus drug drug target functional homology knowledge Like Mitigation N protein nucleocapsid nucleocapsid protein other coronaviruses Potential Protein role SARS-CoV-2 Spread Structure target the N protein the SARS-CoV-2 Vaccine vaccine candidate virus [DOI] 10.3390/v13061115 PMC 바로가기 [Article Type] Review
Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 SurvivorsCOVID-19 생존자의 생물학적 연령 가속 및 텔로미어 단축에 대한 증거Hypothesis Published on 2021-06-072022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, 바이오마커, 유전자 메커니즘, [키워드] acceleration ACE2 ACE2 expression age age determination alteration analyzed Biological biological age characterized Cohort COVID-19 CpG cytokine death defined DeltaAge determine difficulty DIFFICULTY CONCENTRATING DNA methylation DPP-4 Dyspnea Epigenetic epigenetics fatigue fibrosis Immunosuppression increase in Inflammatory cytokine memory memory loss non-infected normality post-COVID-19 Post-COVID-19 patients PPCs pyrosequencing respiratory distress SARS-COV-2 infection Severe respiratory distress shortening sleep disorders subject survivor Survivors syndrome telomere telomeres Volunteer world population younger patient younger patients [DOI] 10.3390/ijms22116151 PMC 바로가기 [Article Type] Hypothesis
IABS/CEPI platform technology webinar: Is it possible to reduce the vaccine development time?IABS/CEPI 플랫폼 기술 웨비나: 백신 개발 시간 단축이 가능한가?Article Published on 2021-06-012022-08-31 Journal: Biologicals : journal of the International Associa [Category] MERS, SARS, 변종, 신약개발, [키워드] Alliance backbone Biological Biological Standardization Coalition component COVID-19 COVID-19 vaccine development disease Diseases Emerging infectious diseases faster Genetic Infectious diseases Innovation input joint meeting organized pandemic pathogen Pathogens platform Platform technology protein sequences rapid response reduce Regulatory Regulatory Authorities regulatory authority SARS-CoV-2 the vaccine Vaccine development variants of SARS-CoV-2 [DOI] 10.1016/j.biologicals.2021.04.005 PMC 바로가기 [Article Type] Article
A Portrait of the OPE as a Biological Agent생물학적 제제로서의 OPE의 초상Review Published on 2021-05-212022-09-10 Journal: Molecules [Category] SARS, 치료기술, 치료제, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 agent antimicrobial Antiviral compounds Antiviral effect antiviral effects aromatic rings biocides Biological Cell coronavirus COVID-19 pandemic drug delivery systems Fluorescent probe induce living cells luminescent probe modulated oligomers oligophenylene ethynylenes organelle Pathogens photodynamic therapy Portrait position quantum yields researcher respiratory responsible selective sequence severe acute respiratory syndrome Coronavirus therapy Toxicity triple bonds virus [DOI] 10.3390/molecules26113088 PMC 바로가기 [Article Type] Review
Predict Score: A New Biological and Clinical Tool to Help Predict Risk of Intensive Care Transfer for COVID-19 PatientsArticle Published on 2021-05-182022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] age Analysis baseline Biological biological parameter biological parameters Biology Body C-reactive protein clinical Cohort composed COVID-19 COVID-19 crisis COVID-19 patient develop health care systems Hospitalization Hospitalized identify independent variable index intensive care lactate dehydrogenase limitation Marseille mass multivariate neutrophil–lymphocyte ratio New oxygen saturation Patient performed powerful tool Rate recruited respiratory risk score strained treated university validation cohort [DOI] 10.3390/biomedicines9050566 PMC 바로가기 [Article Type] Article
Molecular and Biological Mechanisms Underlying Gender Differences in COVID-19 Severity and MortalityCOVID-19 심각도 및 사망률의 성별 차이의 근간이 되는 분자 및 생물학적 메커니즘Review Published on 2021-05-072022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술, [키워드] ACE-2 ACE2 receptor angiotensin Biological caused Clinical outcome Comorbidities contribute COVID-19 COVID-19 patients detrimental difference disease epidemiological Factor Gender Gender difference genders highlighting Host immune response include involved male males mechanism molecules Mortality offer pandemic pathogenicity Prognosis progression protease Proteases RAS Renin renin-angiotensin system SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 vaccines severity sexual dimorphisms signaling molecule signaling molecules Vaccine Variation variations viral S viral S protein virus viruses [DOI] 10.3389/fimmu.2021.659339 PMC 바로가기 [Article Type] Review
Biological responses to COVID-19: Insights from physiological and blood biomarker profilesCOVID-19에 대한 생물학적 반응: 생리학적 및 혈액 바이오마커 프로필에서 얻은 통찰력Article Published on 2021-05-012022-08-31 Journal: Current research in translational medicine [Category] MERS, SARS, 바이오마커, [키워드] accompanied Admission adverse outcomes Analysis baseline best Biological biological response biological responses Biomarker Biomarkers Blood C-reactive protein Characteristics class Classes collected Comorbidities Comorbidity coronavirus disease Coronavirus disease 2019 Course COVID-19 CRP death declined elevated empirical evidence Evidence except for exhibited FIVE heterogeneous highest hospitalised Hyperinflammatory Hyperinflammatory response Implications Inflammation Inflammatory Inflammatory response insight intensive care kidney Kidney injury laboratory-confirmed Laboratory-confirmed COVID-19 Latent latent profile analysis lowest male measure median age mortality rate mortality risk neutrophil neutrophil counts older patients pathophysiology Patient performed physiological Platelet Platelet count profile provide provided renal renal failure response retrospective cohort study rising SARS-CoV-2 severe COVID-19 Spectrum targeted therapy therapeutic understanding unique was performed white cell [DOI] 10.1016/j.retram.2021.103276 PMC 바로가기 [Article Type] Article
Biological Cloth Face Coverings—The Reduction of SARS-CoV-2 and Influenza (H1N1) Infectivity by Viruferrin™ TreatmentArticle Published on 2021-04-302022-10-30 Journal: Materials [Category] COVID-19, [키워드] acute respiratory syndrome Aerosols Anti-viral application Biological Contact coronavirus COVID-19 decrease demonstrated droplet evaluated face Face masks FIVE H1N1 Infectious virus Infectivity influenza A influenza A virus influenza A viruses influenza viruses offer pandemic Particle Personal protective equipment personal protective material positive control reduce reduction remained Saliva SARS-CoV-2 significant difference stability statistically significant tested Transmission transmission of SARS-CoV-2 treated unique unlikely virus [DOI] 10.3390/ma14092327 PMC 바로가기 [Article Type] Article
Seasonal Stability of SARS-CoV-2 in Biological FluidsArticle Published on 2021-04-302022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Aerosols Biological biological fluid biological fluids Blood breast milk close contact condition conditions contaminated surfaces droplets environmental condition fomite half-life Human humans implication nasal occur potential risk remained Saliva SARS-CoV-2 SARS-CoV-2 stability SARS-CoV-2 transmission seasonal secreted significantly sputum stability surface survived transmission of SARS-CoV-2 Urine virus virus stability [DOI] 10.3390/pathogens10050540 PMC 바로가기 [Article Type] Article
Autoimmune Diseases and COVID-19 as Risk Factors for Poor Outcomes: Data on 13,940 Hospitalized Patients from the Spanish Nationwide SEMI-COVID-19 RegistryArticle Published on 2021-04-232022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Admission Admissions age all-cause mortality Analysis antirheumatic agents Autoimmune disease Autoimmune diseases Barthel Index Biological biological therapy Clinical characteristics Clinical course Comorbidity complications Corticosteroid COVID-19 death decrease diagnosed with COVID-19 disease disease-modifying anti-rheumatic drug Effects Factor female General population Glucocorticoids greater Habitual hospitalized patient ICU immune system diseases in-hospital complications increased risk information intensive care invasive involved mechanical ventilation Mortality multivariate logistic regression Non-invasive Older outcome outcomes Patient patients patients with COVID-19 Poor Primary outcome Prognosis readmission registry SARS-CoV-2 secondary outcome selected Spanish subsequent Treatment variables Weighting with COVID-19 [DOI] 10.3390/jcm10091844 PMC 바로가기 [Article Type] Article