capture – Page 10 – Communicable Diseases Research

An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility

인간 질병과 분자 표현형의 공유 유전 구조를 연결하는 아틀라스는 COVID-19 감수성에 대한 통찰력을 제공합니다

Software

Published on 2021-05-172022-09-10
Journal: Genome Medicine [Category] SARS, 유전자 메커니즘,

Unknown Disease Outbreaks Detection: A Pilot Study on Feature-Based Knowledge Representation and Reasoning Model

미지의 질병 발병 탐지: 기능 기반 지식 표현 및 추론 모델에 대한 파일럿 연구

Public Health

Published on 2021-05-132022-09-11
Journal: Frontiers in Public Health [Category] MERS, SARS, 치료기술, 치료제,

[키워드] Accuracy acute respiratory syndrome bases capture Clinical data COVID-19 COVID-19 case COVID-19 outbreak defined detect Diagnosis diagnostic disease disease outbreak disease outbreaks early response Emerging infectious disease feasibility illness onset IMPROVE Infection Infectious disease initial knowledge knowledge bases knowledge representation Local Logistic median time medical diagnosis medical expert systems MERS Middle East Middle East respiratory syndrome Model offer outbreak Outbreaks pandemic Pandemics Reasoning reasoning model reduced reliability representation respiratory response Severe acute respiratory syndrome shown Surveillance the median transfer Transmission Unknown unknown disease outbreaks Wuhan
[DOI] 10.3389/fpubh.2021.683855 PMC 바로가기 [Article Type] Public Health

Network medicine framework for identifying drug-repurposing opportunities for COVID-19

COVID-19에 대한 약물 용도 변경 기회를 식별하기 위한 네트워크 의학 프레임워크

435

Published on 2021-05-112022-08-31
Journal: Proceedings of the National Academy of Sciences of [Category] 신약개발, 치료제,

[키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Algorithm Algorithms approved approved drug approved drugs artificial intelligence best can not candidate capture clinical trial clinical trials clinically Compound Consensus coronavirus COVID-19 COVID-19 pandemic dataset de novo develop diffusion disease Diseases drug Drug repurposing drugs Effectiveness Efficacy evaluate expected human cell human cells identify infections Infectious diseases mechanism methodological Metrics network network medicine offer outcome pathogen Pathogens pathway Predictive Protein reduced respiratory SARS-CoV-2 screened screenings severe acute respiratory syndrome Coronavirus Significance Systems biology treat treatments for COVID-19 VeroE6 cells Viral viral infection
[DOI] 10.1073/pnas.2025581118 PMC 바로가기 [Article Type] 435

Automated, multiparametric monitoring of respiratory biomarkers and vital signs in clinical and home settings for COVID-19 patients

COVID-19 환자를 위한 임상 및 가정 환경에서 호흡기 바이오마커 및 바이탈 사인에 대한 자동화된 다중 매개변수 모니터링

Clinical Trial

Published on 2021-05-112022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 바이오마커, 임상, 진단,

[키워드] (heart rate ambient approach automated Biomarker Biomarkers biometrics can be used can not capture Care Continuous continuous monitoring Conventional Convolutional neural networks correlation correlations cough coughing Course COVID-19 COVID-19 infection COVID-19 infections COVID-19 pandemic COVID-19 patient COVID-19 patients Data analysis demographic groups Digital health disease disease spread Diseases effort events feature Frequency Health care health care workers Health status healthy control healthy controls healthy individual heart rate high fidelity high risk hospital Immunity individual Infection Infectious diseases infectiousness intensity limitations methodology monitoring system overcome parameter Patient physiological populations Probability quantitative measurement respiratory respiratory activity Respiratory disease respiratory rate response sick Significance Soft Spread temperature Therapeutics translational Trial Variation vital sign vital signs wearable electronics
[DOI] 10.1073/pnas.2026610118 PMC 바로가기 [Article Type] Clinical Trial

Efficacy and safety of nelfinavir in asymptomatic and mild COVID-19 patients: a structured summary of a study protocol for a multicenter, randomized controlled trial

무증상 및 경증 COVID-19 환자에 대한 nelfinavir의 효능 및 안전성: 다기관, 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-04-282022-09-10
Journal: Trials [Category] SARS, 임상, 치료기술,

[키워드] 1:1 Administered administration adverse event adverse events age all-cause mortality ALT Analysis anticipated Antigen antiviral efficacy AST Asymptomatic asymptomatic patients blinded blinded outcome assessment Blinding blood glucose body temperature both group both groups capture caused childbearing potential clearance clinical Clinical efficacy clinical examinations Clinical symptoms clinical trial clinical trials comparator Patients condition Consent contraceptive method Controlled clinical trial cough COVID-19 creatinine creatinine clearance dataset Day defervescence diabete diabetes diarrhea discretion dissemination distribution drug element enrolled enrolment evaluate event exclusion criteria exploratory Factor female patient Fever Frequency Glucose group hazard ratio Hemophiliac Hemorrhagic history HIV infection hospital hypersensitivity incidence incidence rate Inclusion inclusion and exclusion criteria inclusion criteria Infection Informed consent initial investigator investigator-initiated investigators Japan Japanese LAMP limit log-rank test male Mild mild COVID-19 patient Mild disease mixed-effects model multicenter Nasopharyngeal swab Negative conversion Negative PCR nelfinavir null hypothesis number objective Open-label outcome oxygen Oxygen administration p value parallel group parameter participant Patient patients with asymptomatic PCR PCR test Pneumonia power Pregnancy primary endpoint Primary outcome principal investigator Probability probability distribution protocol random randomization Randomized Randomized controlled trial Registered registry reported required respiratory tract rifampicin room air safety endpoint Saliva saliva samples Sample size SARS-CoV-2 SARS-CoV-2 vaccination secondary efficacy endpoint serious complication serum creatinine severity specimen Standard status study period Study protocol supplementary material survival survival function Symptom symptomatic symptomatic COVID-19 Symptomatic treatment the log-rank test Three times daily Treatment treatment for HIV treatment period Trial Trial registration two-sided Unsuitable Viral viral dynamics Viral load virus was determined website Withdrawal withdrawal of consent
[DOI] 10.1186/s13063-021-05282-w PMC 바로가기 [Article Type] Letter

A Novel Immunofluorescence Assay for the Rapid Serological Detection of SARS-CoV-2 Infection

SARS-CoV-2 감염의 신속한 혈청학적 검출을 위한 새로운 면역형광 분석법

Article

Published on 2021-04-242022-09-01
Journal: Viruses [Category] MERS, SARS, 변종, 진단, 치료기술,

Human ACE2-Functionalized Gold “Virus-Trap” Nanostructures for Accurate Capture of SARS-CoV-2 and Single-Virus SERS Detection

Article

Published on 2021-04-132022-10-30
Journal: Nano-Micro Letters [Category] COVID-19,

T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses

T 세포 분석은 임상 및 준임상 SARS-CoV-2 감염을 교차 반응성 항바이러스 반응과 구별합니다

Article

Published on 2021-04-062022-09-10
Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단, 치료기술, 치료제,

[키워드] Antigen antigens antiviral response capture cellular characteristic convalescent COVID-19 immune response cross-reactive cross-reactive immune response Cross-reactive immune responses dependent on ELISPOT Ex vivo healthcare worker ICS identification immune function immune response immune responses Immunity Immunological memory infected with SARS-CoV-2 Infection Lactate Memory responses multiple antigen multiple antigens ORF3 other coronaviruses PCR-confirmed populations pre-existing immunity proliferation Protective Protein response responses S1/S2 SARS-CoV-2 SARS-COV-2 infection seronegative Strong subunit T cell T cell assay T cell assays T cell proliferation T cell response T cell responses understanding uninfected viral infection volunteers
[DOI] 10.1038/s41467-021-21856-3 PMC 바로가기 [Article Type] Article

Single-step, wash-free digital immunoassay for rapid quantitative analysis of serological antibody against SARS-CoV-2 by photonic resonator absorption microscopy

광자 공명기 흡수 현미경으로 SARS-CoV-2에 대한 혈청학적 항체의 신속한 정량 분석을 위한 단일 단계, 무세척 디지털 면역분석

Article

Published on 2021-04-012022-09-11
Journal: Talanta [Category] MERS, SARS, 진단, 치료기술,

[키워드] Active capture and digital counting acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody antibody tests Antibody titer antigen-antibody interactions antigens Biomarkers Blood Blood Transfusion calculated capture coated with complex coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 counting COVID-19 COVID-19 antibody COVID-19 antibody test COVID-19 IgG Cytokines demonstrated Diagnosis Digital Donor donors Efficacy global public health gold human serum IgG IgGs immune response immunoassay interactions invasive limit Microscopy optical Photonic resonator absorption microscopy platform point-of-care Precision Protein quantification Quantitative Quantitative analysis quantitative measurement Recombinant spike protein respiratory route SARS-CoV-2 SARS-CoV-2 antibody serological Serological diagnosis serum serum samples Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus specific antigen Spike protein threat Transfusion therapy Vaccines Variability
[DOI] 10.1016/j.talanta.2020.122004 PMC 바로가기 [Article Type] Article

Between two storms, vasoactive peptides or bradykinin underlie severity of COVID‐19?

두 폭풍 사이에 혈관 활성 펩타이드 또는 브래디키닌이 COVID-19의 심각성을 뒷받침합니까?

Review

Published on 2021-03-092022-08-31
Journal: Physiological Reports [Category] 바이오마커, 진단,

[키워드] accumulation ACE acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition bradykinin capture cause caused complications contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 cytokine Cytokines develop disease disease severity dysregulated Evidence explain focus Inflammation mechanism microvascular permeability modulation molecular molecular mechanism neprilysin neurolysin neurotensin pandemic pathology Patient peptide peptidergic peptides primary mechanism progression provided respiratory responsible SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus severity Signaling substance P the disease Treatment underlie vascular permeability Vasoactive
[DOI] 10.14814/phy2.14796 PMC 바로가기 [Article Type] Review