xViTCOS: Explainable Vision Transformer Based COVID-19 Screening Using RadiographyxViTCOS: 방사선 사진을 사용한 설명 가능한 비전 변환기 기반 COVID-19 스크리닝Article Published on 2022-12-082022-09-10 Journal: IEEE Journal of Translational Engineering in Healt [Category] SARS, 치료기술, [키워드] AI for COVID-19 detection capture Care Chest radiography CNN code collapse country COVID-19 COVID-19 positive patient COVID-19 positive patients CT scan and CXR deep deep learning demonstrated diagnosis of COVID-19 feature globe Health Health care Health care system Healthcare system help identify imperative implementation inherent issue learning Localization outbreak outperform Radiography Radiologists reduce Region researcher resources RT-PCR Screening screening test Spread the disease transfer transformer verge Virus Disease vision vision transformer X-ray [DOI] 10.1109/JTEHM.2021.3134096 PMC 바로가기 [Article Type] Article
Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2기계 학습과 결합된 펩티드 마이크로어레이는 SARS-CoV-2에 대한 중화 기능을 가진 인간 항체 반응의 개별 에피토프를 나타냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] anti-SARS-CoV-2 antibody Antibody binding assays binding epitope capture causative agent cellular coronavirus coronavirus SARS-CoV-2 Course COVID-19 detectable epitope Epitopes human antibody response IgA IgG IgM antibody immunoassays incubated infected with SARS-CoV-2 machine learning Microarray N-terminus negative control samples neutralization neutralization assays Neutralizing Neutralizing antibodies nine overlapping Patient peptide peptide arrays peptides positive protective effect Protective effects random Random forest response S protein SARS CoV SARS CoV-2 SARS-CoV-2 sera serology Specific structural protein structural proteins the disease the S protein vaccine candidate vaccine candidates Viral [DOI] 10.1080/22221751.2022.2057874 PMC 바로가기 [Article Type] Article
X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturationArticle Published on 2022-09-032022-11-16 Journal: Nature Communications [Category] SARS, 변종, [키워드] Analysis Antiviral binding C-terminal C-terminally capture catalytic cause cleavage cleavage site cleavage sites Complete complex coronavirus 2 COVID-19 enzyme event form Interaction M pro maturation mutant non-structural protein pathogen plasticity polyprotein polyproteins Prevent protease provide representing respiratory responsible SARS-CoV-2 specificity substrates the SARS-CoV-2 therapeutic unique X-ray X-ray crystallographic structure [DOI] 10.1038/s41467-022-32854-4 PMC 바로가기
Electrochemical genosensor for the specific detection of SARS-CoV-2SARS-CoV-2의 특정 검출을 위한 전기화학적 제노센서Article Published on 2022-08-012022-09-11 Journal: Talanta [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] alternative biotinylated capture caused cell cultures complex complexes coronavirus disease COVID-19 cultures detect Diagnosis diagnostic discrimination disease DNA-RNA followed by Genosensor homologous horseradish peroxidase imperative in vitro Increases limit of detection maleimide molecular mortality rate Nanobioconjugate pandemic Particles peroxidase probe probes respiratory respiratory viruses responsible SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 detection sensitivity serological test Serological tests Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Signaling streptavidin Surveillance tested the patient virus [DOI] 10.1016/j.talanta.2022.123482 PMC 바로가기 [Article Type] Article
High SARS-CoV-2 seroprevalence in Karaganda, Kazakhstan before the launch of COVID-19 vaccinationCOVID-19 예방 접종이 시작되기 전에 카자흐스탄 카라간다에서 높은 SARS-CoV-2 혈청 유병률Article Published on 2022-07-272022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 95% CI Administered Antibody-mediated immunity appear Asia asymptomatic subjects capture Clinical characteristics Cohort collected Continuous correlated COVID-19 COVID-19 transmission COVID-19 vaccination death demographic and clinical characteristics detect detectable effort IgA IgG Immunity Infection Kazakhstan mitigate nasopharyngeal swabs National pandemic participant PCR-negative performed positive Prevalence provide public health Questionnaires recruited reported respiratory Respiratory illness RT-qPCR SARS-CoV-2 SARS-CoV-2 seroprevalence serological assays serological surveillance Serologically Seropositivity subject subset Swab tested the antibodies thresholds titre vaccination Virus neutralization were used [DOI] 10.1371/journal.pone.0272008 PMC 바로가기 [Article Type] Article
Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructuresSARS-CoV-2 스파이크 단백질과 DNA-펩티드 나노구조의 결합 상호작용 특성 규명Article Published on 2022-07-272022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Amino acid amino acid sequence analyte angiotensin angiotensin converting enzyme Beta binding binding interaction binding interactions binding modes capture characterization complement concentrations Corona virus DNA ELISA enzyme full-length spike protein geometric hACE2 immunosorbent inactivated increase in Interaction investigated moiety mono peptide Protein binding quantified Quantitative RBD receptor SARS-CoV-2 SARS-CoV-2 spike protein sequence Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus shown Spike protein Spike proteins subunit subunits tested the spike protein trimeric trivalent variant variations virus virus strain viruses while wild type [DOI] 10.1038/s41598-022-16914-9 PMC 바로가기 [Article Type] Article
Electrochemical immunosensors using electrodeposited gold nanostructures for detecting the S proteins from SARS-CoV and SARS-CoV-2SARS-CoV 및 SARS-CoV-2에서 S 단백질을 검출하기 위해 전기도금된 금 나노구조를 사용하는 전기화학적 면역센서Article Published on 2022-07-012022-09-11 Journal: Analytical and bioanalytical chemistry [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] amperometry Analysis antibody capture carbon carried Complete Device Diagnosis electrode Features gold Gold nanoparticles group immunosensor Ion limit of detection MAA mercaptoacetic acid monolayer point-of-care proof proof of concept Protein protocol reduction S protein S proteins Saliva SAM SARS-CoV SARS-CoV-2 selectivity sensitivity target protein target proteins the S protein Volume was performed was tested [DOI] 10.1007/s00216-022-03956-1 PMC 바로가기 [Article Type] Article
Ultrasensitive Detection of COVID-19 Virus N Protein Based on p-Toluenesulfonyl Modified Fluorescent Microspheres Immunoassayp-톨루엔설포닐 변형 형광 미소구 면역분석법을 기반으로 한 COVID-19 바이러스 N 단백질의 초고감도 검출Article Published on 2022-06-222022-09-11 Journal: Biosensors [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] addition antibody buffer capture caused coronary pneumonia COVID-19 COVID-19 N protein COVID-19 virus detect detection Detection limit Fc region fluorescent fluorescent microspheres group hydrophobic immunochromatographic immunochromatographic assay Infection ionic strength Lateral lateral flow lateral flow immunochromatographic assay LFIA Ligand Mortality N protein p-toluenesulfonyl. pandemic Pneumonia Population screening promote reactive reactivity strip sulfhydryl tosyl [DOI] 10.3390/bios12070437 PMC 바로가기 [Article Type] Article
Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients표적 포획 시퀀싱은 성인 혈액학 환자들 사이에서 호흡기 세포융합 바이러스 B 감염의 단일 클론 발병을 보여줍니다Article Published on 2022-06-212022-09-11 Journal: Antimicrobial Resistance and Infection Control [Category] Coronavirus, 변종, 치료기술, 치료제, [키워드] Analysis approach capture Capture probe sequencing capture sequencing cause caused circulating clinical samples contribute contributed Course COVID-19 pandemic demonstrated described disease Early detection effective Genome hematologic Hematologic malignancy hematological hematology hospital Hospital staff increased risk Infection infection control integration involved Isolation measure Measures molecular molecular analysis Molecular epidemiology monoclonal occur oligonucleotide probe outbreak Patient probe respiratory respiratory syncytial virus respiratory tract infection Respiratory tract infections respiratory virus respiratory viruses reveal RSV sequence Sequencing significantly strain target targeted prevention transmission pathways variant virus ward was performed whole-genome sequencing Winter [DOI] 10.1186/s13756-022-01120-z PMC 바로가기 [Article Type] Article
Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins기억 B 세포의 분석은 변이체 SARS-Cov-2 스파이크 단백질의 N-말단 도메인에서 보존된 중화 에피토프를 식별합니다Article Published on 2022-06-142022-09-11 Journal: Immunity [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] anti-NTD neutralizing antibodies. antibodies antibody capture Cell class clinical outcomes Cohort conserved contribute Course domain epitope Epitopes Gamma group identify infected individuals Infection memory B cell memory B cells N-terminal domain neutralized Neutralizing Neutralizing antibodies Neutralizing antibody response neutralizing antibody responses neutralizing epitope NTD omicron plasma Plasma cell probe producing Rapid RBD Re-infection Receptor-binding domain recruitment SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants Spike protein spike trimer Subsequent infection subsequent infections target targeted epitope vaccination variant [DOI] 10.1016/j.immuni.2022.04.003 PMC 바로가기 [Article Type] Article