Virus-induced senescence is a driver and therapeutic target in COVID-19
Research
[키워드] accompanied
activation of platelet
affected
airway
cascade
cells
cellular senescence
Clinical severity
Combination
complement
COVID-19
cytokine
demonstrated
eliminated
endothelial cells
endothelial damage
Escalation
Factor
Factors
feature
form
hallmark
Immune cell
infected cells
Inflammation
lung
Lung disease
Macrophage
macrophage activation
marker
mice
mucosa
Neutrophil extracellular trap
neutrophil infiltration
organ damage
pathogenic
phenotype
pro-inflammatory cytokines
quercetin
reduced
SARS-CoV-2
SARS-CoV-2-infected hamster
SASP
secretion
Serum level
Stress
supernatant
therapeutic target
thrombosis
Treatment
viral infections
virus-infected cell
viruses
widespread
with COVID-19
[DOI] 10.1038/s41586-021-03995-1 [Article Type] Research
[DOI] 10.1038/s41586-021-03995-1 [Article Type] Research