Computational Alanine Scanning and Structural Analysis of the SARS-CoV-2 Spike Protein/Angiotensin-Converting Enzyme 2 Complex
Article
[키워드] ACE2
ACE2 receptor
acute respiratory syndrome
allelic variant
angiotensin-converting enzyme 2
Blood
cellular receptor
computational alanine-scanning mutagenesis
contributing to
coronavirus
coronavirus disease
COVID-19
COVID-19 patient
Critical
D38
determinant
domain
effective
etiological agent
free energy
of binding
global pandemic
global public health
glycoprotein
homeostasis
Host
in silico
inhibitor
Interaction
K31
K353
molecular
mechanics/Poisson−Boltzmann surface area
molecular
molecular dynamics
Neutralizing antibodies
New coronavirus
pathogen
provide
Q498
Quantitative
R403
Receptor-binding domain
residue
S-protein
SARS-CoV-2
SARS-CoV-2 host cell
SARS-CoV-2 spike protein
scanning
spike
stability
structure-based design
T500
the binding affinity
the receptor-binding domain
the SARS-CoV-2
transmembrane spike
Vaccines
Vascular
Viral protein
Volume
[DOI] 10.1021/acsnano.0c04674 PMC 바로가기 [Article Type] Article
[DOI] 10.1021/acsnano.0c04674 PMC 바로가기 [Article Type] Article