Transcription Factors Encoded on Core and Accessory Chromosomes of Fusarium oxysporum Induce Expression of Effector GenesFusarium oxysporum의 코어 및 액세서리 염색체에 인코딩된 전사 인자는 이펙터 유전자의 발현을 유도합니다Research Article Published on 2016-11-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accessory accessory chromosome accessory chromosomes activate autonomous bind binding site chromatin chromatin condensation chromosome chromosomes colonisation connection conserved constitutive promoter core core genome determine DNA binding effector effectors ENCODE Evolution example expression extreme facilitate Factor FTF1 FTF2 fungal fungi Fusarium GC content Gene Expression Genes Genome genomic genomic region homolog homolog FTF2 homologous Host independent induce Infection Interaction investigated maintain motif motifs nine occurred oligonucleotide oligonucleotide arrays outcome overlapping pathogen Pathogenesis pathogenic pathogenicity Pathogens predicted promoters reference strain Region required RNAseq analysis secreted Sge1 specificity strain Strains tomato Transcription transcription factor transcription factor gene transcription factor genes transcription factors transcriptional transcriptionally transfer transferred transposon up-regulated virulence yeast [DOI] 10.1371/journal.pgen.1006401 PMC 바로가기 [Article Type] Research Article
Neocentromeres Provide Chromosome Segregation Accuracy and Centromere Clustering to Multiple Loci along a Candida albicans Chromosome네오센트로미어는 칸디다 알비칸스 염색체를 따라 여러 유전자좌에 염색체 분리 정확도 및 중심체 클러스터링을 제공합니다Research Article Published on 2016-09-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accuracy adaptation addition approach assembly benefit Cancer cancer cell Cancer cells cancers Candida Candida albican Candida albicans caused Cell cell division centromere change Chemotherapy chromosome chromosome 5 chromosome segregation chromosomes Cluster Clustering complexes consequence Contact copy number de novo defined disease DNA DNA sequence drug resistance error rate exhibit function functional functions Gene Expression Genes Genome greater independent independent of instance kinetochore leads Like loci maintain mechanisms Multiple nuclear nucleus observation occur organism protein complex Proteins provide recent reduced Region reorganization required segregation speciation stability Support the cells three-dimensional structure Transcription yeast [DOI] 10.1371/journal.pgen.1006317 PMC 바로가기 [Article Type] Research Article
Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure심부전의 사망률과 관련된 염색체 5q22의 유전적 변이 발견Research Article Published on 2016-05-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting activate addition African allergic allergy applied approach assays association Asthma Blood Cell chemokine chemokines chromosome clinical trial clinical trials cytokine death dendritic cell dendritic cells determinant development DNA methylation ENhance enhancer region epigenomic Evidence evidence of expressing expression Factor failure Follow-up gene encode Genetic Genetic variant Genome-wide association studies Genome-wide association study genotyping heart heart failure HEK293 high mortality human cell human tissues identify increase increased risk independent induce inhibiting knockdown leads maintain Mast cells maturation Meta-analysis molecular Monocytes Mortality multiple tissues NHLH1 Patient performed polymorphism Population populations Positive selection predicted promote replicated reporter reporter gene responses risk allele subject T helper T-cell therapeutic Therapeutics Therapies transcription factor TSLP turn variant Whole blood [DOI] 10.1371/journal.pgen.1006034 PMC 바로가기 [Article Type] Research Article
A Conserved DNA Repeat Promotes Selection of a Diverse Repertoire of Trypanosoma brucei Surface Antigens from the Genomic Archive보존된 DNA 반복은 게놈 아카이브에서 트리파노소마 브루세이 표면 항원의 다양한 레퍼토리 선택을 촉진합니다Research Article Published on 2016-05-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated addition African African trypanosomiasis antigenic variation archive assumption bloodstream catastrophic Cell cell cycle Chromosomal translocation Chromosomal translocations chromosome chronic condition conserved demonstrated DNA DNA sequence Donor event expression gene conversion genetic change Genome genomic homolog homology Host Hypothesis identify implicated induce infect Infection iteration mammalian manipulation natural infection observation observé outcome parasite pathogen Pathogens promote Protein proximal Recombination recombination event reduction in Region Repeat repertoire required selected Selection sequence silent species Support surface Surface glycoprotein switching synthetic tested the cell These data transcribed translocation Trypanosoma Trypanosoma brucei Trypanosome trypanosomiasis Variant Surface Glycoprotein VSG [DOI] 10.1371/journal.pgen.1005994 PMC 바로가기 [Article Type] Research Article
Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common VirusesHLA 클래스 II 단백질의 아미노산 변이는 일반적인 바이러스에 대한 체액 반응의 주요 결정 요인입니다Report Published on 2015-11-052022-08-07 Journal: American Journal of Human Genetics [Category] 유전자 메커니즘, [키워드] acid affecting Amino acid amino acid residue Antigen association Autoimmune disease Autoimmune diseases causal variant chromosome chromosome 6 class common complex determinant EBV Epstein-Barr virus Genome-wide association studies Genome-wide association study HLA HLA class II HLA class II variation HLA-DRβ1 haplotype HLA-DRβ1 haplotypes human antibody response human genetic contribution humans humoral humoral immune response Humoral response humoral-response regulation immunocompetent adults Immunoglobulin Immunoglobulin G immunoglobulin G response Influenza influenza A influenza A virus JC polyomavirus leucocyte Local magnitude Major major histocompatibility complex Merkel cell Merkel cell polyomavirus modulation overlap pathogen-specific role pathogenic virus pathogenic viruses performed Protein response Significant the major histocompatibility these viruses Variability variant variants Variation Viral Viral antigen viral antigens virus virus-specific pattern virus-specific patterns viruses [DOI] 10.1016/j.ajhg.2015.09.008 PMC 바로가기 [Article Type] Report
Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative CrossResearch Article Published on 2015-10-092022-10-28 Journal: PLoS Genetics [Category] Coronavirus, [키워드] Animal host animal model approach assist candidate gene chromosome classical complex contribute contributing to disease disease severity E3 ubiquitin ligase evaluate fiber Genes Genetic genetic data Genetic variation genetics genome region Health highly pathogenic Host host gene identification identify Inflammation Inflammatory response knockout mice loci locus Lung pathology mice microbial mouse model New Noncoding RNAs outcome outcomes pathogen Pathogenesis Pathogens pathology phenotype phenotypic platform populations regulate resource respiratory viruses responses SARS patient SARS-CoV SARS-CoV infection single gene Spread statistical susceptibility loci the disease traits transcriptomic data utility Vascular viral titer virus replication viruses weight loss were used [DOI] 10.1371/journal.pgen.1005504 PMC 바로가기 [Article Type] Research Article
Unisexual Reproduction Drives Meiotic Recombination and Phenotypic and Karyotypic Plasticity in Cryptococcus neoformans단성 생식은 Cryptococcus neoformans에서 감수성 재조합과 표현형 및 핵형 가소성을 유도합니다Research Article Published on 2014-12-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele alleles analyzed Aneuploidy asexual asexual reproduction bisexual reproduction C. neoforman C. neoformans Candida albican Candida albicans characterized chromosomal chromosomal region chromosome chromosome 4 chromosomes collected comparison Cryptococcus Cryptococcus neoforman Cryptococcus neoformans diploid meiotic progeny drive duplication Evidence Evolution examined Frequency fungal fungal pathogen fungi heterozygosity implication initiated loss of heterozygosity MAT locus mating type mating types meiosis meiotic meiotic progeny meiotic recombination mitotic mitotic recombination mixing genetic material occur occurred Pathogenesis Pathogens phenotype phenotypic produced producing progeny quantification Quantitative Recombination recombination frequencies reflected Region regions reported reproduction sexual development sexual reproduction similarity spore spores thought undergo while [DOI] 10.1371/journal.pgen.1004849 PMC 바로가기 [Article Type] Research Article
A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach새로운 MMP12 유전자좌는 게놈 전체 발병 연령 정보 접근 방식을 사용하여 대동맥 죽상경화성 뇌졸중과 연관됩니다Research Article Published on 2014-07-312022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (atherosclerosis) affected affection age analyses Analysis approach arteries Artery association associations Atherosclerosis atherosclerotic carotid carotid artery chromosome chromosome 11 Conditioning controls covariate demonstrated detect disease disease risk European evaluate Evidence evidence of examined explain Fold change fraction genetic association genetic associations genetic component Genetic predisposition Genetic variant Genome-wide association studies global healthcare GWAS heterogeneity identify IMPROVE increased risk independent information Informed investigated ischaemic stroke large artery lead loci locus Meta-analysis MMP12 mRNA expression novel novel association novel associations overexpressed performed phenotype phenotypic plaque plaques power prevalence rate prevalence rates Regression regression analysis Replication risk significantly small vessel SNP association SNP associations stroke subtype Subtypes the disease variant variants was performed [DOI] 10.1371/journal.pgen.1004469 PMC 바로가기 [Article Type] Research Article
Sequence of a Complete Chicken BG Haplotype Shows Dynamic Expansion and Contraction of Two Gene Lineages with Particular Expression Patterns완전한 치킨 BG 일배체형의 시퀀스는 특정 발현 패턴을 가진 두 유전자 계통의 동적 확장 및 수축을 보여줍니다Research Article Published on 2014-06-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin allelic Antigen presentation appear association Autoimmune disease Autoimmune diseases B12 brush border Cell cells change chicken chromosome chromosome 2 CNV complex contraction copy number Deletion domain dynamic Evolution expansion expressed expression family fixed Genes genetic association genetic associations Haplotype haplotypes homolog homologue homologues Human humans identify immune immune gene immune genes Immunity implicated Interaction intestinal involved major histocompatibility complex mammal mammals MHC multigene families multigene family myosin Particular pathogen Pathogens pattern polymorphism promoter promoters Recombination Region scrutiny sequence show single gene species tandem repeats the major histocompatibility tissue tissue expression tissues undergo untranslated regions Variation Viral diseases whole genome [DOI] 10.1371/journal.pgen.1004417 PMC 바로가기 [Article Type] Research Article
A HECT Ubiquitin-Protein Ligase as a Novel Candidate Gene for Altered Quinine and Quinidine Responses in Plasmodium falciparum플라스모듐 팔시파룸(Plasmodium falciparum)에서 변경된 퀴닌 및 퀴니딘 반응에 대한 새로운 후보 유전자로서의 HECT 유비퀴틴-단백질 리가제Research Article Published on 2014-05-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Altered Analysis antimalarial antimalarial drug Asia association candidate candidate gene changes in chromosome chromosome 13 complex conducted contribute contributing to cross cytotoxic activity defend demonstrated drug Efficacy experiment Factor Factors Genetic genetic screens genetic trait identify IMPROVE initial isolate Laboratory Ligase likelihood locus malaria malaria parasite moderate multiple allele multiple alleles mutated novel occur P. falciparum Plasmodium falciparum preservation progeny Quantitative quantitative trait locus quinidine Quinine response responsiveness segment sensitivity strain subset Surveillance susceptibility These data Treatment treatment failure ubiquitin ligase [DOI] 10.1371/journal.pgen.1004382 PMC 바로가기 [Article Type] Research Article