Chimeric Porcine Deltacoronaviruses with Sparrow Coronavirus Spike Protein or the Receptor-Binding Domain Infect Pigs but Lose Virulence and Intestinal TropismArticle Published on 2021-01-172022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Alter cDNA chimeric Clinical signs clone diarrhea domain evaluate fecal gnotobiotic group Host identity infect initial inoculated intestinal tract intestine log nasal nasal swab Neonatal nucleotide Pathogenesis phenotype pig Porcine deltacoronavirus Protein RBD reduced reverse genetics S protein Sparrow spike spillover Strains the RBD the S protein tissue tropism tropism upper respiratory viral replication Viral RNA Viral RNA shedding virus [DOI] 10.3390/v13010122 PMC 바로가기 [Article Type] Article
SARS-CoV-2 in Danish Mink Farms: Course of the Epidemic and a Descriptive Analysis of the Outbreaks in 2020Article Published on 2021-01-122022-10-28 Journal: Animals : an Open Access Journal from MDPI [Category] COVID-19, [키워드] Neovision vision Clinical sign Clinical signs close contact collected Contact COVID-19 COVID-19, increased mortality Denmark disease Environment evaluated examined feed intake global pandemic humans increase in increased mortality Infection median mink Netherland Netherlands number of infected occurred outbreak positive Prevalence rapid increase respiratory symptom SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 prevalence Seroprevalence simple Spread spread to susceptible tested Transmission virus virus transmission [DOI] 10.3390/ani11010164 PMC 바로가기 [Article Type] Article
Genetic manipulation of porcine deltacoronavirus reveals insights into NS6 and NS7 functions: a novel strategy for vaccine designArticle Published on 2020-12-202022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, MERS, [키워드] accessory protein cause cDNA Clinical signs clone coronavirus described diarrhea effective exhibited fluorescent full-length generate genetics GFP high mortality in viral in vitro in vivo Infection infectous clone Injury inoculated live-attenuated vaccine mutant virus Neonatal outbreak Pathogenesis PDCoV platform Porcine deltacoronavirus Protein provide reduction replacing replicate Replication resulting reveal start codon Vaccine Vaccine design viral titer virulence widespread wild-type [DOI] 10.1080/22221751.2019.1701391 PMC 바로가기 [Article Type] Article
Effects of curcumin-piperine co-supplementation on clinical signs, duration, severity, and inflammatory factors in patients with COVID-19: a structured summary of a study protocol for a randomised controlled trialCOVID-19 환자의 임상 징후, 기간, 중증도 및 염증 요인에 대한 커큐민-피페린 공동 보충제의 효과: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2020-12-172022-09-10 Journal: Trials [Category] 임상, [키워드] 1:1 age analyses anticipated Anticoagulant anticoagulant drugs assigned Blinding calculated Capsule clinical Clinical signs Clinical symptoms clinical trial clinical trials Co-supplementation completion conducted control group coronavirus coronavirus disease COVID-19 Curcumin Curcumin-piperine Diagnosis dinner disease Disease duration dissemination double-blind drugs Effect Efficacy element Enrollment exclusion criteria female Gender hospital hospital ward Hospital wards ICU include independent Inflammatory factor inflammatory factors inflammatory mediator Inflammatory mediators Inpatient intensive care intensive care unit Intervention Iran less male maltodextrin matching placebo mediators Medical Sciences number objective outcome Outpatient packaged Parallel Arm participant Patient patients PCR test piperine Placebo placebo-controlled placebo-controlled clinical trial protocol provided randomised randomised controlled trial Randomized Randomly receive Registered registration date registry researcher Sample size sealed sensitivity sequence severity status Stratification Study protocol supplementary material title total sample size Trial Trial registration turmeric university Version Warfarin website [DOI] 10.1186/s13063-020-04924-9 PMC 바로가기 [Article Type] Letter
Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility골든 시리아 햄스터 모델에서 코로나바이러스 질병 2019(COVID-19)의 임상 및 병리학적 징후 시뮬레이션: 질병 발병 및 전염성에 대한 의미Article Published on 2020-12-032022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 진단, 치료법, [키워드] ACE2 Activation adaptive airway alveolar damage angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal Antibody titer Antibody titers Apoptosis atrophy binding Blood change chemokine clinical Clinical sign Clinical signs Contact convalescent serum coronavirus COVID-19 Diffuse alveolar damage docking expression hamster hamsters histopathological Histopathology immunoprophylaxis initial intestinal involvement with Koch's postulates Laboratory lung Lung pathology lung viral load lymphoid mammal manifestation molecular docking Mortality Mutation Neutralizing antibody titer nonsynonymous option organ Pathogenesis pathological pathology performed physiological proliferative rapid breathing Receptor-binding domain resulting SARS-CoV-2 Serum neutralizing antibody significant decrease Simulation Spike protein spleen suggested the receptor-binding domain tissue tissue repair titer Transmission Treatment vaccination Viral Viral load viral nucleocapsid protein virus virus titer viruses weight loss [DOI] 10.1093/cid/ciaa325 PMC 바로가기 [Article Type] Article
Asymptomatic deep vein thrombosis in critically ill COVID-19 patients despite therapeutic levels of anti-Xa activity치료 수준의 항-Xa 활성에도 불구하고 중환자 COVID-19 환자의 무증상 심부 정맥 혈전증Comment Published on 2020-12-012022-09-11 Journal: Thrombosis research [Category] SARS, 치료기술, [키워드] anticoagulation Clinical sign Clinical signs COVID-19 patient Critically ill critically ill COVID-19 patients dose DVT occur Prevalence severe COVID-19 patients therapeutic thrombosis [DOI] 10.1016/j.thromres.2020.08.043 PMC 바로가기 [Article Type] Comment
Clinical Characteristics of Hospitalized Patients with COVID-19 in Sofia, BulgariaArticle Published on 2020-12-012023-07-06 Journal: Vector Borne and Zoonotic Diseases [Category] SARS, [키워드] Clinical outcome Clinical signs COVID-19 imaging procedures Laboratory results therapy [DOI] 10.1089/vbz.2020.2679
Lung ultrasound in outpatient approach to children with suspected COVID 19COVID 19 의심되는 어린이에 대한 외래 환자 접근의 폐 초음파Observational Study Published on 2020-11-232022-09-10 Journal: Italian Journal of Pediatrics [Category] SARS, 임상, 진단, 치료기술, [키워드] absence addition analysed approach children clinical examination Clinical sign Clinical signs cough COVID 19 detect diagnostic diagnostic test diagnostic tests disease distress Dyspnoea evaluate Evidence evidence of Fever Frequency highlight Hypoxemia Infection interstitial Italy lesion lung Lung injury lung involvement lung lesion lung lesions medical resource Mild Mild disease nasal swab observation pandemic performed persistent cough reliability reported respiratory distress Result Symptom test results [DOI] 10.1186/s13052-020-00938-w PMC 바로가기 [Article Type] Observational Study
Seroprevalence of anti‐SARS‐CoV‐2 antibodies in COVID‐19 patients and healthy volunteers up to 6 months post disease onset질병 발병 후 최대 6개월까지 COVID-19 환자 및 건강한 지원자에서 항-SARS-CoV-2 항체의 혈청유병률Clinical Trial Published on 2020-11-102022-08-13 Journal: European Journal of Immunology [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] age Anti‐SARS‐CoV‐2 antibody response Anti‐SARS‐CoV‐2 antibody responses anti‐SARS‐CoV‐2 IgG antibody antibody antibody production Antibody Response Antibody titer Asymptomatic circulating classic Clinical signs COVID‐19 COVID‐19 patient COVID‐19 described detect detectable disease onset Fever healthcare Healthcare workers healthy volunteer highlight hospital human pathogen humoral immune response IgA antibodies IgA antibody IgG IgG antibodies IgM immune response immunological information initial longitudinal analysis men Mild MONITOR neutralising antibody neutralization activity Neutralizing antibodies Patient peaking proportion protective immunity Protein provide quantified rapid increase RBD receptor‐binding domain recognizing reduce remained robust SARS‐CoV‐2 SARS‐CoV‐2 screened Seroprevalence setup Severity of disease Spread subject subjects Symptoms tested the Spike titre titres university virus volunteers were infected [DOI] 10.1002/eji.202048970 PMC 바로가기 [Article Type] Clinical Trial
SARS-CoV-2 infection, disease and transmission in domestic catsResearch Article Published on 2020-10-252022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] abnormality airway animal antibody Antigen Asymptomatic Blood Bronchoalveolar lavage fluid cats Clinical course Clinical signs clinically coronavirus 2 Course COVID-19 Critical disease felines Host intranasal introduced nasal Oropharyngeal pandemic performed postmortem examination recent rectal swab replicate respiratory responsible risk RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 susceptibility susceptibility susceptible Transmission various tissues Viral RNA viral shedding virus [DOI] 10.1080/22221751.2020.1833687 PMC 바로가기 [Article Type] Research Article