Gold nanoparticle based plasmonic sensing for the detection of SARS-CoV-2 nucleocapsid proteinsSARS-CoV-2 뉴클레오캡시드 단백질 검출을 위한 금 나노입자 기반 플라즈몬 감지Article Published on 2022-01-012022-09-11 Journal: Biosensors & bioelectronics [Category] SARS, 치료기술, 치료법, [키워드] Absorption spectrum aggregation assistance biosensors characterized Colorimetric Concentration concentrations COVID-19 virus defined detect detection diagnostics gold Gold nanoparticle identify intensity linear relationship LSPR methodology N protein N proteins naked eye optical Pandemics parameter Plasmonic GNP POC point-of-care Protein Proteins Quantitative SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 nucleocapsid Sensitivity and specificity surface plasmon surface plasmon resonance the N protein virus virus detection [DOI] 10.1016/j.bios.2021.113669 PMC 바로가기 [Article Type] Article
Association of Vitamin D Status and COVID-19-Related Hospitalization and MortalityOriginal Research Published on 2022-01-012022-10-31 Journal: Journal of General Internal Medicine [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Affair Blood Care Clinical outcome Cohort cohort study Concentration concentrations conducted Contact Continuous continuous variable Controlled trial coronavirus covariate covariates COVID-19 death deficiency Department died evaluate exposure Health homogeneous Hospitalization independent Isolation log-transformed measure Mortality objective outcomes Patient patients Population positive Probability receiving Result risk SARS-CoV-2 SARS-CoV-2 test social determinant status study outcome supplementary material veteran Vitamin D Vitamin D status Vitamin D supplementation [DOI] 10.1007/s11606-021-07170-0 PMC 바로가기 [Article Type] Original Research
A Tri-Channel Oxide Transistor Concept for the Rapid Detection of Biomolecules Including the SARS-CoV-2 Spike ProteinSARS-CoV-2 스파이크 단백질을 포함한 생체 분자의 신속한 검출을 위한 삼중 채널 산화물 트랜지스터 개념Article Published on 2022-01-012022-09-11 Journal: Advanced Materials (Deerfield Beach, Fla.) [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody Biomolecule Concentration concentrations concept conditions coronavirus demonstrated detect detection electron mobility electrostatic heterojunction highlighting Including Interaction large-area electronics metal oxide semiconductors Oxide Perturbation physiological Rapid real time receptors required respiratory robust S1 protein SARS-CoV-2 sensor severe acute respiratory syndrome Coronavirus solid-state devices solution solution process spike the SARS-CoV-2 transistor transistors sensors. unique [DOI] 10.1002/adma.202104608 PMC 바로가기 [Article Type] Article
The pH Dependence of Niclosamide Solubility, Dissolution, and Morphology: Motivation for Potentially Universal Mucin-Penetrating Nasal and Throat Sprays for COVID19, its Variants and other Viral Infections니클로사미드 용해도, 용해도 및 형태의 pH 의존성: COVID19, 그 변종 및 기타 바이러스 감염에 대한 잠재적으로 보편적인 점액 침투 비강 및 인후 스프레이에 대한 동기Article Published on 2022-01-012022-09-11 Journal: Pharmaceutical research [Category] 변종, 치료제, [키워드] Bioavailability cold chain Concentration concentrations contagious coronavirus COVID19 dependence dissolution distribution early treatment effective Efficacy epithelial cells Final help host cell host cell modulation Infection Local morphology motivation much lower nasal niclosamide niclosamide-solubility observé pandemic pH-dependent-dissolution polymorph precipitated Prevent Prophylactic reduce respiratory viral infections resulting sigma solubility Spectroscopy spray supernatant supersaturated solution Throat treat Universal universal nasal-throat-spray variants viral infection viral infections Viral load was used were measured [DOI] 10.1007/s11095-021-03112-x PMC 바로가기 [Article Type] Article
Small molecule interactions with the SARS-CoV-2 main protease: In silico all-atom microsecond MD simulations, PELE Monte Carlo simulations, and determination of in vitro activity inhibitionSARS-CoV-2 주요 프로테아제와의 소분자 상호작용: 인실리코 전 원자 마이크로초 MD 시뮬레이션, PELE 몬테카를로 시뮬레이션 및 시험관 내 활성 억제 결정Article Published on 2022-01-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] MERS, SARS, 변종, 진단, 치료제, [키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral caused clinical evaluation clinical trials concentrations coronavirus COVID-19 COVID-19 pandemic Critical Cyanidin-3-O-glucoside demonstrated domain dose-dependent manner Effective vaccines enzymatic activity eradication experiments FDA GC376 glucoside highlight Hypericin in vitro in vitro activity inhibit inhibitor Interaction less Ligand ligands M pro main protease MD simulations molecular molecular dynamics Molecular modelling notable Orphan Drug performed positive control Previous studies protease respiratory Safe SARS-CoV-2 SARS-CoV-2 main protease severe acute respiratory syndrome Coronavirus situation small molecule stability the SARS-CoV-2 Trajectories Vaccine hesitancy variants of concern was used [DOI] 10.1016/j.jmgm.2021.108050 PMC 바로가기 [Article Type] Article
Aptamer-based electrochemical biosensor for rapid detection of SARS-CoV-2: Nanoscale electrode-aptamer-SARS-CoV-2 imaging by photo-induced force microscopySARS-CoV-2의 신속한 검출을 위한 앱타머 기반 전기화학 바이오센서: 광유도 힘 현미경에 의한 나노스케일 전극-압타머-SARS-CoV-2 이미징Article Published on 2022-01-012022-09-11 Journal: Biosensors & bioelectronics [Category] SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody applied aptamer aptasensor carbon Chain Reaction complex concentrations coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical detection Diagnosis diagnosis of COVID-19 electromagnetic spectrum gold Infection investigated limit of detection Microscopy PCR Photo-induced force microscopy platform polymerase chain polymerase chain reaction probe produced Rapid RBD Receptor-binding domain RNA S-protein SARS-CoV-2 SARS-CoV-2 pseudovirus Screen screening method serology severe acute respiratory syndrome Coronavirus Spike protein Spread the receptor-binding domain the SARS-CoV-2 the spike protein viral infection virus yielding [DOI] 10.1016/j.bios.2021.113595 PMC 바로가기 [Article Type] Article
Hydroxychloroquine and azithromycin used alone or combined are not effective against SARS-CoV-2 ex vivo and in a hamster modelArticle Published on 2022-01-012022-10-04 Journal: Antiviral Research [Category] SARS, 신약개발, [키워드] airway airway epithelia antiviral drug antiviral molecule antivirals Azithromycin cell lines Clinical course clinical trial concentrations coronavirus COVID-19 COVID-19 pandemic doses drug effective Ex vivo Human Human airway epithelium Hydroxychloroquine identify in vitro in vitro data in vivo inhibitory inhibitory activity lung lung tissue no significant effect quantification SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 replication shown Support Syrian hamster. tested the disease Treatment use of hydroxychloroquine viral replication weakness [DOI] 10.1016/j.antiviral.2021.105212 PMC 바로가기 [Article Type] Article
Paper-based microfluidic chip for rapid detection of SARS-CoV-2 N proteinResearch Article Published on 2021-12-302022-10-27 Journal: Bioengineered [Category] COVID-19, [키워드] antibody Antigen antigen detection average Characteristics chromogenic response coated Concentration concentrations enzyme-linked immunosorbent Linear regression N protein p-ELISA Paper-based microfluidic chip Research SARS-CoV-2 N protein sensitivity standard curve statistically significant was obtained was tested [DOI] 10.1080/21655979.2021.2014385 PMC 바로가기 [Article Type] Research Article
Paper-based microfluidic chip for rapid detection of SARS-CoV-2 N proteinResearch Article Published on 2021-12-302022-10-27 Journal: Bioengineered [Category] Coronavirus, COVID-19, [키워드] antibody Antigen antigen detection average Characteristics chromogenic response coated Concentration concentrations enzyme-linked immunosorbent Linear regression N protein p-ELISA Paper-based microfluidic chip Research SARS-CoV-2 N protein sensitivity standard curve statistically significant was obtained was tested [DOI] 10.1080/21655979.2021.2014385 PMC 바로가기 [Article Type] Research Article
Synergistic Interferon-Alpha-Based Combinations for Treatment of SARS-CoV-2 and Other Viral InfectionsArticle Published on 2021-12-112022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Affect Analysis Antiviral antiviral drug combination antiviral property Calu-3 cell changes in clinical development Combination concentrations convalescent serum coronavirus cycloheximide demonstrated drug effective EIDD-2801 HCV hepatitis C virus hepatitis E virus HIV homeostasis Human immunodeficiency virus IFN IFNs IFNα in vitro indicated influenza A virus interferon interferon-alpha lung organoids metabolomic NITD008 organoids Other protein synthesis Remdesivir Replication ribavirin SARS-CoV-2 Side effects suppressed synergistic target tested therapeutic potential tolerable Transcription uninfected cell viral infections Viral RNA while [DOI] 10.3390/v13122489 PMC 바로가기 [Article Type] Article