Pulse Therapy With Corticosteroids and Intravenous Immunoglobulin in the Management of Severe Tocilizumab-Resistant COVID-19: A Report of Three Clinical CasesEmergency Medicine Published on 2020-07-072022-10-31 Journal: Cureus [Category] COVID-19, [키워드] changes clinical clinical manifestation Combination Corticosteroids COVID-19 CRS Cytokine release syndrome Efficacy and safety Evidence high-dose methylprednisolone Immunoglobulin intravenously life-threatening life-threatening coronavirus disease Methylprednisolone Patient patients persistence pulmonary CT pulse pulse therapy Randomized controlled trial report required Respiratory failure Safe SARS-CoV-2 therapy Treatment treatment regimen virus [DOI] 10.7759/cureus.9038 PMC 바로가기 [Article Type] Emergency Medicine
Pharmacotherapy in COVID-19; A narrative review for emergency providersReview article Published on 2020-07-012022-10-05 Journal: The American journal of emergency medicine [Category] SARS, 치료제, [키워드] ACE ACE inhibitor active against acute respiratory distress angiotensin receptor blocker antagonist antimalarial Antiviral antivirals ARB ARBs ARDS Care Chloroquine Clinical guidelines clinical trial Combination combination treatment conducted convalescent plasma COVID 19 COVID-19 COVID-19 pandemic Critical CRS current current therapy Cytokine release syndrome develop disease drug Effectiveness Efficacy enzyme established therapy evaluated Evidence Favipiravir Fever Health Healthcare provider Hydroxychloroquine IL-6 information inhibitors lack literature review non-steroidal anti-inflammatory drug NSAIDS objective off-label pandemic Patient patients with moderate pharmacotherapy potential therapies professionals recommendation Remdesivir resource SARS-CoV-2 Septic shock syndrome systematic reviews therapeutic drug therapy Transmission Treatment treatment guidelines Trial [DOI] 10.1016/j.ajem.2020.04.035 [Article Type] Review article
“Small” Intestinal Immunopathology Plays a “Big” Role in Lethal Cytokine Release Syndrome, and Its Modulation by Interferon-γ, IL-17A, and a Janus Kinase InhibitorImmunology Published on 2020-06-262022-10-31 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] accompanied administration affected antibodies Antigen blood pressure bowel caused characterized contribute contributed coronavirus disease COVID-19 CRS cytokine cytokine production Cytokine release syndrome deficiency Degradation down-regulated expression Extracellular matrix HLA class II transgenic mice HLA-DR3 IFN-γ IL-17A immune Immunopathogenesis immunopathology indicated inflammatory pathway inhibitor inhibitors intestinal intestinal tissue JAK inhibitor janus kinase lethal maintain mice Mortality multiple organ multiple organ dysfucntion multiple organ dysfunction organ organ function pathogenic pathology pathway pro-apoptotic receptor Release RNA sequencing role SARS-CoV-2 selective severity signaling pathway significantly significantly increased specific treatment staphylococcal superantigens Support systemic level T cell T cell activation therapy Toxic shock syndrome transgenic mice Treatment TSS [DOI] 10.3389/fimmu.2020.01311 PMC 바로가기 [Article Type] Immunology
A complex COVID-19 case with rheumatoid arthritis treated with tocilizumabCase Based Review Published on 2020-06-192022-10-31 Journal: Clinical Rheumatology [Category] COVID-19, SARS, [키워드] administration applied Aspergillus fumigatus close monitoring complex Coronavirus disease 2019 COVID-19 COVID-19 case CRS cytokine cytokine release storm disciplinary disease drug glucocorticoid Hydroxychloroquine IL-6 immune responses Immunity leflunomide long-term treatment opportunistic infection Patient patients patients with COVID-19 receptor signaling recurrence rheumatoid arthritis Secondary opportunistic infection Sequencing supplementary material Tocilizumab treated Treatment [DOI] 10.1007/s10067-020-05234-w PMC 바로가기 [Article Type] Case Based Review
Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19Review article Published on 2020-06-172022-10-05 Journal: Trends in pharmacological sciences [Category] SARS, 신약개발, [키워드] acute respiratory syndrome characterized Clinical outcome Control coronavirus COVID-19 Critical CRS cytokine Cytokine release syndrome Cytokine storm IL-10 IL-2 IL-7 indicated Infection intracellular signaling involved Jak jak inhibitors Jak-STAT Janus kinase pathophysiologic pathway Patient recent Release SARS-CoV-2 severe coronavirus disease severe COVID-19 targeting therapeutic strategy Treatment [DOI] 10.1016/j.tips.2020.06.007 [Article Type] Review article
Cytokine Release Syndrome (CRS) and Nicotine in COVID-19 Patients: Trying to Calm the StormImmunology Published on 2020-06-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] “cytokine storm” activate acute respiratory syndrome affected Anti-inflammatory approach approved cause caused characterized China Cholinergic anti-inflammatory pathway clinically COVID- 19 COVID-19 CRS Cytokine Release Syndrom (CRS) Cytokine release syndrome effort epidemiological Evidence Hospitalized hyperinflammation Hypothesis Inflammation inhibit less lung many cases New coronavirus Nicotine pathway patients pro-inflammatory cytokine Proinflammatory cytokine receptor reduce Release rising mortality Safe SARS-CoV-2 SARS-CoV-2 (virus) severe SARS-CoV-2 Signal transduction smoker statistically storm Therapies therapy Treatment ulcerative colitis worldwide pandemic [DOI] 10.3389/fimmu.2020.01359 PMC 바로가기 [Article Type] Immunology
The amount of cytokine-release defines different shades of Sars-Cov2 infectionArticle Published on 2020-05-282023-06-15 Journal: Experimental Biology and Medicine [Category] MERS, SARS, [키워드] COVID-19 CRS Cytokines HLH/MAS SARS-CoV2 [DOI] 10.1177/1535370220928964 PMC 바로가기
Cytokine Release Syndrome in COVID-19 Patients, A New Scenario for an Old Concern: The Fragile Balance between Infections and AutoimmunityReview Published on 2020-05-082022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] accompanied Antiviral approach Autoimmunity balance Baricitinib China close monitoring complex cough COVID-19 CRS Cytokine release syndrome disease Dyspnea Effectiveness fatigue Features Fever flu-like symptom health emergency Host Hydroxychloroquine immunomodulation Immunosuppressant immunosuppressive agent increase in induce Infection infection risk initiated life-threatening manifestation New Novel coronavirus Patient patients patients with COVID-19 pro-inflammatory response receiving Release researcher Rheumatic diseases rheumatoid arthritis SARS-CoV-2 scenario sequenced serological severe interstitial pneumonia Spread therapy Tocilizumab Treatment trials Typical [DOI] 10.3390/ijms21093330 PMC 바로가기 [Article Type] Review
Emerging trends in COVID-19 treatment: learning from inflammatory conditions associated with cellular therapiesArticle Published on 2020-05-072023-06-15 Journal: Cytotherapy [Category] MERS, [키워드] cellular therapy COVID-19 CRS cytokine release HLH hyperimmune response Immunotherapy IRIS SARS-CoV-2 [DOI] 10.1016/j.jcyt.2020.04.100 PMC 바로가기 [Article Type] Article