Alpha (B.1.1.7) and Delta (B.1.617.2 – AY.40) SARS-CoV-2 variants present strong neutralization decay at M4 post-vaccination and a faster replication rates than D614G (B.1) lineage알파(B.1.1.7) 및 델타(B.1.617.2 - AY.40) SARS-CoV-2 변이체는 백신 접종 후 M4에서 강력한 중화 붕괴를 나타내며 D614G(B.1) 계통보다 더 빠른 복제 속도를 나타냅니다.Comment Published on 2022-03-012022-09-11 Journal: The Journal of Infection [Category] MERS, SARS, 변종, 진단, [키워드] Abstract B.1 B.1.1.7 B.1.617.2 BNT162b2 BNT162b2 vaccine D614G Delta faster Lineage neutralization Replication rate SARS-CoV-2 SARS-CoV-2 variant seroneutralization vaccination [DOI] 10.1016/j.jinf.2021.11.012 PMC 바로가기 [Article Type] Comment
Changing predominant SARS-CoV-2 lineages drives successive COVID-19 waves in Malaysia, February 2020 to March 20212020년 2월부터 2021년 3월까지 말레이시아에서 지배적인 SARS-CoV-2 계통의 변화로 인해 연속적인 COVID-19 파동이 발생했습니다.Article Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] A701V Alpha analyzed anti-SARS-CoV-2 B.1.1.7 B.1.351 B.6 Beta Changing China circulating collected coronavirus disease Coronavirus disease 2019 COVID-19 Critical D614G Direct driven by First wave genomic imported cases Increased Lineage lineages Malaysia Molecular epidemiology Phylogenetic Phylogenetic analysis population immunity predominant SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 sequence SARS-CoV-2 seroprevalence second wave Sequencing Seroprevalence serum sample spike mutation spike mutations super-spreading event super-spreading events Surveillance susceptible tested total antibodies variants of concern virus viruses whole genome Whole genome sequencing whole-genome [DOI] 10.1002/jmv.27441 PMC 바로가기 [Article Type] Article
Genomic characterization unravelling the causative role of SARS-CoV-2 Delta variant of lineage B.1.617.2 in 2nd wave of COVID-19 pandemic in Chhattisgarh, India인도 차티스가르(Chhattisgarh)에서 발생한 COVID-19 대유행의 2차 물결에서 SARS-CoV-2 혈통 B.1.617.2의 델타 변이형의 원인 역할을 밝히는 게놈 특성 분석Article Published on 2022-03-012022-09-11 Journal: Microbial pathogenesis [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 receptor Alpha Alpha variant Antibody Response B.1 B.1.1.7 B.1.617.1 B.1.617.2 catastrophic categories Chhattisgarh cleaving co-occurrence COVID-19 COVID-19 pandemic D614G D950N dead dead patient Deceased Deletion Delta delta variant ENhance Evolution FIVE furin furin site G142D genomic genomic data HCW healthcare worker help India Intensive L452R Lineage Lineage B.1.1.7 Mild nine outbreak P681R pandemic Patient patients predominant Replication required S1/S2 SARS-CoV-2 SARS-CoV-2 variant second second wave Sequencing spike mutation Surveillance T19R T478K the SARS-CoV-2 Transmissibility Vaccine variant VoC was performed were infected whole-genome sequencing [DOI] 10.1016/j.micpath.2022.105404 PMC 바로가기 [Article Type] Article
Neutralizing Antibodies and Cytokines in Breast Milk After Coronavirus Disease 2019 (COVID-19) mRNA VaccinationContents Published on 2022-02-282022-10-28 Journal: Obstetrics and gynecology [Category] COVID-19, COVID19(2023년), SARS, [키워드] acute respiratory syndrome Anti-RBD antibody anti-RBD IgA Anti-RBD IgG antibody B.1.1.7 B.1.351 Beta Blood Breast breast milk Breastfeeding Cellular immune response cohort study collected controls coronavirus coronavirus disease correlated COVID-19 COVID-19 vaccination Cutoff cytokine D614G domain Dried blood spots driven by enrolled enzyme-linked immunosorbent evaluate expressed first dose Gamma IgG immune response Immunoglobulin Infant Infants interferon-γ lactating women Level milk mother mRNA mRNA-based mRNA-based COVID-19 vaccine mRNA-based vaccine neutralize neutralized neutralizing antibody P.1 passive immunity positive provided RBD reflected SARS-CoV-2 second dose second vaccination Side effects Stool Stool sample tested transfer transferred vaccination Vaccine variant variants of concern were measured were used women [DOI] 10.1097/AOG.0000000000004661 PMC 바로가기 [Article Type] Contents
Inhibitor screening using microarray identifies the high capacity of neutralizing antibodies to Spike variants in SARS-CoV-2 infection and vaccination마이크로어레이를 사용한 억제제 스크리닝은 SARS-CoV-2 감염 및 백신 접종에서 스파이크 변이체에 대한 항체를 중화하는 높은 능력을 식별합니다Article Published on 2022-02-282022-09-11 Journal: Theranostics [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition anti-S antibody antibody antibody diversity B.1.1.7 B.1.351 B.1.617.2 Cohort convalescent COVID-19 patient convalescent COVID-19 patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccines D614G Drug development Efficacy FIVE glass slides group help heterogeneous identify Microarray Mutation NAb titers NAbs neutralization Neutralization assay neutralize Neutralizing antibodies neutralizing antibody neutralizing effect P.1 peptide peptide microarray platform Population prevalent protective effect Protein purified reduce responsible S variant SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 spike Screening serum spike spike-ACE2 These data utility vaccination vaccinee vaccinees variant variants were assessed wild-type [DOI] 10.7150/thno.67038 PMC 바로가기 [Article Type] Article
Distinct shifts in site-specific glycosylation pattern of SARS-CoV-2 spike proteins associated with arising mutations in the D614G and Alpha variantsD614G 및 알파 변이체의 돌연변이 발생과 관련된 SARS-CoV-2 스파이크 단백질의 부위 특이적 글리코실화 패턴의 뚜렷한 변화Article Published on 2022-02-262022-09-11 Journal: Glycobiology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] accumulated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Alpha variant Analysis arising binding changes in complex contribute coronavirus coronavirus disease Course cryo cryo-EM D614G domain Extensive feature glycan glycans glycosylation host immune responses host receptor immune responses immunogenic information Lineage mass spectrometry Mutation N-glycan N-glycans N-terminal domain Neutralizing antibodies neutralizing antibody NTD pandemic produced proportion SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus site-specific glycosylation. Spike protein Spike proteins Structure the spike protein Transmissibility variants variants of concern virus [DOI] 10.1093/glycob/cwab102 PMC 바로가기 [Article Type] Article
Delta Variant with P681R Critical Mutation Revealed by Ultra-Large Atomic-Scale Ab Initio Simulation: Implications for the Fundamentals of Biomolecular Interactions초대형 원자 규모 Ab 초기 시뮬레이션으로 밝혀진 P681R 치명적 돌연변이가 있는 델타 변이체: 생체 분자 상호 작용의 기본 사항에 대한 의미Article Published on 2022-02-242022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] Affect Amino acid amino acids amino-acid–amino-acid bond pair atomic resolution computational modeling D614G D614G mutation damage Delta delta variant domain dominant Efficiency explain faster flexibility furin furin cleavage site human cell human cells infection rate interacting residue interacting residues Interaction interactions interatomic interaction machine learning Mutation mutations offer P681R protocol reduce reduced reported responsible Revealed SARS-CoV-2 Spike protein spike-protein Spread the spike protein unique virus wild type [DOI] 10.3390/v14030465 PMC 바로가기 [Article Type] Article
Cross-Neutralizing Breadth and Longevity Against SARS-CoV-2 Variants After Infections감염 후 SARS-CoV-2 변종에 대한 교차 중화 폭 및 수명Article Published on 2022-02-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against Antibody titer Antibody titers B.1.1.7 B.1.351 breadth center convalescent sera coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 cross-neutralizing D614G D614G mutation decrease epitope Epitopes infected with SARS-CoV-2 Infection Longevity maintain neutralization Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers not significantly different P.1 pandemic Patient patients produced Protective public health recognize respiratory responsible SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selected sera several variant several variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly sustained variant variants variants of concern virus Virus neutralization viruses VoC VOCs was performed [DOI] 10.3389/fimmu.2022.773652 PMC 바로가기 [Article Type] Article
A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice광범위 교차 반응성 항체는 마우스에서 사베코바이러스 공격을 중화하고 보호합니다.Article Published on 2022-02-232022-09-14 Journal: Science Translational Medicine [Category] SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome against SARS-CoV antibody B.1.1.7 B.1.351 B.1.429 B.1.526 B.1.617.1 B.1.617.2 bat coronavirus binding caused conserved coronavirus cross-reactive antibody D614G domain effective epitope events high affinity in vivo Infection infections mice mitigate Mortality neutralization neutralize outbreak P.1 Prevent PROTECT Protective RBD RsSHC014 sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-related viruses strain Structural analysis Therapeutic treatment Vaccine zoonotic [DOI] 10.1126/scitranslmed.abj7125 PMC 바로가기 [Article Type] Article
An adjuvanted subunit SARS-CoV-2 spike protein vaccine provides protection against Covid-19 infection and transmission Research Published on 2022-02-232022-10-05 Journal: NPJ Vaccines [Category] 변종, 임상, 치료기술, [키워드] Administered anti-spike antibody approach B.1.617.2 characterized Complete COVID-19 vaccine D614G effective elicited hamsters humoral induce Infection intramuscularly mice monomeric naïve neutralizing antibody offer prevented provide provided RBD Recombinant protein Recombinant spike protein Safe SARS-COV-2 infection SARS-CoV-2 spike protein spike receptor-binding domain subunit T-cell Response Transmission Vaccine variants Viral transmission wild-type [DOI] 10.1038/s41541-022-00450-8 [Article Type] Research