Study of the SARS-CoV-2-specific immune T-cell responses in COVID-19-positive cancer patients코로나19 양성 암 환자의 SARS-CoV-2 특이 면역 T 세포 반응 연구Clinical Trial Published on 2021-06-012022-09-12 Journal: European journal of cancer (Oxford, England : 1990 [Category] MERS, SARS, 임상, 진단, [키워드] Cancer cancer patient Cancer patients Chemotherapy COVID-19 pandemic Deleterious Effect Evolution haematological malignancies highlight immune immune memory immune response immune system Immune T cell response impair infected patients intensity lack microenvironment Patient produced Protective question raised respond responses against S protein SARS-CoV-2 SARS-CoV-2 antibodies SARS-COV-2 infection SARS-CoV-2 virus severity specific antibodies survival T cell T-cell immunity T-cell Response the SARS-CoV-2 virus therapy Trial Tumours vaccination virus [DOI] 10.1016/j.ejca.2021.03.033 PMC 바로가기 [Article Type] Clinical Trial
Prevalence and changes in boredom, anxiety and well-being among Ghanaians during the COVID-19 pandemic: a population-based studyResearch Published on 2021-05-262022-10-28 Journal: BMC Public Health [Category] COVID-19, SARS, [키워드] adjusted age age and sex Anxiety boredom changes in collected consequence coronavirus COVID-19 COVID-19 pandemic decrease Deleterious disorder Evidence examined Factor Ghana Health Inclusion increase in Infectious disease information Intervention investigated mean scores measure Measures medical condition mental health Multiple linear regression outbreak Outbreaks outcomes pandemic participant predictor predictor variable Prevalence protocol Psychological well-being public health reported Result retrospective second sub-Saharan Africa supplementary material Symptom was used [DOI] 10.1186/s12889-021-10998-0 PMC 바로가기 [Article Type] Research
Need for and use of contraception by women before and during COVID-19 in four sub-Saharan African geographies: results from population-based national or regional cohort surveysArticles Published on 2021-05-182022-10-30 Journal: The Lancet. Global health [Category] COVID-19, Fulltext, MERS, [키워드] Abstract Action African Analysis anticipated baseline change changes in Cohort collected Contraception Contraceptive use country COVID-19 COVID-19 pandemic cross-sectional survey Deleterious determine expected finding Follow-up foundation French funding Health hindrance increase in investigated Kenya Lago Lagos material Melinda Gate monitoring National Nigeria nulliparous pandemic performance PMA Pregnancy proportion reproductive risk selected significantly significantly increased Sociodemographic Sociodemographic characteristics Stage sub-Saharan Africa Support translation women [DOI] 10.1016/S2214-109X(21)00105-4 PMC 바로가기 [Article Type] Articles
COVID-19 and IL-6: Why vitamin D (probably) helps but tocilizumab might notCOVID-19 및 IL-6: 비타민 D(아마도)가 도움이 되지만 토실리주맙이 도움이 되지 않는 이유Review Published on 2021-05-152022-09-12 Journal: European journal of pharmacology [Category] 진단, [키워드] Administered administration antagonists Anti-inflammatory anti-inflammatory action antibody block conducted COVID-19 COVID-19 patient Cytokine storm Deleterious demonstrated effective Effects help IL-6 IL-6 antagonist Immune cell immunomodulator immunomodulatory effect interleukin involved Lower modulate monoclonal outcomes positive presenting pro-inflammatory pro-inflammatory action receptor receptors reducing reported Safe the cytokine storm therapeutic agent therapeutic option therapeutic target Tocilizumab Trial Vitamin D while [DOI] 10.1016/j.ejphar.2021.174031 PMC 바로가기 [Article Type] Review
A complementary critical appraisal on systematic reviews regarding the most efficient therapeutic strategies for the current COVID-19 (SARS-CoV-2) pandemic현재 COVID-19(SARS-CoV-2) 전염병에 대한 가장 효율적인 치료 전략에 관한 체계적인 검토에 대한 보완적인 비판적 평가Meta-Analysis Published on 2021-05-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료제, [키워드] Administered article Chloroquine clinical symptom Clinical symptoms clinical trial clinical trials complementary concept coronavirus COVID-19 COVID-19 drug treatment COVID-19 pandemic COVID-19 treatment criteria critical appraisal database death Deleterious drug drug treatment Effect Efficacy Evidence Favipiravir Hydroxychloroquine Hypotension Immunoglobulin immunoglobulins Increasing initial initial screening Liver function test Lopinavir Lopinavir/ritonavir maintain mechanical ventilation Medicine mesh terms meta-analyses mortality rate pandemic Patient plasma reduced Remdesivir Research resources Ritonavir SARS-CoV-2 Science Direct searched severe symptoms severely ill patients Side effect Side effects steroid Steroids subsequent suggested systematic review systematic reviews the cytokine storm therapeutic strategy Tocilizumab Treatment viral clearance were assessed [DOI] 10.1002/jmv.26811 PMC 바로가기 [Article Type] Meta-Analysis
The Use of the Anticoagulant Heparin and Corticosteroid Dexamethasone as Prominent Treatments for COVID-19Medicine Published on 2021-04-232022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 Administered administration Alter Anti-inflammatory anti-inflammatory drug anti-SARS-CoV-2 Anti-viral Anticoagulant Antithrombotic applicability approach ARDS binding Blood complement Complication Corticosteroid COVID-19 COVID-19 disease severity COVID-19 severity Cytokine storm death case death rate Deleterious derivatives detrimental Dexamethasone diabetics disease downregulation drug early stage ENhance Evidence exacerbated feasible fibrinolytic global healthcare glucocorticoid glucocorticoid dexamethasone groups heparin highlight hyperglycemia hypertensive patients IL-6 immune responses impairing Inflammation initial Invasive mechanical ventilation LTB medical condition modulate Mounting Occurrence Patient presenting Prominent Protein reduce required respiratory risk SARS-CoV-2 secretion severe COVID-19 patients severe patients significantly sodium spike standard treatment therapy Treatment upregulated viral clearance viral infection viral infectivity [DOI] 10.3389/fmed.2021.615333 PMC 바로가기 [Article Type] Medicine
Single-Cell RNA-seq Reveals Angiotensin-Converting Enzyme 2 and Transmembrane Serine Protease 2 Expression in TROP2 + Liver Progenitor Cells: Implications in Coronavirus Disease 2019-Associated Liver DysfunctionMedicine Published on 2021-04-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome analyzed angiotensin-converting enzyme 2 binding caused cell death cell population China cirrhotic liver co-expression Comorbidities coronavirus coronavirus disease COVID-19 COVID-19 patient Cytokine storms Deleterious develop disease fetal FIVE globe healthy host cell human liver impair implicated indicated liver Liver cirrhosis liver dysfunction liver tissue mammalian mammalian cell pandemic pathophysiology Patient prevalent progenitor Protein receptor reported respiratory symptom Respiratory virus infection RNA-Seq SARS-CoV-2 scRNA-seq serine protease significantly Single Cell single-cell RNA-seq spike the S protein tissue TMPRSS2 transmembrane serine protease Trop2 viral infection [DOI] 10.3389/fmed.2021.603374 PMC 바로가기 [Article Type] Medicine
Protective Role of a TMPRSS2 Variant on Severe COVID-19 Outcome in Young Males and Elderly Women젊은 남성과 노인 여성의 심각한 COVID-19 결과에 대한 TMPRSS2 변이체의 보호 역할Multicenter Study Published on 2021-04-192022-09-10 Journal: Genes [Category] MERS, 변종, [키워드] Affect affected affecting allele frequency analyzed appear clinical feature Clinical features co-morbidities Cohort correlated COVID-19 Deleterious drug elderly expression facilitate Frequency Hospitalization implicated individual information inhibiting intubation Italy male Missense mutation missense variant morbidities not need oxygen Oxygen therapy Pathogenesis pathogenesis of SARS-CoV-2 Patient patients PolyPhen-2 protease Protease activity protective effect Protein provide required risk role sequence the disease TMPRSS2 two subgroup two subgroups Usage V197M variant Ventilation Viral viral infection viral infections Whole-Exome Sequencing (WES) [DOI] 10.3390/genes12040596 PMC 바로가기 [Article Type] Multicenter Study
The impact of the COVID-19 pandemic on the quality of life of head and neck cancer survivorsOriginal Article Published on 2021-04-152022-10-28 Journal: Supportive Care in Cancer [Category] COVID-19, MERS, SARS, [키워드] Administered Cancer changed Cohort composed consequence control group COVID-19 COVID-19 pandemic Deleterious Effect emotional evaluated global pandemic greater head head and neck cancer high risk lockdown material pandemic Patient patients physical Quality of life reported Result significantly social distancing survivor Survivors Total laryngectomy two groups unique worsening [DOI] 10.1007/s00520-021-06198-6 PMC 바로가기 [Article Type] Original Article
In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 InfectionResearch Article Published on 2021-04-092022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 protein ADP-ribosylation analyzed Angiotensin-converting enzyme bioinformatics ConSurf cumulative score Deleterious functional Human human host cell in silico analysis information less missense variant Modification nucleotide pathogenic Protein proteolytic cleavage PROVEAN provide receptor SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus SIFT stability susceptibility variant were used [DOI] 10.1155/2021/6685840 PMC 바로가기 [Article Type] Research Article