Comparative effectiveness of ChAdOx1 versus BNT162b2 covid-19 vaccines in health and social care workers in England: cohort study using OpenSAFELY영국의 의료 및 사회 복지 종사자에 대한 ChAdOx1 대 BNT162b2 covid-19 백신의 비교 효과: OpenSAFELY를 사용한 코호트 연구Article Published on 2022-07-202022-09-11 Journal: The BMJ [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval Accident Administered Admission Alpha variant BNT162b2 BNT162b2 mRNA Care ChAdOx1 clinical information clinically Cohort cohort study Comparative COVID-19 disease cumulative cumulative incidence disease dominant dropped Effectiveness England event expected Follow-up General practice Health Health status healthcare healthcare worker Healthcare workers healthy hospital Hospital admission Hospital admissions Immunity incidence Infection Information System National NHS no substantial difference no substantial differences OpenSAFELY outcome over Oxford-AstraZeneca Pfizer-BioNTech platform positive Positive test primary care receipt recorded Registered representing Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 tests Surveillance the SARS-CoV-2 Trial vaccination Vaccine vaccine dose [DOI] 10.1136/bmj-2021-068946 PMC 바로가기 [Article Type] Article
Origin, virological features, immune evasion and intervention of SARS-CoV-2 Omicron sublineagesSARS-CoV-2 오미크론 하위 계통의 기원, 바이러스학적 특징, 면역 회피 및 개입Review Published on 2022-07-192022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] Coronavirus, COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 B.1.1.529 benefit breakthrough infections carried caused circulating coronavirus dominant Features global public health Immune escape immune evasion Infection Intervention Mutation Neutralizing antibodies neutralizing antibody omicron Omicron variant origin other variant other variants Re-infection Re-infections SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein Spread Therapeutics Transmissibility vaccination Vaccine variant variants Virological VOCs [DOI] 10.1038/s41392-022-01105-9 PMC 바로가기 [Article Type] Review
Duration of protection of CoronaVac plus heterologous BNT162b2 booster in the Omicron period in Brazil브라질의 Omicron 기간에 CoronaVac + 이종 BNT162b2 부스터의 보호 기간Article Published on 2022-07-182022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] analysed BNT162b2 booster booster dose Brazil CoronaVac COVID-19 vaccine database death dominance dominant Duration Effectiveness evaluated Heterologous Hospitalization inactivated individual information offered omicron Omicron variant outcome outcomes symptomatic infection tested the SARS-CoV-2 the vaccine vaccinee vaccinees variant [DOI] 10.1038/s41467-022-31839-7 PMC 바로가기 [Article Type] Article
Peptide-Antibody Fusions Engineered by Phage Display Exhibit an Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants파지 디스플레이가 조작한 펩티드-항체 융합은 SARS-CoV-2 변이체의 초강력 및 광범위한 중화를 나타냅니다Article Published on 2022-07-152022-09-11 Journal: ACS chemical biology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] affinities affinity approach approved B.1.1.529 Bivalent bivalent IgG breadth clinically Coverage COVID-19 demonstrated display domain dominant ENhance exacerbated fused fusion fusions generate implicated IMPROVE Infection infection assay low potency Mutation N-terminal domain N-terminus NAb NAbs naïve neutralization neutralization potency neutralize neutralizing antibody NTD omicron peptide peptides phage RBD RBD mutation RBD mutations S-protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein spread of COVID-19 tetravalent the RBD the spike protein therapeutic Therapeutics trimer variant variants variants of concern vulnerability [DOI] 10.1021/acschembio.2c00411 PMC 바로가기 [Article Type] Article
Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity1년 동안 SARS-CoV-2-특이적 T 세포 사이토카인 생성 반응에 대한 종단 평가는 질병 중증도와 관련된 더 큰 면역과 함께 다중 사이토카인 증식 반응의 지속성을 보여줍니다Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 all subjects assessment average CD4 CD8 Cell Cell-mediated immunity clone coronavirus Coronaviruses Critical cytokine cytokine response Cytokines declined demonstrated dominant ELISPOT ELISpot assay envelope enzyme-linked immunosorbent epitope Epitopes Ex vivo female Frequency gamma interferon granzyme B greater GzmB highlight IFN-γ IL-2 immune immune modeling. Immunity immunodominant immunodominant epitope immunodominant epitopes induce Infection interferon interleukin interleukin 2 kill longitudinal male median membrane nucleocapsid observation other coronaviruses peaked persistence post-symptom onset potent predicted produced producing proliferative PSO reduced regions response robust SARS-CoV-1 SARS-CoV-2 seasonal coronavirus seasonal coronaviruses severe acute respiratory syndrome Coronavirus severe disease structural protein structural proteins subject survivor T cell T cell immunity T cell memory T cell response T cell responses T cells target cells Vaccine viral infections Year [DOI] 10.1128/jvi.00509-22 PMC 바로가기 [Article Type] Article
An integrated analysis and comparison of serum, saliva and sebum for COVID-19 metabolomics Research Published on 2022-07-132022-10-05 Journal: Scientific Reports [Category] 바이오마커, 치료기술, 치료법, [키워드] alteration analysed Analysis biofluid Blood changes in Cohort correlation COVID-19 COVID-19 infection dominant dyslipidaemia hallmark hospitalised immunostimulatory Lipid majority metabolite metabolites metabolomics negative controls participant Pathologies pathophysiological conditions Patient performed plasma positive profile provided Saliva salivary Sebum sensitivity Sensitivity and specificity serum specificity Triglyceride utilised [DOI] 10.1038/s41598-022-16123-4 [Article Type] Research
Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses강력한 CD8 T 세포 반응에도 불구하고 손상된 체액성 면역은 장기간의 COVID-19와 관련이 있습니다Article Published on 2022-07-112022-09-11 Journal: Cancer cell [Category] COVID19(2023년), SARS, 치료법, [키워드] Affect Analysis analyzed antibody B cell B cells Cancer CD20 CD4 CD8 CD8 T cell cellular clearance convalescent COVID-19 COVID-19 infection Delayed demonstrated disease disease control dominant dysregulation effective exhibited functional highlight humoral immune response Humoral immunity immune dysregulation immune responses Impaired incidence increase in nucleocapsid Patient Patients with cancer Peripheral blood peripheral blood samples prolonged disease response rituximab robust SARS-CoV-2 SARS-CoV-2 clearance Spike protein Spike proteins T cell T cell memory T cell receptor T cell responses T cells TCR viral clearance [DOI] 10.1016/j.ccell.2022.05.013 PMC 바로가기 [Article Type] Article
Metagenomic Next-Generation Sequencing Reveals the Profile of Viral Infections in Kidney Transplant Recipients During the COVID-19 PandemicMetagenomic 차세대 시퀀싱은 COVID-19 팬데믹 기간 동안 신장 이식 수혜자의 바이러스 감염 프로필을 보여줍니다Article Published on 2022-07-112022-09-11 Journal: Frontiers in Public Health [Category] 치료기술, [키워드] Analysis BALF Biomarker Blood Blood samples Bronchoalveolar lavage fluid CMV compared and analyzed COVID-19 COVID-19 pandemic cytomegalovirus database detection rate dominant higher risk IMPROVE indicated Infection JC polyomavirus kidney kidney transplant recipient kidney transplant recipients Kidney transplantation metagenomic Metagenomic next-generation sequencing Next-generation sequencing nucleic acid nucleic acids profile recipient rejection reveal sequence simian virus torque teno virus Transplant Urine viral infection viral infections viral nucleic acid viral nucleic acids virus virus infection viruses [DOI] 10.3389/fpubh.2022.888064 PMC 바로가기 [Article Type] Article
Integrating Conformational Dynamics and Perturbation-Based Network Modeling for Mutational Profiling of Binding and Allostery in the SARS-CoV-2 Spike Variant Complexes with Antibodies: Balancing Local and Global Determinants of Mutational Escape Mechanisms항체가 있는 SARS-CoV-2 스파이크 변이체 복합체에서 결합 및 알로스테리의 돌연변이 프로파일링을 위한 형태 역학 및 섭동 기반 네트워크 모델링 통합: 돌연변이 탈출 메커니즘의 로컬 및 글로벌 결정인자 균형 조정Article Published on 2022-07-102022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Affect allosteric communication Analysis antibodies antibody Antibody binding antibody combination antibody escape approach balancing binding binding affinity binding energy binding hotspots binding interaction change complexes conformational conformational dynamics conserved cross-reactive determinant determined by dominant dynamic network modeling Dynamics Effect Efficiency energetics escape escape mutant escape mutants Factors flexibility fluctuation host receptor identify Interaction interactions Local MD simulations mechanism modeling modulate Mutation mutational profiling mutations network neutralization neutralize omicron pattern predict Profiling Protein protein folding protein stability residue SARS-CoV-2 spike SARS-CoV-2 spike protein single antibody spike spike plasticity Spike protein stability suggested the antibody the SARS-CoV-2 ultrapotent antibodies. variant [DOI] 10.3390/biom12070964 PMC 바로가기 [Article Type] Article
Effectiveness and protection duration of Covid-19 vaccines and previous infection against any SARS-CoV-2 infection in young adults젊은 성인의 모든 SARS-CoV-2 감염에 대한 Covid-19 백신 및 이전 감염의 효과 및 보호 기간Article Published on 2022-07-082022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI Ad26 Ad26.COV2.S Adults B.1.617 BNT162b2 caused Community contribute COVID-19 vaccination COVID-19 vaccines decrease delta variant dominant dropped Effectiveness Estimated evaluate General population increase in infected individuals Infection mRNA mRNA vaccine mRNA-1273 offer provide repeated SARS-COV-2 infection SARS-CoV-2 variant Spread surveillance testing vaccinated individual vaccinated individuals vaccination Vaccine variant while [DOI] 10.1038/s41467-022-31469-z PMC 바로가기 [Article Type] Article