Protease Activated Receptors: A Pathway to Boosting Mesenchymal Stromal Cell Therapeutic Efficacy in Acute Respiratory Distress Syndrome?Review Published on 2022-01-242022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, [키워드] anticipated benefit boost Cell COVID-19 pandemic critically ill patients Defense develop Efficiency effort endothelial ENhance epithelial expressed G-protein growth Host Infection inflammatory condition Lung injury Mesenchymal stromal cell Mesenchymal stromal cells mortality rate MSC MSCs outcomes pharmacological protease activated receptors receptor respiratory Respiratory failure secretion Sepsis Severe case shown Steroids supportive care survival tested therapeutic Therapeutic benefit therapeutic effect translational [DOI] 10.3390/ijms23031277 PMC 바로가기 [Article Type] Review
The Role of Von Willebrand Factor in the Pathogenesis of Pulmonary Vascular Thrombosis in COVID-19Article Published on 2022-01-212022-10-28 Journal: Viruses [Category] COVID-19, [키워드] ARDS Bacterial correlation COVID-19 demonstrated died disease disease severity Duration endothelial Endothelium Factor histological immunostaining independent independent predictor intensity lung Mortality nonsurvivor Pathogenesis Patient patients with COVID-19 performed plasma Pneumonia pulmonary Pulmonary embolism reported role SARS-CoV-2 significant increase significantly more staining intensity the disease the patient thrombosis thrombotic complication Thrombotic complications thrombus formation Vascular endothelium Ventilation venular vessels von Willebrand factor vWF [DOI] 10.3390/v14020211 PMC 바로가기 [Article Type] Article
Inflammation-Induced Coagulopathy Substantially Differs Between COVID-19 and Septic Shock: A Prospective Observational StudyMedicine Published on 2022-01-172022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Activation age Biomarkers biomarkers of inflammation CD40L characterized Clinical characteristics co-morbidity Coagulation Coagulopathy controls COVID-19 COVID-19 patient Critical critical COVID-19 patients dysregulated endothelial Endothelium evaluated exhibited fibrinogen Gender help ICU IL-6 IL-7 IL-8 Improving incidence increase in Inflammation less myeloid NETosis Organ failure outcomes pathophysiology Patient Platelet platelet activation Platelets Prospective Respiratory failure sepsis-induced coagulopathy septic Septic shock systemic inflammatory T lymphocyte therapeutic target thrombosis tissue Treatment were used [DOI] 10.3389/fmed.2021.780750 PMC 바로가기 [Article Type] Medicine
The Impact of Age and BMI on the VWF/ADAMTS13 Axis and Simultaneous Thrombin and Plasmin Generation in Hospitalized COVID-19 PatientsMedicine Published on 2022-01-102022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ADAMTS13 addition age aging Analysis analyzed Antigen axis binding activity BMI body mass index Coagulation Coagulopathy collagen collected conditions contribute contributed Corona COVID-19 COVID-19 negative cross-sectional elevated endothelial Endothelial dysfunction factor VIII Generation Health hospital Impact increases in increasing age individual obesity Older parameter Patient plasma plasmin populations positive reduced risk severity Simultaneous thrombin von Willebrand factor vWF [DOI] 10.3389/fmed.2021.817305 PMC 바로가기 [Article Type] Medicine
COVID-19 in Joint Ageing and Osteoarthritis: Current Status and Perspectives관절 노화 및 골관절염의 COVID-19: 현황 및 전망Review Published on 2022-01-102022-09-12 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] accelerated adipose Adipose tissue Ageing aging aging process analyzed angiotensin angiotensin-converting enzyme 2 calcium Characteristics Connective tissues contribute COVID-19 COVID-19 patients current deficiency dysfunction Effect endothelial evaluated explain exploration expression hypovitaminosis Hypovitaminosis D Inflammation joint joint and muscle pain knowledge long-COVID long-lasting molecular morbidity muscle pain Musculoskeletal musculoskeletal aging musculoskeletal symptom neuronal function new treatment strategy Osteoarthritis Pain Perturbation perturbations phenotype primary site recent Renin renin-angiotensin system road SARS-CoV-2 Society status Symptom tissue Topic Treatment [DOI] 10.3390/ijms23020720 PMC 바로가기 [Article Type] Review
C5a and C5aR1 are key drivers of microvascular platelet aggregation in clinical entities spanning from aHUS to COVID-19C5a 및 C5aR1은 aHUS에서 COVID-19에 이르는 임상 기관에서 미세혈관 혈소판 응집의 주요 동인입니다Article Published on 2022-01-082022-09-11 Journal: Blood advances [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome added aggregation Alternative pathway antithrombogenic Atypical Bacterial infection Bacterial infections binding blockade C5a C5aR1 C5b-9 caused CCX168 Cell chronic inflammatory diseases clinical entity clinical implications Comorbidities Comorbidity complement complement system coronavirus COVID-19 Critical demonstrated develop driver dysfunction dysregulation Effect endothelial endothelial cells Endothelial dysfunction Endothelium Ex vivo Exocytosis Genetic hemolytic uremic syndrome highlight human serum Hyperactivation Infection Inflammatory diseases Microvascular thrombosis normal human serum P-selectin pathogenic mechanisms Patient patients treated Platelet platelet adhesion prothrombotic RalA rare disease Registered selectin serum severe acute respiratory syndrome Coronavirus severe COVID-19 severely ill patients suffered thrombosis Thrombus thrombus formation translate Trial triggered uremic syndrome viral infections von Willebrand factor [DOI] 10.1182/bloodadvances.2021005246 PMC 바로가기 [Article Type] Article
Association between plasma glycocalyx component levels and poor prognosis in severe influenza type A (H1N1)Article Published on 2022-01-072022-10-04 Journal: Scientific Reports [Category] 바이오마커, 신종인플루엔자, [키워드] 28-day mortality acute lung injury Admission albumin levels Analysis APACHE II association blood sample cause Clinical data collected component contribute correlated Cutoff demonstrated determine disease severity Diseases Disruption endothelial Factor H1N1 H1N1 influenza healthy control hospital indicated Influenza influenza A influenza type A interleukin-6 Lactate mild cases organ dysfunction Patient patients with influenza plasma poor prognosis positively correlated Predictive Predictive markers prospective observational study sensitivity Sepsis severity significantly higher SOFA score specificity survival Syndecan-1 tumor necrosis factor-α viral infection virus infection were measured [DOI] 10.1038/s41598-021-04146-2 PMC 바로가기 [Article Type] Article
Translational studies of adrenomedullin and related peptides regarding cardiovascular diseases Reviews Published on 2022-01-062022-10-05 Journal: Hypertension research : official journal of the Ja [Category] 바이오마커, [키워드] Administered adrenomedullin bloodstream cardiovascular disease clinical trial CVD derivative derivatives Diseases endothelial expand expected heart failure increase in Infarction Inflammation Inflammatory bowel disease intervals less limitation marker Myocardial infarction peptide physiological functions pulmonary hypertension reduce restrict severe inflammation subcutaneous injection therapeutic translational Vascular [DOI] 10.1038/s41440-021-00806-y [Article Type] Reviews
Vasculopathy in COVID-19Research article Published on 2022-01-052022-10-05 Journal: Blood [Category] COVID19(2023년), SARS, 바이오마커, [키워드] activated acute respiratory syndrome addressed Affect arise Biomarker change changes in Complication complications of COVID-19 consequence coronavirus COVID-19 dysfunction Effect endothelial Endothelial cell Endothelium help infect Infection Inflammation Inflammatory information molecular organ system outcomes Pathogenesis pathway phenotype predict prothrombotic Pulmonary edema receptor Respiratory illness response SARS-CoV-2 SARS-COV-2 infection severe respiratory disease Therapeutic approach therapy thrombosis unique Vascular vascular beds vasculature Vasculopathy virus with COVID-19 [DOI] 10.1182/blood.2021012250 [Article Type] Research article
Generation of Spike-Extracellular Vesicles (S-EVs) as a Tool to Mimic SARS-CoV-2 Interaction with Host CellsSARS-CoV-2와 숙주 세포의 상호 작용을 모방하는 도구로 스파이크-세포외 소포(S-EV) 생성Article Published on 2022-01-032022-09-12 Journal: Cells [Category] SARS, 진단, [키워드] Analysis anti-ACE2 antibody biogenesis bronchial epithelial cell Cell cells characterized clinical trials co-expressed coding Colchicine collected COVID-19 drugs embryonic kidney endothelial EVs expressing Extracellular vesicles generate Generation host-virus interaction internalization mechanism Microscopy MIMIC non-transfected reduced S1 and S2 Safe SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein significantly spike Spike protein subunits the SARS-CoV-2 therapeutic Vesicle virus [DOI] 10.3390/cells11010146 PMC 바로가기 [Article Type] Article