epithelial cell – Page 10 – Communicable Diseases Research

Human Kidney Spheroids and Monolayers Provide Insights into SARS-CoV-2 Renal Interactions

인간 신장 회전 타원체 및 단층은 SARS-CoV-2 신장 상호 작용에 대한 통찰력을 제공합니다

Article

Published on 2021-09-012022-09-11
Journal: Journal of the American Society of Nephrology : JA [Category] SARS, 유전자 메커니즘,

Differential host circRNA expression profiles in human lung epithelial cells infected with SARS-CoV-2

SARS-CoV-2에 감염된 인간 폐 상피 세포의 차등 숙주 circRNA 발현 프로필

Article

Published on 2021-09-012022-09-11
Journal: Infection, genetics and evolution : journal of mol [Category] 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis binding cause cell death Circular circular RNA coronavirus coronavirus disease COVID-19 death down-regulated dysregulated enrichment analysis epithelial epithelial cell epithelial cells expression pattern expression profile function functions Gene Expression Gene ontology genomic highly pathogenic Host host immune responses human lung human lung epithelial cells immune immune responses Immunity implicated in viral indicated infected with SARS-CoV-2 Infection Inflammatory responses involved KEGG Lung epithelial cells miRNAs mRNA stability network analysis Ontology parental Pathogenesis performed Proteins regulate regulated RNA RNA binding protein RNA-Seq RNAs SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly up-regulated viral pathogenesis Virus-host interactions
[DOI] 10.1016/j.meegid.2021.104923 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Spike protein enhances ACE2 expression via facilitating Interferon effects in bronchial epithelium

SARS-CoV-2 스파이크 단백질은 기관지 상피에서 인터페론 효과를 촉진하여 ACE2 발현을 향상시킵니다.

Article

Published on 2021-09-012022-09-11
Journal: Immunology letters [Category] SARS, 치료기술,

[키워드] ACE2 ACE2 expression activate Activation Analysis Antiviral association BEAS-2B BEAS-2B cell Beas-2B cells Bronchial epithelium co-immunoprecipitation co-IP downstream Effect Effects ENhance epithelial cell epithelial cell line expression help Host identify IFN Infection Interaction interferon ISG ISG15 ISGs JAK-STAT signaling JAK1 non-structural protein non-structural proteins overexpressed overexpression Phosphorylation promote Protein qRT-PCR receptor ACE2 RNA-Seq S protein SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 S spike STAT Stat1 STAT2 the SARS-CoV-2 Transcriptome transcriptome analysis Type upstream was performed were measured western blot
[DOI] 10.1016/j.imlet.2021.06.008 PMC 바로가기 [Article Type] Article

Immunohistochemical and qPCR Detection of SARS-CoV-2 in the Human Middle Ear Versus the Nasal Cavity: Case Series

인간 중이 대 비강에서 SARS-CoV-2의 면역조직화학 및 qPCR 검출: 케이스 시리즈

Case Reports

Published on 2021-08-282022-09-10
Journal: Head and Neck Pathology [Category] COVID19(2023년), MERS, SARS, 치료기술,

[키워드] ACE2 Adhesion Molecule angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Biomarker Cell cell adhesion molecule colonize control patients coronavirus COVID-19 COVID-19 patient detection disorder ear EpCAM epithelia epithelial epithelial cell epithelial cells evaluate Evidence expression hearing loss histologic Human immunohistochemistry implicated Infection middle Middle ear mucosa nasal Nasal cavity nasal epithelial cell Nasal Epithelial cells nasal tissue nasal tissue samples otitis otitis media pathophysiology Post-mortem qPCR Quantitative Quantitative RT-PCR receptor required RT-PCR SARS-CoV-2 SARS-CoV-2 entry sensorineural hearing loss Sery Spread Viral viral infections Viral load
[DOI] 10.1007/s12105-021-01378-6 PMC 바로가기 [Article Type] Case Reports

AHR signaling is induced by infection with coronaviruses

Article

Published on 2021-08-262022-10-04
Journal: Nature Communications [Category] MERS, SARS, 치료제,

[키워드] activate activated Activation AhR Analysis antagonist antiviral immunity antiviral response antiviral therapy Aryl hydrocarbon receptor association boost common cold contribute coronavirus Coronaviruses COVID-19 pandemic COVID-19 patients decrease Dengue epithelial cell evade evaluate expression Future HCoV-229E Host Human illnesses immune response in vitro in vivo increased expression Infection Infectious diseases life-threatening limit Lung epithelial cells Lung pathology lung tissue Medical research Mild pathology pharmacological promote Replication Respiratory failure respiratory tract restrict RNA viruses SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 replication severity Signaling single-cell RNA-seq suppressed targets transcriptional Viral load viral replication viral titer Zika
[DOI] 10.1038/s41467-021-25412-x PMC 바로가기 [Article Type] Article

Transcriptomic Signatures of Airway Epithelium Infected With SARS-CoV-2: A Balance Between Anti-infection and Virus Load

Cell and Developmental Biology

Published on 2021-08-232022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells

Resource and Technical Advance

Published on 2021-08-232022-10-30
Journal: JCI Insight [Category] COVID-19, SARS,

[키워드] ACE2 ACE2 expression AIDS/HIV analyzed antiviral genes antiviral response canonical cause change chronic controls COVID-19 disease severity downregulation Enterocyte epithelial cell expression fatality GI Tract Gut highest HIV infection homeostasis impair increased risk individual individuals infect Innate immunity interferon response interferon signaling intestinal lymphoid mucosal Prevent Protein reduction SARS-CoV-2 SARS-CoV-2 entry receptor SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 receptor single-cell small intestine Symptoms target cell target cells tissue TMPRSS2 TMPRSS4 transcriptional profile treated uninfected upregulation vaccine response
[DOI] 10.1172/jci.insight.148920 PMC 바로가기 [Article Type] Resource and Technical Advance

Review of proposed different irradiation methods to inactivate food‐processing viruses and microorganisms

Review

Published on 2021-08-222022-10-31
Journal: Food Science & Nutrition [Category] COVID-19,

Age and gender differences in ACE2 and TMPRSS2 expressions in oral epithelial cells

구강 상피 세포에서 ACE2 및 TMPRSS2 발현의 연령 및 성별 차이

Research

Published on 2021-08-192022-09-10
Journal: Journal of Translational Medicine [Category] MERS, SARS, 치료기술, 치료제,

[키워드] ACE2 activate age age and gender Analysis angiotensin Angiotensin-converting enzyme bioinformatics Cell co-expressed collected coronavirus COVID-19 patients dataset detect elderly patients entry of SARS-CoV-2 entry route epithelial cell epithelial cells Evidence exhibited expression expression level expression levels expressions facilitate Factor Gender Gender differences genders Gene Expression human cell human cells immunofluorescence Infection Localization male mucosal tissues nucleic acid nucleic acids oral cavity oral mucosa oral tissue oral tissues Patient patient age patients performed Perspective positive rate potential risk protease Protein qRT-PCR receptor reported Research Result S protein Saliva SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleic acid SARS-CoV-2 susceptibility sequencing data Serine serine 2 staining supplementary material susceptibility target cells the S protein the SARS-CoV-2 tissues TMPRSS2 TMPRSS2 expression transmembrane transmembrane protease serine 2 was used western blot
[DOI] 10.1186/s12967-021-03037-4 PMC 바로가기 [Article Type] Research

Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells

Article

Published on 2021-08-142022-11-01
Journal: The European Respiratory Journal [Category] COVID-19, Fulltext, SARS,

[키워드] Abstract ACE2 ACE2 expression activated acute respiratory distress acute respiratory syndrome ADAM17 addition Air-liquid interface airway airway epithelial cell airways amplify Angiotensin-converting enzyme baseline caused Cell changes in ciliated cleavage cleave Co-infection coronavirus coronavirus disease COVID-19 COVID-19 pandemic distal Donor effort epithelial cell expressed expression goblet IAV increase Infection Influenza influenza A interactions investigated kDa lung Lung disease lung homogenates Lung injury multiplicity of infection Pathogenesis pathogenic predict protease protease TMPRSS2 proteolytic receptor required respiratory viruses Result risk of COVID-19 SARS-CoV-2 SARS-COV-2 infection severity Single-cell RNA sequencing Stat1 Support syndrome TACE TMPRSS2 transcription factor treatment of influenza viral infections virus infection viruses
[DOI] 10.1183/13993003.03988-2020 PMC 바로가기 [Article Type] Article