Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: Use of cell‐free products and human pluripotent stem cell‐derived mesenchymal stem cellsMesenchymal Stem Cells Published on 2021-05-192022-10-28 Journal: Stem cells translational medicine [Category] Coronavirus, SARS, [키워드] addition advance Allogeneic Autoimmune diseases autologous Cell clinical trial clinical trials COVID‐19 demonstrated Efficacy Endpoint Evidence Exosome Exosomes Extracellular vesicles graft rejection Human human pluripotent stem cells immune Immune cell immunomodulatory property Increasing indication Inflammatory inflammatory disease inflammatory disorders liver Liver cirrhosis mesenchymal stem cell mesenchymal stem/stromal cell therapy MSC MSCs organ transplantation Osteoarthritis outcome prevalent pulmonary disease pulmonary inflammation rejection stem cell Stem cell therapy supported therapeutic therapeutic use therapy tissue Trial while [DOI] 10.1002/sctm.21-0021 PMC 바로가기 [Article Type] Mesenchymal Stem Cells
Cascading from SARS-CoV-2 to Parkinson’s Disease through Protein-Protein InteractionsArticle Published on 2021-05-122022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] appear cascade Central nervous system Clinical finding Cluster CNS connection coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Effect Exosome Exosomes expected explain expressed Extensive host protein host proteins human tissues hypothese Hypothesis include Interaction joint lung Lungs mechanism molecular mechanisms organs/systems Parkinson’s disease Parkinson’s disease Patient post-translational modification post-translational modifications Protein protein-protein interaction protein–protein interactions Proteins proteome provide random reported SARS-CoV-2 significantly significantly more supported Transport Trigger triggering Viral protein Viral proteins [DOI] 10.3390/v13050897 PMC 바로가기 [Article Type] Article
The interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entryArticle Published on 2021-05-122022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 치료제, [키워드] acute respiratory syndrome Antiviral cell entry cell types coronavirus coronavirus disease COVID-19 Ex vivo exhibiting Exosome expression global pandemic hACE2 human Angiotensin-converting enzyme IFN in vitro indicated inhibit Innate immunity interferon Microbiology outbreak Protein receptor recognize released replication of SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 replication Treatment virus entry [DOI] 10.1038/s41392-021-00604-5 PMC 바로가기 [Article Type] Article
Therapeutic mechanisms of mesenchymal stem cells in acute respiratory distress syndrome reveal potentials for Covid-19 treatment급성 호흡곤란 증후군에서 중간엽 줄기세포의 치료 기전은 Covid-19 치료의 가능성을 보여줍니다Review Published on 2021-05-102022-09-10 Journal: Journal of Translational Medicine [Category] SARS, 비임상, [키워드] acute respiratory distress acute respiratory distress syndrome adipose Adipose tissue administration adverse effect adverse effects Allogeneic analyzed animal experiments ARDS attenuate Bone marrow breath cell infusion cells Clinical studies clinical trial coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critically ill Critically ill patient critically ill patients cytokine Cytokines Effects Endoplasmic reticulum Evidence Exosome Exosomes experiment fibrosis highlight inflammatory cells inhibit mechanism mesenchymal stem cell Mesenchymal stem cells modulate mortality rate MSC MSC therapy MSCs paracrine patients with ARDS pulmonary fibrosis raising recent respiratory distress severe COVID-19 stem cell Stress syndrome therapeutic tissue Treatment umbilical Umbilical cord [DOI] 10.1186/s12967-021-02862-x PMC 바로가기 [Article Type] Review
Clinical applications for exosomes: Are we there yet?Review Article Published on 2021-05-032022-10-28 Journal: British Journal of Pharmacology [Category] Coronavirus, MERS, SARS, [키워드] approach Biomarker Cancer carrier clinical clinical development clinical trials Clinical use cross diagnostic diagnostic biomarker disease Efficacy Exosome extracellular vesicle functional protein good manufacturing practice Health immunomodulation Infectious diseases Inflammation limitation Liposome manufacturing metabolites nucleic acids physiological reduced Research subset therapeutic therapeutic agents therapeutic purposes Therapeutics Transport Viral vector [DOI] 10.1111/bph.15432 PMC 바로가기 [Article Type] Review Article
MSC-derived exosomes carrying a cocktail of exogenous interfering RNAs an unprecedented therapy in era of COVID-19 outbreakReview Published on 2021-04-222022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] acute respiratory distress antiviral immune response candidate clinical status COVID-19 COVID-19 complication COVID-19 outbreak COVID-19 therapy ENhance Exosome Exosomes Gene therapy Immune suppression immunomodulatory involved lung management Mesenchymal stem cells miRNA MSCs pandemic Pathogenesis platform Prevent regenerative regimen RNA RNA interference SARS-CoV-2 SARS-CoV-2 pathogenesis siRNA syndrome target targets the SARS-CoV-2 therapeutic therapeutic option therapeutic strategy therapy Treatment viral spread Virus life cycle [DOI] 10.1186/s12967-021-02840-3 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human MicrogliaImmunology Published on 2021-04-142022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] addition Anomaly association axis bystander catastrophic CNS COVID-19 COVID-19 case declining deubiquitinase distress downstream dysfunction Exosome Exosomes explain expression gene product Host Host immune response Human Hyperactivation IFN-β immune cascade IRF9 knowledge microglia microRNA modify mRNA nervous Neuroinflammation neurological NF-κB Novel coronavirus infection organ pathway patients pro-inflammatory gene expression Protein provide regulate Replication SARS-CoV-2 shown Specific spike spike gene supported suppress syndrome System target target gene tissue TNFα transfected cell transported ubiquitin uninfected USP33 Vaccine Viral load virus [DOI] 10.3389/fimmu.2021.656700 PMC 바로가기 [Article Type] Immunology
A study of differential circRNA and lncRNA expressions in COVID-19-infected peripheral blood코로나19에 감염된 말초혈액에서 차등적인 circRNA와 lncRNA 발현에 관한 연구Article Published on 2021-04-122022-09-10 Journal: Scientific Reports [Category] MERS, 바이오마커, 유전자 메커니즘, 치료제, [키워드] activities Apoptosis Biomarkers carried cell cycle Clinical genetics conducted COVID-19 COVID-19 infection COVID-19 patient COVID-19 virus database diagnostic differentially expressed Diseases enrichment analysis Exosome Exosomes expression Gene Expression genetic interaction healthy host cell immune immune tolerance infection mechanism Inflammation information involved KEGG life lncRNA mRNA outbreak pathway Peripheral blood Perspective recurrence Regulation reported sequenced Sequencing signaling pathway therapeutic Transmission Treatment [DOI] 10.1038/s41598-021-86134-0 PMC 바로가기 [Article Type] Article
COVID-19 in a lung transplant recipient: Exploring the diagnostic role of circulating exosomes and the clinical impact of advanced immunosuppression폐 이식 환자의 COVID-19: 순환 엑소좀의 진단 역할 및 고급 면역 억제의 임상 영향 탐색Case Reports Published on 2021-04-012022-09-11 Journal: Transplant infectious disease : an official journa [Category] MERS, SARS, 진단, 치료기술, [키워드] Allograft allograft dysfunction Analysis antibodies Antigen cellular circulating exosome circulating exosomes clinical impact collagen COVID-19 detect diagnostic driven by dysfunction Exosome Exosomes female fluorescent intensity HLA HLA class II human leukocyte antigen Immunosuppression increase in Infection Injury leukocyte lung lung self antigens lung transplant mean fluorescent intensity Methylprednisolone Pathogens plasma recipient rejection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein self-antigen Spike protein Symptoms the mean the patient the SARS-CoV-2 treated tubulin Viral viral pathogens Viral protein Viral proteins [DOI] 10.1111/tid.13480 PMC 바로가기 [Article Type] Case Reports
Proteomic Characterization, Biodistribution, and Functional Studies of Immune-Therapeutic Exosomes: Implications for Inflammatory Lung Diseases면역 치료 엑소좀의 단백질 특성, 생체 분포 및 기능 연구: 염증성 폐 질환에 대한 시사점Immunology Published on 2021-03-252022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 activated acute respiratory syndrome acute respiratory syndrome coronavirus addition analyzed binding biodistribution blocking bone disease Cell characterization circulation clinical trial clinical trials complex controls coronavirus COVID-19 DCs dendritic cell dendritic cells disease downregulate downstream Effect Efficacy Exosome Exosomes experiment expression followed by functions identify immature immune immune response immune therapy immunoblot Immunotherapy implication In-vitro Inflammatory Inflammatory diseases inflammatory disorders initial Interaction internalization Intravenous injection involved liver tissue lung Lung diseases Lungs major organ major organs mice parenchymal parenchymal cells peripheral tissues predominant presenting Protein Proteins proteomics respiratory scrutiny Signaling spleen suggested sustained target target proteins target receptor therapeutic therapy transmigration various inflammatory diseases [DOI] 10.3389/fimmu.2021.636222 PMC 바로가기 [Article Type] Immunology