Impact of COVID-19 pandemic on ophthalmic presentations to an Australian outer metropolitan and rural emergency department: a retrospective comparative studyResearch Published on 2022-01-282022-10-28 Journal: BMC ophthalmology [Category] COVID-19, SARS, [키워드] analysed coding conducted COVID-19 COVID-19 pandemic demographics Diagnosis difference District emergency medicine Epidemiology First wave flexible Follow-up healthcare hospital Impact independent New ophthalmic Ophthalmic emergencies pandemic Patient care remained Result retrospective South supplementary material T-tests Tele-ophthalmology Triage were assessed [DOI] 10.1186/s12886-022-02271-8 PMC 바로가기 [Article Type] Research
Trends and Risk Factors of In-Hospital Mortality of Patients with COVID-19 in Germany: Results of a Large Nationwide Inpatient SampleArticle Published on 2022-01-282022-10-28 Journal: Viruses [Category] COVID-19, [키워드] 95%CI acute respiratory distress age analyzed children concerning COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients died Factor fatality FIVE flexible Germany health resources Healthcare systems help highest hospital Hospitalization hospitalized patient In-hospital In-hospital death Inpatient intensive care intensive care unit lowest mechanical ventilation MOST National Patient patients with COVID-19 Pneumonia predictor resources Result Sample SARS-CoV2 syndrome These data treated trend Variation with COVID-19 [DOI] 10.3390/v14020275 PMC 바로가기 [Article Type] Article
University population-based prospective cohort study of SARS-CoV-2 infection and immunity (SARSSURV-ULiège): a study protocolSARS-CoV-2 감염 및 면역에 대한 대학 인구 기반 전향적 코호트 연구(SARSSURV-ULiège): 연구 프로토콜Article Published on 2022-01-252022-09-11 Journal: BMJ Open [Category] SARS, 진단, 치료기술, [키워드] activity All participant All participants Antibody Response Antibody responses Antibody testing approval blood sample Blood samples cohort study collected Complete COVID-19 COVID-19 pandemic detect determine Epidemiology Ethics ethics committee Evidence flexible higher education immune response Immunity immunology incidence Infection lack magnitude management medical histories MONITOR Neutralising Antibodies neutralising antibody participant Phase 1 Phase 2 population-based cohort positive Potential Prevalence profiles prospective cohort study protocol amendment public health questionnaire Rapid test rapid test result reference number Registered required Research Research Ethics Research Ethics Committee respond risk Risk assessment Risk management RT-qPCR Safe Saliva SARS-CoV-2 SARS-CoV-2 antibody testing SARS-COV-2 infection serological serological test Seroprevalence Stage student study period Study protocol submitted university university hospital vaccination Vaccine hesitancy Weekly [DOI] 10.1136/bmjopen-2021-055721 PMC 바로가기 [Article Type] Article
Advances in mixed cell deconvolution enable quantification of cell types in spatial transcriptomic dataArticle Published on 2022-01-192022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] advance Algorithm can be used Cancer cancer cell Cancer genomics Cell cell population cell type classical Computational models dataset defined estimate expression flexible Gene Expression granular heterogeneity identify immune immune response lung tumors mapping marker Proteins quantification Region resolved single cell sequencing Statistical methods tissue transcriptomic data transcriptomics tumors Tumour immunology [DOI] 10.1038/s41467-022-28020-5 PMC 바로가기 [Article Type] Article
Extended ensemble simulations of a SARS-CoV-2 nsp1–5’-UTR complexSARS-COV-2 NSP1–5'-UTR 복합체의 확장 된 앙상블 시뮬레이션Research Article Published on 2022-01-192022-09-10 Journal: PLoS Computational Biology [Category] SARS, 유전자 메커니즘, [키워드] 5’-untranslated region acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Author bind binding block C-terminal causative pathogen characteristic cluster analysis complex Consistency coronavirus COVID-19 cryo cryo-EM Efficiency electron density ENCODE evade experimental evidence experiments Extended flexible Host host cells host immunity host mRNA human cell increase infected cells interactions intrinsically investigated involved mechanism modulate molecular dynamics Molecular dynamics simulation molecular mechanism mutant N-terminal nonstructural protein 1 nsp1 open pandemic of COVID-19 performed predicted Protein Recognition recognize reported residue residues respiratory ribosome RNA SARS-CoV-1 SARS-CoV-2 SARS-CoV-2-infected cells selective severe acute respiratory syndrome Coronavirus Simulation solvent suggested the SARS-CoV-2 translate translation Viral Viral RNA virus X-ray crystallographic structure [DOI] 10.1371/journal.pcbi.1009804 PMC 바로가기 [Article Type] Research Article
Vaccine Liability in the Light of Covid-19: A Defence of Risk–BenefitOriginal Article Published on 2022-01-132022-10-30 Journal: Medical Law Review [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] approach benefit can be used Community concerning COVID-19 COVID-19 pandemic COVID-19 vaccine determine European flexible help Immunity LIGHT medical intervention Medicinal products mitigate product liability risk risk–benefit tort Treatment union Vaccine Vaccines [DOI] 10.1093/medlaw/fwab053 PMC 바로가기 [Article Type] Original Article
What could we do differently next time? Australian parents’ experiences of the short-term and long-term impacts of home schooling during the COVID-19 pandemicResearch Published on 2022-01-132022-10-28 Journal: BMC Public Health [Category] Coronavirus, SARS, [키워드] Analysis approach asked assist Caregivers children competing conducted COVID-19 COVID-19 pandemic Evidence Family Relationships flexible Guidance Home learning Home schooling Impact lack lockdown pandemic parent Parenting parents participant Perceived positive Qualitative question Remote learning reported Result risk social isolation Support Wave [DOI] 10.1186/s12889-022-12495-4 PMC 바로가기 [Article Type] Research
Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizersSARS-CoV-2 엘리트 중화제에서 초강력 광범위 중화 항체 발견Article Published on 2022-01-122022-09-11 Journal: Cell Host & Microbe [Category] Fulltext, SARS, 변종, 진단, [키워드] Analysis analyzed antibodies antibody Antibody Response assembly B.1.1.7 B.1.351 B.1.429 B.1.617 B.1.617.2 binding broadly neutralizing antibodies candidate conformation convalescent individual convalescent individuals COVID-19 cross-reactive cross-reactivity cryo cryo-EM Cryo-EM analysis displaying effective emerging variants flexible fraction humoral IGHV3-53 monoclonal monoclonal antibodies neutralized Neutralizing Neutralizing antibodies neutralizing antibody performed predicted Prevent sarbecovirus SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 sequence SARS-CoV-2 variants single B cell the RBD treat ultrapotent monoclonal antibodies variant variants variants of concern [DOI] 10.1016/j.chom.2021.12.010 PMC 바로가기 [Article Type] Article
Spatiotemporal Associations between Local Safety Level Index and COVID-19 Infection Risks across Capital Regions in South KoreaArticle Published on 2022-01-122022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Area Bayesian Capital complexity correlation COVID-19 disease spread Diseases Effect Effects elevated Evolution explain flexible help heterogeneity Hierarchical identify IMPROVE index infection risk infection risks Infectious disease influence Intervention Level Local local safety level index outcome pandemic reduction in Region reveal risk Safety Seoul capital area significantly South Korea spatiotemporal Spatiotemporal Bayesian Spread Transmission unique unobserved heterogeneity [DOI] 10.3390/ijerph19020824 PMC 바로가기 [Article Type] Article
A first remotely-delivered guided brief intervention to reduce intrusive memories of psychological trauma for healthcare staff working during the ongoing COVID-19 pandemic: Study protocol for a randomised controlled trialArticle Published on 2022-01-122022-10-04 Journal: Contemporary Clinical Trials Communications [Category] 임상, [키워드] 1:1 cognitive consequence COVID-19 COVID-19 pandemic develop digital intervention dissemination event finding flexible groups healthcare Healthcare staff include Inclusion Intervention Intrusive memories memory mental health mitigate outcome pandemic Placebo post-intervention Primary outcome protocol Psychological Psychological trauma psychologically randomised controlled trial Randomly RCT receive reduce reported researcher risk Support Symptoms trauma Two-arm Week [DOI] 10.1016/j.conctc.2022.100884 PMC 바로가기 [Article Type] Article