Temperature Sensitivity: A Potential Method for the Generation of Vaccines against the Avian Coronavirus Infectious Bronchitis VirusArticle Published on 2020-07-142022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Accessory genes affected allelic antigenic clone contagious core body temperature coronavirus days post infection defined determinant determine dissemination effectively deliver eyelid function Generation Genes genetics Host IBV in vivo Infectious Bronchitis Virus investigated lesion molecular mRNA synthesis Mutation pathogenic Potential Proteins replicase replicate respiratory pathogen RNA synthesis sensitivity Seven strain temperature temperature sensitive temperature sensitivity tissue upper respiratory tract Vaccine design Vaccine development vaccine platform viral replication was used [DOI] 10.3390/v12070754 PMC 바로가기 [Article Type] Article
DREAM- in -CDM Approach and Identification of a New Generation of Anti-inflammatory Drugs Targeting mPGES-1Article Published on 2020-06-232022-10-04 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] anti-inflammatory drug Anti-inflammatory drugs anti-inflammatory effect approach caused Clinical data clinically condition COVID-19 disease drug Drug discovery effective FDA-approved drug form Generation identification identify in vitro in vivo Inflammation inhibitor involved Lung inflammation New Pain Screening Side effect targeting targets therapeutic indication treat Virtual drug screening [DOI] 10.1038/s41598-020-67283-0 PMC 바로가기 [Article Type] Article
Airborne Aerosol Generation During Endonasal Procedures in the Era of COVID-19: Risks and RecommendationsSpecial Section on COVID-19 Published on 2020-05-262022-10-29 Journal: Otolaryngology--Head and Neck Surgery [Category] COVID-19, MERS, SARS, [키워드] aerosol Aerosol generation aerosol spread aerosol-generating procedure aerosol-generating surgery aerosolization Aerosols airborne Cadaveric clinical activity clinical examination condition conditions COVID-19 detectable diagnostic did not produce Efficacy endonasal endoscopy evaluated Generation hand Intact Laboratory Mask N95 respirator nasal Nasal endoscopy nose and throat objective optical performed prevented procedure Prospective quantification real time Respirator Result risk SARS-CoV-2 setting Significant surgical Surgical Procedure Transmission was performed [DOI] 10.1177/0194599820931805 PMC 바로가기 [Article Type] Special Section on COVID-19
Critical care transport in the time of COVID-19Ornge Supplement Published on 2020-05-132022-10-31 Journal: CJEM [Category] COVID-19, SARS, [키워드] ambulance services approach bases Care carrier coronavirus disease COVID-19 Critical care eight EMS fixed Generation identify Infectious diseases Microbiology organization pandemic prehospital provide Transport [DOI] 10.1017/cem.2020.400 PMC 바로가기 [Article Type] Ornge Supplement
Generation of a Nebulizable CDR-Modified MERS-CoV Neutralizing Human AntibodyArticle Published on 2019-10-122022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, [키워드] accumulated administration aerosol delivery aggregates amino acids antibody antibody engineering CDRs clone complementarity-determining region complementarity-determining regions FIVE generate Generation glycoprotein greater HCDR HCDR3 Human hydrophobic residue induce infected patients introduced LCDRs lung tissue mechanical ventilation MERS-CoV Middle East Modification Mutation nebulizer Neutralizing Neutralizing activity neutralizing antibody physiological Protein pulmonary disease pulmonary diseases RBD reactive reactivity replaced residue Respiratory failure respiratory syndrome coronavirus resulting S RBD significantly stability the receptor-binding domain therapeutic Val [DOI] 10.3390/ijms20205073 PMC 바로가기 [Article Type] Article
Tetraspanin Is Required for Generation of Reactive Oxygen Species by the Dual Oxidase System in Caenorhabditis elegansTetraspanin은 Caenorhabditis elegans의 이중 산화 효소 시스템에 의한 반응성 산소 종의 생성에 필요합니다Research Article Published on 2012-09-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation addition aerobic aerobic metabolism aging Analysis association Author biosynthetic biosynthetic pathway Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans cause Cell cell surface cellular cellular component cellular components co-expression collagen Combination complex complexes conjunction conserved Defense deficiency demonstrated dependent on disease DOXA dual elegan enzyme Enzymes Evidence experiment exposure to Extracellular matrix failure functions Generation Genetic genetic mutation genetics Host host defense hydrogen hydrogen peroxide Imbalance Immunity in vitro in vivo inhibit isozyme less lipids mammalian cells mammals maturation mechanism member metabolism modifications mucosal mutant mutants Mutation NADPH NADPH oxidase nucleic acids Oxidase oxidative stress oxygen pathway peroxidase physiological produced Protein provide Radiation reactive reactive oxygen species redox state regulated Regulatory required responsible restored ROS Signaling signaling pathway Specy suggested System tetraspanin the cell Thyroid thyroid hormone toxic tyrosine unique UV light [DOI] 10.1371/journal.pgen.1002957 PMC 바로가기 [Article Type] Research Article
Generation of human antibody fragments recognizing distinct epitopes of the nucleocapsid (N) SARS-CoV protein using a phage display approachResearch Article Published on 2005-09-192022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory syndrome antibody antibody fragment Antiviral compound approach cause characterized coated with antigen described detect diagnostic test disease domain ELISA epitope Generation high mortality rate Human immunocytochemistry immunohistochemistry in vitro Infected Isolation MONITOR N protein neutralizing antibody nucleocapsid Particle Prevent Protein reagent recognize recognizing Result SARS epidemic SARS virus SARS-CoV SARS-CoV N protein scFv selected severe Spread target cells treat Vaccine Vero cells virus was used [DOI] 10.1186/1471-2334-5-73 PMC 바로가기 [Article Type] Research Article