hACE2 – Page 10 – Communicable Diseases Research

Characterization of Two Heterogeneous Lethal Mouse-Adapted SARS-CoV-2 Variants Recapitulating Representative Aspects of Human COVID-19

인간 COVID-19의 대표적인 측면을 요약하는 두 가지 이종 치명적인 마우스 적응 SARS-CoV-2 변이체의 특성화

Immunology

Published on 2022-02-072022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘,

HACE2-Exosome-Based Nano-Bait for Concurrent SARS-CoV-2 Trapping and Antioxidant Therapy

동시 SARS-CoV-2 트래핑 및 항산화 요법을 위한 HACE2-엑소좀 기반 나노 미끼

Article

Published on 2022-02-022022-09-11
Journal: ACS applied materials & interfaces [Category] COVID19(2023년), SARS, 치료제,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antioxidant Antiviral approach attenuate binding caused Cell cells concurrent Corona coronavirus COVID-19 COVID-19 pandemic cytokine release Cytokine release syndrome Cytokines death effective epithelial cell epithelial cells Exocytosis Exosome expression hACE2 Health Immune cell infiltration Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines kidney Kidney failure microenvironment nano-bait organ injury oxidative oxidative stress pandemic Pneumonia Polydopamine Protein binding resulting robust S protein Safe SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly Trapping Treatment Virus Disease
[DOI] 10.1021/acsami.1c19541 PMC 바로가기 [Article Type] Article

From Free Binding Energy Calculations of SARS-CoV-2—Receptor Interactions to Cellular Immune Responses

SARS-CoV-2의 자유 결합 에너지 계산 - 수용체 상호 작용에서 세포 면역 반응까지

Brief Report

Published on 2022-02-022022-09-10
Journal: Medicina [Category] COVID19(2023년), MERS, SARS, 변종,

[키워드] angiotensin angiotensin converting enzyme Antigen assumed binding calculation change clinically computational analysis Computational biology danger signal danger signals disease severity energy enzyme expected Free free energy Free energy calculation Free energy calculations hACE2 HLA type Host human angiotensin converting enzyme 2 human leukocyte antigen immune responses infected cell Infection inflammatory immune responses Interaction leukocyte Lower respiratory tract molecular Occurrence omicron partial immunity pathogenicity Positive selection predicted produced RBM receptor Receptor binding Receptor binding domain receptor interaction reduced required respiratory response resulting SARS-CoV-2 SARS-CoV-2 Omicron SARS-CoV-2 spike protein Spike protein trade-off Transmissibility upper respiratory tract Vaccinations variants variants of concern virus viruses VOCs wild type
[DOI] 10.3390/medicina58020226 PMC 바로가기 [Article Type] Brief Report

Computational Analysis of Mutations in the Receptor-Binding Domain of SARS-CoV-2 Spike and Their Effects on Antibody Binding

Article

Published on 2022-01-302022-10-28
Journal: Viruses [Category] COVID-19, SARS,

[키워드] ACE2 ACE2 binding ACE2 receptor administration amino acid replacement Analysis analyzed antibody antigenic antigenic escape approaches binding binding affinity binding free energy bioinformatics Cluster complexes computational analysis computational mutagenesis coronavirus disease Coronaviruses COVID-19 Deleterious Effect epitope Epitopes feature hACE2 human ACE2 receptor human cell identify impairment indicate Infection Interaction monoclonal multiple mutation multiple mutations Mutation Neutralizing neutralizing antibody Pandemics performed produced Protein RBD RBD mutation RBD variant reduce resolved responsible S-protein SAR-CoV-2 SARS-CoV-2 sequence spike Strains Structure the RBD the receptor-binding domain the SARS-CoV-2 the vaccine Trigger Vaccines variants of SARS-CoV-2 virus–host interactions
[DOI] 10.3390/v14020295 PMC 바로가기 [Article Type] Article

Infectivity and antigenicity of pseudoviruses with high-frequency mutations of SARS-CoV-2 identified in Portugal

포르투갈에서 확인 된 SARS-COV-2의 고주파 돌연변이를 갖는 슈도 바이러스의 감염성 및 항원 성

Original Article

Published on 2022-01-272022-09-10
Journal: Archives of Virology [Category] COVID19(2023년), Fulltext, MERS, SARS, 변종, 진단,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus antibodies antigenicity B.1.1.7 binding domain caused cell line coronavirus Cross-species transmission D614G Effectiveness Efficacy Epidemic epidemiological Epidemiological investigation evade evaluated hACE2 Health host immunity Huh7 immunized infect Infectivity monoclonal antibodies monoclonal antibody mouse serum mutant mutant strain Mutant strains mutants Mutation N439K N501Y neutralization activity Neutralizing activity nine overexpressing Portugal Prevalence Prevention and control pseudovirus pseudoviruses Receptor binding domain reduced Region regions respiratory S477N SARS-CoV-2 SARS-CoV-2 mutation severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly Spike protein Spread strain Strains supplementary material susceptible cell tested Vaccine Vaccines Variation Vero was performed was used weakened were used
[DOI] 10.1007/s00705-021-05327-0 PMC 바로가기 [Article Type] Original Article

A Single Dose of an MVA Vaccine Expressing a Prefusion-Stabilized SARS-CoV-2 Spike Protein Neutralizes Variants of Concern and Protects Mice From a Lethal SARS-CoV-2 Infection

사전 융합 안정화 SARS-CoV-2 스파이크 단백질을 발현하는 MVA 백신의 단일 용량은 우려의 변종을 중화하고 치명적인 SARS-CoV-2 감염으로부터 마우스를 보호합니다

Immunology

Published on 2022-01-272022-09-11
Journal: Frontiers in Immunology [Category] 변종, 진단,

[키워드] administration animal models Antibody titers C57BL/6 caused Cell clinical trials concern COVID-19 vaccine Cytokines demonstrated dose Efficacy expressed expressing expression full-length hACE2 histopathological IgG immune responses immunized immunogenicity K18-hACE2 mice lesions lethal Lungs mice modified vaccinia virus morbidity morbidity and mortality mouse model MVA vector Neutralizing antibody titer neutralizing antibody titers parental poxvirus prefusion-stabilized S protein pro-inflammatory cytokine pro-inflammatory cytokines protective efficacy Protein reducing S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 vaccine SARS-CoV-2 viral loads single dose spike T-cell immune responses transgenic vaccine candidate variants variants of concern Viral viral loads viruses wild-type
[DOI] 10.3389/fimmu.2021.824728 PMC 바로가기 [Article Type] Immunology

Site Density Functional Theory and Structural Bioinformatics Analysis of the SARS-CoV Spike Protein and hACE2 Complex

Article

Published on 2022-01-262022-10-30
Journal: Molecules [Category] COVID-19, SARS,

[키워드] 3DRISM Analysis angiotensin-converting enzyme 2 bind binding bioinformatics cause cellular membrane classical complex complexes conformational conformational change conformational dynamics coronavirus COVID-19 density distribution domain exhibit functional glycoprotein H-bond hACE2 homotrimer human host cell Inclusion increase indicate Interaction interaction site interactions intermolecular interaction Modification normal mode analysis promote Proteolytic processing RBD RBD-ACE2 receptor S protein SARS-CoV spike SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 spike protein shown Site site density functional theory spike protein binding to human receptor structural rigidity Structure the RBD the S protein the SARS-CoV-2 the spike protein theory
[DOI] 10.3390/molecules27030799 PMC 바로가기 [Article Type] Article

Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2

순환하는 ACE2 발현 세포외 소포는 광범위한 SARS-CoV-2 균주를 차단합니다

Article

Published on 2022-01-202022-09-10
Journal: Nature Communications [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, 진단, 치료기술, 치료제,

[키워드] ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin angiotensin-converting enzyme 2 Antiviral approach binding biologics caused Cell cellular circulating competing coronavirus COVID-19 COVID-19 patients COVID-19 severity disease Efficacy entry receptor EVs Express extracellular vesicle hACE2 host cell host cells human ACE2 Human plasma identify increase in infect Infection inhibit Lung injury mechanism Mortality neutralize pandemic Pathogenesis plasma preventing infection PROTECT pseudotyped RBD respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severity soluble ACE2 Spike protein strain therapeutic transgenic mice variants of concern Viral viral infection viral spike protein wildtype with COVID-19
[DOI] 10.1038/s41467-021-27893-2 PMC 바로가기 [Article Type] Article

A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs

새로운 STING 효능제가 첨가된 범-사베코바이러스 백신은 마우스, 토끼 및 NHP에서 강력하고 내구성 있는 중화 항체 및 T 세포 반응을 이끌어냅니다.

Article

Published on 2022-01-192022-09-11
Journal: Cell Research [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단,

The Tissue Distribution of SARS-CoV-2 in Transgenic Mice With Inducible Ubiquitous Expression of hACE2

Molecular Biosciences

Published on 2022-01-182022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] ACE2 Activation alteration Brain Brain tissues change clinically COVID-19 COVID-19 pathogenesis Cre recombinase Day death distribution examined expressing expression hACE2 hACE2 switch-on mice histological examination human ACE2 induce Infection infections internal organ intestine intranasal intranasal infection Isolation Laboratory lung Lungs mice Mild murine model novel coronavirus disease offspring prevented provide resulting Safe SARS-CoV-2 SARS-COV-2 infection strain Tamoxifen tissue transgene transgenic mice treated Treatment Viral load virus weighed weight loss
[DOI] 10.3389/fmolb.2021.821506 PMC 바로가기 [Article Type] Molecular Biosciences