Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factorsSARS-CoV-2 숙주 단백질 상호작용체의 기능적 조사는 독특하고 공유된 코로나바이러스 숙주 인자를 식별합니다Article Published on 2021-02-102022-09-12 Journal: Cell Host & Microbe [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome approach cholesterol homeostasis claimed coronavirus coronavirus disease COVID-19 CRISPR CRISPR-Cas9 effort Factor GPI GTPase HCoV HCoV-229E HCoV-NL63 HCoV-OC43 Health help Host host protein human coronavirus 229E identify Infection involved much higher Outbreaks pandemic presenting probe Rab required SARS-CoV-2 SARS-CoV-2 protein seasonal coronaviruses temperature unique virus-host interactome [DOI] 10.1016/j.chom.2020.12.009 PMC 바로가기 [Article Type] Article
Molecular Evolution of Human Coronavirus 229E in Hong Kong and a Fatal COVID-19 Case Involving Coinfection with a Novel Human Coronavirus 229E Genogroup홍콩에서 인간 코로나바이러스 229E의 분자 진화와 새로운 인간 코로나바이러스 229E 유전자 그룹과의 동시 감염을 포함하는 치명적인 COVID-19 사례Case Reports Published on 2021-02-102022-09-10 Journal: mSphere [Category] MERS, 진단, 치료기술, [키워드] 229E addition airway Analysis camelid circulating CLOCK Clustering Coinfection COVID-19 COVID-19 pneumonia described diagnose disease domain Evolution Genetic genetic diversity genetic drift Genome sequencing Genotype HCoV HCoV-229 HCoV-229E Hong Kong human coronavirus human coronavirus 229E human coronaviruses identity infected patients Involving N gene nasopharyngeal sample novel nucleotide path patients Pneumonia positive Positive selection RdRP Receptor-binding domain related viruses required respiratory respiratory sample retrieved SARS-CoV-2 SARS-CoV-2 strain Sequence analysis Sequencing Spike protein strain Strains tested the patient the SARS-CoV-2 the spike protein the United State The United States Transmission Travel type strain United States Viral viral evolution virus viruses Wuhan Wuhan-Hu-1 [DOI] 10.1128/mSphere.00819-20 PMC 바로가기 [Article Type] Case Reports
Coronavirus replication–transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit530 Published on 2021-02-092022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] activity acute respiratory syndrome antiviral drug arterivirus Cell culture cellular complex conserved Coronaviridae coronavirus Coronavirus replication Critical cytidine dependent on domain Evidence family Coronaviridae functional generate HCoV-229E homolog Hypothesis in vitro Interaction Ion M pro marker monophosphate mutant N terminus N-terminal Nidovirale nidovirus NiRAN Nsp12 nsp12 protein Nsp9 Nsps nucleotide nucleotidyltransferase observation polyprotein protease Protein proteolytic provide RdRps released Replication reported residue RNA polymerase RNA synthesis RNA viruses RNA-dependent RNA polymerase selective sequence shown Significance subunit suggested transfer transferase activity virus virus replication Vital [DOI] 10.1073/pnas.2022310118 PMC 바로가기 [Article Type] 530
Human Milk Antibodies against S1 and S2 Subunits from SARS-CoV-2, HCoV-OC43, and HCoV-229E in Mothers with a Confirmed COVID-19 PCR, Viral SYMPTOMS, and Unexposed MothersCOVID-19 PCR, 바이러스성 증상 및 노출되지 않은 산모에서 SARS-CoV-2, HCoV-OC43 및 HCoV-229E의 S1 및 S2 소단위체에 대한 모유 항체Article Published on 2021-02-092022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, 진단, 치료기술, [키워드] β-coronaviruses antibodies antibody Antigen antigens breast milk Breastfeeding Confirmed control group COVID-19 COVID-19 group COVID-19 pandemic COVID-19 PCR test cross-reactive cross-reactive antibodies cross-reactive antibody ELISA evaluate group groups HCoV HCoV-229E HCoV-OC43 HCoVs Human human milk IgG IgG levels IgM Immunity immunoglobulins Infectious diseases milk mother Neonates not differ OC43 passive immunity PCR PCR test polyreactive antibody positive correlation positive correlations Preexisting immunity reactive S1 and S2 S2 subunit SARS-CoV-2 SARS-CoV-2 IgG secretory antibodies secretory IgA SIgA subunit Symptom Symptoms Viral were measured α-coronaviruses [DOI] 10.3390/ijms22041749 PMC 바로가기 [Article Type] Article
Drastic Reduction of Bacterial, Fungal and Viral Pathogen Titers by Cuprous Oxide Impregnated Medical TextilesArticle Published on 2021-02-012022-10-31 Journal: Journal of Functional Biomaterials [Category] COVID-19, [키워드] antiviral activity Bacterial Bacterial infections Candida caused clinical setting Clostridium difficile contaminated surfaces copper coronavirus COVID-19 pandemic cuprous cuprous oxide determine Efficacy Enterococcus fungal pathogens HCoV-229E hospital Hospital acquired infections independent Infection initial Klebsiella pneumoniae Laboratory log manifested medical textiles MRSA nosocomial occur Oxide pathogen Pathogens Patient reduce reduced respiratory viral risk textile titer titre Viable viral infections viruses [DOI] 10.3390/jfb12010009 PMC 바로가기 [Article Type] Article
Pseudo-Dipeptide Bearing α,α -Difluoromethyl Ketone Moiety as Electrophilic Warhead with Activity against CoronavirusesArticle Published on 2021-01-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] A549 activity Antiviral Bearing bind binding carried Cell cells comparable coronavirus cysteine proteases cytotoxicity difluoromethyl ketone distress docking evaluated fibroblast HCoV-229E human coronavirus human coronaviruses human embryonic lung in silico analysis indicated inhibit ketone M pro moiety Molecular dynamics simulation New nucleophilic performed protease SARS-CoV-2 SARS-CoV-2 Mpro similarity transfer viral cytopathic effect viral replication warhead [DOI] 10.3390/ijms22031398 PMC 바로가기 [Article Type] Article
Aerosols modification with H 2 O 2 reduces airborne contamination by dental handpiecesResearch Article Published on 2021-01-292022-10-30 Journal: Journal of Oral Microbiology [Category] COVID-19, [키워드] 229E adopted aerosol Aerosols Contamination coronavirus Coronavirus infections Dental equipment Detection limit disease transmission Efficiency evaluate HCoV-229E hydrogen peroxide in vitro study inoculated Modification objective operator pandemic Patient preventive measure quantitative PCR reduce reduced reducing Result Saliva SARS-CoV-2 SARS-CoV-2 asymptomatic patient significantly significantly lower Spread tested the SARS-CoV-2 Viral load was performed was tested was used [DOI] 10.1080/20002297.2021.1881361 PMC 바로가기 [Article Type] Research Article
HTCC as a Polymeric Inhibitor of SARS-CoV-2 and MERS-CoVSARS-CoV-2 및 MERS-CoV의 고분자 억제제로서의 HTCCArticle Published on 2021-01-282022-09-11 Journal: Journal of Virology [Category] 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity bats block Care characterization China chitosan chloride circulating Cluster Compound Coronaviridae coronavirus demonstrated Entry epithelia escaped ex vivo model HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 Health Health care highly pathogenic HKU1 host cell HTCC human airway human airway epithelia human coronavirus humans in vitro infect information inhibited inhibition inhibitor Interaction life-threatening Local measure mechanism mechanism of action member MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus multiorgan failure NL63 Novel coronavirus OC43 pandemic pathogen Polymer Rapid Research respiratory respiratory infection respiratory syndrome coronavirus S protein SARS-CoV-2 SARS-COV-2 infection Seven severe acute respiratory syndrome Coronavirus Spread the S protein virus virus entry viruses [DOI] 10.1128/JVI.01622-20 PMC 바로가기 [Article Type] Article
The evolutionary dynamics of endemic human coronavirusesRapid Communication Published on 2021-01-202022-10-28 Journal: Virus Evolution [Category] COVID-19, [키워드] accumulated acute respiratory syndrome adaptive Affect amino acid change analyzed antigenic antigenic variant average Bayesian Bayesian framework Cell changes in coronavirus Coronavirus-2 dataset Endemic endemic human coronavirus Evidence Evolution evolutionary dynamics Evolutionary rate expected gene regions Genes genetic variability glycoprotein H3N2 HCoV-229E HCoV-OC43 highest Host HPD human coronavirus human coronaviruses human pathogen IAV influenza A virus influenza vaccines less likelihood maximum mutations neutralizing antibody responses Non-synonymous mutation occurred pandemic Phylogeny Positive selection protective immunity RBD Receptor binding domain representing reservoir RNA virus S gene SARS-CoV-2 SARS-CoV-2 evolution similarities similarity stability Substitution supported target the RBD Vaccine viral entry virus [DOI] 10.1093/ve/veab020 PMC 바로가기 [Article Type] Rapid Communication
Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changesArticle Published on 2021-01-082022-10-29 Journal: Nature Communications [Category] Coronavirus, MERS, [키워드] activated alphacoronavirus Analysis antibody binding conformational change conformational state conformations coronavirus cryo-EM structure Cryoelectron microscopy glycoprotein HCoV-229E host cell host cell membranes Host receptors implication Interaction involved mechanism observé postfusion prefusion promote receptor Receptor binding reported reveal S trimer S-protein S1 subunit S1-NTD S2 subunit spike glycoprotein Spike protein Structure the S1 subunit therapeutic transmembrane glycoprotein trimeric type I Vaccine viral entry Viral membrane fusion Virus structures Virus-host interactions [DOI] 10.1038/s41467-020-20401-y PMC 바로가기 [Article Type] Article