Ototoxicity prevention during the SARS-CoV-2 (COVID-19) emergencySARS-CoV-2(COVID-19) 비상시 이독성 예방Article Published on 2020-12-012022-09-11 Journal: Journal of global antimicrobial resistance [Category] SARS, 치료기술, 치료제, [키워드] Chloroquine COVID-19 detect emission healthy subjects Hydroxychloroquine manifestation Otoacoustic Emissions ototoxic ototoxicity pandemic prevention Prophylactic risk SARS-CoV-2 SARS-CoV-2 (Covid-19). screened subject the SARS-CoV-2 [DOI] 10.1016/j.jgar.2020.09.030 PMC 바로가기 [Article Type] Article
Could KL-6 levels in COVID-19 help to predict lung disease?COVID-19의 KL-6 수치가 폐 질환을 예측하는 데 도움이 될 수 있습니까?Letter to the Editor Published on 2020-11-242022-08-31 Journal: Respiratory Research [Category] 바이오마커, [키워드] affected Biomarker bronchial epithelial cells cellular Cohort collected composed coronavirus coronavirus disease COVID-19 COVID-19 infected patient COVID-19 infection COVID-19 patient determine Diagnosis disease disease severity effective epithelial epithelial cells Evolution glycoprotein healthy subject healthy subjects help heterogenous ILD Increased International Interstitial lung disease Interstitial lung diseases IPF KL-6 Laboratory lesion lung Lung disease Lung diseases Lung infection marker material molecular weight Patient predict produced Prognosis public health emergency quest question raised remains uncertain Result sarcoidosis serum Serum level severity therapeutic response Treatment Type II pneumocyte type II pneumocytes [DOI] 10.1186/s12931-020-01560-4 PMC 바로가기 [Article Type] Letter to the Editor
Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors건강 및 천식, COPD, 비만, 고혈압 및 COVID-19 위험 요소의 조직 및 면역 세포에서 ACE2, CD147, CD26 및 기타 SARS-CoV-2 관련 분자의 분포Article Published on 2020-11-012022-08-31 Journal: Allergy [Category] SARS, 바이오마커, 유전자 메커니즘, 치료제, [키워드] ACE2 Adults age Altered analyzed Asthma atopic dermatitis B cells BAL Blood BMI bronchial epithelial cells Bronchoalveolar lavage fluid BSG caused CD147 CD26 CD4 CD8 clinical presentation co-expression coexpressed Comorbidity contribute COPD correlated COVID-19 COVID-19 children database DCs disease disease status DPP4 epithelial epithelial cells expression expression profile Factor Gender Gene Expression Health healthy children healthy subject healthy subjects human cell human cells hypertension Immune cell immune cells Infection involved lung male material molecular Monocytes mononuclear cell mononuclear cells morbidity Mortality Neutrophils NK cells Novel coronavirus novel coronavirus SARS-CoV-2 obesity Patient PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells plasmablasts PPIA PPIB primary human bronchial epithelial cells primary human cell primary human cells receptor reported risk factor Risk factors RNA sequencing SARS receptor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 receptors severity skin skin biopsies smoking T cell T cells the disease the SARS-CoV-2 tissue tissues TMPRSS2 were expressed Whole blood [DOI] 10.1111/all.14429 PMC 바로가기 [Article Type] Article
Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19Article Published on 2020-10-292022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] activated Algorithm Analysis APOC1 ApoE BAL BCL2A1 Bronchoalveolar lavage Bronchoalveolar lavage (BAL) C1QB canonical category CCL2 CCL3 CCL5 CCL8 CCR1 Cell cellular chemotactic chemotaxis circulation Clustering Cohort complex coronavirus disease correlation COVID-19 CXCL8 Cytokine storm dataset diagnostic disease severity downregulated EPSTI1 FABP4 FIVE FPR1 functional gene signature gene signatures hallmark healthy subject healthy subjects ICGS2 identify IFI27 IFI30 Ifi44 IFI44L IFI6 IFIT1 IFIT3 IFITM1 IFITM2 IFITM3 IFNg IL17 IL1A IL1B IL1RN immune Immune cell Inflammatory inflammatory macrophages Inflammatory response interstitial iterative KLF6 Macrophage MALAT1 Mild mononuclear cell MX1 myeloid cells NEAT1 neutrophil Neutrophils NFkB OAS1 OAS2 OAS3 OASL pathway Patient patients PBMCs Peripheral blood phagocytes phagocytosis PLSCR1 PRL reduction reflected role S100A8 SARS-CoV-2 SAT1 several gene severe COVID-19 severity Signaling Single Cell SPP1 STAT3 subset suppressed systemically TGM2 therapeutic interventions TLR7 TLR9 TNF TYMP UMAP upstream with COVID-19 [DOI] 10.3390/cells9112374 PMC 바로가기 [Article Type] Article
Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker복합 바이오마커로서 아연, 연령 및 셀레노단백질 P에 의한 COVID-19의 생존 확률 예측Clinical Trial Published on 2020-10-202022-08-13 Journal: Redox Biology [Category] MERS, SARS, 바이오마커, 임상, [키워드] age an area Analysis AUC Biomarker characteristic collected Concentration contribute convalescence coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients deficiency deficit different time point different time points EpiC EPIC cohort European healthy subject healthy subjects Hypothesis immune response immune system Inflammation information investigation majority Micronutrient non-survivor Non-survivors nutrition pandemic Patient personalised prediction Prevalence prognostic Prospective provide receiver operating characteristic reference range reference ranges ROC SARS-COV-2 infection SARS-CoV-2 infections Se transporter selenoprotein P Selenium SELENOP Selenoprotein P serum serum sample serum samples status Support survival survival odd survivor tested threshold Trace element trace elements was determined were used yielding Zinc [DOI] 10.1016/j.redox.2020.101764 PMC 바로가기 [Article Type] Clinical Trial
Reduced numbers of T cells and B cells correlates with persistent SARS-CoV-2 presence in non-severe COVID-19 patientsArticle Published on 2020-10-192022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 임상, 치료기술, [키워드] adaptive Adaptive immunity age analyzed B cell CD3 CD4 clinically collected comparable COVID-19 COVID-19 patient demonstrated disease onset healthy controls healthy subject healthy subjects hospital Immune cell immune cells Infectious diseases Laboratory laboratory data lymphocyte subpopulation Microbiology monitoring NK cell non-severe patient Patient patients persistent positive Recovered COVID-19 patients recruited reduced SARS-CoV-2 significantly higher significantly increased T cell T cells the SARS-CoV-2 transferred university Wuhan [DOI] 10.1038/s41598-020-73955-8 PMC 바로가기 [Article Type] Article
Unique immunological profile in patients with COVID-19COVID-19 환자의 독특한 면역 프로필Clinical Trial Published on 2020-10-152022-08-13 Journal: Cellular and Molecular Immunology [Category] MERS, SARS, 바이오마커, 임상, 치료제, [키워드] (PD-1 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptive Analysis CD56 CD57 CD69 CD8 Cell contraction Coronavirus-2 COVID-19 COVID-19 patient Cytokines Deceased disease distribution driven by effective expansion expression FcεRIγ Frequency healthy subject healthy subjects help host immunity IL-1β IL-6 IL-8 IL6 immature immune response immune responses Immunoglobulin immunological profile Increased Infection Inflammatory cytokine Inflammatory cytokines interferon Interleukins lectin Lymphocytes monocyte Monocytes Monocytes and macrophages mucin natural killer NK cell NK cells NKG2D outcome overexpressed Patient patients with COVID-19 PD-1 performed Peripheral blood peripheral blood lymphocytes positive cell positive cells programmed cell death programmed cell death protein proportion Protein reduced respiratory restoration SARS-CoV-2 SARS-COV-2 infection secrete secreted secretion Serum level Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe COVID-19 severe SARS severe SARS-CoV-2 sialic acid Survivors T cell T cells T-cell TIM-3 Treatment unique viral infection with COVID-19 [DOI] 10.1038/s41423-020-00557-9 PMC 바로가기 [Article Type] Clinical Trial
Aerosol persistence in relation to possible transmission of SARS-CoV-2Articles Published on 2020-10-012022-10-28 Journal: Physics of Fluids [Category] COVID-19, [키워드] aerosol Aerosols coughing COVID-19 distribution dynamic estimate healthy subjects humans Infection occur persistence persistence time Probability Reproduction number respiratory droplet Respiratory droplets SARS-CoV-2 symptomatic individual Transmission transmission of SARS-CoV-2 transmitted Viral load viral loads Volume [DOI] 10.1063/5.0027844 PMC 바로가기 [Article Type] Articles
Reliability and Repeatability Analysis of Indices to Measure Gait Deterioration in MS Patients during Prolonged Walking장기간 보행 중 다발성 경화증 환자의 보행 악화를 측정하기 위한 지표의 신뢰성 및 반복성 분석Article Published on 2020-09-062022-08-13 Journal: Sensors (Basel, Switzerland) [Category] 임상, [키워드] (range of motion) 6-min walking test analyzed asymmetry caused changes in clinical disability coefficient Coefficient of variation consequence correlated CoV Deterioration disability Effects evaluated Evolution Expanded Disability Status Scale fatigue FIVE Gait Gait deterioration Gait variability Good healthy subjects involved leads lower limb maximum measure motion multiple sclerosis nine outcome Patient Prolonged protocol Quantitative range of motion reliability repeatability ROM scale severity Standard deviation status subgroup subgroups suggested symmetry index synthetic indices Variability Variation walking were assessed were used [DOI] 10.3390/s20185063 PMC 바로가기 [Article Type] Article
Tyrosine Kinase Inhibitors Play an Antiviral Action in Patients Affected by Chronic Myeloid Leukemia: A Possible Model Supporting Their Use in the Fight Against SARS-CoV-2Oncology Published on 2020-09-022022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] Action Against antiviral action baseline cause caused CD28 CEACAM1 chronic CML comparable Compound COVID-19 deaths demonstrated detrimental disease effective experiments expressed Follow-up FUT4 Gene expression profiling Genes healthy subjects Host IFN Imatinib Immunity immunological Infection International Italian kinase less leukemia Model myeloid NanoString Nilotinib Occurrence offer pandemic Patient rate of infection receiving replicate Replication rate reported responsible SARS-CoV-1 SARS-CoV-2 subject suggested Supporting TKI TKIs Treatment TTV tyrosine kinase inhibitor upregulated viral replication was used were infected [DOI] 10.3389/fonc.2020.01428 PMC 바로가기 [Article Type] Oncology