Coronary artery calcium score as a prognostic factor of adverse outcomes in patients with COVID-19: a comprehensive reviewReview article Published on 2022-03-012022-10-05 Journal: Current problems in cardiology [Category] 바이오마커, [키워드] adverse outcome article association cardiovascular complications Cardiovascular events cardiovascular risk factor Clinical outcome conducted Coronary artery coronavirus disease COVID-19 COVID-19 patient eligible highlight hospitalized COVID-19 patient identify In-hospital death information marker outcome Patient poor prognosis Predictive Prognosis Prognostic factor radiological risk [DOI] 10.1016/j.cpcardiol.2022.101175 [Article Type] Review article
COVID-19-specific metabolic imprint yields insights into multiorgan system perturbationsCOVID-19 관련 대사 흔적은 다기관 시스템 섭동에 대한 통찰력을 제공합니다Article Published on 2022-03-012022-09-11 Journal: European Journal of Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Affect aligned alteration capture cellular circulating metabolome Comorbidities Comorbidity confounding factor Corona Coronavirus-2 COVID-19 COVID-19 severity damage defined disease driven by hospitalized COVID-19 patient immune activation immunological immunology indicated Inflammation integration metabolite metabolome metabolomics molecular multi Multi-omics Multiorgan multiple pathway multiple pathways network Neuroinflammation neurological organ damage organ systems performed Perturbation perturbations proteomic question recent resource respiratory SARS-CoV-2 Seroconversion severe acute respiratory syndrome Coronavirus severe COVID-19 patients severity switch trajectory unique [DOI] 10.1002/eji.202149626 PMC 바로가기 [Article Type] Article
Prognostic factors for predicting severity and mortality in hospitalized COVID-19 patients입원한 COVID-19 환자의 중증도 및 사망률을 예측하기 위한 예후 인자Article Published on 2022-03-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] MERS, SARS, 바이오마커, [키워드] Admission ALT Analysis aPTT association Coagulation coagulation cascade coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient creatine creatine kinase death demonstrated determine disease severity early stage early stages Factor Final global pandemic hematocrit hospital hospitalized COVID-19 patient IMPROVE INR International Kingdom laboratory result Laboratory results Lactate lactate dehydrogenase Logistic regression lymphopenia management medical record medical records moderate moderate to severe Mortality multiple logistic regression on admission outcome Patient patients predict predictor prognostic public health emergency reached reduce mortality Retrospective analysis Saudi Arabia severe COVID-19 patient severity specific biomarker specific biomarkers the disease the WHO variable was performed [DOI] 10.1002/jcla.24216 PMC 바로가기 [Article Type] Article
Cardiac injury and COVID-19 associated coagulopathy in patients with acute SARS-CoV-2 pneumonia: A rotational thromboelastometry study급성 SARS-CoV-2 폐렴 환자의 심장 손상 및 COVID-19 관련 응고병증: 회전 혈전탄성 측정 연구Article Published on 2022-03-012022-09-11 Journal: Advances in medical sciences [Category] SARS, 치료기술, [키워드] Analysis cardiac injury cardiac troponin Coagulation coagulation parameter coagulative Coagulopathy conducted consecutive patient consecutive patients Coronary Coronary thrombosis coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients cross-sectional study defined Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hypercoagulability Injury males material mechanism median age Mortality no differences no significant differences Other parameter Patient patients Retrospective cross-sectional study Rotational thromboelastometry SARS-CoV-2 significant difference study population systemic inflammatory thromboembolic thromboembolic complications thrombosis Traditional troponin troponin I Whole blood [DOI] 10.1016/j.advms.2021.12.001 PMC 바로가기 [Article Type] Article
A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro DataClinical Trial Published on 2022-03-012022-10-05 Journal: European urology [Category] SARS, 임상, [키워드] 95% CI 95% confidence interval Acetate affected Air-liquid interface androgen Androgen deprivation therapy antiandrogen Bicalutamide clinical study clinical trial clinically Combination conducted confounders COVID-19 COVID-19 symptoms Culture death Deprivation discharge Effect enrolled enzalutamide epidemiological Epidemiological study epidemiologically evaluate the effect Evidence evidence of hazard ratio higher risk hospital Hospitalization hospitalized COVID-19 patient immune response include intensive care investigated limitation lung cells mechanical ventilation Patient patients treated Phase 2 Primary outcome Prostate cancer Randomized randomized trial required Research Result Retrospective study risk SARS-CoV-2 SARS-COV-2 infection Standard of care Support Testosterone therapeutic effect therapy Treatment Trial virus replication [DOI] 10.1016/j.eururo.2021.12.013 PMC 바로가기 [Article Type] Clinical Trial
Development of rapid antigen test prototype for detection of SARS-CoV-2 in saliva samples타액 샘플에서 SARS-CoV-2 검출을 위한 신속 항원 검사 프로토타입 개발Original Article Published on 2022-02-252022-09-10 Journal: Upsala Journal of Medical Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-RBD anti-receptor-binding domain Anti-spike antibody Antigen antigen test Asymptomatic capture Chain Reaction clinical analysis Cohort Combination combinations coronavirus coronavirus disease COVID-19 demonstrated detect detection antibody development diagnostic Diagnostic accuracy Diagnostic method diagnostic methods domain early stage ELISA ENhance enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated exhibited followed by hospitalized COVID-19 patient hospitalized COVID-19 patients immunized improvement individual Infection interquartile range lateral flow lateral flow assay median time NPV onset of symptom pilot study point-of-care testing polyclonal antibodies polyclonal antibody polymerase chain reaction positive PPV RBD reference method respiratory Result reverse transcription Reverse transcription-polymerase chain reaction rRBD rRT-PCR Saliva saliva samples sample collection SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus sensitivity severe acute respiratory syndrome Coronavirus specificity Spike protein stratified symptomatic patient tested the median the SARS-CoV-2 validation study virus was used were used [DOI] 10.48101/ujms.v127.8207 PMC 바로가기 [Article Type] Original Article
Retrospective modelling of hospital bed capacities associated with the administration of remdesivir during the first wave of COVID-19 in a German metropolitan city독일 대도시에서 COVID-19의 첫 번째 물결 동안 렘데시비르 투여와 관련된 병상 용량의 후향적 모델링Article Published on 2022-02-232022-09-11 Journal: Journal of Antimicrobial Chemotherapy [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition administration contributed coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient death discharge Eligible patients EMA epidemiological evaluate Fewer patients First wave Germany Healthcare system Healthcare systems hospital Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient ICU admission medical resource Medical resources Novel coronavirus novel coronavirus disease pandemic Patient recorded reduced Remdesivir Treatment were used [DOI] 10.1093/jac/dkab432 PMC 바로가기 [Article Type] Article
BNT162b2 vaccination enhances interferon-JAK-STAT-regulated antiviral programs in COVID-19 patients infected with the SARS-CoV-2 Beta variant Research Published on 2022-02-222022-10-05 Journal: Communications Medicine [Category] 변종, 치료법, [키워드] activate Antiviral approach Beta BNT162b2 BNT162b2 vaccine can be used clinical manifestation correlated COVID-19 patient COVID-19 patients COVID-19 symptom Dexamethasone disease severity elicit elicited ENhance first dose FIVE gene encoding gene signature hospitalized COVID-19 patient identify immune immune cells immune response increases in innate immune response molecular MONITOR naïve individual OAS of BNT162b2 Patient patients Peripheral blood Protein provide receiving Result reveal RNA sequencing RNA-Seq SARS-COV-2 infection signaling pathway the SARS-CoV-2 Transcriptome Treatment vaccination variant [DOI] 10.1038/s43856-022-00083-x [Article Type] Research
miR-155: A Potential Biomarker for Predicting Mortality in COVID-19 PatientsArticle Published on 2022-02-212022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] acute respiratory syndrome addition Admission assist Biomarker Biomarkers Blood Care caused circulating circulating miRNA Clinical course coronavirus 2 COVID-19 COVID-19 mortality COVID-19 patients diagnostic discharged home disease disease severity expression healthy hospital hospitalized COVID-19 patient IMPROVE less mild COVID-19 patient miR-155 miR-21 miRNAs pandemic Patient Peripheral blood Potential predictor of mortality prognostic biomarker quantitative PCR SARS-CoV-2 severe COVID-19 disease Support therapeutic [DOI] 10.3390/jpm12020324 PMC 바로가기 [Article Type] Article
Evaluation of Bi-Lateral Co-Infections and Antibiotic Resistance Rates among COVID-19 PatientsArticle Published on 2022-02-192022-10-27 Journal: Antibiotics [Category] COVID-19, [키워드] Acinetobacter addition antibiotic Antibiotics antimicrobial resistance Antimicrobial stewardship association Bacteria Bacterial bacterial co-infection Bacterial infections chest pain clinical Co-infections cocci collected Compliance conducted COVID-19 COVID-19 patient death rate Diagnosis disease symptoms Dyspnea E. coli employment fatigue Fever hospital hospital-acquired infections hospitalized COVID-19 patient hospitalized COVID-19 patients incidence Klebsiella pneumoniae Laboratory majority MOST MRSA pathogenesis of SARS-CoV-2 patients positive Prevalence progression Pseudomonas aeruginosa Rate resistance rod SARS-CoV-2 SARS-COV-2 infection Severity of infection Staphylococcus aureus Streptococcus pyogene Symptom tested [DOI] 10.3390/antibiotics11020276 PMC 바로가기 [Article Type] Article