host receptor – Page 10 – Communicable Diseases Research

AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells

Article

Published on 2021-01-082022-10-04
Journal: Cell Research [Category] Fulltext, MERS, 치료제,

[Homologous modeling and binding ability analysis of Spike protein after point mutation of severe acute respiratory syndrome coronavirus 2 to receptor proteins and potential antiviral drugs]

[심각한 급성 호흡기 증후군 코로나 바이러스 2의 수용체 단백질 및 잠재적 항바이러스 약물에 대한 점 돌연변이 후 스파이크 단백질의 상동 모델링 및 결합 능력 분석]

Article

Published on 2020-12-212022-09-11
Journal: Beijing da xue xue bao. Yi xue ban = Journal of Pe [Category] SARS, 변종, 치료제,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity affinity binding Amino acid aminopeptidase aminopeptidase N Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral aplaviroc APN AutoDock binding ability Bioinformatics analysis CD13 CD26 change Chimera Chinese conducted coronavirus dipeptidyl peptidase Dipeptidyl peptidase-4 docking DPP4 drug drug candidates drugs English enzyme evaluated Frequency functional glycoprotein greater HIV homologous host receptor Host receptors human cell human cells Human immunodeficiency virus human infection immunodeficiency immunodeficiency virus Infection molecular molecular docking simulation mutate mutated Mutation natural mutation natural mutations peptidase Point mutation PolyPhen-2 Protein protein structure receptor receptor protein respiratory S protein SARS-CoV-2 sequence Sequence alignment Sequencing Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly higher small molecule spike spike glycoprotein Spike glycoprotein, coronavirus. Spike protein spontaneous mutation Taking the S protein Treatment unique virus was performed was used weakened ZDOCK
[DOI] 10.19723/j.issn.1671-167X.2021.01.023 PMC 바로가기 [Article Type] Article

De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2

SARS-CoV-2를 무력화하는 강력하고 탄력적인 hACE2 미끼의 새로운 설계

Report

Published on 2020-12-042022-09-10
Journal: Science (New York, N.y.) [Category] Fulltext, SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect angiotensin best binding Cell cells coronavirus cryo-EM de novo decoy decrease develop effort Extracellular hACE2 hamster hamsters host protein host receptor human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 in vitro in vivo infect Interaction intranasal intrinsically Microscopy mutant nanomolar affinity neutralize neutralized Neutralizing optimization pathogen Pathogens prophylactic dose Protein Protein design RBD RBDs Receptor-binding domain replicate respiratory SARS-CoV-2 SARS-COV-2 infection Science severe acute respiratory syndrome Coronavirus specificity Spike protein subsequent the cell the receptor-binding domain the spike protein therapeutic therapy unlikely Viral virus
[DOI] 10.1126/science.abe0075 PMC 바로가기 [Article Type] Report

Insights on cross-species transmission of SARS-CoV-2 from structural modeling

구조 모델링에서 SARS-CoV-2의 종간 전파에 대한 통찰력

Research Article

Published on 2020-12-032022-08-13
Journal: PLoS Computational Biology [Category] Biochemistry, Fulltext, MERS, SARS, 변종,

[키워드] Accuracy ACE2 ACE2 orthologs ACE2 variant ACE2 variants acute respiratory syndrome acute respiratory syndrome coronavirus affinity-enhancing mutation affinity-enhancing mutations Amino acid amino acid residue amino acids antiviral therapeutics atomic level benefit blueprint chicken complement computational modeling Computational study confirmed case confirmed cases Contact coronavirus country Cross-species transmission develop disrupt Drug development experiments explain geographical distribution global pandemic help highlight host cell host cell membrane host receptor Human humans in some infect Infection infection cycle infection process insight Interaction investigated key amino acid key amino acids key polar Like mice molecular feature non-conservative mutation non-conservative mutations not applicable other coronaviruses pandemic predict protein interactions provide question receptor protein respiratory responsible risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein several ACE2 amino acid residues several ACE2 ortholog several ACE2 orthologs severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 species Spike protein structural framework Structural properties structural property susceptible the SARS-CoV-2 therapeutic purposes Therapeutics thought three-dimensional structure Transmission transmitted Viral viral infection viral infections Viral protein viral spike protein viral-host protein interaction viral-host protein interactions viruses widespread wild animals
[DOI] 10.1371/journal.pcbi.1008449 PMC 바로가기 [Article Type] Research Article

The application of direct viral cytopathic hypothesis to design drug trials in the battle against COVID-19

COVID-19와의 전쟁에서 약물 시험을 설계하기 위해 바이러스 직접 세포병증 가설의 적용

Article

Published on 2020-12-012022-09-11
Journal: Daru : journal of Faculty of Pharmacy, Tehran Univ [Category] SARS, 임상, 치료제,

Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1

Kallikrein 13은 인간 코로나바이러스 HKU1에 감염되는 동안 프라이밍 프로테아제 역할을 합니다.

Research Article

Published on 2020-11-242022-09-25
Journal: Science Signaling [Category] 유전자 메커니즘, 진단,

[키워드] blocked cause Cell cell culture system cell line cells cellular cleavage cleave cleaved complex Coronaviral coronavirus demonstrated determine distribution effort elements enzyme facilitate HCoV-HKU1 help HKU1 Host host receptor Human human airway epithelial in vitro model Infection Interaction Kallikrein KLK13 mechanism mild respiratory overexpression prevalent primary determinant priming protease Protein receptor regulate required Respiratory disease respiratory epithelial cell S protein S1/S2 SARS-CoV-2 specificity target cells the spike protein These data tissue Transmission viral entry viral pathogenesis viral replication viral S protein virus
[DOI] 10.1126/scisignal.aba9902 PMC 바로가기 [Article Type] Research Article

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

초강력 인간 항체는 여러 메커니즘을 통해 SARS-CoV-2 공격으로부터 보호합니다.

Research Article

Published on 2020-11-202022-09-14
Journal: Science (New York, N.y.) [Category] Fulltext, SARS, 진단, 치료법,

[키워드] ACE2 ACE2 receptor activate acute respiratory syndrome angiotensin-converting enzyme 2 antibodies antibody antibody cocktail bind binding block caused characterized circulating coronavirus efficient electron microscopy epitope fatality functions hamster host receptor include Infection initiated Isolation Microscopy multiple mechanism mutants neutralize neutralizing antibody Prevent Prophylaxis PROTECT protective immune response receptor-binding domains S309 SARS-CoV-2 SARS-CoV-2 isolate Science Spread Structure therapeutic option therapy Trimeric spike protein viral escape viral infection virus
[DOI] 10.1126/science.abe3354 PMC 바로가기 [Article Type] Research Article

Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein

Report

Published on 2020-11-062022-10-28
Journal: Science (New York, N.y.) [Category] COVID-19, Fulltext, SARS,

[키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 appear bind binding binding pocket binding pockets caused coronavirus Coronavirus disease 2019 Coronaviruses COVID-19 dataset develop domain effort fatty fatty acid metabolism free fatty acid glycoprotein highly pathogenic host receptor human cells immune modulation in vitro Inflammation inhibitor insect cell Interaction Intervention Locking mechanism membrane MERS-CoV Microscopy Middle East predominant produced Protein Receptor binding domain reduced Remdesivir respiratory syndrome coronavirus resulting reveal S protein SARS-CoV SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 S SARS-CoV-2 spike SARS-CoV-2 spike protein Science severe pathology Structure suggested the SARS-CoV-2 therapeutic therapy tissue tropism trimer trimeric S protein viral infection
[DOI] 10.1126/science.abd3255 PMC 바로가기 [Article Type] Report

Coevolution, Dynamics and Allostery Conspire in Shaping Cooperative Binding and Signal Transmission of the SARS-CoV-2 Spike Protein with Human Angiotensin-Converting Enzyme 2

Article

Published on 2020-11-042022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,

[키워드] ACE2 ACE2 protein adaptive Alanine alanine scanning allosteric interactions Analysis angiotensin-converting enzyme 2 association binding binding energy binding free energy binding interaction binding mechanism biochemical carrier change coevolution complexes computational studies conformational Consensus Cooperative coronavirus SARS-CoV-2 Critical cumulative determinant Drug discovery Dynamics highlight host receptor hotspot Human Infection transmission inhibiting initial Interaction Interface residues molecular molecular dynamics Molecular simulation network analysis performed preference receptor Receptor binding domain residue responsible SARS-CoV SARS-CoV spike protein SARS-CoV-2 SARS-CoV-2 spike protein Sequence analysis shaping signal signal transmission spike Spike protein target cell the SARS-CoV-2 Transmission virus entry virus transmission
[DOI] 10.3390/ijms21218268 PMC 바로가기 [Article Type] Article

Case Report: Paralytic Ileus: A Potential Extrapulmonary Manifestation of Severe COVID-19

Articles

Published on 2020-10-312022-10-28
Journal: The American Journal of Tropical Medicine and Hygi [Category] COVID-19, MERS, SARS,