Receptor-Functionalized Lipid Membranes as Biomimetic Surfaces for Adhesion of Plasmodium falciparum-Infected Erythrocytesarticle Published on 2022-12-312024-09-01 Journal: Methods in molecular biology (Clifton, N.J.) [Category] 말라리아, [키워드] Cell adhesion host receptor Supported membranes [Article Type] article
Using host receptor as a decoy to treat COVID-19: a solution for immune escape?Article Published on 2022-11-082022-11-16 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 antibodies COVID-19 pandemic Critical dose driven by Efficacy evade host receptor immune Immunity IMPROVE inoculated K18-hACE2 transgenic mice Lung injury Medicine neutralizing antibody omicron pandemic reduce survival target the SARS-CoV-2 the vaccine therapeutic Therapies treat variant variants [DOI] 10.15252/emmm.202216818 PMC 바로가기
Understanding and combating COVID-19 using the biology and chemistry of SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Bioprocess and biosystems engineering [Category] SARS, 치료기술, [키워드] ACE acute respiratory syndrome angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) Asymptomatic binding caused combating contributed coronavirus coronavirus disease COVID-19 enzyme high affinity host receptor hydrophobic Infection Interaction lead to fatality Like molnupiravir Mutation Nanotechnology omicron pandemic pathogenic viruses PAXLOVID™ provide quercetin Remdesivir responsible SARS-CoV-2 spike glycoprotein suggested Transmissibility understanding Vaccine Vaccines viability virus [DOI] 10.1007/s00449-022-02788-8 PMC 바로가기
Antioxidant, Anti-inflammatory, and Immunomodulatory Roles of Nonvitamin Antioxidants in Anti-SARS-CoV-2 TherapyArticle Published on 2022-10-132022-11-15 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 바이오마커, 치료제, [키워드] ACE2 receptor Activation activities alleviate Alleviating alveolar antioxidant antiviral role conformational change COVID-19 Cytokine storm Dipeptidyl peptidase 4 Direct dosage Endothelium favor furin Helicase host receptor hyperinflammation Illness severity immunogenic Inflammatory Inflammatory responses influences membranes Organ failure oxidative stress Papain-like protease pathology pathway protease reactive oxygen specy Receptor binding domain Replication risk RNA-dependent RNA polymerase role serine 2 the spike protein transmembrane vicious cycle viral spike protein [DOI] 10.1021/acs.jmedchem.2c01134 PMC 바로가기
Association of ACE2 Gene Variants with the Severity of COVID-19 Disease-A Prospective Observational StudyArticle Published on 2022-10-022022-11-16 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 gene acute respiratory syndrome allele Angiotensin receptors angiotensin-converting enzyme-2 candidate caused coronavirus correlation COVID-19 COVID-19 disease COVID-19 pandemic disease evaluate gene polymorphism genetic susceptibility Hospitalization host cell host receptor identify increased risk intensive care Patient polymorphism Prospective recent risk Risk factors rs2285666 rs4646156 SARS-CoV-2 SARS-COV-2 infection severe disease course severity severity of COVID-19 single nucleotide Single nucleotide polymorphism statistically significant target cells the SARS-CoV-2 virus triggered variant virus [DOI] 10.3390/ijerph191912622 PMC 바로가기
Early shedding of membrane-bounded ACE2 could be an indicator for disease severity in SARS-CoV-2Article Published on 2022-10-012022-11-15 Journal: Biochimie [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 Admission association Biomarker circulating Comorbidities Course COVID-19 COVID-19 patient COVID-19 patients D-dimer Diabetes Mellitus disease disease severity early phase effective ELISA healthy controls host receptor hypertension increase in Infection investigated involved marker membrane moderate outcome plasma Plasma level positive correlation sACE2 SARS-CoV-2 Severe case shown significant increase soluble ACE2 the SARS-CoV-2 was determined was obtained was performed [DOI] 10.1016/j.biochi.2022.06.005 PMC 바로가기
Omicron variant (B.1.1.529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2?Review Published on 2022-10-012022-10-06 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE-2 analyzed Angiotensin converting enzyme-2 B.1.1.529 catastrophic circulating contagious COVID-19 COVID-19 cases COVID-19 pandemic detrimental dissemination dominant Efficacy effort Evolution explained feasible feature FIVE Genetic hazard host receptor immune evasion immunization implication include Lineage Measures mechanism Mutation omicron Omicron variant other variant pandemic pharmacological physical Population prevalent strain raise RBD reported S-protein SARS-CoV-2 South Africa spike mutation Spread Sublineages surpassed Surveillance susceptible the receptor-binding domain the spike protein United Kingdom Vaccine vaccine effectiveness variant variants variants of concern variants of SARS-CoV-2 viral entry VoC VOCs [DOI] 10.1016/j.biopha.2022.113522 PMC 바로가기 [Article Type] Review
Biophysical and Biochemical Characterization of the Receptor Binding Domain of SARS-CoV-2 VariantsArticle Published on 2022-10-012022-11-16 Journal: The protein journal [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 adopted affinity antibody biochemical characterization Degradation help host cell receptor host receptor immune response immunological IMPROVE increase in infected individual interact Intervention medical intervention mutant Mutation mutations natural selection neutralizing antibody parental protease Rapid RBD receptor Receptor binding domain responses SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant sensitivity the RBD thermal stability Transmissibility understanding variant variants variants of concern [DOI] 10.1007/s10930-022-10073-6 PMC 바로가기
Omicron Binding Mode: Contact Analysis and Dynamics of the Omicron Receptor-Binding Domain in Complex with ACE2오미크론 결합 모드: ACE2와 복합된 오미크론 수용체 결합 도메인의 접촉 분석 및 역학Article Published on 2022-08-222022-09-11 Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 affected angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies B.1.1.529 binding complex complexes Contact COVID-19 Department distribution domain Dynamics edge Effect electrostatic form H-bond host receptor human ACE2 IMPROVE Interaction Lineage molecular molecular dynamics Mutation mutations N501Y omicron Omicron variant Open Science Framework Protein Proteins Receptor-binding domain resistance S-RBD Salt Bridge salt bridges SARS-CoV-2 virus spike Spike protein Spike proteins Stanford the receptor-binding domain the SARS-CoV-2 virus the Spike the WHO unique variant VoC [DOI] 10.1021/acs.jcim.2c00397 PMC 바로가기 [Article Type] Article
ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodiesACE2 결합은 코로나바이러스 항체를 광범위하게 중화시키는 SARS-CoV-2 융합 펩타이드를 노출시킵니다Article Published on 2022-08-122022-09-11 Journal: Science (New York, N.y.) [Category] COVID19(2023년), MERS, SARS, 비임상, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity Alpha alpha- Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal coronavirus Animal coronaviruses antibody approach betacoronaviruses binding breadth breath conserved coronavirus coronavirus spike protein donors enzyme epitope functional fusion peptide hidden host receptor Host receptors immune in vitro in vivo mAb mAbs monoclonal antibodies monoclonal antibody motif neutralize Neutralizing Neutralizing activity omicron pathology peptide prefusion recognize reduce respiratory SARS-CoV-2 selected Seven severe acute respiratory syndrome Coronavirus somatic mutations spike glycoprotein Spike proteins the SARS-CoV-2 Viral viral burden virus viruses [DOI] 10.1126/science.abq2679 PMC 바로가기 [Article Type] Article