Lead Discovery of SARS-CoV-2 Main Protease Inhibitors through Covalent Docking-Based Virtual Screening공유 도킹 기반 가상 스크리닝을 통한 SARS-CoV-2 주요 프로테아제 억제제의 선도적 발견Article Published on 2021-04-262022-09-11 Journal: Journal of Chemical Information and Modeling [Category] SARS, 치료제, [키워드] acting acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approval candidate characterized chymotrypsin Clinical data coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients cure cysteine cysteine protease database docking drug Economy effective drug effective drugs effort EMA enzyme European Medicines Agency FDA food Health house identify in silico inhibitor Ligand M pro Michael pandemic peptide predict predictive power risk SARS-CoV-2 Screening severe acute respiratory syndrome Coronavirus target protein the SARS-CoV-2 treat Vaccine Virtual screening [DOI] 10.1021/acs.jcim.1c00184 PMC 바로가기 [Article Type] Article
SARS-CoV-2 serology increases diagnostic accuracy in CT-suspected, PCR-negative COVID-19 patients during pandemicSARS-CoV-2 혈청학은 팬데믹 기간 동안 CT가 의심되는 PCR 음성 COVID-19 환자의 진단 정확도를 높입니다.Research Published on 2021-04-232022-09-01 Journal: Respiratory Research [Category] MERS, 진단, [키워드] absence Accuracy Algorithm chemiluminescent immunoassay Computed tomography Consensus Course COVID-19 COVID-19 patient CT finding CT findings definite diagnosis detect diagnose Diagnosis diagnosis of COVID-19 diagnostic diagnostic value discrimination Efficacy feature First wave Frequency hospitalized patient hospitalized patients house IgM/IgG IMPROVE increase intensive care units low-dose negative patients Negative PCR non-ICU non-ICU patients non-specific occur pandemic Patient patients PCR PCR-negative Pneumonia Probability pulmonary infiltrate pulmonary infiltrates radiological Result SARS-CoV-2 SARS-CoV-2 RNA sensitivity Seroconversion seroconversion rates serology serology testing symptom onset tested university hospital Viral Viral pneumonia was performed was used [DOI] 10.1186/s12931-021-01717-9 PMC 바로가기 [Article Type] Research
Mechanical transmission of SARS-CoV-2 by house flies집파리에 의한 SARS-CoV-2의 기계적 전파Research Published on 2021-04-202022-09-10 Journal: Parasites & Vectors [Category] MERS, SARS, 치료기술, [키워드] Abstract acute respiratory syndrome acute respiratory syndrome coronavirus addition Aerosols animals asymptomatic to mild Bacterial causative agent characterized collected conditions Contact contact with contagious coronavirus coronavirus disease Coronavirus disease 2019 Coronaviruses COVID-19 death determine droplet droplets evaluated events exposure to genomic RNA house House flies house fly Human implication independent Infectious virus Laboratory Live virus Mechanical Mechanical vector media medium milk occur pandemic performed positive Previous studies previous study public health respiratory Result RT-qPCR SARS-CoV-2 SARS-CoV-2 transmission severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown substrate supplementary material Symptom tested through contact Transmission transmission of SARS-CoV-2 transmitted vectors Viral viral disease Viral diseases Viral RNA virus virus isolation was determined wide range of symptoms [DOI] 10.1186/s13071-021-04703-8 PMC 바로가기 [Article Type] Research
Single-cell analysis of angiotensin-converting enzyme II expression in human kidneys and bladders reveals a potential route of 2019 novel coronavirus infection인간의 신장과 방광에서 안지오텐신 전환 효소 II 발현의 단일 세포 분석은 2019년 신종 코로나바이러스 감염의 잠재적 경로를 보여줍니다Article Published on 2021-04-202022-09-11 Journal: Chinese medical journal [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] 2019 novel coronavirus 2019-nCoV 2019-nCoV infection ACE2 ACE2 expression ACE2 gene Acute kidney injury acute respiratory syndrome addition Analysis angiotensin Angiotensin-converting enzyme bioinformatics bladder Cell cell type cells co-expression coronavirus disease Coronavirus disease 2019 datasets detectable enzyme II epithelial cells evaluate Evidence evidence of expression Fever healthy house human kidney in urine independent Infection intermediate cell kidney kidney damage nCoV Novel coronavirus p value p values Patient Pearson correlation Pearson correlation coefficient provided proximal proximal convoluted tubule proximal tubule recent findings receptor Respiratory complications reveal SAME AS sequencing data Severe acute respiratory syndrome single-cell analysis Single-cell RNA sequencing subtype urinary system Urine virus [DOI] 10.1097/CM9.0000000000001439 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Seroprevalence among Health Care Workers—A Voluntary Screening Study in a Regional Medical Center in Southern Germany의료 종사자 사이의 SARS-CoV-2 혈청 유병률 - 독일 남부 지역 의료 센터의 자발적 선별 연구Article Published on 2021-04-082022-09-10 Journal: International Journal of Environmental Research an [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Care center clinical manifestation close contact collected confirmation Contact contact with coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 early phase effective ELISA followed by Germany HCW HCWs Health Health care health care personnel Health care system health care workers house hygiene IgA information Neutralization assay Neutralizing no significant difference pandemic pathogen Patient Personal protective equipment preventive measure preventive measures PROTECT protocols Regional respiratory risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody Screening Seroprevalence serum sample serum samples Seven Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 specific antibodies technique tested Transmission virus voluntary were used [DOI] 10.3390/ijerph18083910 PMC 바로가기 [Article Type] Article
Evaluation of 11 SARS-CoV-2 antibody tests by using samples from patients with defined IgG antibody titersIgG 항체가가 정의된 환자의 검체를 이용한 11건의 SARS-CoV-2 항체 검사 평가Article Published on 2021-04-072022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, 치료기술, [키워드] Antibody test antibody tests Antibody titers assays contributed COVID-19 patients defined determined by diagnostic tests diagnostics epidemiological evaluated FIVE heat-inactivated heterogeneity house IFA IgG antibody IgG antibody titer IgG antibody titers IgG titers immunofluorescence assay immunology Microbiology Patient performed ranged Rapid diagnostic test SARS-CoV-2 antibody test SARS-CoV-2 IgG antibody sensitivity specificity symptom onset Variation [DOI] 10.1038/s41598-021-87289-6 PMC 바로가기 [Article Type] Article
Are Historical Buildings More Adaptive to Minimize the Risks of Airborne Transmission of Viruses and Public Health? A Study of the Hazzazi House in Jeddah (Saudi Arabia)Article Published on 2021-03-302022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] adopted Airborne transmission assist building coronavirus COVID-19 Critical demonstrated develop disease transmission Effectiveness ENhance Evidence historic buildings house Infectious disease Infectious virus infectious viruses information Jeddah pandemic potential risk Public public health Quantitative reducing Research risk Risk management Saudi Arabia selected Spread Structure Ventilation virus [DOI] 10.3390/ijerph18073601 PMC 바로가기 [Article Type] Article
A faster and less costly alternative for RNA extraction of SARS-CoV-2 using proteinase k treatment followed by thermal shock열 충격 후 proteinase k 처리를 사용하여 SARS-CoV-2의 RNA 추출을 위한 더 빠르고 저렴한 대안Research Article Published on 2021-03-242022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, 치료제, [키워드] addition alternative method average conducted costly COVID-19 Critical Ct values decrease detect diagnose Effectiveness epidemiological experiment faster followed by house initial INS Internal control lack less measure molecular Molecular diagnosis Molecular tests not differ pandemic Patient proteinase Proteinase K protocol reagents real time RNA RNA extraction RT-PCR RT-PCR reaction RT-PCR reactions SARS-CoV-2 SARS-COV-2 infection Shock significantly submitted targets tested the disease the SARS-CoV-2 Treatment Viral virus spread [DOI] 10.1371/journal.pone.0248885 PMC 바로가기 [Article Type] Research Article
Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics고 처리량 스크리닝 데이터베이스의 마이닝은 COVID-19 치료제의 잠재적 표적으로서 AP-1 및 자가포식 경로를 나타냅니다Article Published on 2021-03-242022-09-10 Journal: Scientific Reports [Category] SARS, 신약개발, 유전자 메커니즘, 임상, 치료제, [키워드] addition Anti-SARS-CoV-2 Activity Antiviral AP-1 approved approved drug approved drugs autophagy autophagy pathway Candidates caused class coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 therapeutics CPE Cytopathic effect Data mining database drug drug activity drug library effective effort global pandemic High-throughput screening Hope house human clinical trials in vivo mechanism New coronavirus new coronavirus SARS-CoV-2 phenotypic Potential treatment potential treatments profile pursuit reveal SARS-CoV-2 SARS-COV-2 infection signaling pathway significantly target Target identification therapeutic Viral [DOI] 10.1038/s41598-021-86110-8 PMC 바로가기 [Article Type] Article
Developing Pandemic Prevention and Control by ANP-QFD Approach: A Case Study on Urban Furniture Design in China CommunitiesArticle Published on 2021-03-062022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Affect Analytic Network Process (ANP) applicability China Community Contact contribute Control COVID-19 Critical demonstrated Developing DRs effective Effectiveness emotional feasible FIVE function Health house Infectious disease network pandemic pandemic prevention and control Pandemics Perspective prevention Process public health Quality Quality Function Deployment (QFD) reduction Research selected Seven threat urban urban furniture design worldwide pandemic [DOI] 10.3390/ijerph18052653 PMC 바로가기 [Article Type] Article