A serological investigation in Southern Italy: was SARS-CoV-2 circulating in late 2019?남부 이탈리아의 혈청학적 조사: 2019년 말에 SARS-CoV-2가 유행했습니까?Article Published on 2022-11-302022-09-11 Journal: Human vaccines & immunotherapeutics [Category] MERS, SARS, 진단, 치료기술, [키워드] 2019 affected antibodies antibodies. Apulia can not caused circulating circulation collected coronavirus country cross-reactive ELISA epitope Evidence Health Organization house human serum Italy pandemic positive presence of antibody SARS-CoV-2 serological subject tested unknown antigen specificity virus World Health Organization [DOI] 10.1080/21645515.2022.2047582 PMC 바로가기 [Article Type] Article
Label free detection of SARS CoV-2 Receptor Binding Domain (RBD) protein by fabrication of gold nanorods deposited on electrochemical immunosensor (GDEI)전기화학적 면역센서(GDEI)에 증착된 금 나노막대를 제작하여 SARS CoV-2 수용체 결합 도메인(RBD) 단백질의 무표지 검출Article Published on 2022-09-152022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, [키워드] AFM antibody binding Blot chain Chain Reaction characterized cloned collected coronavirus disease Coronavirus disease 2019 COVID-19 Cross reactivity cyclic Detection limit DPV dynamic early diagnosis Efficiency electrochemical electron electron carrier Electrophoresis ELISA enzyme enzyme-linked immunosorbent assay expressed fabrication flight fluorine followed by force FTO gel electrophoresis gold Gold nanorods house immobilization Infectious disease kDa lAbel Laser LIGHT MERS middle Middle East Middle East respiratory syndrome molecular weight nasopharyngeal sample Outbreaks output Oxide pandemic polyacrylamide Population Protein RBD RBD antigen RBD gene reaction Receptor binding domain respiratory reverse transcription Reverse transcription-polymerase chain reaction RT-PCR SARS CoV SARS CoV-2 SDS-PAGE shown Spectroscopy spike Spike protein spike protein. stability TEM tested the patient Tin Tin Oxide transmission electron microscopy viral transport media VTM was determined western blot [DOI] 10.1016/j.bios.2022.114406 PMC 바로가기 [Article Type] Article
Discovery of 2-(furan-2-ylmethylene)hydrazine-1-carbothioamide derivatives as novel inhibitors of SARS-CoV-2 main proteaseSARS-CoV-2 주요 프로테아제의 신규 억제제로서의 2-(푸란-2-일메틸렌)히드라진-1-카르보티오아미드 유도체의 발견Article Published on 2022-08-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 2-(furan-2-ylmethylene)hydrazine-1-carbothioamide derivatives Compound COVID-19 cytotoxicity demonstrated derivative drug design drug target furan Health house inhibitor inhibitors of SARS-CoV-2 kinetic library screening M pro main protease mass spectrometry MDCK cells Non-peptidomimetic inhibitors protease SARS-CoV-2 SARS-CoV-2. starting point Treatment treatment of COVID-19 Vero [DOI] 10.1016/j.ejmech.2022.114508 PMC 바로가기 [Article Type] Article
Evaluation of Metagenomic and Targeted Next-Generation Sequencing Workflows for Detection of Respiratory Pathogens from Bronchoalveolar Lavage Fluid Specimens기관지폐포 세척액 표본에서 호흡기 병원체 검출을 위한 메타게놈 및 표적 차세대 시퀀싱 워크플로 평가Article Published on 2022-07-202022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] 95% confidence interval Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antimicrobial resistance applied approach approaches automated Bacteria BAL bioinformatic analysis Bronchoalveolar lavage carbapenem complementary complex coronavirus cytomegalovirus defined demonstrated detection diagnostics ENhance evaluated house Illumina in some Inc. lavage less Lower respiratory tract lower respiratory tract infection marker metagenomic Next-generation sequencing next-generation sequencing. NGS nonpathogenic Organisms pathogen Pathogens phenotypic positive Pseudomonas aeruginosa reagent reagents replacement required respiratory Respiratory pathogens respiratory tract infection rhinovirus sequence Sequencing severe acute respiratory syndrome Coronavirus specimen standardized criteria Ureaplasma [DOI] 10.1128/jcm.00526-22 PMC 바로가기 [Article Type] Article
Graphene-Based Field-Effect Transistor for Ultrasensitive Immunosensing of SARS-CoV-2 Spike S1 AntigenSARS-CoV-2 스파이크 S1 항원의 초민감 면역 감지를 위한 그래핀 기반 전계 효과 트랜지스터Article Published on 2022-07-182022-09-11 Journal: ACS applied bio materials [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition AFM antibody Antigen buffer carbodiimide caused conducted coronavirus disease COVID-19 Device diagnosis of SARS-CoV-2 disease electrical electron ELISA enzyme enzyme-linked immunosorbent assays evaluated field-effect transistor force Fourier-transform infrared spectroscopy Graphene Graphene. Health house Infectious disease infrared infrared spectroscopy Interaction limit of detection management MERS MERS-CoV MERS-CoV antigen Optical Microscopy Photoelectron Raman spectroscopy real time reduction SARS-CoV-2 SARS-CoV-2 Spike S1 antigen SARS-CoV-2 virus scanning scanning electron microscopy SEM Spectroscopy spike stability tested the SARS-CoV-2 virus traceability transistor Treatment ultraviolet viral spread X-ray [DOI] 10.1021/acsabm.2c00503 PMC 바로가기 [Article Type] Article
Towards Control and Oversight of SARS-CoV-2 Diagnosis and Monitoring through Multiplexed Quantitative Electroanalytical Immune Response Biosensors다중 정량 전기 분석 면역 반응 바이오센서를 통한 SARS-CoV-2 진단 및 모니터링의 제어 및 감독Article Published on 2022-07-112022-09-11 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] acquired immunity biosensor circulating Control Delta ectodomain Efficiency Electroanalytical Bioplatforms expressed FIVE house HRP-conjugated secondary antibodies IgA IgG IgM immune response Immunity Immunoglobulin immunoglobulins individuals Infection isotype isotypes magnetic microbead magnetic microbeads monitoring non-infected nucleocapsid omicron Population Protein reported response responsible SARS-CoV-2 SARS-CoV-2 variant Vaccine variant Viral viral antigens Viral Antigens. Vulnerable populations was performed [DOI] 10.1002/anie.202203662 PMC 바로가기 [Article Type] Article
CoVITEST: A Fast and Reliable Method to Monitor Anti-SARS-CoV-2 Specific T Cells From Whole BloodCoVITEST: 전혈에서 Anti-SARS-CoV-2 특정 T 세포를 모니터링하는 빠르고 신뢰할 수 있는 방법Article Published on 2022-07-052022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] adjust antibodies Antibody detection automated Blood blood test can be used Cellular immune response Cellular immune response. cellular immunity cellular response comparable complex convalescent COVID-19 demonstrated determine diagnostic Donor ELISPOT Evidence explained gold gold standard healthy help house humoral immune response humoral immune responses IFN-γ IFN-γ ELISPOT immune protection immune responses Immune status IMPROVE individual less MONITOR pandemic Patient protocol Reinfection SARS-CoV-2 side simple Specific Support T cell T cells Test therapeutic approaches vulnerable patient vulnerable patients weakened immune system [DOI] 10.3389/fimmu.2022.848586 PMC 바로가기 [Article Type] Article
Development of an in-house quantitative ELISA for the evaluation of different Covid-19 vaccines in humans인간에서 다양한 Covid-19 백신 평가를 위한 사내 정량 ELISA 개발Article Published on 2022-07-042022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] Accuracy anti-RBD antibody approved carried convalescent individual COVID-19 COVID-19 vaccine COVID-19 vaccines development ectodomain Effectiveness Efficacy Efficiency Elecsy ELISA Genscript house Human immune responses in-house ELISA inactivated infected with SARS-CoV-2 mounted mRNA vaccine nucleocapsid Pfizer Pfizer/BioNTech positive Program Protein Quantitative recipient recipients responses Roche RT-PCR SARS-CoV-2 SARS-CoV-2 IgG sensitivity Serological assay serum sample serum samples shown specificity spike the SARS-CoV-2 vaccination Vaccine Vaccines virus [DOI] 10.1038/s41598-022-15378-1 PMC 바로가기 [Article Type] Article
Repurposing drugs as COVID-19 therapies: A toxicity evaluationCOVID-19 치료제로 약물 용도 변경: 독성 평가Review Published on 2022-07-012022-09-11 Journal: Drug discovery today [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] analyzed anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity approved autophagy blockers chemical structures clinical trials contributed correlated COVID-19 CPE Cytopathic effect cytotoxicity database drug drug candidate drug candidates Drug interactions Drug repurposing Efficiency enrolled ether hERG hERG. High-throughput screening highlight house identify In vitro assay induce nonspecific pandemic Phospholipidosis profile repurposing SARS-CoV-2 Severe acute respiratory syndrome significantly Structure Toxicity [DOI] 10.1016/j.drudis.2022.04.001 PMC 바로가기 [Article Type] Review
Evaluation of commercial Anti-SARS-CoV-2 neutralizing antibody assays in seropositive subjects혈청 양성 환자에서 상업용 Anti-SARS-CoV-2 중화 항체 분석 평가Article Published on 2022-07-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] absence added addition anti-RBD Anti-RBD antibodies Anti-RBD antibody anti-spike antibody anti-Spike IgG antibody Antibody titer Area bioMérieux cells cellular receptor Commercial tests Competitive anti-RBD immunoassays correlation difficulty functional highlight house immunoassay immunoassays immunochromatographic test Interaction marker NAb titer NAb titers neutralization test Neutralizing antibodies neutralizing antibody neutralizing antibody assay New P-value patients plaque reduction neutralization PRNT qualitative test Quantitative reduction SARS-CoV-2 SARS-CoV-2 entry Sensitivity and specificity sera seropositive subject seropositive subjects Spike protein surrogate surrogate markers Surrogate markers of protection. sVNT tested the spike protein threshold thresholds titer variants of concern virus neutralization test VNT VoC [DOI] 10.1016/j.jcv.2022.105169 PMC 바로가기 [Article Type] Article