Structural and Functional Analysis of Female Sex Hormones against SARS-CoV-2 Cell EntryArticle Published on 2021-10-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 receptor alveolar cells COVID-19 disrupt ENhance Estrogen estrogenes Evidence female females glycosylation hormone human ACE2 human ACE2 receptor Interaction male mechanism molecular basis Protein reduced SARS-CoV-2 Severe infection sex hormone Sex hormones Spike protein susceptible the SARS-CoV-2 the SARS-CoV-2 virus therapy underlie variety [DOI] 10.3390/ijms222111508 PMC 바로가기 [Article Type] Article
The Impact of ACE2 Polymorphisms on COVID-19 Disease: Susceptibility, Severity, and TherapyCOVID-19 질병에 대한 ACE2 다형성의 영향: 감수성, 중증도 및 치료Review Published on 2021-10-222022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] ACE ACE2 ACE2 variant ACE2 variants acquisition acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age angiotensin Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 benefit caused Characteristics circulating combating contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease develop disease Effect effective Epigenetic Ethnicity explain Factor functional Gender gene polymorphism help high morbidity and mortality homeostatic host genetics hrsACE2 human ACE2 human body Impact increase in measure mechanism morbidity and mortality organ organs outbreak outcome peptide peptides physiological progression putative receptor Regulation respiratory rises SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severity severity of COVID-19 Spread Stage susceptibility the disease Transmissibility variants various tissue various tissues widespread [DOI] 10.3389/fcimb.2021.753721 PMC 바로가기 [Article Type] Review
Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants최근에 등장한 SARS-CoV-2 변이체의 수용체 결합에 대한 분자적 통찰력Article Published on 2021-10-202022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 치료제, [키워드] ACE2 ACE2-RBD Alpha angiotensin Beta binding binding affinity cells changes in complexes crystal structure crystal structures domain enzyme examined FIVE Gamma hACE2 hACE2 protein help human ACE2 human Angiotensin-converting enzyme identify increase in information Interaction lack molecular molecular basis Multiple mutants Mutation Prevent Prophylactic Protein pseudovirus pseudoviruses RBD receptor Receptor binding Receptor-binding domain residue S protein SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike SARS-CoV-2 variant susceptible the S protein therapeutic variant Viral viral entry Viral proteins virus transmissibility VoC VOCs X-ray crystallography [DOI] 10.1038/s41467-021-26401-w PMC 바로가기 [Article Type] Article
Computational prediction of the effect of amino acid changes on the binding affinity between SARS-CoV-2 spike RBD and human ACE2408 Published on 2021-10-192022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] Accuracy ACE2 protein acute respiratory syndrome amino acid change association binding binding affinities binding affinity binding energy calculated can be used caused cellular entry change changes in circulating coronavirus correlation coefficient decrease energy term hACE2 help host adaptation hosts human ACE2 human Ace2 protein human Angiotensin-converting enzyme immune evasion implicated implication independent Infection Metrics MM-GBSA molecular Neural network offer predict predicted proceed public health RBD Receptor binding domain required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 Spike RBD SARS-CoV-2 variant Significance Spike protein Spread the binding affinity the RBD the spike protein trajectory transmissible variant Van der Waals variant variants viral surface viral variant worsening [DOI] 10.1073/pnas.2106480118 PMC 바로가기 [Article Type] 408
A Vimentin-Targeting Oral Compound with Host-Directed Antiviral and Anti-Inflammatory Actions Addresses Multiple Features of COVID-19 and Related Diseases숙주 지향적 항바이러스 및 항염 작용이 있는 Vimentin 표적 경구 화합물은 COVID-19 및 관련 질병의 여러 특징을 다룹니다Research Article Published on 2021-10-122022-09-10 Journal: mBio [Category] MERS, 변종, 치료제, [키워드] Action affected Anti-inflammation anti-inflammatory actions Antiviral Bleomycin cellular cellular processe complications Compound COVID-19 cultured cells damage disease symptom Diseases drug effective Efficacy endosomal trafficking Factor fibrosis filaments focus function host immune responses host-directed antiviral human ACE2 hyperinflammation identify immune responses Infection inhibited late-stage disease lung damage Lung injury macrophages mechanism mice Multiple oral outcome overactive pathogen pathogen clearance Patient physical physical properties Protein RATs reduced reducing regulatory T cells Safe SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus small molecule Spike protein T cells targets the SARS-CoV-2 the SARS-CoV-2 virus therapeutic agent therapeutic agents therapeutic potential treating COVID-19 triggered unique vimentin Viral Viral load Viral mutations [DOI] 10.1128/mBio.02542-21 PMC 바로가기 [Article Type] Research Article
Anti-COVID-19 activity of some benzofused 1,2,3-triazolesulfonamide hybrids using in silico and in vitro analysesResearch article Published on 2021-10-012022-10-05 Journal: Chemometrics and Intelligent Laboratory Systems [Category] 신약개발, 치료제, [키워드] 3CLpro acute respiratory syndrome Analysis Anti-COVID-19 anti-SARS-CoV-2 Antiviral approved binding binding score Ceftazidime Complete Compound coronavirus derivative displaying docking study enzyme evaluated examined exhibited highest human ACE2 IC50 in silico in vitro Infection Interaction Lopinavir manuscript N3 pandemic protease Protein reached Remdesivir RNA RNA polymerase SARS-CoV-2 SARS-CoV-2 virus Scientific community severity Sinefungin spike spike protein S1 the disease Treatment viral mutation were assessed [DOI] 10.1016/j.chemolab.2021.104421 [Article Type] Research article
Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates마우스 및 인간이 아닌 영장류에서 SARS-CoV-2 감염에 대한 비활성화 백신의 보호 효능Article Published on 2021-10-012022-09-12 Journal: Virologica Sinica [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome addition applied approach approved caused clinical trial coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 death effective Efficacy evaluated High dose human ACE2 human populations humans Inactivated vaccine Infection low dose mice Non-human non-human primate non-human primates outcome pandemic pathogen positive primate provided SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific neutralizing antibody serum severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tested the disease the vaccine transferred Transgenic mouse Vaccine viral particle [DOI] 10.1007/s12250-021-00376-w PMC 바로가기 [Article Type] Article
Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2치명적인 마우스 적응 SARS-CoV-2의 특성 및 구조적 기초Article Published on 2021-09-272022-09-10 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] ACE2 adaptation age Amino acid amino acid substitutions Analysis animal hosts animal model animal models binding affinity cause characterization complex cryo decrease deep deep sequencing ENhance Evolution exhibit generate hACE2 human ACE2 in vivo K417N mACE2 Microscopy molecular basis molecular mechanism Mortality mouse-adapted SARS-CoV-2 Mutation N501Y pathogenicity Pathogens platform provide RBD RBD mutation receptor Receptor binding domain reduce respiratory respiratory symptoms reveal SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 strain Sequencing severe COVID-19 severe respiratory symptoms significantly structural biology the binding affinity the RBD virus Virus-host interactions [DOI] 10.1038/s41467-021-25903-x PMC 바로가기 [Article Type] Article
Peptides Derived From S and N Proteins of Severe Acute Respiratory Syndrome Coronavirus 2 Induce T Cell Responses: A Proof of Concept for T Cell VaccinesMicrobiology Published on 2021-09-242022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome administration alleviate CD8 concept coronavirus coronavirus 2 CTL cytotoxic T lymphocyte dose-dependent manner effective effector memory elicit epitope hamster highlight human ACE2 immunization in vivo increase indicated induce interferon-γ mice neutralizing antibody nucleocapsid protein peptide peptide vaccine Peptide vaccines peptides proof proportion Pulmonary pathology reduce respiratory response RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike significantly statistically significant T cell T cell response T cell responses T cells target cell the SARS-CoV-2 transgenic mice tumor necrosis factor-α Vaccine variant viral titer virus [DOI] 10.3389/fmicb.2021.732450 PMC 바로가기 [Article Type] Microbiology
Inhibitory activity of FDA-approved drugs cetilistat, abiraterone, diiodohydroxyquinoline, bexarotene, remdesivir, and hydroxychloroquine on COVID-19 main protease and human ACE2 receptor: A comparative in silico approachResearch article Published on 2021-09-222022-10-05 Journal: Informatics in Medicine Unlocked [Category] 신약개발, 치료제, [키워드] ACE2 ACE2 receptor animal models claimed clinical trials COVID-19 Culture demonstrated drug drugs Dynamic simulation effective inhibitor Ex vivo FDA-approved drug host cell human ACE2 Hydroxychloroquine in silico Approach Infection inhibit inhibitor inhibitors investigated main protease MD simulation molecular molecular docking organ organoids Patient Potential treatment protease Protein Proteins Remdesivir respiratory virus SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 main protease specific treatment systemic effect tested the SARS-CoV-2 virus were used [DOI] 10.1016/j.imu.2021.100745 [Article Type] Research article