Neutralizing-antibody-independent SARS-CoV-2 control correlated with intranasal-vaccine-induced CD8 + T cell responses비강내 백신 유도 CD8 + T 세포 반응과 상관관계가 있는 중화 항체 비의존적 SARS-CoV-2 대조군Article Published on 2022-01-192022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen antigen-specific neutralizing antibodies appearance CD8 CD8+ CD8+ T cell Containment contribute controls coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 cynomolgus macaques effective Effective vaccines Efficacy expressing highlighting intranasal macaque NAb NAbs Nasopharyngeal swab nasopharyngeal swabs Neutralizing antibodies neutralizing antibody nine pandemic reduced respiratory S variant SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus significantly specific neutralizing antibodies T cell T cell response T cell responses vaccination Vaccine variant variants Viral viral control Viral load Viral vector virus viruses [DOI] 10.1016/j.xcrm.2022.100520 PMC 바로가기 [Article Type] Article
The Tissue Distribution of SARS-CoV-2 in Transgenic Mice With Inducible Ubiquitous Expression of hACE2Molecular Biosciences Published on 2022-01-182022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 Activation alteration Brain Brain tissues change clinically COVID-19 COVID-19 pathogenesis Cre recombinase Day death distribution examined expressing expression hACE2 hACE2 switch-on mice histological examination human ACE2 induce Infection infections internal organ intestine intranasal intranasal infection Isolation Laboratory lung Lungs mice Mild murine model novel coronavirus disease offspring prevented provide resulting Safe SARS-CoV-2 SARS-COV-2 infection strain Tamoxifen tissue transgene transgenic mice treated Treatment Viral load virus weighed weight loss [DOI] 10.3389/fmolb.2021.821506 PMC 바로가기 [Article Type] Molecular Biosciences
Allergic patients during the COVID‐19 pandemic—Clinical practical considerations: An European Academy of Allergy and Clinical Immunology surveyOriginal Article Published on 2022-01-172022-10-31 Journal: Clinical and Translational Allergy [Category] COVID-19, [키워드] Academy affected allergen immunotherapy allergic allergic rhinitis allergies allergy anaphylaxis Asthma biologics Care changed clinical consequence Corticosteroid COVID‐19 COVID‐19 diagnostic European evaluate food allergies food allergy hcp Health Health care system ICS Immunotherapy indicated inhaled corticosteroid initiated International intervals intranasal management Modification modify MOST oral pandemic Patient professional recommendations reduction remote reported Result significantly survey Telemedicine therapeutic approaches Treatment was increased [DOI] 10.1002/clt2.12097 PMC 바로가기 [Article Type] Original Article
Preclinical Evaluation of Chicken Egg Yolk Antibody (IgY) Anti-RBD Spike SARS-CoV-2—A Candidate for Passive Immunization against COVID-19Article Published on 2022-01-172022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] absence accumulated anti-RBD anti-receptor-binding domain antibody biodistribution study can be used candidate Cell Characteristics chicken coronavirus disease COVID-19 effective Egg evaluate Ex vivo exceeded feasibility Health IgY anti-RBD spike SARS-CoV-2 immunization in vitro in vivo International intranasal mice Mortality neutralize other organs Passive passive immunization Preclinical preclinical data preclinical evaluation preclinical studies Prophylactic radiolabeled radiolabeled IgY RBD resulting safety profile SARS-CoV-2 spike the SARS-CoV-2 Treatment virus yolk [DOI] 10.3390/vaccines10010128 PMC 바로가기 [Article Type] Article
Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates비인간 영장류에서 COVID-19에 대한 재조합 식물 유래 바이러스 유사 입자 백신 후보의 비보조제 및 애주번트 제형이 제공하는 안전성, 면역원성 및 보호Article Published on 2022-01-052022-09-12 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), MERS, SARS, 비임상, 임상, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome adjuvant adjuvants administration animal Antiviral AS03 BALF booster Bronchoalveolar lavage fluid CD4 T cells Cell-mediated immune responses chemotactic factor clinical trials coronavirus coronavirus disease COVID-19 CoVLP CoVLP vaccine CpG CpG1018 demonstrated dose effective vaccine Efficacy Evidence expression humoral IL-4 Immune cell immunization immunized Infection Influenza Intramuscular injection intranasal Lower lung nasal swab Non-humane primates ocular pandemic pathologic plaque-forming unit priming Proinflammatory cytokine Protein vaccines provided reduced responses rhesus macaque Safety SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2-infected cell selected significantly single dose stimulated System vaccine candidate Vaccine development vaccine-associated enhanced disease viral replication virus-like particle vaccine virus-like particles VLP [DOI] 10.1038/s41423-021-00809-2 PMC 바로가기 [Article Type] Article
Gut microbiota-derived metabolites confer protection against SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 보호를 제공하는 장내 미생물총 유래 대사산물Article Published on 2022-01-012022-09-11 Journal: Gut Microbes [Category] SARS, 치료제, [키워드] ACE2 adaptive Adaptive immunity airway airways angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-viral immunity antiviral immunity characterized Coagulation coronavirus disease Coronavirus disease 2019 COVID-19 downregulating entry receptor enzyme fatal COVID-19 Fatty acid fiber function Gut gut bacteria gut microbiome Host Hypercoagulation identify immune regulation Immunity Infection intestine intestines intranasal male males mammalian metabolism metabolite Microbiome multiple pathway multiple pathways Platelet proliferation promote PROTECT reduced SARS-CoV-2 SARS-CoV-2 entry receptor SARS-COV-2 infection SCFA SCFAs Sh2b3 short-chain fatty acids systemically the SARS-CoV-2 viral burden viral entry [DOI] 10.1080/19490976.2022.2105609 PMC 바로가기 [Article Type] Article
Osteoclast-mediated bone loss observed in a COVID-19 mouse modelCOVID-19 마우스 모델에서 관찰된 파골세포 매개 뼈 손실Article Published on 2022-01-012022-09-11 Journal: Bone [Category] SARS, 치료기술, [키워드] added affected aging analyzed animal Asymptomatic body weight bone Bone mass consequence controls cortical cortical bone COVID-19 criteria days post infection death Decline decrease develop eight euthanized examined expressing fraction greater group groups hACE2 Health healthy help human ACE2 human disease human SARS-CoV-2 increase in increases in Infection intranasal K18-ACE2 K18-hACE2 K18-hACE2 transgenic mice knowledge mice moderate moderate disease moderate to severe Musculoskeletal Musculoskeletal health musculoskeletal system no difference no differences non-infected Osteoclasts parameter Patient plaque forming units Post-infection posture receiving reduction in remained resulting risk robust SARS-CoV-2 SARS-COV-2 infection severe disease skeletal staining TRAP treated Viral load viral loads Volume volume fraction were infected while [DOI] 10.1016/j.bone.2021.116227 PMC 바로가기 [Article Type] Article
Evaluation of health-related quality of life of Covid-19 patients: a hospital-based study in South Central EthiopiaResearch Published on 2021-12-202022-10-31 Journal: Health and Quality of Life Outcomes [Category] COVID-19, SARS, [키워드] adjusted analysed Analysis Arsi Zone average can be used cause Clinical characteristics Comorbidity conducted confirmed case COVID-19 cross-sectional death Dexamethasone Elderly patient EQ-5D Ethiopia evaluate Factor Follow-up groups Health Hospital stay HRQoL intranasal IQR Kruskal–Wallis test manifestation Mann–Whitney U test median Mild Multiple linear regression Older oxygen Patient patients psychological treatment Quality of life questionnaire Result severe disease significantly lower Sociodemographic South Stata Study design Symptom the median Treatment treatment intervention utility Visual Analogue Scale were used Zimbabwe [DOI] 10.1186/s12955-021-01900-y PMC 바로가기 [Article Type] Research
Preclinical evaluation of a candidate naked plasmid DNA vaccine against SARS-CoV-2Article Published on 2021-12-202022-10-04 Journal: NPJ Vaccines [Category] 비임상, [키워드] acute respiratory syndrome administration Applying binding cellular response clinical trial comparable coronavirus demonstrated DNA plasmid DNA vaccine DNA vaccines dominant IgG immune responses immunogenic Intradermal intramuscular intranasal lung Lung infection mice neutralizing antibody New Plasmid platform Preclinical protective effect rhesus macaque rhesus macaques robust Safe SARS-CoV-2 Spike protein tested Th1 the SARS-CoV-2 the vaccine Vaccine vaccine platform viral pathogens viral replication [DOI] 10.1038/s41541-021-00419-z PMC 바로가기 [Article Type] Article
An Intranasal OMV-Based Vaccine Induces High Mucosal and Systemic Protecting Immunity Against a SARS-CoV-2 Infection비강내 OMV 기반 백신은 SARS-CoV-2 감염에 대한 높은 점막 및 전신 보호 면역을 유도합니다Immunology Published on 2021-12-172022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, 치료제, [키워드] administer Administered administration Against antibody booster vaccination booster vaccinations candidate vaccine CHO cells clinical development clinical testing control group control groups COVID-19 COVID-19 vaccine COVID-19 vaccines Cramp D614G effective eight greater hamster hamsters Histopathology IgA IgG IgG response immune protection immune response Immunity Immunoglobulin Immunoglobulin G inactivated induce intramuscular intramuscular vaccination intramuscularly intranasal intranasally lesion Local lung Lungs majority membrane vesicles mice mRNA mucosal mucosal immunity Neisseria Neisseria meningitidis Neutralizing antibodies nose offer OMV outer membrane outer membrane vesicle pandemic peptide peptide sequence practicality produced proline Protecting reduced Registered required SARS-CoV-2 SARS-CoV-2 pandemic second vaccination sequence serum Spike protein subunit Subunit vaccine Support systemic the SARS-CoV-2 Transmission vaccination Vaccinations Vaccine variants Vesicle Viral viral entry viral replication Viral vector weight loss [DOI] 10.3389/fimmu.2021.781280 PMC 바로가기 [Article Type] Immunology