isolates – Page 10 – Communicable Diseases Research

Potent neutralizing RBD‐specific antibody cocktail against SARS‐CoV‐2 and its mutant

Original Article

Published on 2021-06-242022-10-30
Journal: MedComm [Category] COVID-19,

Comparative Genomics Reveals Early Emergence and Biased Spatiotemporal Distribution of SARS-CoV-2

비교 유전체학은 SARS-CoV-2의 조기 출현 및 편향된 시공간 분포를 나타냅니다

Discoveries

Published on 2021-06-192022-09-10
Journal: Molecular Biology and Evolution [Category] SARS, 변종, 유전자 메커니즘,

[키워드] 3′-UTR absence Analysis approach approaches changes in China circulation classification Clinical characteristics Clusters Comparative Comparative genomics complement conserved contributing to convergent evolution COVID 19 Defense distribution driven by early emergence emergence epidemiological epidemiological studies Epidemiological study Evidence evidence of Evolution exhibiting facilitate fixation functional genetic profile Genetic variant genetic variants Genome sequences genomes genomic Genomic surveillance Genomic variability Genomics Geographic distribution highlight human pathogen independent Infectious disease Infectious diseases isolates Isolation Metadata molecular data open outbreak outlined pandemic pathogen Pathogens phenotypic feature Phylogenetic polymorphic site positive predicted question sampling SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates secondary structure Seven spatiotemporal Spread Strains substitutions Surveillance unlikely UTR UTRs Validity Variability variant Viral viral genome viral strains virus widespread
[DOI] 10.1093/molbev/msab049 PMC 바로가기 [Article Type] Discoveries

Field and Molecular Epidemiology: How Viral Sequencing Changed Transmission Inferences in the First Portuguese SARS-CoV-2 Infection Cluster

현장 및 분자 역학 : 바이러스 시퀀싱이 제 1 포르투갈 SARS-COV-2 감염 클러스터에서 전송 추론을 변화시키는 방법

Brief Report

Published on 2021-06-102022-09-10
Journal: Viruses [Category] MERS, SARS, 치료기술,

Genomic and Phenotypic Analysis of COVID-19-Associated Pulmonary Aspergillosis Isolates of Aspergillus fumigatus

Aspergillus fumigatus의 COVID-19 관련 폐 아스페르길루스증 분리물의 게놈 및 표현형 분석

Research Article

Published on 2021-06-092022-09-10
Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] A. fumigatus acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed aspergillosis Aspergillus Aspergillus fumigatus caused Cell cell wall Characteristics characterized Coinfection conducted copy number copy number variant Copy number variants coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient deleted described drugs etiological agent example expand Factors fungal disease fungal pathogen fungal pathogens genetic determinant Genome Genome sequencing genomes genomic genus Germany global pandemic growth had more information isolate isolates loss-of-function mutation metabolite microbial modulate mutational spectrum North nucleotide osmotic outcome oxidative pathogenicity Pathogens patients treated Phenotypes phenotypic Polymorphisms profile pulmonary pulmonary aspergillosis reference strain reference strains reported respiratory responsible SARS-CoV-2 Secondary infection secondary infections Secondary Metabolite severe acute respiratory syndrome Coronavirus significant difference significant differences significantly more single nucleotide polymorphisms strain Strains stressors subset superinfection virulence virulence factors virulent Wuhan Wuhan, China
[DOI] 10.1128/Spectrum.00010-21 PMC 바로가기 [Article Type] Research Article

Epidemiology and Mycology of Candidaemia in non-oncological medical intensive care unit patients in a tertiary center in the United States: Overall analysis and comparison between non-COVID-19 and COVID-19 cases

미국 3차 센터의 비종양내과 중환자실 환자의 칸디다혈증 역학 및 균류: 비COVID-19 및 COVID-19 사례 간의 종합 분석 및 비교

Article

Published on 2021-06-012022-09-11
Journal: Mycoses [Category] SARS, 치료기술,

[키워드] accounted Admissions analysed Analysis Candida albicans Candidaemia candidiasis Central venous catheter Characteristics coronavirus COVID-19 COVID-19 case COVID-19 group COVID-19 patient COVID-19 patients Critical care Critically ill Critically ill patient critically ill patients determine disease distribution Epidemiology globe ICU ICU admission ICUs identify incidence intensive care invasive invasive candidiasis isolates less medical icu medical intensive care unit mycology mycology. Non-COVID-19 non-COVID-19 and COVID-19 patients non-COVID-19 group non-COVID-19 patient Non-COVID-19 patients occurred pandemic Patient provide SARS-CoV-2 pandemic SOFA score the patient the SARS-CoV-2 the United State United States venous catheter
[DOI] 10.1111/myc.13258 PMC 바로가기 [Article Type] Article

Antibody evasion by the P.1 strain of SARS-CoV-2

SARS-CoV-2의 P.1 균주에 의한 항체 회피

Article

Published on 2021-05-272022-09-11
Journal: Cell [Category] Fulltext, SARS, 변종, 진단,

[키워드] Abstract ACE2 ACE2 binding site ACE2-binding site Analysis antibodies antibody Antibody responses B.1.1.7 B.1.351 Brazil change changes in chimeric chimeric antibodies current E484K elicit escape explain functional isolates K417N less light chain mAb monoclonal antibody multiple mutations Mutation mutations N501Y natural infection neutralization neutralization potency neutralize Neutralizing antibody response neutralizing antibody responses new strain P.1 P.1 variant pandemic RBD RBD mutations Receptor-binding domain restored reveal SARS-CoV-2 SARS-CoV-2 pandemic significantly South Africa spike Structural analysis Structure the receptor-binding domain the SARS-CoV-2 vaccination Vaccine vaccine-induced antibody response variant VH3-53 Virus spike
[DOI] 10.1016/j.cell.2021.03.055 PMC 바로가기 [Article Type] Article

Self-Assembling Nanoparticle Vaccines Displaying the Receptor Binding Domain of SARS-CoV-2 Elicit Robust Protective Immune Responses in Rhesus Monkeys

SARS-CoV-2의 수용체 결합 도메인을 표시하는 자가 조립 나노입자 백신은 붉은털 원숭이에서 강력한 보호 면역 반응을 이끌어냅니다

Article

Published on 2021-05-192022-09-11
Journal: Bioconjugate chemistry [Category] SARS, 비임상, 진단,

[키워드] Analysis Antigen benefit breath candidate vaccine caused Cell Clinical trial design COVID-19 pandemic cross-neutralize domain effective effective vaccine Efficiency elicit eukaryotic expression ferritin Focusing Humoral immunity immune response immunization immunization program immunized Infection inhibited isolates Monkey nanoparticle nasal Neutralizing antibodies neutralizing antibody new SARS-CoV-2 observation pathology platform protection test purified RBD respiratory response Rhesus monkey Rhesus monkeys Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 strain SARS-CoV-2 virus significantly specific antigen Spike protein T cell the vaccine Vaccine vaccine candidate vaccine platform virus replication
[DOI] 10.1021/acs.bioconjchem.1c00208 PMC 바로가기 [Article Type] Article

Carbapenem-Resistant Klebsiella pneumoniae Infections in ICU COVID-19 Patients—A Scoping Review

Review

Published on 2021-05-122022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] age analyzed Antibiotic therapy Antibiotics applied Bacteria Bacterial carbapenem carbapenem-resistance caused change Cochrane Library Community conducted contribute Course COVID-19 CTX-M database drug exclusion criteria exhibiting hospital ICU Immunocompromised patient infected patient Infection infections isolates Klebsiella pneumoniae KPC literature review majority male multidrug-resistant NDM New coronavirus new SARS-CoV-2 Organisms pandemic pathogen Patient patients hospitalized patients with COVID-19 predominant Prevalence Prevent PROTECT protocol ranged recommendations review searched Spread Surveillance TEM
[DOI] 10.3390/jcm10102067 PMC 바로가기 [Article Type] Review

Emerging variants of concern in SARS-CoV-2 membrane protein: a highly conserved target with potential pathological and therapeutic implications

SARS-CoV-2 막 단백질에서 우려되는 새로운 변종: 잠재적인 병리학적 및 치료적 의미를 지닌 고도로 보존된 표적

Research Article

Published on 2021-05-092022-09-10
Journal: Emerging Microbes & Infections [Category] SARS, 변종,

[키워드] accounted age B.1 lineage B.1.1.7 B.1.429 clade conjunction conserved COVID-19 defined dominant lineage e genes effort ENCODE Europe Frequency functions genomic Genomic surveillance Glucose host cell implicated implication Implications incidence increase in initial isolate isolates Lineage lineages M gene M:I82T mutation membrane membrane protein Mutation mutations pangolin pathogenic Patient patient age Protein reported SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes structural protein sulphate Surveillance the SARS-CoV-2 therapeutic transmembrane Transport USA variant of concern variants of concern Viral Viral protein viral replication while
[DOI] 10.1080/22221751.2021.1922097 PMC 바로가기 [Article Type] Research Article

Imaging Enterobacterales infections in patients using pathogen-specific positron emission tomography

Article

Published on 2021-05-072022-11-01
Journal: Science Translational Medicine [Category] COVID-19, MERS,

[키워드] acute respiratory syndrome Analysis antibiotic Bacteria bacterial pathogen cartridge Clinical improvement Complication conserved coronavirus death decrease demonstrated detect Efficacy enrolled facilitate hospitalized patient Human imaging in vitro Infection infections Inflammation isolates Klebsiella pneumoniae lesions MDR microbiologically multidrug-resistant murine models noninvasive occur pathogen pathogen-specific Pathogens pathology pathway Patient pet PET/CT Pneumonia Repeat responsible resulting Safe SARS-CoV-2 Sepsis specificity Strains Support temperature tomography with COVID-19
[DOI] 10.1126/scitranslmed.abe9805 PMC 바로가기 [Article Type] Article