Biogenesis and Dynamics of the Coronavirus Replicative StructuresReview Published on 2012-11-212022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] association biogenesis cellular membrane complexes coronavirus cytoplasmic detected Dynamics humans Infection infectious agent interior involved knowledge live cell imaging membrane membrane anchoring membrane rearrangements membranes nonstructural protein protein-protein interactions Proteins provided recent replication complex replicative RNA RNA synthesis RNA virus Structure structures Vesicle viral RNA synthesis [DOI] 10.3390/v4113245 PMC 바로가기 [Article Type] Review
SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic ReticulumResearch Article Published on 2008-09-162022-10-28 Journal: PLoS Biology [Category] Coronavirus, [키워드] acute respiratory syndrome alteration Analysis Antiviral applied arising Author biochemical characterized complex connection coronavirus cytoplasm cytosol Defense defined dissect double-stranded RNA driven by early stage electron tomography Endoplasmic reticulum endoplasmic reticulum membrane enzyme ER membrane host cell host cell membrane host cell membranes host cells human pathogen implicated in viral induce Infected infected cell interior invagination mechanism mechanisms membrane membrane-bound membranes Microscopy network question raise replicate Replication replication complex replicative protein reported Reticulum reveal RNA RNA genome RNA synthesis RNA virus RNA viruses SARS-coronavirus SARS-CoV Structure subunits Support thought tomography ultrastructure unique Vesicle vesicles viral replication viral RNA synthesis virus Virus-host interactions Web [DOI] 10.1371/journal.pbio.0060226 PMC 바로가기 [Article Type] Research Article
SARS-Coronavirus Replication/Transcription Complexes Are Membrane-Protected and Need a Host Factor for Activity In VitroResearch Article Published on 2008-05-022022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] activity acute respiratory syndrome addition Author cause centrifugation characteristic complex complexes connection Critical cytoplasm cytoplasmic Degradation dependent on develop digestion dissect eight enzyme Enzymes Factor fraction functional genomic RNA Host host cell membranes host cells in vitro in vitro activity Infected infected cell life-threatening membrane membrane structure membrane structures membranes non-structural protein NSP Nsps polyproteins precursor produced protease PROTECT protein synthesis released remained replicate Replication required RNA RNA synthesis robust RTC SARS-coronavirus SARS-CoV SARS-CoV-infected cells Structure subgenomic mRNA subgenomic mRNA synthesis subunit susceptible Transcription Treatment viral genome replication Viral RNA viral RNA synthesis virus-induced membrane structure virus-induced membrane structures [DOI] 10.1371/journal.ppat.1000054 PMC 바로가기 [Article Type] Research Article