Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS-CoV-2 receptorMendelian randomization analysis는 추정되는 SARS-CoV-2 수용체인 ACE2의 발현에 대한 흡연의 인과관계를 제공합니다Research Article Published on 2021-07-062022-09-10 Journal: eLife [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 expression acute respiratory syndrome adipose adopted alcohol alcohol consumption Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach association Brain Colon conducted coronavirus coronavirus disease Coronavirus disease 2019 Council COVID-19 COVID-19 related adverse outcomes expression Factor funding Genetic variant horizontal pleiotropy Human identify instrumental variable instrumental variables intensity life liver mendelian randomization MR-Egger regression MR-PRESSO Odds ratio outlier performed phenome Pleiotropy predict predicted provide receptor Research respiratory risk of COVID-19 SARS-CoV-2 receptor severity significantly increased smoking smoking intensity smoking status statistically significant supported susceptibility Swedish Thyroid weighted median Welfare were used working [DOI] 10.7554/eLife.64188 PMC 바로가기 [Article Type] Research Article
Genomic Association vs. Serological Determination of ABO Blood Types in a Chinese Cohort, with Application in Mendelian Randomization멘델식 무작위 배정에 적용한 중국 코호트에서 ABO 혈액형의 게놈 연관성 대 혈청학적 결정Article Published on 2021-06-242022-09-10 Journal: Genes [Category] MERS, 변종, 유전자 메커니즘, [키워드] ABO ABO blood types ABO gene ABO type Analysis application biochemically Blood blood pressure Chinese Chinese cohort Cohort conducted Determination determined by evaluated Genetic polymorphism genetic polymorphisms Genetic variant Genome-wide association study genotyping Han Chinese high accuracy human population human populations instrumental variables macro mapped mechanism mendelian randomization nucleotide Predictive Respiratory failure rs8176719 severe COVID-19 Significant Single nucleotide polymorphism single nucleotide polymorphisms Type [DOI] 10.3390/genes12070959 PMC 바로가기 [Article Type] Article
Circulating Cytokines and Coronavirus Disease: A Bi-Directional Mendelian Randomization StudyGenetics Published on 2021-06-072022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] 95% CI 95% confidence interval affected CCL4 conducted controls coronavirus disease COVID-19 cytokine Cytokines estimates GCSF genetic risk genetics Genome-wide association studies granulocyte hepatocyte growth factor HGF Hospitalized hospitalized COVID-19 immune response immune system Immunity Infection Inflammatory Intervention IVW Laboratory Ligand mendelian randomization motif multiple comparisons Prevent replicated Result risk sensitivity analysis was related Weighting with COVID-19 [DOI] 10.3389/fgene.2021.680646 PMC 바로가기 [Article Type] Genetics
Educational Attainment Decreases the Risk of COVID-19 Severity in the European Population: A Two-Sample Mendelian Randomization Study교육 성취는 유럽 인구의 COVID-19 심각성 위험 감소: 2표본 멘델식 무작위 배정 연구Public Health Published on 2021-06-032022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 유전자 메커니즘, [키워드] 95% confidence interval Analysis approach association attainment condition COVID-19 COVID-19 Host Genetics Initiative COVID-19 severity data set data sets decrease educational attainment epidemiological European European population Evidence evidence of Genetic genetic association Genome-wide association studies Genome-wide association study GWAS GWASs increase in initiative instrumental variable instrumental variables investigated lower risk measure mechanism mechanisms mendelian randomization MR study observational studies observational study Odds ratio outcome participant physical physical conditions polymorphism reported risk risk of COVID-19 SARS-CoV-2 Science Sensitivity analyses sensitivity analysis severity severity of COVID-19 significantly single-nucleotide Single-nucleotide polymorphisms SNP SNPs socioeconomic status Standard deviation was obtained was performed years of schooling [DOI] 10.3389/fpubh.2021.673451 PMC 바로가기 [Article Type] Public Health
Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization studyCOVID-19 Host Genetics Initiative의 비타민 D 및 COVID-19 감수성 및 심각성: 멘델식 무작위 배정 연구Research Article Published on 2021-06-012022-08-13 Journal: PLoS Medicine [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] 2-sample MR 25-hydroxy vitamin D 25OHD 25OHD level 25OHD levels 95% CI analyses Analysis association associations circulating confounder confounders confounding variables Control control group control groups controlled trials controls COVID-19 COVID-19 case COVID-19 cases COVID-19 Host Genetics Initiative COVID-19 susceptibility deficiency described determined by ecological Ecological studies European Evidence General population Genetic genetic determinant genetic determinants genetic evidence genetic instrument genetic instruments Genetic variant genetic variants Genome-wide association study Guillaume GWAS GWASs had no horizontal pleiotropy Hospitalization IMPROVE in some in vitro Increased individual individuals with COVID-19 initiative instrument bia instrumental variables inverse-weighted MR Laboratory testing large-scale vitamin D randomized trials limit logarithmic scale mendelian randomization Mendelian randomization studies Mendelian randomization study meta-analytic methods observational studies observé Odds ratio Other outcome outcomes participant Population predicted PROTECT provide provided Randomized controlled trial Randomized controlled trials randomized trials rationale reduce reflected removal researcher risk SARS-CoV-2 positivity Sensitivity analyses sensitivity analysis severe disease severity Standard deviation Support supported susceptibility therapeutic therapy trials UK biobank variant variants Vitamin D vitamin D deficiency vitamin D level vitamin D levels Vitamin D Mendelian randomization vitamin D Mendelian randomization studies Vitamin D supplementation vitamin D supplementation randomized trials was determined were used with COVID-19 worsened [DOI] 10.1371/journal.pmed.1003605 PMC 바로가기 [Article Type] Research Article
Liver and Kidney Function Biomarkers, Blood Cell Traits and Risk of Severe COVID-19: A Mendelian Randomization StudyGenetics Published on 2021-05-272022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] abnormality albumin association Bilirubin Biomarker Biomarkers Blood Cell Coronavirus disease 2019 corpuscular hemoglobin COVID-19 COVID-19 pathogenesis COVID-19 severity eight Europeans Evidence function Genetic Health hematological independent individual Kidney function liver Liver function Lymphocyte count mean corpuscular hemoglobin mechanism mendelian randomization Mendelian randomization analysis neutrophil count observational studies pandemic performed remained risk risk factor Risk factors risk stratification severe COVID-19 White blood cell White blood cells [DOI] 10.3389/fgene.2021.647303 PMC 바로가기 [Article Type] Genetics
Alcohol Consumption Is Associated with Poor Prognosis in Obese Patients with COVID-19: A Mendelian Randomization Study Using UK Biobank알코올 소비는 COVID-19에 걸린 비만 환자의 나쁜 예후와 관련이 있습니다: UK Biobank를 사용한 멘델식 무작위 배정 연구Clinical Trial Published on 2021-05-102022-08-13 Journal: Nutrients [Category] SARS, 변종, 임상, [키워드] 95% CI Acute and chronic alcohol abuse acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Adaptive immune response ADH1B adverse effect adverse effects adverse impact alcohol Alcohol Abuse alcohol consumption Alcohol Dehydrogenase allele Analysis applied association average carrier Clinical outcome conducted Consumption coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 patients death death in COVID-19 dehydrogenase Evidence family GCKR Genetic variant glucokinase heavy drinking higher risk Infection instrumental variable instrumental variables Logistic regression member mendelian randomization Mendelian randomization analyses Mendelian randomization analysis Mortality obesity outcome outcomes participant Participants Patient patients patients with COVID-19 patients with obesity Poor positive progression promote reduced regulator respiratory risk risk of death SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positivity Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 SLC39A8 Solute susceptibility tested UK biobank [DOI] 10.3390/nu13051592 PMC 바로가기 [Article Type] Clinical Trial
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19실행 가능한 약물 가능 게놈 전체 멘델식 무작위화, COVID-19의 용도 변경 기회 식별Article Published on 2021-04-012022-09-11 Journal: Nature Medicine [Category] MERS, SARS, 바이오마커, 변종, 비임상, 신약개발, 유전자 메커니즘, 임상, 진단, 치료법, 치료제, [키워드] ACE2 approach approved drug approved drugs association Colocalization conducted controls COVID-19 COVID-19 hospitalization drug Drug development drugs targeting Evidence expression genetic instrument genetic instruments Hospitalization identify IFNAR2 IL10RB initiative loci management mendelian randomization Mendelian randomization analyses Million Veteran Program Pathway enrichment analysis patients hospitalized Protein proteomic provide Quantitative suggested therapeutic target therapeutic targets Therapeutics transcriptomic Trial with COVID-19 [DOI] 10.1038/s41591-021-01310-z PMC 바로가기 [Article Type] Article
Evaluation of glycemic traits in susceptibility to COVID-19 risk: a Mendelian randomization studyResearch Article Published on 2021-03-242022-10-28 Journal: BMC Medicine [Category] COVID-19, SARS, [키워드] 95%CI Analysis applied association conducted confidence interval controls coronavirus disease COVID-19 COVID-19 case COVID-19 phenotype COVID-19 phenotypes diabetes estimate Evidence fasting glucose Genetic genetic instrument Genetic predisposition Genome Glucose glycated hemoglobin glycemic hemoglobin Hospitalized increase in initiative log mendelian randomization MR-Egger observational study predisposition Result risk risk of COVID-19 severe cases severe COVID-19 severity of COVID-19 supplementary material susceptibility type 2 diabete type 2 diabetes unlikely weighted median Weighting [DOI] 10.1186/s12916-021-01944-3 PMC 바로가기 [Article Type] Research Article
White Blood Cells and Severe COVID-19: A Mendelian Randomization StudyArticle Published on 2021-03-122022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] Analysis association basophil basophils bidirectional conducted coronavirus disease COVID-19 COVID-19 severity COVID-19 susceptibility effective evaluate Evidence Genetic Genome-wide association studies Increasing indicated individual lower risk mendelian randomization Odds ratio predicted protective effect risk severe COVID-19 severity Standard deviation susceptibility therapeutic strategy white White blood cell White blood cells [DOI] 10.3390/jpm11030195 PMC 바로가기 [Article Type] Article