Induction of humoral and cellular immune responses to COVID-19 mRNA and vector vaccines: A prospective cohort study in Bulgarian healthcare workersCOVID-19 mRNA 및 벡터 백신에 대한 체액 및 세포 면역 반응의 유도: 불가리아 의료 종사자를 대상으로 한 전향적 코호트 연구Article Published on 2022-05-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] advanced age age anti-SARS-CoV-2 immune responses anti-SARS-CoV-2 vaccine anti-SARS-CoV-2 vaccines BNT162b2 Bulgarian cellular Cellular immune response circulating Cohort comparable Complete coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 COVID-19 vaccine Donor donors dose Enumeration evaluated healthcare worker humoral humoral immune response IFNγ IgA immune responses Immunity immunization Immunoglobulin immunoglobulin A increased risk induce induction Infection Installing interferon gamma Longevity Messenger RNA mRNA mRNA vaccine Neutralizing activity neutralizing antibody overcome Pandemics participant peaking priming prospective cohort study protective immunity Receptor-binding domain SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 specific T-cell significantly single dose T cell T cells tested Vaccine vaccine cohort virus-neutralizing virus-neutralizing antibody virus-neutralizing antibody. [DOI] 10.1002/jmv.27572 PMC 바로가기 [Article Type] Article
Humoral Responses Against Variants of Concern by COVID-19 mRNA Vaccines in Immunocompromised Patients면역 저하 환자의 COVID-19 mRNA 백신에 의한 우려 변종에 대한 체액 반응Article Published on 2022-05-012022-09-11 Journal: JAMA Oncology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 2019-nCoV Against age All participant All participants Alpha anti-spike antibody Antibody titer Antibody titers association Autoimmune disease Autoimmune diseases best Beta Beta variant binding BNT162b2 BNT162b2 vaccine BNT162b2 vaccines Cancer cancers circulating concern conducted COVID-19 decrease Delta delta variant Delta variants dose Effectiveness elicited enrolled female Gamma greater healthy control healthy controls hematologic Humoral response humoral responses IgG Immunocompromised patient Immunocompromised patients median Messenger RNA Moderna mRNA mRNA vaccine mRNA-1273 NAb NAb responses NAbs nCoV neutralizing antibody neutralizing antibody titers outcome participant Participants Patient patient population performed persistence Pfizer-BioNTech Primary outcome proportion proportions response response to vaccination responses against SARS-CoV-2 SARS-CoV-2 variants secondary outcome solid cancers solid organ solid organ transplant solid organ transplants study group the healthy the patient the SARS-CoV-2 Treatment underlying disease university vaccination vaccination schedule Vaccine Vaccines variant variants variants of concern VoC VOCs were measured [DOI] 10.1001/jamaoncol.2022.0446 PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific T-cell epitope repertoire in convalescent and mRNA-vaccinated individuals회복기 및 mRNA 백신 접종 개인의 SARS-CoV-2 특이적 T 세포 에피토프 레퍼토리Article Published on 2022-05-012022-09-11 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] benefit booster vaccination breadth CD8 combating comparison Complete conserved convalescent convalescent individual convalescent individuals epitope Epitopes Humoral immunity individual Infection initial Messenger RNA mRNA vaccines multiple mutation multiple mutations omicron pandemic SARS-CoV-2 SARS-CoV-2 pandemic Spike protein spike-specific T-cell response Support T-cell T-cell epitope T-cell epitopes T-cell Response the SARS-CoV-2 the spike protein vaccination vaccinee vaccinees variant variants of concern VoC VOCs wild-type SARS-CoV-2 [DOI] 10.1038/s41564-022-01106-y PMC 바로가기 [Article Type] Article
Antibody response after a third dose mRNA-1273 vaccine among vaccinated healthcare workers with two doses of inactivated SARS-CoV-2 vaccine비활성화된 SARS-CoV-2 백신을 2회 접종한 예방접종을 받은 의료 종사자의 mRNA-1273 3차 접종 후 항체 반응Article Published on 2022-05-012022-09-12 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Administered anti-S anti-S antibody Antibody Response antibody response against booster CoronaVac COVID-19 COVID-19 disease COVID-19 vaccination dose elicit evaluate HCW HCWs Health care healthcare healthcare worker Healthcare workers Heterologous inactivated Inactivated vaccine interquartile range IQR median Messenger RNA Moderna mRNA mRNA-1273 mRNA-1273 booster mRNA-1273 vaccine Protein RBD receive SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine significantly increased the receptor-binding domain the SARS-CoV-2 vaccination Vaccine [DOI] 10.1016/j.ijid.2022.02.036 PMC 바로가기 [Article Type] Article
Antibody response to the COVID-19 ChAdOx1nCov-19 and BNT162b vaccines after temporary suspension of DMARD therapy in immune-mediated inflammatory disease (RESCUE)면역매개염증질환(RESCUE)에서 DMARD 치료를 일시적으로 중단한 후 COVID-19 ChAdOx1nCov-19 및 BNT162b 백신에 대한 항체 반응Randomized Controlled Trial Published on 2022-05-012022-09-11 Journal: RMD Open [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, 치료제, [키워드] Adult patients Antibody Response Antibody responses antirheumatic agents AstraZeneca AZ vaccine baseline biologic BNT162b Control control group control groups controls COVID-19 csDMARD dose Final first and second dose first dose first vaccination group groups IgG Immune-mediated immunogenicity inflammatory disease Messenger RNA multicentre not significantly different Patient Pfizer Protein randomised randomised controlled trial registration number response S1/S2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV2 second dose second vaccination Seroconversion seroconversion rate seroconversion rates significantly lower the antibody response the mean therapy titre titres U/mL vaccination Vaccine were measured [DOI] 10.1136/rmdopen-2022-002301 PMC 바로가기 [Article Type] Randomized Controlled Trial
mTOR inhibitors improve both humoral and cellular response to SARS-CoV-2 messenger RNA BNT16b2 vaccine in kidney transplant recipientsmTOR 억제제는 신장 이식 수혜자의 SARS-CoV-2 메신저 RNA BNT16b2 백신에 대한 체액 및 세포 반응을 모두 개선합니다Article Published on 2022-05-012022-09-12 Journal: American journal of transplantation : official jou [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] anti-SARS-CoV-2 anti-SARS-CoV-2 IgG association cell-mediated immune cellular response COVID-19 COVID-19 vaccination COVID-19 vaccine disease severity enrolled evaluated higher risk humoral IFNγ immune response Immunosuppression IMPROVE inhibitors kidney kidney transplant recipient Kidney transplantation Messenger RNA mRNA BNT162b2 mTOR inhibitor mTOR inhibitors. Multivariate analysis Patient patients treated percentage Pfizer-BioNTech recipient SARS-CoV-2 SARS-CoV-2 vaccine significantly higher significantly increased T cell response therapy treated vaccinated against COVID-19 Vaccine vaccine-induced antibody were assessed [DOI] 10.1111/ajt.16958 PMC 바로가기 [Article Type] Article
Humoral immune response following prime and boost BNT162b2 vaccination in people living with HIV on antiretroviral therapy항레트로바이러스 요법을 받고 있는 HIV 감염자의 프라임 및 부스트 BNT162b2 백신 접종 후 체액성 면역 반응Article Published on 2022-05-012022-09-12 Journal: HIV medicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome anti-S IgG antibody Antiretroviral therapy ART BNT162b2 boost CD4 CD4 count CD4 T-cell cellular circulating Clinical efficacy Cohort Complete Concentration Control controls coronavirus coronavirus disease coronavirus disease 2019 (COVID-19) vaccination correlated COVID-19 COVID-19 vaccination domain examined Health care worker higher risk HIV HIV-1 HIV-negative humoral immune response Humoral immunity IgG immune response Immune status Immunoglobulin less majority Messenger RNA mounted mRNA mRNA vaccination neutralizing antibody Neutralizing antibody response outcome plasma PLHIV PLWH prime and boost priming produced receiving response RNA robust SARS-CoV-2 severe coronavirus disease significantly higher significantly lower T-cell the SARS-CoV-2 vaccination Variability Viral load WHO with HIV World Health Organization [DOI] 10.1111/hiv.13202 PMC 바로가기 [Article Type] Article
The Incidence of SARS-CoV-2 Reinfection in Persons With Naturally Acquired Immunity With and Without Subsequent Receipt of a Single Dose of BNT162b2 Vaccine : A Retrospective Cohort StudyBNT162b2 백신의 후속 접종 유무에 관계없이 자연적으로 획득된 면역이 있는 사람의 SARS-CoV-2 재감염 발생률 : 후향적 코호트 연구Randomized Controlled Trial Published on 2022-05-012022-09-11 Journal: Annals of internal medicine [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] Acquired acquired immunity addition BNT162b2 BNT162b2 vaccine combined effect COVID-19 database death eligible Evidence hazard ratio Hospitalization hybrid incidence rate infected with SARS-CoV-2 Infection magnitude Messenger RNA Mortality Naturally naturally acquired immunity of BNT162b2 Older outcome Person Randomized Randomized controlled trial receipt receive Reinfection remained retrospective cohort study risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination service single dose statistically significant subsequent symptomatic disease Trial trials vaccination Vaccine Vaccine-induced immunity variant [DOI] 10.7326/M21-4130 PMC 바로가기 [Article Type] Randomized Controlled Trial
An analysis of antibody response following the second dose of CoronaVac and humoral response after booster dose with BNT162b2 or CoronaVac among healthcare workers in Turkey터키 의료 종사자의 코로나백 2차 접종 후 항체 반응 및 BNT162b2 또는 코로나백 추가 접종 후 체액성 반응 분석Article Published on 2022-05-012022-09-11 Journal: Journal of medical virology [Category] Fulltext, MERS, 변종, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration age Analysis Anti-RBD IgG anti-receptor-binding domain antibody antibody levels Antibody Response asked blood draw BNT162b2 booster booster dose booster doses chronic disease circulating variants Complete CoronaVac coronavirus dose evaluated Follow-up groups healthcare worker Healthcare workers Heterologous heterologous vaccination homologous or heterologous humoral Humoral response IgG Immunoglobulin Immunoglobulin G Inactivated vaccine independent predictor independent predictors levels of antibody Limited Messenger RNA Odds ratio participant Participants prospective cohort study Quantitative questionnaire RBD reduction respiratory risk SARS-CoV-2 second dose Seropositivity severe acute respiratory syndrome Coronavirus single booster dose the median Turkey university hospital vaccination Vaccine waning immunity were infected were measured [DOI] 10.1002/jmv.27620 PMC 바로가기 [Article Type] Article
The effect of an mRNA vaccine against COVID-19 on endothelial function and arterial stiffnessRandomized Controlled Trial Published on 2022-05-012022-10-04 Journal: Hypertension research : official journal of the Ja [Category] 바이오마커, 임상, 치료기술, 치료법, [키워드] administration adopted age arterial Arterial stiffness baseline Blood BNT162b2 mRNA brachial cause confidence interval COVID-19 COVID-19 pandemic COVID-19 vaccine Deterioration dose Endothelial dysfunction endothelial function evaluated High-sensitivity C-reactive protein hsCRP increase in Inflammation inflammatory markers median men Messenger RNA mRNA mRNA vaccine outcome participant Placebo Primary outcome pulse remained returned SARS-CoV-2 secondary outcome significantly the vaccine vaccination Vaccine were assessed [DOI] 10.1038/s41440-022-00876-6 PMC 바로가기 [Article Type] Randomized Controlled Trial