SARS-CoV-2-Encoded MiRNAs Inhibit Host Type I Interferon Pathway and Mediate Allelic Differential Expression of Susceptible GeneImmunology Published on 2021-12-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome allelic coronavirus coronavirus disease COVID-19 differential expression evade expressed functional genetic background Host inhibit innate immune response IRF7 IRF9 microRNA (miRNA) miRNA molecular mechanism OAS1 OAS2 public health crisis SARS-CoV-2 SARS-COV-2 infection sequence several gene signaling pathway single-nucleotide polymorphisms (SNPs) small RNA Spread STAT2 susceptible Type type I interferon type I interferon pathway unique virus–host interaction [DOI] 10.3389/fimmu.2021.767726 PMC 바로가기 [Article Type] Immunology
Integrated miRNA/cytokine/chemokine profiling reveals severity-associated step changes and principal correlates of fatality in COVID-19Article Published on 2021-12-202022-10-04 Journal: iScience [Category] 바이오마커, 유전자 메커니즘, [키워드] Abstract Accuracy association Blood blood sample CCL20 change chemokine circulating clinical clinical feature Clinical finding Cohort complex system Complex system biology COVID-19 COVID-19 pathology COVID-19 patients cytokine demonstrated disease severity fatal COVID-19 fatality feasibility greater hallmark Health Sciences highlight hospital hospitalized COVID-19 patient IL10 IL6 IMPROVE independent microRNA miRNA miRNA profiles miRNA signature Patient profile reveal separated Severe case severe COVID-19 severe disease [DOI] 10.1016/j.isci.2021.103672 PMC 바로가기 [Article Type] Article
A virus‐derived microRNA targets immune response genes during SARS‐CoV‐2 infection바이러스 유래 마이크로 RNA는 SARS-CoV-2 감염 시 면역 반응 유전자를 표적으로 한다Article Published on 2021-12-162022-09-10 Journal: EMBO Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] 3′UTR Argonaute conserved COVID‐19 COVID‐19 patients COVID‐19 cultured cells Dicer enzyme evade expression help Host Host immune response host immune responses host miRNA human cell identify immune response immune response gene immune response genes immune responses infected cell infected cells innate immune response interfere interferon interferon response isoform Microbiology, Virology & Host Pathogen Interaction microRNA miRNA miRNAs Nasopharyngeal swab nasopharyngeal swabs Patient predominant Proteins repress represse RNA Biology SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2‐infected SARS‐CoV‐2 sequence small RNA Small RNAs target transcript Viral viral genome viral miRNA [DOI] 10.15252/embr.202154341 PMC 바로가기 [Article Type] Article
Cellular miR-150-5p may have a crucial role to play in the biology of SARS-CoV-2 infection by regulating nsp10 gene세포 miR-150-5p는 NSP10 유전자를 조절함으로써 SARS-COV-2 감염의 생물학에서 중요한 역할을 할 수있다.Research Article Published on 2021-12-142022-09-10 Journal: RNA Biology [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] analysed Analysis biology of SARS-CoV-2 Biomarker Biomarkers Cell Chain Reaction change circulating circulating biomarkers circulating miRNA circulating miRNAs co-transfection coding strand Combination conducted COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients disease Effect experiment expression followed by healthy controls in vitro Infection infection assays inhibit SARS-CoV-2 inhibited inhibitor mechanism miR-150 miR-150-5p miR-375 miRNA miRNA profile miRNAs moderate-severe modulating NGS nsp10 performed plasma Plasma levels polymerase chain polymerase chain reaction promote provide real-time polymerase chain reaction remains uncertain reversed RT-qPCR SARS-CoV-2 SARS-COV-2 infection Sequencing significant changes in significantly Support T cells transfection western blotting [DOI] 10.1080/15476286.2021.2010959 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes407 Published on 2021-12-132022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Argonaute basic BATF2 cell lines cellular cellular RNA component conserved contribute coronavirus coronavirus disease COVID-19 described detect expresse Factor Health Host host gene host miRNA identify independent individuals interferon signaling investigated micoRNA microRNA miRNA moderate Nasopharyngeal swab noncoding RNA ORF7a pathway Population Protein regulate repress RNA RNA interference SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis sequence Significance target therapeutic intervention transcripts Zipper [DOI] 10.1073/pnas.2116668118 PMC 바로가기 [Article Type] 407
Identifying Putative Causal Links between MicroRNAs and Severe COVID-19 Using Mendelian Randomization멘델식 무작위화를 사용하여 MicroRNA와 심각한 COVID-19 사이의 추정 인과 관계 식별Article Published on 2021-12-112022-09-11 Journal: Cells [Category] SARS, 바이오마커, [키워드] approaches assessment Biomarker Biomarkers canonical Causal causal relationship Causality caused circulating circulating miRNA circulating miRNAs COVID-19 COVID-19 case COVID-19 cases COVID-19 severity death diagnose early treatment Effect eQTL evaluated expression data group GWAS summary statistics help identify identifying imperative IMPROVE independent investigated measure mendelian randomization microRNA miRNA miRNA biomarker miRNA expression miRNAs Multiple Multiple studies outcomes pandemic phenotype Prognosis provide retrieved risk Risk assessment risk assessments SARS-CoV-2 severe cases severe COVID-19 shown unique with COVID-19 [DOI] 10.3390/cells10123504 PMC 바로가기 [Article Type] Article
Extracellular Vesicle Associated miRNAs Regulate Signaling Pathways Involved in COVID-19 Pneumonia and the Progression to Severe Acute Respiratory Corona Virus-2 Syndrome세포 외 소포 관련 miRNA는 COVID-19 폐렴에 관여하는 신호 전달 경로를 조절하고 심한 급성 호흡기 코로나 바이러스 -2 증후군으로의 진행Immunology Published on 2021-12-092022-08-31 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] ACE2 expression activated adjusted alveolar cell among others Analysis analyzed ARDS ARDS patients bind Biomarker Biomarkers carrier carriers Cell cell-free microRNAs cell-to-cell communication cells circulating community acquired pneumonia controls Corona COVID-19 COVID-19 ARDS patient COVID-19 pneumonia CXCL8 Differential gene expression differential gene expression analysis differentially expressed miRNA downregulated epithelial evaluated EVs Extracellular vesicles function group healthy control healthy controls IL6 increase Inflammatory inhibited interleukin interleukin-6 interleukin-8 investigated let-7e-5p log2FC lung Lung diseases mechanically ventilated patient mediators miR-146 miR-146a-5p miRNA miRNAs mRNA mRNA transcript mRNA transcripts nasal epithelium network network analysis neutrophil neutrophil recruitment olfactory OR52N2 pathophysiology Pathways Pneumonia Precipitation prospectively studied receptor regulate regulated respiratory Result resulting RNA sequencing SARS-CoV-2 spike protein secrete Sepsis Severe Acute Respiratory Corona Virus-2 Syndrome severe COVID-19 Signaling signaling pathway significantly small RNA small RNA sequencing Spike protein symptomatic patient syndrome the healthy therapeutic targets TLR4 Toll-like receptor toll-like receptor 4 total RNA transcript upregulated Vesicle with COVID-19 [DOI] 10.3389/fimmu.2021.784028 PMC 바로가기 [Article Type] Immunology
Expression of plasma IFN signaling-related miRNAs during acute SARS-CoV-2 infection and its association with RBD-IgG antibody response급성 SARS-COV-2 감염 동안 혈장 IFN 신호 관련 miRNA의 발현 및 RBD-IgG 항체 반응과의 연관성Research Published on 2021-12-072022-09-01 Journal: Virology Journal [Category] SARS, 진단, [키워드] acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute SARS-CoV-2 infection Analysis analyzed antibody Antibody Response association biological significance cell count Characteristics Clinical characteristics controls coronavirus disease Coronavirus disease 2019 Coronavirus-2 correlated correlation COVID-19 COVID-19 patient COVID-19 patients domain ELISA exhibited expression expression level expression profiles Future Glucose healthy control healthy controls IFN IFN-I IFN-I signaling pathway IgG antibody Infection inhibit microRNA miRNA miRNAs performed plasma positively correlated Previous studies previous study profile RBD RBD-IgG Receptor-binding domain respiratory Result RT-qPCR SARS-CoV-2 SARS-COV-2 infection shown significantly Spearman suggested supplementary material T cell the healthy type I interferon virus replication was determined was done [DOI] 10.1186/s12985-021-01717-7 PMC 바로가기 [Article Type] Research
MicroRNA-Mediated Regulation of the Virus Cycle and Pathogenesis in the SARS-CoV-2 DiseaseArticle Published on 2021-12-072022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] Alter approach cell physiology cellular cellular response conserved COVID-19 COVID-19 infection cycle diagnostic disease Evidence experimental evidence Host human cells human microRNAs immune in silico analysis in viral infections information involved microRNA miRNA molecular mechanism prognostic biomarker Prognostic marker provided regulate Regulation Research researcher SARS-CoV-2 SARS-CoV-2 variant sequence sequence homology shown the SARS-CoV-2 the SARS-CoV-2 genome Therapies variants of concern (VOCs) viral microRNAs viral miRNA viral replication Viral RNA virus virus cycle Virus life cycle VOCs [DOI] 10.3390/ijms222413192 PMC 바로가기 [Article Type] Article
MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cellsmicroRNA는 표적 세포로 거의 전달되지 않는 세포 외 소포의 작은 성분입니다.Research Article Published on 2021-12-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Alter analyzed applied approach Biological functions Blood cells carried Cell cell line cell lines cell types cell-to-cell communication cellular cellular membrane cellular membranes contribute defined document effector effectors Evidence EVs Exosome Exosomes experiments extracellular vesicle Extracellular vesicles fraction functional FUSE had no majority mammalian cells messenger RNAs microRNA MicroRNAs Microvesicles miRNA miRNAs mRNA mRNAs packaged purified Quantitative recipient regulate RNAs Sensitivity and specificity stability target target cell target cells target mRNA Transcriptome Vesicle vesicles Viral viral miRNAs [DOI] 10.1371/journal.pgen.1009951 PMC 바로가기 [Article Type] Research Article