NMPylation and de-NMPylation of SARS-CoV-2 nsp9 by the NiRAN domainAcademicSubjects/SCI00010 Published on 2021-09-072022-10-31 Journal: Nucleic Acids Research [Category] COVID-19, SARS, [키워드] active site Bisphosphonates catalytic characterized conserved domain Drug discovery inhibited inhibitor inhibitors modify N-terminal Nsp9 nucleotide Protein Proteins RdRP reaction Remdesivir reported residue RNA RNA polymerase RNA synthesis RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp subsequent Substitution substrates subunit Support transfer viral replication viruses [DOI] 10.1093/nar/gkab677 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Comprehensive landscape of the renin-angiotensin system in Pan-cancer: a potential downstream mediated mechanism of SARS-CoV-2Research Paper Published on 2021-09-032022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE ACE2 affecting AGT AGTR1 AGTR2 alteration analyzed binding biological processe Cancer cancer type cancers Cell cell lines classical clinical phenotype Comprehensive conducted correlated COVID-19 pandemic demographic determine differentially expressed distribution DNA methylation downstream expression expression pattern fibroblast Frequency Genomic alterations highest Host immune immune infiltration independent Injury kidney low expression macrophages MAS1 mechanism Modification modify ovarian Pan-cancer positively correlated posttranslational modification Prognostic factor Prognostic value promoter RAS RAS family Regulation renal renin-angiotensin system SARS-CoV-2 survival tissue tissues Tumor tumor microenvironment tumors [DOI] 10.7150/ijbs.53312 PMC 바로가기 [Article Type] Research Paper
“When will it be over?” U.S. children’s questions and parents’ responses about the COVID-19 pandemicResearch Article Published on 2021-08-262022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] age Amazon’s Mechanical Turk Analysis asked cause change children cognitive coronavirus COVID-19 COVID-19 pandemic events global pandemic Guidance information knowledge modify National occurred pandemic parent preventative measure preventative measures PROTECT question recruited reported response Spread United States virus [DOI] 10.1371/journal.pone.0256692 PMC 바로가기 [Article Type] Research Article
On the Use of Deep Learning for Imaging-Based COVID-19 Detection Using Chest X-rays흉부 X선을 이용한 영상 기반 COVID-19 탐지를 위한 딥 러닝 활용에 대하여Article Published on 2021-08-242022-09-10 Journal: Sensors (Basel, Switzerland) [Category] MERS, SARS, 치료기술, [키워드] Accuracy approach Chest radiography chest X-ray Chest X-ray image Chest X-ray images CNN Convolutional neural network COVID-19 COVID-19 cases COVID-19 pandemic dataset deep deep learning demonstrated detection diagnosis of COVID-19 Diagnostic method evaluated examined hand healthy individuals highest image classification imaging modality imperative individual individuals with COVID-19 infected individual infected individuals learning Medical imaging modify offer Pneumonia Radiography resources solution Viral Viral pneumonia [DOI] 10.3390/s21175702 PMC 바로가기 [Article Type] Article
Identifying Frail Populations for Disease Risk Prediction and Intervention Planning in the Covid-19 Era: A Focus on Social Isolation and VulnerabilityPsychiatry Published on 2021-08-202022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] Adults age categories category changes changes in consequence Contagion contributed COVID-19 develop disease risk distress Effect female females focus frailty Gender General population Government greater Health Health status help identifying induce Isolation Italian linear lockdown loneliness long-lasting male males modify Older outbreak pandemic Planning Population prediction Prevent psychosocial variables reduce Resilience resource risk SARS-CoV2 social distancing social isolation Social vulnerability stressors targeted intervention vulnerability while [DOI] 10.3389/fpsyt.2021.626682 PMC 바로가기 [Article Type] Psychiatry
The degree of frailty as a translational measure of health in aging Reviews Published on 2021-08-122022-10-05 Journal: Nature Aging [Category] 바이오마커, 비임상, 유전자 메커니즘, [키워드] Adults age Care cellular and molecular clinical manifestations clinical trial condition disease explain expressed expressing expression favor frailty Health help increased risk less modify Older organ outcomes risk social determinants subcellular the disease tissue translational [DOI] 10.1038/s43587-021-00099-3 [Article Type] Reviews
Positive aspects of the mRNA platform for SARS-CoV-2 vaccinesSARS-CoV-2 백신을 위한 mRNA 플랫폼의 긍정적인 측면Article Published on 2021-08-032022-09-11 Journal: Human vaccines & immunotherapeutics [Category] SARS, 유전자 메커니즘, [키워드] assumed BNT162b1 causative agent clinical trial clinical trials coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mRNA vaccine COVID-19 mRNA vaccines COVID-19 vaccines develop effective Effective vaccines Efficacy host genome humans imperative individual lack mechanism mechanism of action media Messenger RNA misinformation modify mRNA mRNA platform mRNA vaccine mRNA-1273 mRNA-based COVID-19 vaccine offer Pfizer raised receiving Safe SARS-CoV-2 SARS-CoV-2 vaccine skepticism skepticism. social media Strains vaccination vaccination against COVID-19 Vaccine Vaccine hesitancy vaccine platform [DOI] 10.1080/21645515.2021.1900713 PMC 바로가기 [Article Type] Article
The interplay between partisanship, forecasted COVID-19 deaths, and support for preventive policies Research Published on 2021-08-032022-10-05 Journal: Humanities & Social Sciences Communications [Category] 치료법, [키워드] Brazil country COVID-19 COVID-19 pandemic death deaths effective Evidence experiment Government greater individual intensity Intervention less lockdowns modify National observation optimism pandemic participant preferences Prevent preventive measure preventive measures provided question Research severity shown Support the United State translate Variability [DOI] 10.1057/s41599-021-00870-2 [Article Type] Research
A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic Research Published on 2021-08-022022-10-05 Journal: Nature human behaviour [Category] 유전자 메커니즘, 임상, 치료법, [키워드] assigned change conditions control condition country COVID-19 pandemic creating did not reduce Effectiveness Effects emotional Exploratory analysis Health impacts indicated Intention Intervention left Measures modify negative emotion participant Positive emotion positive emotions protocol Randomly reduce reduced Region report Result tested viability [DOI] 10.1038/s41562-021-01173-x [Article Type] Research
Molecular determinants of disease severity in urinary tract infection요로 감염에서 질병 중증도의 분자적 결정인자Review Published on 2021-08-012022-09-12 Journal: Nature reviews. Urology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] acute pyelonephritis aggression approach asymptomatic bacteriuria Bacteria Bacterial bacterial pathogen bladder caused COVID-19 pandemic defined determinant disease disease severity function Health Host host immune system host response host susceptibility immune response immune responsiveness Infection inhibiting innate immune innate immune activation innate immune system Innate immunity kidney infection Measures microbial modify morbidity morbidity and mortality observation outcome Pathogens provide responsible severe disease severity susceptible patients symptomatic therapeutic Treatment urinary tract infection virulence [DOI] 10.1038/s41585-021-00477-x PMC 바로가기 [Article Type] Review