modulated – Page 10 – Communicable Diseases Research

Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation

SARS-CoV-2 NSP1과 인간 리보솜의 mRNA 간의 동적 경쟁은 번역 개시를 억제합니다

408

Published on 2021-02-092022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, 유전자 메커니즘,

Tracking the time course of pathological patterns of lung injury in severe COVID-19

Research

Published on 2021-01-292022-10-28
Journal: Respiratory Research [Category] COVID-19,

[키워드] activated age alveolar analysed Analysis ARDS Autopsy biopsies bronchopneumonia Characteristics characterized clinical picture correlated Course COVID COVID-19 COVID-19 patient DAD death died Diffuse alveolar damage disease Disease progression dysregulated eight Elderly patient Evolution Factors H&E Hospital admission Infarction invasive less lung cell Lung injury Lung pathology lung tissue Minimally Invasive Autopsy modulated occur parameters pathologist pathway Patient patients prevalent proportion pulmonary pulmonary involvement pulmonary microthrombosis pulmonary thrombosis Region respiratory Result SARS-CoV-2 severe COVID-19 severe COVID-19 patient submitted the disease the patient thrombosis variable Vascular vascular lesion
[DOI] 10.1186/s12931-021-01628-9 PMC 바로가기 [Article Type] Research

Effect of ambient temperature on respiratory tract cells exposed to SARS-CoV-2 viral mimicking nanospheres-An experimental study

SARS-CoV-2 바이러스 모방 나노스피어에 노출된 호흡기 세포에 대한 주변 온도의 영향-실험 연구

Article

Published on 2021-01-282022-09-12
Journal: Biointerphases [Category] 진단,

[키워드] ACE-2 ACE-2 receptor acute respiratory syndrome airway epithelial cell ambient angiotensin-converting enzyme 2 binding bovine Calu-3 caused change coated with Community coronavirus country denaturing Effect fibroblast cell fluctuation had no Host host cell incubated indicated infect Infection Infectious disease Interaction lung epithelia mimicking modulated nonspecific Novel coronavirus occurred pandemic Polymer Protein RBD reached reported respiratory tract respiratory tract cell S protein S-RBD SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 viral seasonal serum Spread stability surface receptor temperature the S protein the SARS-CoV-2 Transmission Viral transmission virus
[DOI] 10.1116/6.0000743 PMC 바로가기 [Article Type] Article

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

SARS-CoV-2 뉴클레오캡시드 인단백질은 RNA 및 막 관련 M 단백질과 상호 배타적인 축합물을 형성합니다.

Article

Published on 2021-01-212022-09-10
Journal: Nature Communications [Category] 치료법,

Biological and Clinical Consequences of Integrin Binding via a Rogue RGD Motif in the SARS CoV-2 Spike Protein

Review

Published on 2021-01-202022-10-28
Journal: Viruses [Category] COVID-19, MERS,

[키워드] ACE2 activate Activation aggregation Alternative pathway alveolar cell Amino acid amplify Angiogenesis B.1.1.7 binding Biological Blood Cell cell entry clinical Coagulation consequence Consequences contribute COVID-19 developmental domain dysregulation endothelial Endothelial cell ENhance enzyme Factor Factors high variability Host Hypothesis Impact impacts in viral include independent integrin integrin-mediated integrin-mediated signaling Integrins Interaction microthrombi modulated motif Mutation N501Y Numerous pathway Pathways Platelet Platelets Pneumocytes procoagulant receptor Receptor-binding domain resulting RGD motif SARS CoV-2 sequence Signaling signaling pathway spike Spike protein strain stroke suggested susceptibility the receptor-binding domain the SARS-CoV-2 virus the spike protein thrombosis thrombotic tissue tissue damage tissue microenvironment variant viral entry virion virion binding virus widespread
[DOI] 10.3390/v13020146 PMC 바로가기 [Article Type] Review

Transmission heterogeneities, kinetics, and controllability of SARS-CoV-2

Research Article

Published on 2021-01-152022-10-28
Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome age Alter approaches can be used Case isolation center China clinical factors Clinical severity close contact Combination Community condition Contact Contact tracing Control coronavirus Course disease distribution driven by duration of exposure Effect Effectiveness effort Epidemic epidemiological evaluate event fraction generate help heterogeneity highest household contact identify increase indicate individual infected individual infected individuals Infection infection control infections Infectious disease information interactions interval Intervention Isolation lockdown measure Measures modeling modulated no significant difference nonpharmaceutical intervention observé occur occurred outbreak Outbreaks parameter pathogen Patient presymptomatic presymptomatic transmission prevention Primary infection profiles quarantine question reconstructed reduce Region representing risk risk factor SARS-CoV-2 SARS-CoV-2 transmission Science secondary case Secondary infection secondary infections secondary transmission social interaction statistical Sun susceptibility Symptom symptom onset synergistic time Transmission Transmission dynamics transmission kinetics turn virus virus transmission was collected
[DOI] 10.1126/science.abe2424 PMC 바로가기 [Article Type] Research Article

Transcriptomic Analysis of Respiratory Tissue and Cell Line Models to Examine Glycosylation Machinery during SARS-CoV-2 Infection

SARS-CoV-2 감염 중 당화 기계를 검사하기 위한 호흡기 조직 및 세포주 모델의 전사체 분석

Article

Published on 2021-01-082022-09-10
Journal: Viruses [Category] MERS, 바이오마커,

[키워드] addition affecting Analysis approach biological significance Biomarker correlation COVID-19 immunity cytokine Cytokine storm database differentially expressed downstream epitope Epitopes expression functional functional enrichment Functional genomics glycan glycans glycosylation glycosylation pathway glycosylation pathways Host immune response host inflammatory response hypothetical immune function immune response immunomodulatory implicated in silico Infection infectious agents inflammatory signaling LINE Localization macromolecule macromolecules marker Model modulated modulating negative and positive pathogen Pathways performed post-translational modification Protein Proteoglycan proteoglycans receptor Repository respiratory SARS-CoV-2 SARS-COV-2 infection Stratification susceptibility therapeutic Transcription transcriptomic analysis Treatment Viral
[DOI] 10.3390/v13010082 PMC 바로가기 [Article Type] Article

An epidemic model integrating direct and fomite transmission as well as household structure applied to COVID-19

Research

Published on 2021-01-052022-10-30
Journal: Journal of Mathematics in Industry [Category] COVID-19,

Pulmonary pathology of ARDS in COVID-19: A pathological review for clinicians

COVID-19에서 ARDS의 폐 병리: 임상의를 위한 병리학적 검토

Review

Published on 2021-01-012022-09-12
Journal: Respiratory medicine [Category] MERS, SARS, 진단,

[키워드] acute lung injury acute respiratory distress alveolar-capillary barrier ARDS binding cell receptor characterized Clinical findings clinician Compliance correlation COVID-19 Critical cytoplasm DAD Diagnosis Diffuse alveolar damage domain endothelial cells epithelial cell Evolution expression flu-like symptoms Gas exchange host cells hyaline membrane formation Hypoxemia Inflammatory Intersection knowledge mechanism modulated molecular molecular mechanism Molecular pathology pandemic pathology pathophysiological pathway Patient phenotypic Protein Proteins pulmonary Pulmonary pathology radiological reached reduced Replication reported responsible RNA viruses SARS-CoV-2 SARS-COV-2 infection Symptom syndrome the disease thrombosis transcribed Transcription Treatment vascular permeability viral genome viral infection virus with COVID-19
[DOI] 10.1016/j.rmed.2020.106239 PMC 바로가기 [Article Type] Review

Is Gut Microbiota Dysbiosis a Predictor of Increased Susceptibility to Poor Outcome of COVID-19 Patients? An Update

Review

Published on 2020-12-282022-10-29
Journal: Microorganisms [Category] COVID-19,

[키워드] “cytokine storm” ACE2 acute respiratory syndrome addition affected angiotensin-converting enzyme 2 association clinical manifestation consequence coronavirus COVID-19 COVID-19 patient disease Dysbiosis Evidence Gut gut microbiota gut microbiota dysbiosis hospital human cell immune immune response immune system Increased infect Inflammation inflammatory condition intensive care intestinal knowledge microbiota modulated Older outcome Patient patients phenotype Poor presenting Prevalence pulmonary diseases renal SARS-CoV-2 severe cases Stage suggested susceptibility susceptibility to progress the disease the patient virus receptor
[DOI] 10.3390/microorganisms9010053 PMC 바로가기 [Article Type] Review