monocyte – Page 10 – Communicable Diseases Research

Immune transcriptome analysis of COVID-19 patients infected with SARS-CoV-2 variants carrying the E484K escape mutation identifies a distinct gene module

E484K 탈출 돌연변이를 갖는 SARS-COV-2 변이체로 감염된 COVID-19 환자의 면역 전 사체 분석은 별개의 유전자 모듈을 식별합니다.

Article

Published on 2022-02-182022-09-01
Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료법,

Trained Immunity: An Overview and the Impact on COVID-19

Immunology

Published on 2022-02-172022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, COVID19(2023년), MERS, SARS,

[키워드] activate alleviate approach B-glucan Bacillus BCG cell type cells clinical study clinical trials component Corona COVID-19 COVID-19 crisis COVID-19 pandemic develop disease pathogenesis effective greater Health immune immune protection immune response immune system Immunity Impact in vitro in vivo Infection Infectious disease innate immune cell innate immune system Innate immunity involved LPS mechanism monocyte Monocytes natural killer natural killer (NK) non-specific Pathogens pathway potential therapeutic target Protective respiratory SARS-CoV-2 SARS-COV-2 infection signaling pathway therapeutic target trained immunity understanding
[DOI] 10.3389/fimmu.2022.837524 PMC 바로가기 [Article Type] Immunology

Activation of Complement Components on Circulating Blood Monocytes From COVID-19 Patients

COVID-19 환자의 순환 혈액 단핵구에 대한 보체 성분 활성화

Immunology

Published on 2022-02-172022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커,

[키워드] Activation acute infection amyloid A Asymptomatic Biomarker blood monocyte C1q caused CD55 Cell cell surface cells cellular characterized circulating classical Coagulopathy complement Complement activation Complement inhibitor component coronavirus coronavirus disease COVID-19 COVID-19 disease COVID-19 pathogenesis COVID-19 patient COVID-19 patients CRP death downstream elevated HCs healthy control healthy controls highlight hyperinflammation implicated IMPROVE increase Increased Increases Inflammation Inflammatory marker inhibitor Interaction membrane membrane-bound monocyte Monocytes multi-organ failure myeloid cell myeloid cells plasma remained SARS-CoV-2 virus serum amyloid Severe infection surface expression the cell the SARS-CoV-2 virus upregulated upregulation with COVID-19
[DOI] 10.3389/fimmu.2022.815833 PMC 바로가기 [Article Type] Immunology

Cell specific peripheral immune responses predict survival in critical COVID-19 patients

세포 특이적 말초 면역 반응은 중요한 COVID-19 환자의 생존을 예측합니다

Article

Published on 2022-02-152022-09-10
Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘,

[키워드] Accuracy Activation antibody Antigen presentation Applied immunology Blood CD14 CD16 Cell cell cycle cell type cell types cells circulating Clinical management complex COVID-19 COVID-19 patients Critical critical COVID-19 patient critical COVID-19 patients Critically ill critically ill COVID-19 patients dataset Differential gene expression framework identify identifying Immune cell immune cell type independent Infection interferon interferon signaling machine mechanism monocyte Monocytes mononuclear cells Mortality NK-cell Pathogens pathway Peripheral blood peripheral immune response predict predictor prognostic indicator promote Regulation risk stratification SARS-CoV-2 sequence Single Cell single cell sequencing Single-cell RNA sequencing survival systemic immune response transcriptional transcriptomes transcriptomics Trigger triggers viral infection
[DOI] 10.1038/s41467-022-28505-3 PMC 바로가기 [Article Type] Article

Platelets mediate inflammatory monocyte activation by SARS-CoV-2 spike protein

혈소판은 SARS-CoV-2 스파이크 단백질에 의한 염증성 단핵구 활성화를 매개합니다

Research Article

Published on 2022-02-152022-09-10
Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 바이오마커,

Unlike Chloroquine, Mefloquine Inhibits SARS-CoV-2 Infection in Physiologically Relevant Cells

Article

Published on 2022-02-112022-10-28
Journal: Viruses [Category] COVID-19, COVID19(2023년), SARS,

[키워드] accumulate Analysis anti-SARS-CoV-2 antimalarial antimalarial drug Antiviral approved drug assays Calu-3 Calu-3 cell Cell cell line Chloroquine clinical benefit clinical trials clinically concentrations COVID-19 differential expression example HCQ Human IL-6 in vitro in vitro activity information inhibit inhibited Interaction investigated lack Lungs mechanism of action mefloquine modulated monocyte Monocytes optimal dose parameter pathway pharmacological plasma predicted prevented reduced Respiratory Coronavirus respiratory diseases SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 replication SARS-CoV-2 RNA solidarity therapeutic therapy TMPRSS2-expressing cells TNF-α type II pneumocytes virus entry were assessed
[DOI] 10.3390/v14020374 PMC 바로가기 [Article Type] Article

Potential of Bacillus subtilis Against SARS-CoV-2 – A Sustainable Drug Development Perspective

Microbiology

Published on 2022-02-112022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

순찰 단핵구 및 CD16+ NK 세포의 TIM3+ TRBV11-2 T 세포 및 IFNγ 시그니처는 MIS-C를 설명합니다

Article

Published on 2022-02-072022-09-12
Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), MERS, SARS, 진단,

The associations between air pollutant exposure and neutralizing antibody titers of an inactivated SARS-CoV-2 vaccine

비활성화된 SARS-CoV-2 백신의 대기 오염 물질 노출과 중화 항체 역가 사이의 연관성

Article

Published on 2022-02-012022-09-12
Journal: Environmental science and pollution research inter [Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] addition Administered Affect Air pollutants Air pollution Antibody titer applied association calculate China chronic chronic inflammation collected Combined Combined toxic effects complex conducted CoronaVac COVID-19 epidemic Critical dose Efficacy elevated eligible environmental factor exposure group expression geometric healthcare worker Healthcare workers identify Immunity inactivated Inactivated SARS-CoV-2 vaccine inhibit knowledge median monocyte NAb titers neutralizing antibody Neutralizing antibody titer Neutralizing antibody titer. observation participant plasma plasma NAb titer prevalence of COVID-19 recruited risk factor SARS-CoV-2 SARS-CoV-2 vaccine the mean the SARS-CoV-2 toxic effect two group vaccination Vaccine Vero Cell White blood cell
[DOI] 10.1007/s11356-021-16786-y PMC 바로가기 [Article Type] Article

Prognostic Significance of Urinary Biomarkers in Patients Hospitalized With COVID-19

COVID-19로 입원한 환자의 요도 바이오마커의 예후적 의미

Article

Published on 2022-02-012022-09-11
Journal: American journal of kidney diseases : the official [Category] COVID19(2023년), SARS, 바이오마커,

[키워드] Acute kidney injury Acute kidney injury (AKI) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 AKI association Biomarker Chronic kidney disease chronic kidney disease (CKD) cohort study Combination comparable Composite coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient COVID-19 prognosis Cox proportional hazard creatinine death defined dialysis discrimination EGF elevated epidermal epidermal growth factor epidermal growth factor (EGF) events Evidence evidence of growth factor highest Hospital admission Hospitalized Improving individual Inflammation Inflammatory Inflammatory marker information Injury investigated KDIGO kidney Kidney disease Kidney injury kidney injury molecule 1 (KIM-1) lower risk MCP-1 Microscopy moderate MONITOR monocyte monocyte chemoattractant protein 1 monocyte chemoattractant protein 1 (MCP-1) neutrophil neutrophil gelatinase-associated lipocalin (NGAL) outcome outcomes Patient patients patients hospitalized patients with COVID-19 Primary outcome prognostic progression Prospective prospective cohort study Protein provided rationale repair respiratory risk Sample size serum creatinine setting severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Significance small sample size subclinical AKI tubular injury Urinalysis urinary urinary biomarkers Urine urine microscopy. with COVID-19
[DOI] 10.1053/j.ajkd.2021.09.008 PMC 바로가기 [Article Type] Article