mononuclear cell – Page 10 – Communicable Diseases Research

Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip

Pharmacology

Published on 2021-10-252022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

Sex-Related Differences in Innate and Adaptive Immune Responses to SARS-CoV-2

Immunology

Published on 2021-10-202022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] Activation addition CD86 chemokine complications Coronavirus disease 2019 COVID-19 CTLs CXCL-10 DCs dendritic cell dendritic cells difference exhibit expression female females healthy HLA-DR Hospitalization IFN-α immune responses in vitro individual Infection initial Innate innate immune response interferon-α lung male males mDC mDCs mechanism monocyte Monocytes mononuclear cell morbidity and mortality not significant PBMC PBMCs pDC pDCs Peripheral blood response responsible reversed SARS-CoV-2 secreted secretion severe disease Sex sex differences significantly higher stimulated Symptoms the patient these cell Treatment upregulated virus
[DOI] 10.3389/fimmu.2021.739757 PMC 바로가기 [Article Type] Immunology

BPIFB4 Circulating Levels and Its Prognostic Relevance in COVID-19

BPIFB4 순환 수준 및 COVID-19에서의 예후 관련성

THE JOURNAL OF GERONTOLOGY: Biological Sciences

Published on 2021-10-162022-09-10
Journal: The Journals of Gerontology Series A: Biological S [Category] SARS, 바이오마커, 변종,

[키워드] aging animal models BPIFB4 CD69 cell lines characterized circulating Comorbidities Comorbidity contrary correlated COVID-19 COVID-19 patient COVID-19 patients cytotoxicity deleterious inflammation demonstrated develop disease severity downregulation early stage early stages enrichment event Evidence Genotype Haplotype healthy healthy control homeostatic homozygous IL-18 IL-1B Immunity function immunomodulatory in vitro individual infected cells Inflammation Inflammatory response inflammatory stimuli involved less Level Longevity lysate lysates MCP-1 minor allele minor alleles Missense mononuclear cell mononuclear cells Mortality open Peripheral blood plasma plasma concentration polymorphism Prognostic value progression of disease Protective Protein rapid increase Recombinant protein reduction Relevance risk of COVID-19 SARS-CoV-2 SARS-CoV-2-infected cell SARS-CoV-2-infected cells selected senescence shown significantly significantly higher single-nucleotide single-nucleotide polymorphism susceptible T cell T cells target cell TCD4 TCD8 therapeutic therapeutic use variant virus infection
[DOI] 10.1093/gerona/glab208 PMC 바로가기 [Article Type] THE JOURNAL OF GERONTOLOGY: Biological Sciences

SARS-CoV-2 specific memory T cell epitopes identified in COVID-19-recovered subjects

SARS-CoV-2 특정 기억 T 세포 에피토프가 COVID-19 회복 대상에서 확인됨

Article

Published on 2021-10-152022-09-11
Journal: Virus research [Category] SARS, 치료법,

[키워드] Activation Analysis B cell caused CD4 CD8 T cell Cell Coronaviral COVID-19 COVID-19 pandemic COVID-19 vaccine design defined ELISPOT enzyme enzyme-linked immunosorbent epitope epitope mapping Epitopes evaluated examined explicit flow cytometry followed by foundation glycoprotein HLA Hope host immunity IgG immune immune responses immunodominant epitopes immunogenic immunogenicity in some individual induce mapped memory T memory T cells mononuclear cell N protein neutralizing antibody Neutralizing antibody response neutralizing antibody responses nucleocapsid nucleoprotein Outbreaks PBMCs peptide peptides Peripheral blood Peripheral blood mononuclear cells positively correlated proportion protective immunity Protein public health RBD receptor Receptor-binding domain Reinfection response robust S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S spike spike glycoprotein stimulate structural proteins subject subjects T cell T cell activation T cell epitope T cell epitopes T cell response T cell responses T cells the receptor-binding domain the S protein Therapeutics vaccination Vaccine Vaccine design virus-specific T cell virus-specific T cell responses were used
[DOI] 10.1016/j.virusres.2021.198508 PMC 바로가기 [Article Type] Article

Fulminant H1N1 and severe acute respiratory syndrome coronavirus-2 infections with a 4-year interval without an identifiable underlying cause: a case report

전격성 H1N1 및 중증급성호흡기증후군 코로나바이러스-2 감염, 4년 간격으로 뚜렷한 근본 원인 없이: 증례 보고

Case Reports

Published on 2021-10-082022-09-10
Journal: Journal of Medical Case Reports [Category] MERS, SARS, 변종, 신종인플루엔자,

[키워드] acute kidney acute respiratory syndrome Admission age Analysis Antiviral asymptomatic infection autoantibody Case report challenge clinical picture clinical recovery Comorbidity contributing to Coronavirus-2 Course COVID-19 demonstrated disease disease-causing enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Exome expression Factor fulminant genetic change Genetic changes genetic defect genetic defects Genetic variant genetic variants H1N1 H1N1 influenza healthy ICU immune immunological impairment indicate Infection infections Influenza intensive care intensive care unit admission interferon Interferon (INF) interferon pathway interferon response interferon-stimulated gene mechanical ventilation mononuclear cell mononuclear cells Pathways Patient Peripheral blood Perturbation reduced respiratory risk factor Risk factors SARS-CoV-2 Sequencing Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity suffered susceptibility the interferon the patient triggered type I Variation Viral viral infection viral infections virus infection
[DOI] 10.1186/s13256-021-03113-9 PMC 바로가기 [Article Type] Case Reports

Single-cell analysis of COVID-19, sepsis, and HIV infection reveals hyperinflammatory and immunosuppressive signatures in monocytes

COVID-19, 패혈증 및 HIV 감염에 대한 단일 세포 분석은 단핵구에서 과염증 및 면역 억제 신호를 나타냅니다

Article

Published on 2021-10-052022-09-11
Journal: Cell Reports [Category] SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caused Cell cellular and molecular coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cytokine storm Cytokine storms Guidance help heterogeneity HIV infection Hyperinflammatory identify Immunosuppression immunosuppressive IMPROVE Infection infections Infectious disease Infectious diseases Inflammation Inflammatory Inflammatory response Inflammatory responses Integrative analysis monocyte Monocytes mononuclear cell mortality risk other infectious diseases Patient patients with COVID-19 Peripheral blood Peripheral blood mononuclear cells provide reveal SARS-CoV-2 SARS-COV-2 infection Sepsis severe acute respiratory syndrome Coronavirus single-cell analysis single-cell transcriptome single-cell transcriptomes subset subtype the cytokine storm therapeutic Therapeutic strategies transcriptional difference Treatment understanding with HIV
[DOI] 10.1016/j.celrep.2021.109793 PMC 바로가기 [Article Type] Article

Adipose-Tissue-Derived Mesenchymal Stem Cells Mediate PD-L1 Overexpression in the White Adipose Tissue of Obese Individuals, Resulting in T Cell Dysfunction

Article

Published on 2021-10-032022-10-31
Journal: Cells [Category] Coronavirus, MERS, SARS,

A snapshot of the immunogenicity, efficacy and safety of a full course of BNT162b2 anti-SARS-CoV-2 vaccine in cancer patients treated with PD-1/PD-L1 inhibitors: a longitudinal cohort study

PD-1/PD-L1 억제제로 치료받은 암 환자를 대상으로 한 BNT162b2 항-SARS-CoV-2 백신 전체 과정의 면역원성, 효능 및 안전성에 대한 스냅샷: 종단적 코호트 연구

Article

Published on 2021-10-012022-09-11
Journal: ESMO open [Category] MERS, SARS, 바이오마커, 진단,

[키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive administration anti-SARS-CoV-2 blood sample Blood samples BNT162b2 BNT162b2 anti-SARS-CoV-2 vaccine BNT162b2 vaccine Cancer cancer patient Cancer patients CD4 CD4+ CD4+ T follicular response CD8+ T-cell CD8+ T-cell response cell-mediated immune cellular response Complete coronavirus coronavirus disease coronavirus disease-2019 Course COVID-19 case COVID-19 cases demonstrated Efficacy and safety elicit elicited enrolled enzyme enzyme-linked immunospot assay Focusing follicular humoral IFN-γ Immune checkpoint inhibitors immune response inhibitor interferon interferon-γ interquartile range IQR knowledge longitudinal cohort study mandatory median Messenger RNA mononuclear cell naïve naïve subjects Neutralizing antibodies no difference no differences of BNT162b2 participant Patient patients PBMC PD-1/PD-L1 inhibitors Peripheral blood primary endpoint programmed cell death programmed cell death protein proportion Protein reached reported respiratory response SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody second dose severe acute respiratory syndrome Coronavirus significant increase significantly higher significantly increased Specific T-cell response spike-specific T-cell response subject subjects sustained T cells T-cell Response the primary endpoint treated undetectable vaccination vaccination schedule Vaccine
[DOI] 10.1016/j.esmoop.2021.100272 PMC 바로가기 [Article Type] Article

Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19

말초 혈액 세포의 단일 세포 전사체는 COVID-19의 심각성을 나타내고 설명합니다.

Article

Published on 2021-10-012022-09-11
Journal: Science China. Life sciences [Category] SARS, 유전자 메커니즘,

[키워드] accumulated activities addition Blood CD8 Cell cell interaction cell interactions cellular cellular and molecular Characteristics conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical critical cases critical COVID-19 patients cytokine Cytokines cytotoxicity declined discrepancy disease severity effector T cell exhibited healthy donors heterogeneous immune Immune cell immune function immune functions immune response immune responses immune system infected patient Inflammatory cytokine Inflammatory cytokines moderate monocyte Monocytes mononuclear cell natural killer pathogenic mechanisms patients PBMCs Peripheral blood peripheral blood cell Peripheral blood mononuclear cells proliferative quantity reduced regulatory network severity severity of COVID-19 significantly single-cell RNA-seq single-cell transcriptome single-cell transcriptomes stages T cells T/NK cell transcription factor transcriptional Transcriptome Treatment Variation variations weakened with COVID-19
[DOI] 10.1007/s11427-020-1880-y PMC 바로가기 [Article Type] Article

Network-based transcriptomic analysis identifies the genetic effect of COVID-19 to chronic kidney disease patients: A bioinformatics approach

Research article

Published on 2021-10-012022-10-05
Journal: Saudi Journal of Biological Sciences [Category] 신약개발,

[키워드] Actin Analysis analyzed approach ARHGEF12 Aspirin BCL2L1 bioinformatics CAV1 chronic Chronic kidney disease CKD Comorbidity COVID-19 COVID-19 patient DEGs detect differentially expressed gene drug E2F1 EPHB2 gene signature Genetic Health high risk HSP90B1 hub protein identify infected with SARS-CoV-2 Infection Interaction investigated ITGA2B Kidney disease microRNA molecular pathways mononuclear cell Ontology pathway Patient patients PBMC Peripheral blood PPI PRKAR2B protein-protein interaction Rapamycin regulate SARS-CoV-2 Systems biology the SARS-CoV-2 therapeutic target Threats transcription factor Transcriptional signature transcriptomic transcriptomic analysis transcriptomic data TUBB1
[DOI] 10.1016/j.sjbs.2021.06.015 [Article Type] Research article