Immunogenicity and protectivity of intranasally delivered vector-based heterologous prime-boost COVID-19 vaccine Sputnik V in mice and non-human primatesArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] accompanied Blood clinical investigation Coverage COVID-19 COVID-19 pandemic COVID-19 vaccine cytokine release Diseases effective effort elicit Gam-COVID-Vac Health heterologous prime-boost IgA antibody IgG immune response Immunity immunization immunogenic immunogenicity Infection intranasal intranasal vaccine. intranasally K18-hACE2 transgenic mice less lung immunopathology mice mononuclear cell Mortality mucosal nasal mucosa neutralizing antibody non-human primate pandemic Peripheral blood Prevent proliferation protective immunity provided revaccination robust SARS-CoV-2 SARS-COV-2 infection SARSCoV-2 serum Sputnik V systemic and local the vaccine Transmission vaccination Vaccination strategy Vaccine vaccine candidate variants of concern virus virus infection virus spread [DOI] 10.1080/22221751.2022.2119169 PMC 바로가기
Humoral and Cellular Immune Response to Covid-19 Vaccination in Patients with Chronic Graft-versus-Host Disease on ImmunosuppressionArticle Published on 2022-11-012022-11-15 Journal: Transplantation and cellular therapy [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome amplified anti-spike antibody antibody association cellular Characteristics chronic coronavirus COVID-19 COVID-19 vaccination demonstrated detect disease dose Efficacy enrolled Escalation evaluated group HCT humoral Humoral response immune immune response Immunosuppression immunosuppressive immunosuppressive therapy Infection initial management mononuclear cell natural infection neutralizing antibody Neutralizing antibody response neutralizing antibody titers Patient patient population patients Peripheral blood positive positive correlation present progression proportion Quantitative receiving Responder responders response Sample size SARS-CoV-2 sequence Significant statistical difference susceptibility T cell T cell receptor T cell response T cell responses the antibody response the patient therapy unique vaccination Vaccine was measured were measured worsened worsening [DOI] 10.1016/j.jtct.2022.08.026 PMC 바로가기
Deep immunophenotyping reveals biomarkers of multisystemic inflammatory syndrome in children in a Latin American cohortArticle Published on 2022-11-012022-11-15 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome Biomarker Biomarkers CCL5 Cell cellular response characterized chemokine children Chilean clinical clinical feature Cohort Complication convalescent coronavirus COVID-19 CXCL10 CXCL8 Cytokine storm deep degranulation disease dysregulation elevated enzyme-linked immunosorbent enzyme-linked immunospot flow cytometry gastrointestinal involvement humoral identify IL-10 IL-18 IL-6 immune dysregulation immune response Immunity Inflammation Inflammatory intestinal inflammation laboratory biomarker Latin life-threatening Ligand MIS-C mononuclear cell MOST motif multisystemic multisystemic inflammatory syndrome in children. natural killer neutralizing antibody neutralizing antibody assays NK cell NK cell deficiency occur organ Patient patients predict representing reveal robust severe multisystemic severity Shock significantly stools susceptibility sustained syndrome T-cell activation underlie was increased was performed [DOI] 10.1016/j.jaci.2022.09.006 PMC 바로가기
The Peripheral Immune Landscape in a Patient with Myocarditis after the Administration of BNT162b2 mRNA VaccineArticle Published on 2022-10-312022-11-15 Journal: Molecules and cells [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Analysis approved BNT162b2 BNT162b2 mRNA vaccination causes cell clusters change changes in complications coronavirus Differentially expressed genes global public health help IL7R immune increased expression increased risk landscape Messenger RNA monocyte mononuclear cell mRNA myocarditis of BNT162b2 pandemic Pathogenesis Patient PBMC PBMCs peripheral Peripheral blood peripheral blood mononucleear cells reported Research SARS-CoV-2 Sequencing severe acute respiratory syndrome coronavirus 2 single-cell Single-cell RNA sequencing T cell receptor Transcriptome transcriptomic profile vaccinated individual vaccination Vaccine [DOI] 10.14348/molcells.2022.0031 PMC 바로가기
Cellular interferon-gamma and interleukin-2 responses to SARS-CoV-2 structural proteins are broader and higher in those vaccinated after SARS-CoV-2 infection compared to vaccinees without prior SARS-CoV-2 infectionArticle Published on 2022-10-172022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, [키워드] assays BNT162b2 BNT162b2 vaccine class correlated demonstrated develop dose doses epitope exhibited Frequency greater healthcare worker healthy IFN-γ IgG response IL-2 IL2 Immunity individual infected with SARS-CoV-2 Infection Interferon-gamma interleukin-2 magnitude Moderna mRNA-1273 vaccine mononuclear cell mRNA-1273 N and M nine participant Participants PCR testing peptide Peripheral blood Pfizer-BioNTech positive Post-infection Proteins proteome repeated responders response responses against robust S glycoprotein S1 and S2 S2 subunit SARS-CoV-2 SARS-COV-2 infection structural protein subunit subunits T cell response T-cell Response the SARS-CoV-2 uninfected vaccination vaccinee was determined were expressed with COVID-19 [DOI] 10.1371/journal.pone.0276241 PMC 바로가기
Reconstructed Genome-Scale Metabolic Model Characterizes Adaptive Metabolic Flux Changes in Peripheral Blood Mononuclear Cells in Severe COVID-19 PatientsArticle Published on 2022-10-172022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome adaptive aerobic Analysis anti-inflammatory effect antiviral drugs biogenesis caused change changes in Coronavirus disease 2019 Coronavirus-2 COVID-19 differentially expressed enzyme FASN fatty flux Glycolysis Health Immune cell Inflammation Inflammatory lipids mechanism metabolic metabolic model metabolism metabolism-directed therapy. metabolites Model mononuclear cell nucleotide oxidative phosphorylation pathogenic PBMC PBMCs peripheral Peripheral blood potential therapeutic targets provide reaction reconstructed Regulation responsible retinol SARS-CoV-2 severe COVID-19 patients SLC2A3 therapy Transcriptome Treatment Vitamin [DOI] 10.3390/ijms232012400 PMC 바로가기
TIMELESS is a key gene mediating thrombogenesis in COVID-19 and antiphospholipid syndromeArticle Published on 2022-10-142022-11-15 Journal: Scientific Reports [Category] 유전자 메커니즘, 진단, [키워드] Analysis antibody autoantibody autophagy gene Bioinformatics analysis Cell circadian clock Coagulation contribute COVID-19 COVID-19 patient COVID-19 patients Critically ill cytoHubba Cytoscape software dataset Differentially expressed genes evaluated expression Genes Genetic GSK3B identify Immune-mediated Immunotherapy increased risk Interference investigated Kyoto mechanism Mild Modification mononuclear cell ontology term pathway Patient patients protein-protein interaction Proteins regulate severe COVID-19 severe COVID-19 patient severe COVID-19 patients severity suggested Symptom syndrome therapeutic potential thrombosis Transcriptome were used with COVID-19 [DOI] 10.1038/s41598-022-21694-3 PMC 바로가기
Differences in the immune response elicited by two immunization schedules with an inactivated SARS-CoV-2 vaccine in a randomized phase 3 clinical trialArticle Published on 2022-10-132022-11-15 Journal: eLife [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation acute respiratory syndrome antibody approved blood sample Brazil CD4 cellular Chilean China circulating antibodies clinical clinical trial Concentration CoronaVac coronavirus coronavirus disease correlation COVID-19 difference dose Efficacy elicited Emergency use enrolled evaluate evaluated exhibited expression flow cytometry healthy Human humoral immune response humoral immune responses IFN-γ immune response immunization immunogenicity data immunology inactivated Indonesia Inflammation interferon marker Medicine Ministry of Health mononuclear cell multicenter neutralizing antibody neutralizing capacity pandemic PBMCs performed Peripheral blood Phase 3 phase 3 clinical trial phase 3 trial Production progression promote Randomized reported robust Sample SARS-CoV-2 SARS-CoV-2 vaccine secretion separated single center Stimulation T cell Trial Turkey Vaccine Vaccines variants of concern virus VOCs Volunteer were assessed [DOI] 10.7554/eLife.81477 PMC 바로가기
Aseptic meningitis in multisystem inflammatory syndrome in children associated with coronavirus disease 2019: a case reportArticle Published on 2022-10-042022-11-15 Journal: Journal of Medical Case Reports [Category] COVID19(2023년), SARS, 진단, [키워드] abdominal pain Aseptic aseptic meningitis C-reactive protein capillary blood Case report case sery children clinical manifestations coronavirus disease Corticosteroid COVID COVID 19 Deterioration Diagnosis early treatment effective Electrolyte elevated erythrocyte sedimentation rate fatigue Fever functions headache immune response Immunoglobulin Infection Inflammatory inflammatory markers intensive care Intravenous immunoglobulin laboratory result Leukocytosis life-threatening lymphopenia male manifestation Manifestations Meningitis Methylprednisolone MIS-C mononuclear cell Multiorgan dysfunction neurological manifestation Neurological symptoms obesity organ dysfunction pediatric polymorphonuclear procalcitonin renal syndrome vomiting White blood cell [DOI] 10.1186/s13256-022-03617-y PMC 바로가기
Upregulation of hsa_circ_0004812 promotes COVID-19 cytokine storm via hsa-miR-1287-5p/IL6R, RIG-I axisArticle Published on 2022-10-012022-11-16 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Asymptomatic bioinformatics Bioinformatics analysis cDNA synthesis competing contagious correlation Correlation analysis CoV COVID-19 COVID-19 cytokine storm cytokine Cytokine storm expressed expression expression level expressions healthy controls hsa_circ_0004812 hsa-miR-1287-5p IL-6R IL6R in silico In-vitro Interaction material molecular mechanisms mononuclear cell negative control outcome pandemic Patient patients patients with asymptomatic PBMC Peripheral blood positive correlation positively correlated predicted promote qRT-PCR relative expression RIG-I RNA SARS-CoV-2 sponging effect. Symptom symptomatic the Coronaviridae the SARS-CoV-2 total RNA virus was performed [DOI] 10.1002/jcla.24666 PMC 바로가기