Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants스파이크 단백질의 NTD 및 RBD에서 에피토프의 글리칸 마스킹은 SARS-CoV-2 변이체에 대한 광범위하게 항체를 중화시킵니다Immunology Published on 2021-12-022022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] Against Alpha Antibody titers Antigen antigenic antigenic site B-cell response B.1.1.7 B.1.351 B.1.617.2 Beta COVID-19 COVID-19 vaccine Delta demonstrated develop domain elicited Epitopes examined glycan glycan masking glycosylation help increase increase in masking motif mutant N-terminal domain neutralization titer Neutralizing antibody titer neutralizing antibody titers NTD RBD Receptor-binding domain S protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants the RBD the S protein the Spike the vaccine Vaccine vaccine antigen variant variants without affecting Wuhan-Hu-1 [DOI] 10.3389/fimmu.2021.795741 PMC 바로가기 [Article Type] Immunology
Structural, energetic and lipophilic analysis of SARS-CoV-2 non-structural protein 9 (NSP9)Article Published on 2021-11-262022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] addition Amino acid Analysis appear approach binding binding affinity binding energy Clustering complement complex Computational chemistry computational method contribute coronavirus Critical dimeric drugs form hydrogen bond interaction hydrophobic hydrophobicity interactions molecular molecular dynamics motif mutant Mutation non-structural protein nucleic acid prevention of COVID-19 Protein responsible RNA SARS-CoV-2 SARS-CoV-2 replication stability subunit Treatment van der Waal [DOI] 10.1038/s41598-021-02366-0 PMC 바로가기 [Article Type] Article
Dynamic, but Not Necessarily Disordered, Human-Virus Interactions Mediated through SLiMs in Viral ProteinsReview Published on 2021-11-262022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Amino acid amino acid residue benefit Critical database disorder Disordered dynamic enzyme example flexible function functional functions generate Genome highlighting Host host cell host protein host proteins in viral Interaction interfere intrinsic intrinsically disordered protein regions less linear mechanism Mediated MOST motif occur overlap pathogenicity predicted promote Protein protein region proteome provide related viruses selective short eukaryotic linear motifs SLiMs structural property the ELM database Variation viral family viral-host protein interaction virulence virus [DOI] 10.3390/v13122369 PMC 바로가기 [Article Type] Review
High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19Article Published on 2021-11-222022-10-04 Journal: Communications Biology [Category] MERS, SARS, 바이오마커, 변종, 진단, [키워드] Adaptive immunity analyzed antibody epitopes Antibody Response Antigen applied approach Bacterial binding coronavirus 2 Coronaviruses COVID-19 cross-reactive D614G Data mining data-driven Diagnostic markers disease severity dominant epitope effective vaccine elicit epitope epitope mapping Evolution of SARS-CoV-2 highlight humoral identify immune response in silico analysis infected patient large cohort Mild motif mutant Mutant SARS-CoV-2 neutralization activity organism other coronavirus Patient peptide platform proteome proteomes random reduced Region repertoire respiratory SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 epitope SARSCoV-2 serum samples severe disease specificity Spread Strains subject the vaccine Therapies therapy treat viral infection with COVID-19 [DOI] 10.1038/s42003-021-02835-2 PMC 바로가기 [Article Type] Article
Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilitiesArticle Published on 2021-11-192022-10-04 Journal: Nature Communications [Category] SARS, 신약개발, 치료제, [키워드] Affect Antiviral approach cellular coronavirus coronavirus strain Coronaviruses disrupt disrupting Factors Host host protein identify information inhibitor Interaction interactions Intrinsically disordered proteins mechanism molecular motif motifs nucleocapsid peptide peptide-based Protein Protein-protein interaction networks provide reagents reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 N stress granules Support the SARS-CoV-2 translated viral replication Virus-host interactions [DOI] 10.1038/s41467-021-26498-z PMC 바로가기 [Article Type] Article
Can the SARS-CoV-2 Spike Protein Bind Integrins Independent of the RGD Sequence?Cellular and Infection Microbiology Published on 2021-11-182022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] ACE2 analyzed angiotensin-converting enzyme 2 Betacoronavirus betacoronaviruses bind binding bioinformatics Can canonical changes in collected Computational study conformational change conserved coronavirus 2 coronavirus strains domain ENhance entry receptor explain expression Factor help Host host cell identify independent independent of integrin integrin-binding motif Integrins ligands mapped motif motifs Mutation occur Other phylogenetically predicted RaTG13 recent recorded Region RGD rotaviruses SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein sequence sequence similarity shown solvent spike Spike protein Spike proteins spike receptor-binding domain suggested the SARS-CoV-2 the spike protein viral pathogens virus [DOI] 10.3389/fcimb.2021.765300 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody인간 항체에 의한 SARS-CoV-2의 보존된 취약성 사이트 발견Article Published on 2021-11-172022-09-11 Journal: EMBO Molecular Medicine [Category] MERS, SARS, 변종, 진단, [키워드] Affect Alpha antibody antiviral drugs attachment B.1.1.7 B.1.351 B.1.617.2 Beta characterized concern conserved convalescent Convalescent patients COVID‐19 patient COVID‐19 cross‐reactivity cross‐active neutralizing antibody Delta Delta variants destruction of spike electron microscopy engage epitope epitope distal escape mutants functional Gamma generate hamsters host cell host cell receptor mechanism Microbiology, Virology & Host Pathogen Interaction Microscopy monoclonal antibody MOST motif mutable mutants Mutation neutralization neutralize neutralized Neutralizing antibodies neutralizing antibody P.1 predicted RBD RBM receptor‐binding domain receptor‐binding domain reduce residue residues SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 spike spike Strains structural biology the RBD the Spike variants variants of concern Viral viral replication [DOI] 10.15252/emmm.202114544 PMC 바로가기 [Article Type] Article
The interplay between pathogens and Atg8 family proteins: thousand‐faced interactionsReview Published on 2021-11-172022-10-31 Journal: FEBS Open Bio [Category] COVID-19, SARS, [키워드] activate adaptive immune responses Analysis autophagy Bacteria Bacterial Cell Degradation Effects example GABARAP hfAIM iLIR Interaction LC3 LIR motif methodology motif outcome pathogen pathogen protein pathogenic Protein protein interactions Proteins Replication Research SARS‐CoV‐2 proteins SARS‐CoV‐2 selected Viral protein virus [DOI] 10.1002/2211-5463.13318 PMC 바로가기 [Article Type] Review
PDZ-Containing Proteins Targeted by the ACE2 ReceptorCommunication Published on 2021-11-152022-10-28 Journal: Viruses [Category] COVID-19, [키워드] ACE2 benefit binding binding assay Brain C-terminal COVID-19 domain enzyme expressed Extracellular host cell host factors human epithelial cell in viral intensity Interaction involved main receptor membrane protein Modification motif N-terminal peptidase Neurological symptom neuronal neuronal cells organs PDZ domain Protein protein trafficking SARS-CoV-2 SARS-CoV-2 entry SNX27 specificity transmembrane trimeric spike type I virus entry [DOI] 10.3390/v13112281 PMC 바로가기 [Article Type] Communication
Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19Medicine Published on 2021-11-042022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] agonist airways binding clearance COVID-19 COVID-19 patient domain down-regulate Effect epithelial cell Health Hypothesis impaired lung function imperative include Infection Inflammation kill knowledge mitigate motif New coronavirus novel other respiratory virus Pathogenesis pathophysiology Pollution Potential receptor role S protein SARS-CoV-2 SNPs subtype susceptibility Symptom Symptoms the disease therapeutic interventions therapy Transient translate Treatment TRPV TRPV-1 [DOI] 10.3389/fmed.2021.753819 PMC 바로가기 [Article Type] Medicine