mounted – Page 10 – Communicable Diseases Research

B Cell Subsets as Severity-Associated Signatures in COVID-19 Patients

COVID-19 환자의 중증도 관련 시그니처로서의 B 세포 하위 집합

Clinical Trial

Published on 2020-12-032022-08-13
Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단,

SARS-CoV-2-specific T cell responses and correlations with COVID-19 patient predisposition

SARS-CoV-2-특이 T 세포 반응 및 COVID-19 환자 소인과의 상관관계

Clinical Trial

Published on 2020-12-012022-08-31
Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 바이오마커, 임상, 치료법,

[키워드] Active disease acute physiology and chronic health evaluation II acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age analyzed Antigen caused CD4+ CD4+ T cells cells cellular immunity cellular response Cellular responses Comorbidity comparable coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 defined died diminished disease elevated Ex vivo exhibited expression Factor Frequency global pandemic Health helper cell impairment individual intensive care magnitude membrane membrane protein Mild Mild disease moderate mounted nucleocapsid Patient patient age patients PD-1 predisposition proliferation Protein Proteins respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe infection Spike protein Spike proteins T cell T cell response T cell responses T cells T helper cell target Viral with COVID-19
[DOI] 10.1172/JCI140965 PMC 바로가기 [Article Type] Clinical Trial

Remote continuous glucose monitoring during the COVID-19 pandemic in quarantined hospitalized patients in Denmark: A structured summary of a study protocol for a randomized controlled trial

덴마크의 격리된 입원 환자에서 COVID-19 전염병 동안 원격 연속 혈당 모니터링: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Randomized Controlled Trial

Published on 2020-11-252022-09-01
Journal: Trials [Category] SARS, 임상, 진단, 치료기술,

[키워드] 1:1 able to communicate addition Admission age Analysis association band-aid blinded blood glucose blood glucose monitoring calibrated Care CGM Clinical outcome clinically Confirmed COVID-19 infection Contact contagious disease contagious diseases contagious infection contagious infections Controlled trial COVID-19 COVID-19 infected patient COVID-19 infection COVID-19 pandemic Date defined detect diabete diabetes diabetes - diabetes management Diagnosis Diagnostic Criteria dissemination distribution element Endpoint enrolled exclusion criteria exploratory female Finger prick form Glucose glucose control glycaemic control group groups Healthcare provider Hospitalization Hospitalized hospitalized patient hypersensitivity Hypothesis Identifier Improved In-hospital Inclusion inclusion criteria increased risk infected patients Infection infections Informed consent management masking MONITOR mounted must Non-COVID-19 not need number objective open open label outcome parallel group participant Patient patients with diabete performed Pneumonia PPE primary endpoint protocol quarantine randomisation randomised randomised controlled trial randomization randomization list Randomized Randomized controlled trial Real-time PCR recorded reduce remote reported required risk Sample size SARS-COV-2 infection secondary Secondary endpoints service stratified Study protocol subject supplementary material the patient the primary endpoint transmitted Trial trial protocol Trial registration Type 1 diabetes type 2 diabetes variable website World Health Organization written Informed Consent
[DOI] 10.1186/s13063-020-04872-4 PMC 바로가기 [Article Type] Randomized Controlled Trial

COVID ‐19: a pandemic experience that illuminates potential reforms to health research

Commentary

Published on 2020-10-192022-11-01
Journal: EMBO Molecular Medicine [Category] COVID-19, MERS, SARS,

[키워드] Biomedical research clinical trial COVID COVID‐19 globe Health help IMPROVE Microbiology, Virology & Host Pathogen Interaction mounted overcome pandemic provide Research researcher resource S&S: Ethics Science therapeutic option
[DOI] 10.15252/emmm.202013278 PMC 바로가기 [Article Type] Commentary

High levels of SARS-CoV-2–specific T cells with restricted functionality in severe courses of COVID-19

Clinical Medicine

Published on 2020-10-152022-10-30
Journal: JCI Insight [Category] COVID-19, MERS, SARS,

[키워드] Activation acute respiratory syndrome affecting alteration analyzed Anergy antibody CD4 CD8 Cellular immune response Characteristics characterized controls convalescent individuals Convalescent patients coronavirus coronavirus disease correlated Course COVID-19 COVID-19 patient cytokine disease severity ELISA expression functional IFN-γ IgA IgA antibody IgG IgG levels IL-2 Immunity immunoglobulins immunopathology lung lymphocyte lymphocyte subpopulation lymphopenia marker mounted Patient patient group peptide pool phenotypical plasmablast proliferation quantified Rolf SARS-CoV-2 SARS-CoV-2 specific T-cell severe disease Severity of disease significantly higher state subpopulations supported T cell T cells TNF-α uninfected uninfected control university viral replication
[DOI] 10.1172/jci.insight.142167 PMC 바로가기 [Article Type] Clinical Medicine

Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients

Research Article

Published on 2020-10-072022-10-29
Journal: Science Translational Medicine [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome adaptive immune responses Adults age Anti-spike Antibody titer Antibody-dependent cellular phagocytosis antiviral immune response caused CD25 CD4 Cellular immune response children circulating clinical manifestation clinical outcomes Concentration concentrations coronavirus coronavirus disease correlated COVID-19 cytokine described difference disease evidenced Factor Frequency generate hospital Hospitalization Hospitalized human coronaviruses humoral identify IFN-γ IL-17A IL-6 immune response increased expression Inflammatory interferon-γ interleukin-17A lower mortality mechanical ventilation mechanisms modulate Mortality mounted Necrosis Neutralizing antibody titer New York City no difference outcome Patient patients with COVID-19 pediatric Pediatric patient people with COVID-19 Pierce Protein response robust SARS-CoV-2 SARS-COV-2 infection serum Serum neutralizing antibody syndrome T cell T cell response T cells TNF-α viral spike protein with COVID-19 younger patients
[DOI] 10.1126/scitranslmed.abd5487 PMC 바로가기 [Article Type] Research Article

Immune Checkpoints in Viral Infections

Review

Published on 2020-09-212022-10-28
Journal: Viruses [Category] COVID-19,

Convalescent plasma treatment of severe COVID-19: a propensity score–matched control study

Research

Published on 2020-09-152022-10-05
Journal: Nature Medicine [Category] SARS, 임상, 치료기술, 치료법, 치료제,

A tertiary center experience of multiple myeloma patients with COVID-19: lessons learned and the path forward

Research

Published on 2020-07-142022-10-29
Journal: Journal of Hematology & Oncology [Category] COVID-19, SARS,

[키워드] 2000 COVID-19 patient age anti-SARS-CoV-2 antibody antibody Antibody Response association Cancer cancer patient cardiovascular risk Care caused Characteristics Chronic kidney disease Cohort Comorbidities Complete COVID-19 COVID-19 infection COVID-19 pandemic CRP D-dimer death demonstrated Diabetes Mellitus diagnosed with COVID-19 Diagnosis died disease status disorder drug elevated epidemiological ferritin had no Hospitalization Hospitalized hospitalized patients hyperlipidemia Hypogammaglobulinemia impacted IMPROVE Inflammatory marker inflammatory markers Inflammatory response initial initiated Intervention Laboratory laboratory characteristics Lung disease majority male Male sex median median age median time Mortality Mount Sinai mounted Mounting Multiple myeloma New York New York City obesity outbreak outcome outcomes pandemic Patient PCR PCR negativity performed persistence polymerase chain positive PCR Result Retrospective study SARS SARS-CoV-2 SARS-CoV-2 virus serological response significantly Smoldering multiple myeloma treated Treatment USA Viral detection
[DOI] 10.1186/s13045-020-00934-x PMC 바로가기 [Article Type] Research

Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

530

Published on 2020-07-142022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome addition animal model antiviral drugs Characteristics China consequence consolidation convalescent serum coronavirus coronavirus disease countermeasure COVID-19 patient disease feature Ground glass opacity hamster hamsters Health human lung immunotherapies Infection inhibited intranasal isolate lesion lung lung lesion Lungs mounted naïve Neutralizing antibody response Novel coronavirus pathogenesis of SARS-CoV-2 Pneumonia Postinfection Region replicate replicated Replication replicative reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolate SARS-CoV-2 pathogenesis serum severe lung injury Significance Spread subsequent suppressed Syrian hamsters transfer Vaccine Vaccines virus virus replication Wuhan, China
[DOI] 10.1073/pnas.2009799117 PMC 바로가기 [Article Type] 530