Human mesenchymal stromal cells do not express ACE2 and TMPRSS2 and are not permissive to SARS‐CoV‐2 infectionTissue‐specific Progenitor and Stem Cells Published on 2021-01-262022-10-28 Journal: Stem cells translational medicine [Category] COVID-19, MERS, SARS, [키워드] ACE2 adipose adult stem cells angiotensin Blood Bone marrow cell line cellular therapy complications conditioned COVID‐19 Critical Cytopathic effect demonstrated Effect ELISA enzyme evaluated Evidence excluded Express fetal fetal stem cells host cell host cell factor Human human tissue immunomodulatory properties medium Mesenchymal stromal cell mesenchymal stromal cells (MSCs) MSC MSCs not express potential therapy Proteins pseudovirus raised SARS‐CoV‐2 SARS‐CoV‐2 infection stromal cell Support tested therapy tissue TMPRSS2 transmembrane serine protease Treatment Viral particles virus were expressed western blot wild strain [DOI] 10.1002/sctm.20-0385 PMC 바로가기 [Article Type] Tissue‐specific Progenitor and Stem Cells
Double-blind, randomized, controlled, trial to assess the efficacy of allogenic mesenchymal stromal cells in patients with acute respiratory distress syndrome due to COVID-19 (COVID-AT): A structured summary of a study protocol for a randomised controlled trialCOVID-19(COVID-AT)로 인한 급성 호흡 곤란 증후군 환자에서 동종 간엽 기질 세포의 효능을 평가하기 위한 이중 맹검, 무작위, 대조 시험: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-01-062022-09-10 Journal: Trials [Category] MERS, 바이오마커, 임상, 치료제, [키워드] 1:1 24 hours 7-point ordinal scale acute respiratory distress acute respiratory distress syndrome Administered administration Admission Adult patient Adult patients Adverse Adverse drug reactions AEs age All trial participants all-cause mortality allergy Allogeneic ARDS assessment assigned baseline Biomarker blinded Blinding C-reactive protein carcinoma carcinoma in situ carried cellular chain change childbearing potential Chloroquine Clinical practice clinical status clinical trial coagulation test coagulation tests conducted Control control arm Course COVID COVID-19 CRF criteria CT scan cumulative incidence current Cytokines D-dimer Day death described determined by Diagnosis disease dissemination double-blind drug Duration ECMO Efficacy Efficacy and safety element eligible End endpoints enrolment EudraCT evaluate evaluate the effect event exclusion criteria Extracorporeal extracorporeal membrane oxygenation failure ferritin fibrosis FiO2 form GRADE grade 3 greater Haemodialysis handling hemofiltration history hospital Hospitalization hydroxy ICU ICU admission IMPROVE include inclusion criteria Informed consent intravenous Intravenous administration intravenous dose intubation Invasive mechanical ventilation invasive ventilation investigational medicinal product involved laboratory confirmation laboratory-confirmed SARS-CoV-2 infection lactation LDH less Level Local Lopinavir Lopinavir/ritonavir lung disorder lymphocyte marker Mechanical mechanical ventilation Medicine Medicines Mesenchymal stromal cells moderate to severe Mortality MSC negative pregnancy test neoplasm neutrophil neutrophil counts Non-invasive number objective occur off-label opinion Ordinal Scale organ oropharyngeal swab oropharyngeal swabs Other outcome oxygen oxygen saturation Oxygen therapy PaO2 PaO2/FiO2 ratio parameters participant Patient PCR percentage Placebo polymerase chain reaction Pregnancy primary endpoint product Production profile progression protocol Pulmonary embolism pulmonary fibrosis Pulmonary function tests randomised randomised controlled trial randomization Randomized Randomly Rapid antigen tests reaction receive recruitment Registered Remdesivir report respiratory Respiratory distress syndrome Resuscitation Ritonavir SAEs Sample size SARS-COV-2 infection secondary Secondary endpoints Sequential Organ Failure Assessment Serious Adverse Events SOFA Spain specificity specimen Sponsor Standard of care status stromal cell stromal cells Study protocol subpopulations supplemental oxygen supplementary material syndrome the cell the disease the patient the primary endpoint the WHO time Tocilizumab Tolerability Treatment treatment arm treatment for COVID-19 treatment group Treatment protocol Trial trial participant Trial registration unit website women worldwide pandemic written consent [DOI] 10.1186/s13063-020-04964-1 PMC 바로가기 [Article Type] Letter
A Retrospective Look at Recent COVID-19 Articles Published in Cell Transplantation: Research Leading to Further Understanding세포 이식에 게재된 최근 COVID-19 기사에 대한 회고적 검토: 더 많은 이해를 이끄는 연구Article Published on 2021-01-012022-09-11 Journal: Cell transplantation [Category] 변종, [키워드] ACE2 acute respiratory diseases androgen Androgen receptors angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 article cell transplantation cellular cellular therapy Characteristics consequence COVID-19 COVID-19 pandemic COVID-19 severity Cytokines disease disease severity enzyme Genes group Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients immune infused Intervention leading mesenchymal stem cell Mesenchymal stem cells modulating MSC offered pandemic Perspective principle proof recent receptor reduced Research respiratory diseases SARS-CoV2 Serine stem cells supported the disease therapy TMPRSS2 transmembrane serine protease transplantation Treatment understanding unique Variability variant variants [DOI] 10.1177/09636897211049814 PMC 바로가기 [Article Type] Article
Mesenchymal stem cell (MSC)-derived exosomes as a cell-free therapy for patients Infected with COVID-19: Real opportunities and range of promises중간엽줄기세포(MSC) 유래 엑소좀, 코로나19 감염 환자를 위한 무세포 치료제로 활용: 진정한 기회와 약속의 범위Review Published on 2021-01-012022-09-11 Journal: Chemistry and physics of lipids [Category] SARS, 임상, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome antiviral medication Antiviral medications ARDS carrier carriers cells clinical trial coronavirus disease COVID-19 death derivative drugs effective Exosome Exosome based therapy Exosomes include induce Inflammation Intercellular communication medical need mesenchymal stem cell Mesenchymal stem cells miRNA miRNAs MOST mRNA mRNAs MSC MSC exsosomes Novel coronavirus novel coronavirus disease Patient Potential potential therapy respiratory distress second Secretome shown stem cell suppress syndrome therapy transfer Treatment treatment of COVID-19 Vaccine virus [DOI] 10.1016/j.chemphyslip.2020.105009 PMC 바로가기 [Article Type] Review
Umbilical cord: an allogenic tissue for potential treatment of COVID-19탯줄: COVID-19의 잠재적인 치료를 위한 동종 조직Review Published on 2021-01-012022-09-11 Journal: Human Cell [Category] 임상, [키워드] acute respiratory distress acute respiratory distress syndrome alveolar alveolar damage ARDS associated symptoms autologous best chemokine chemokines clinical Clinical studies clinical study compassionate use complications controlled trials coronavirus COVID-19 COVID-19 pandemic Cytokines demonstrated detrimental effective Efficacy Evidence Factors globe Health care Health care system health care systems Hope immunomodulatory immunomodulatory effect lead limitations manuscript mesenchymal stem cell Mesenchymal stem cells MSC MSCs organ damage positioned Potential treatment pro-inflammatory cytokine pro-inflammatory cytokines randomized, controlled trial reduce regenerative respiratory distress Respiratory distress syndrome Safe SARS-COV-2 infection Symptom Symptoms syndrome therapeutic use therapy for COVID-19 tissue tissue repair treat Treatment treatment of COVID-19 umbilical Umbilical cord Vaccine Wharton's Jelly Wharton’s jelly Wharton’s jelly. [DOI] 10.1007/s13577-020-00444-5 PMC 바로가기 [Article Type] Review
The Systematic Effect of Mesenchymal Stem Cell Therapy in Critical COVID-19 Patients: A Prospective Double Controlled Trial중증 코로나19 환자에서 중간엽 줄기세포 치료의 체계적인 효과: 전향적 이중 대조 시험Controlled Clinical Trial Published on 2021-01-012022-09-11 Journal: Cell transplantation [Category] 유전자 메커니즘, 임상, [키워드] Analysis anti-inflammatory cytokine anti-inflammatory cytokines Apoptosis Biochemical parameters CD16 CD19 CD3 CD4 CD45 CD56 CD8 Cell cellular chemokines clinical manifestation clinical manifestations clinical trial Controlled COVID-19 COVID-19 patient COVID-19 patients Critical critical cases Critically ill critically ill COVID-19 patients critically ill patients CRP level CRP levels cytokine Cytokine storm Cytokines demonstrated died dose Effect evaluate evaluated fibrinogen group groups growth growth factor Growth factors HLA-DR IFNγ IL-10 IL-12 IL-13 IL-17A IL-1ra IL-2 IL-6 immunomodulatory effect immunomodulatory effects intravenously investigated KGF lymphocyte Lymphocyte subsets marker matrix metalloproteinases mechanism of action mesenchymal stem cell Mesenchymal stem cells moderate MSC MSCs Neutrophils NGF overall mortality Patient positive proinflammatory proinflammatory cytokines Prospective reducing mortality separated Serum ferritin significantly statistical STEM stem cell TGF-β the cytokine storm therapy tissue regeneration treated Treatment VEGF [DOI] 10.1177/09636897211024942 PMC 바로가기 [Article Type] Controlled Clinical Trial
Efficacy and safety of mesenchymal stem cells for the treatment of patients infected with COVID-19: a systematic review and meta-analysis protocol코로나19 환자 치료를 위한 중간엽줄기세포의 효능 및 안전성: 체계적 고찰 및 메타분석 프로토콜Article Published on 2020-12-182022-08-31 Journal: BMJ Open [Category] MERS, meta-analysis, SARS, [키워드] academic conference adverse events antivirus drug assessment bias risk Biomarker Biomarkers Case series case sery CBM Cell Cell Biology changes in chest pain China Chinese CINAHL CNKI Cochrane Library collected conducted Controlled trial COVID-19 pandemic critical cases data extraction database development Dexamethasone difficulty difficulty breathing dose duration of fever Efficacy and safety eligibility criteria Ethical approval Ethics evaluate Evidence high mortality immunology inception incidence include Infectious diseases Infrastructure journal Laboratory laboratory examination life literature mesenchymal stem cell Meta-analysis Mild moderate moderate to severe Mortality movement MSC MSC therapy Patient patients with COVID-19 peer-reviewed performed pressure Prevent Primary outcome Primary outcomes progression PROSPERO protocol public health Quality of life Randomised controlled trials reduce registration number respiratory searched secondary outcome Secondary outcomes sensitivity analysis service severity Shortness of breath SinoMed speech stem cell strength Symptom System systematic review Therapeutic approach therapy treat Treatment Vaccine ventilator VIP Web of Science [DOI] 10.1136/bmjopen-2020-042085 PMC 바로가기 [Article Type] Article
The Role of MSC Therapy in Attenuating the Damaging Effects of the Cytokine Storm Induced by COVID-19 on the Heart and Cardiovascular SystemCardiovascular Medicine Published on 2020-12-092022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome alleviate appear ARDS attenuate Cardiac arrhythmia cardiovascular cardiovascular complications cardiovascular system cause caused Cell clinical study Complication coronavirus coronavirus disease COVID-19 COVID-19 patients COVID-19 positive patient CXCL10 Cytokine storm deaths develop drug Effect elevated global pandemic hallmark heart help IL-2 IL-22 IL-6 IL-7 immune system immunomodulatory Immunosuppression induced infected case Infection lung Mesenchymal stem cells Mortality MSC MSCs myocardial injury myocarditis organ systems Patient Prevent primary site pro-inflammatory cytokine regeneration and repair role SARS-CoV-2 Severe case shown storm stromal cell suggested syndrome System the cytokine storm therapy Thromboembolism tissue repair TNFα [DOI] 10.3389/fcvm.2020.602183 PMC 바로가기 [Article Type] Cardiovascular Medicine
Molecular investigation of adequate sources of mesenchymal stem cells for cell therapy of COVID‐19‐associated organ failureCOVID-19 관련 장기부전의 세포치료제를 위한 중간엽 줄기세포의 적절한 공급원에 대한 분자 조사Enabling Technologies for Cell‐based Clinical Translation Published on 2020-11-252022-09-10 Journal: Stem cells translational medicine [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 adipose Adipose tissue adult human bone marrow Analysis Bone marrow Cell Cell therapy COVID‐19 COVID‐19 infection cultures determine embryonic embryonic stem cell embryonic stem cells Express expressed expression facilitate induced pluripotent stem cells infections less lowest Lymphocytes Mesenchymal stem cells MSC MSCs Organ failure outbreak passage Patient pluripotent stem cell receptor ACE2 stem cell Stem cell therapy stem cells suggested target target cell target cells therapy tissue Transcriptome transcriptome analysis transfused umbilical virus virus entry [DOI] 10.1002/sctm.20-0189 PMC 바로가기 [Article Type] Enabling Technologies for Cell‐based Clinical Translation
Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of SARS-CoV-2-Induced Acute Respiratory Distress SyndromeResearch Article Published on 2020-11-202022-10-28 Journal: Analytical Cellular Pathology (Amsterdam) [Category] COVID-19, Fulltext, MERS, SARS, [키워드] acute respiratory distress acute respiratory syndrome aerosol alleviate alveolar injury ARDS Characteristics clinical study conducted coronavirus country COVID-19 COVID-19 infection described disease drug etiological agent Immune cell life-threatening lung Lung inflammation modulation molecular mechanism MSC MSCs New coronavirus oxygen supply pathogenic penetrate Potential Prevent provided respiratory responsible SARS-CoV-2 Secretome severe pneumonia STEM stem cell Support syndrome therapeutic therapeutic potential therapy Vaccine virus [DOI] 10.1155/2020/1939768 PMC 바로가기 [Article Type] Research Article