Feline Chronic Gingivostomatitis Diagnosis and Treatment through Transcriptomic InsightsCase Report Published on 2024-02-212024-09-05 Journal: Pathogens [Category] update2024, [키워드] Biomarkers dentistry feline gingivitis MSC stem cells stomatitis transcriptomics [DOI] 10.3390/pathogens13030192 PMC 바로가기 [Article Type] Case Report
Engineered clinical-grade mesenchymal stromal cells combating SARS-CoV-2 omicron variants by secreting effective neutralizing antibodiesarticle Published on 2023-08-312024-09-05 Journal: Cell & Bioscience [Category] update2024, [키워드] anti-SARS-CoV-2 antibodies COVID-19 Gene modification mAbs delivery platform MSC [DOI] 10.1186/s13578-023-01099-z PMC 바로가기 [Article Type] article
iPSC-derived mesenchymal stem cells attenuate cerebral ischemia-reperfusion injury by inhibiting inflammatory signaling and oxidative stressOriginal Article Published on 2023-07-152024-09-05 Journal: Molecular Therapy [Category] update2024, [키워드] BMMSC focal cerebral ischemia model rats iMSC Intravenous administration IPSC Ischemic Stroke mesenchymal stem cell Mesenchymal stromal cell MSC Stem cell therapy [DOI] 10.1016/j.omtm.2023.07.005 PMC 바로가기 [Article Type] Original Article
2,4-Di-tert-butylphenol Induces Adipogenesis in Human Mesenchymal Stem Cells by Activating Retinoid X ReceptorsResearch Article Published on 2023-04-082024-09-05 Journal: Endocrinology [Category] update2024, [키워드] adipogenesis Endocrine disruptor MSC Obesogen PPAR RXR [DOI] 10.1210/endocr/bqad021 PMC 바로가기 [Article Type] Research Article
Preclinical safety evaluation and tracing of human mesenchymal stromal cell spheroids following intravenous injection into cynomolgus monkeysResearch article Published on 2022-10-012022-10-05 Journal: Biomaterials [Category] Coronavirus, 비임상, [키워드] addressed administration ambient Blood blood vessel Cell death demonstrated dissociate Efficacy feasible Host hypoxic condition injection intravenous Intravenous injection less lung Mesenchymal stem cells mice Monkey MSC MSCs multiple sclerosis occurred Osteoarthritis physiological change Preclinical promote retention Safe Safety Single Cell small blood vessel small vessel Spheroid Stress stromal cell survival viability wound healing [DOI] 10.1016/j.biomaterials.2022.121759 [Article Type] Research article
NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived VesiclesArticle Published on 2022-09-232022-11-16 Journal: Cells [Category] SARS, 유전자 메커니즘, [키워드] airway epithelial cells anti-apoptotic approach BCl2 BCL2 antagonist/killer caused cell death cell-free mitochondrial DNA changes co-culture co-cultured COVID-19 COVID-19 patient Effect Effects epithelial cells functional induce inhibit Inner Interaction intercellular intercellular mitochondrial transfer knockdown MCL1 mechanism membrane vesicle mitigate mitochondrial mitochondrial DNA Mortality MSC MSCs myeloid cell myeloid cell leukemia-1 nsp4 Orf9b outer membrane overexpression plasma pro-apoptotic pro-inflammatory Protein Release reversed SARS-CoV-2 SARS-CoV-2 protein screened significantly stem cell therapeutic Therapeutic approach these cell transfer Treatment tunneling nanotubes. [DOI] 10.3390/cells11192969 PMC 바로가기
Immunomodulatory Mechanisms of Mesenchymal Stem Cells and Their Potential Clinical ApplicationsArticle Published on 2022-09-022022-11-16 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] application Autoimmune disease Cell Characteristics chemokines clinical Clinical applications Contact contribute COVID-19 Cytokines disease Diseases Effect Engineering Factor Growth factors homing immune immune cells immune disorders Immune homeostasis immune response immunomodulation immunomodulatory immunomodulatory effect immunomodulatory property IMPROVE incurable Inflammatory diseases Inflammatory responses maintain mechanism mesenchymal stem cell mesenchymal stem cells (MSCs). MSC MSCs multifunctional Potential regenerative Regulation Secretome shown signaling molecules STEM stem cell systemic lupus erythematosus therapeutic strategy treat [DOI] 10.3390/ijms231710023 PMC 바로가기
Mesenchymal stem cell treatment for hyperactive immune response in patients with COVID-19COVID-19 환자의 과민성 면역 반응을 위한 중간엽 줄기세포 치료Review Published on 2022-09-012022-09-11 Journal: Immunotherapy [Category] COVID19(2023년), SARS, 변종, [키워드] Biomarker Biomarkers clinical clinical immunology clinical trials COVID-19 COVID-19 mortality COVID-19 patients CRP Cytokines decrease Effect effective Endothelitis epithelial cells Human immune system IL-6 immune response immune system independent invasive mesenchymal stem cell Mesenchymal stem cells MSC MSC therapy MSCs organism patients with COVID-19 potential treatment option pro-inflammatory cytokine pro-inflammatory cytokines PROTECT reduction in regenerative regimen reported Respiratory failure Safe sick stem cell stem cells systemic systemic effects therapy Treatment Trial [DOI] 10.2217/imt-2021-0245 PMC 바로가기 [Article Type] Review
Stem cell-based therapy for human diseases Reviews Published on 2022-08-062022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 임상, 치료제, [키워드] acute respiratory distress adipose Bone marrow Brain burns candidate cardiovascular conditions Cell cell type cellular phenotype clinical setting clinical trial contribute defined disease Diseases disorder disorders downstream human disease human diseases Hypothesis in vitro ISCT lineages mechanism MSC MSCs Neurological disorders Patient pluripotent stem cell progenitor cell provide pulmonary disease recent regenerative reproductive Research Society Spinal cord injury STEM stem cell Support syndrome targeted therapy therapy tissue translational treated Treatment UC-MSC umbilical [DOI] 10.1038/s41392-022-01134-4 [Article Type] Reviews
Nebulization Therapy with Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for COVID-19 PneumoniaClinical Trial Published on 2022-08-012022-10-05 Journal: Stem cell reviews and reports [Category] COVID19(2023년), SARS, 임상, [키워드] allergic allergic reaction Chinese clinical clinical study collected CORD COVID-19 COVID-19 pneumonia demonstrated duration of hospitalization effective Efficacy evaluated Exosome Exosomes Immunity induce Lung injury Mesenchymal stem cells mild case MSC MSCs nebulization outcome Patient patients with COVID-19 Pneumonia promote pulmonary lesion purified reduce reducing registry Safe SARS-CoV-2 scientist secreted Seven STEM stem cell suggested therapeutic strategy therapy treated Treatment Trial was performed [DOI] 10.1007/s12015-022-10398-w PMC 바로가기 [Article Type] Clinical Trial