Prediction of SARS-CoV-2 Variant Lineages Using the S1-Encoding Region Sequence Obtained by PacBio Single-Molecule Real-Time SequencingArticle Published on 2021-12-182022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute respiratory syndrome amplification Bioscience clade coronavirus COVID-19 pandemic COVIDSeq E484K feasibility G142D Illumina Illumina sequencing Lineage molecule monoclonal antibody Mutation mutations N501Y Neutralizing outbreak PacBio SMRT sequencing prediction protocol Region reported S1 domain SARS-CoV-2 sequenced Sequencing the spike protein variant virus whole genome [DOI] 10.3390/v13122544 PMC 바로가기 [Article Type] Article
Mechanisms of SARS-CoV-2 Evolution Revealing Vaccine-Resistant Mutations in Europe and America유럽과 미국에서 백신 내성 돌연변이를 드러내는 SARS-CoV-2 진화 메커니즘Article Published on 2021-12-162022-09-11 Journal: The journal of physical chemistry letters [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] America antibody binding domain can not complementary disrupt domain drugs Europe favor Frequency mechanism Mutation mutations N501Y natural selection neutralize occurred Occurrence omicron pathway Protein recent reduced SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genomes trajectory Transmission vaccination rate vaccination rates Vaccine Viral viral evolution viral infectivity virus [DOI] 10.1021/acs.jpclett.1c03380 PMC 바로가기 [Article Type] Article
The Development of SARS-CoV-2 Variants: The Gene Makes the DiseaseReview Published on 2021-12-152022-10-29 Journal: Journal of Developmental Biology [Category] COVID-19, [키워드] accumulated mutation Affect affected Alpha variant antigenicity Beta caused characteristic concerning Contact COVID-19 COVID-19 vaccines D614G defined Deleterious delta variant described determine development E484K Effectiveness escape mutation functions Gamma genetic profile Human immune defense Immune escape initial knowledge L452R Lineage morbidity and mortality MOST Mutation mutations N501Y neutralizing antibodies (NAbs) Novel coronavirus nucleocapsid occurred other variants P681R pandemic prevalent Protein receptor binding domain (RBD) SARS-CoV-2 SARS-CoV-2 genome scrutiny severe respiratory disease severity Spike protein Spread synonymous T478K the disease the SARS-CoV-2 the Spike the spike protein Transmissibility unique Vaccines variant variant of concern (VOC) Variation viral fitness virus virus genome virus variant [DOI] 10.3390/jdb9040058 PMC 바로가기 [Article Type] Review
Clinical Characteristics of Patients with SARS-CoV-2 N501Y Variants in General Practitioner Clinic in JapanArticle Published on 2021-12-142022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% confidence interval adjust age analyzed Celsius Characteristics clinic clinical Clinical characteristics clinical symptom Clinical symptoms COVID-19 COVID-19 patient demographics deviation Fever General practice groups Japan lung involvement Multivariate analysis Mutation N501Y N501Y mutation no significant difference Odds ratio Patient Pneumonia Practitioner Prevalence radiological radiological finding remained retrospective cohort study SARS-CoV-2 SARS-CoV-2 variant severe acute respiratory syndrome coronavirus-2 significantly significantly higher Treatment wild-type [DOI] 10.3390/jcm10245865 PMC 바로가기 [Article Type] Article
Rapid Identification of SARS-CoV-2 Variants of Concern Using a Portable peak PCR Platform휴대용 피크 PCR 플랫폼을 사용하여 우려되는 SARS-CoV-2 변이체의 신속한 식별Article Published on 2021-12-142022-09-11 Journal: Analytical Chemistry [Category] SARS, 변종, 치료기술, [키워드] approach clinical sample clinical samples collected concern continuous monitoring COVID-19 Culture detect diagnostic E484K Equatorial Guinea equipment facilitate gene deletion greater Healthcare systems identification Laboratory Lineage mutations N501Y PCR platform polymorphism pressure Rapid RNA robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants simplicity single-nucleotide SNPs spike gene tested Usage variant VoC VOCs [DOI] 10.1021/acs.analchem.1c02368 PMC 바로가기 [Article Type] Article
Differential Interactions between Human ACE2 and Spike RBD of SARS-CoV-2 Variants of Concern인간 ACE2와 SARS-CoV-2 변이의 RBD 스파이크 간의 차등 상호작용 우려Comparative Study Published on 2021-12-142022-09-11 Journal: Journal of chemical theory and computation [Category] SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus addition Alpha angiotensin Beta binding interaction binding interactions causative agent center concern contagious Control coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta disease control drug entry of SARS-CoV-2 Epsilon experiment followed by force Gamma highest Human human Angiotensin-converting enzyme inhibit SARS-CoV-2 interact interactions investigated K417N L452R molecular molecular dynamics N501Y N501Y mutation pandemic performed prevention RBD RBD of SARS-CoV-2 receptor Receptor-binding domain reported SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 SMD spike Spike protein the receptor-binding domain the spike protein the United State United States variant variants variants of concern variants of interest [DOI] 10.1021/acs.jctc.1c00965 PMC 바로가기 [Article Type] Comparative Study
Development of an efficient Sanger sequencing-based assay for detecting SARS-CoV-2 spike mutationsResearch Article Published on 2021-12-142022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] Accuracy acute respiratory syndrome amino acid change antibody-resistance approach caused clinical setting coronavirus Culture detect development dose FIVE G142D H655Y helping IMPROVE infective L452R limit of detection management median mutant Mutation mutations N501Y Neutralizing Neutralizing antibodies nine novel nucleotide change patients with COVID-19 primer primer pair SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 transmission Sequencing sequencing-based assay specificity spike gene Spike mutant spike mutation strain TCID the receptor-binding domain tissue Transmissibility virulence [DOI] 10.1371/journal.pone.0260850 PMC 바로가기 [Article Type] Research Article
Droplet digital RT-PCR to detect SARS-CoV-2 signature mutations of variants of concern in wastewater폐수에서 우려되는 변이체의 SARS-CoV-2 서명 돌연변이를 감지하는 물방울 디지털 RT-PCRArticle Published on 2021-12-102022-09-11 Journal: The Science of the total environment [Category] SARS, 변종, 치료기술, [키워드] aligned allocation antibody B.1.1.7 B.1.351 can be used causative agent Community coronavirus COVID-19 demonstrated detect detection determine droplet E484K indicate information K417N L452R limit Lineage measure MONITOR monitoring Mutation mutation N501Y N501Y N501Y mutation Netherlands Occurrence proportion Public public health quantification RNA RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant SARS-CoV-2 variants sewage Sewage surveillance shown Spread Support Surveillance Transmissibility Type vaccination variant variants variants of concern viral spread VoC wastewater [DOI] 10.1016/j.scitotenv.2021.149456 PMC 바로가기 [Article Type] Article
Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal세네갈에서 SARS-CoV-2 스파이크 수용체 결합 도메인 변이체의 새로운 조합의 출현Article Published on 2021-12-082022-09-10 Journal: Scientific Reports [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Combination coronavirus Course Diseases E484K emergence escape mutation Evidence evidence of Evolution genetics genomes Health care L452R Lineage lineages Local MONITOR Mutation mutations N501Y new SARS-CoV-2 next generation sequencing pandemic parallel evolution Receptor binding domain respiratory S477N SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike mutations second wave sequence sequenced Sequencing severe acute respiratory syndrome Coronavirus specimen specimens spike gene Treatment variant whole genome [DOI] 10.1038/s41598-021-02874-z PMC 바로가기 [Article Type] Article
A Conservative Replacement in the Transmembrane Domain of SARS-CoV-2 ORF7a as a Putative Risk Factor in COVID-19Article Published on 2021-12-052022-10-28 Journal: Biology [Category] COVID-19, [키워드] allosteric effect Alter analyses Analysis Clinical data Comorbidities Comorbidity Conservative Contact COVID-19 COVID-19 disease COVID-19 pandemic D614G driven by E484K Evolution explain Factor function gain-of-function Interaction less molecular molecular dynamics molecular feature Mutation N439K N501Y NSP6 ORF7a pathogenicity patients Protein Protein modeling protein stability replacement residue resulting RMSF SARS-CoV-2 SARS-CoV-2 virus severe COVID-19 severity shown simple the SARS-CoV-2 virus the spike protein Transmissibility vaccination variants of concern viral mutation Viral RNA virulence [DOI] 10.3390/biology10121276 PMC 바로가기 [Article Type] Article