Host cell entry mediators implicated in the cellular tropism of SARS‑CoV‑2, the pathophysiology of COVID‑19 and the identification of microRNAs that can modulate the expression of these mediators (Review)SARS-CoV-2의 세포 친화성, COVID-19의 병태생리학 및 이러한 매개체의 발현을 조절할 수 있는 microRNA의 식별에 연루된 숙주 세포 진입 매개체(검토)Review Published on 2022-02-012022-09-11 Journal: International journal of molecular medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADAM17 Affect angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 association Basigin binding Biomarker Candidates canonical cell entry cellular tropism changes in Clinical outcome clinical utility complexity coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 dependent on domain enzyme expression expression level Future Genes Glucose Glutamate GRP78 host cell host cells implicated in silico analysis indicated Kidney injury mechanism microRNA miRNA miRNAs modulate Necrosis NPR1 pathophysiology Patient protease Protein provide recent receptor Regulation review SARS‑CoV2 Serine serine 2 severe acute respiratory syndrome Coronavirus therapeutic target TLR4 TMPRSS2 TMPRSS4 transmembrane [DOI] 10.3892/ijmm.2021.5075 PMC 바로가기 [Article Type] Review
Safety and tolerability of the COVID-19 messenger RNA vaccine in adolescents with juvenile idiopathic arthritis treated with tumor necrosis factor inhibitors종양 괴사 인자 억제제로 치료한 소아 특발성 관절염 청소년에서 COVID-19 메신저 RNA 백신의 안전성 및 내약성Article Published on 2022-02-012022-09-12 Journal: Arthritis & rheumatology (Hoboken, N.J.) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] COVID-19 inhibitor juvenile idiopathic arthritis Messenger RNA Necrosis Safety Tolerability treated Vaccine [DOI] 10.1002/art.41977 PMC 바로가기 [Article Type] Article
SARS-CoV-2 (COVID-19) pneumonia patient treated with two doses of infliximab within 2 weeks for acute severe ulcerative colitis A case reportSARS-CoV-2(COVID-19) 폐렴 환자, 급성 중증 궤양성 대장염 2주 이내 인플릭시맙 2회 투여 증례 보고Case Reports Published on 2022-01-282022-09-12 Journal: Medicine [Category] 진단, [키워드] abdominal pain acute COVID-19 acute respiratory syndrome Administered an infectious disease caused by the SARS-CoV-2 virus anti-TNF anti-TNF-α azathioprine bleeding bloody can be used Case report caused Clostridium difficile Colitis Colon complications coronavirus Corticosteroid Corticosteroids COVID-19 COVID-19 infection COVID-19 patient COVID-19 symptom COVID-19 symptoms current cytomegalovirus deteriorate diagnosed diagnosis of COVID-19 diarrhea dose Fever Immune-mediated inflammatory diseases Immunosuppressant immunosuppressants Immunotherapy IMPROVE induce Infection Infectious disease Inflammatory diseases infliximab inhibitor intravenous Loading dose male mesalamine Nasopharyngeal swab Necrosis necrosis factor antagonists nine outcomes pandemic Patient Pneumonia positive receiving Remission Research SARS-CoV-2 SARS-CoV-2 virus Severe acute respiratory syndrome Sigmoidoscopy spontaneous bleeding surgery tested the SARS-CoV-2 virus therapy treated Treatment Tumor tumor necrosis tumor necrosis factor ulcerative colitis [DOI] 10.1097/MD.0000000000028722 PMC 바로가기 [Article Type] Case Reports
Interim analysis of a multicenter registry study of COVID-19 patients with inflammatory bowel disease in Japan (J-COSMOS)Observational Study Published on 2022-01-282022-10-04 Journal: Journal of Gastroenterology [Category] MERS, SARS, 임상, [키워드] age Analysis analyzed Anti-TNF-α antibodies antibodies BMI body mass index Clinical course Cohort conditions coronavirus disease COVID-19 COVID-19 patient COVID-19 severity COVID-19 symptom COVID19 diagnosed with COVID-19 Disease activity had no Health IBD incidence independent risk factor Inflammatory bowel disease Interim Japan Japanese Logistic regression analysis majority multicenter Necrosis nine Older age Patient patients patients with COVID-19 receiving Registered Result SARS-CoV-2 Severe case severity Sex Spread steroid supplementary material the WHO Treatment vaccination with COVID-19 [DOI] 10.1007/s00535-022-01851-1 PMC 바로가기 [Article Type] Observational Study
Clinico-histopathologic and single-nuclei RNA-sequencing insights into cardiac injury and microthrombi in critical COVID-19중요한 COVID-19에서 심장 손상 및 미세 혈전에 대한 임상 조직 병리학 및 단일 핵 RNA 시퀀싱 통찰력Clinical Trial Published on 2022-01-252022-09-10 Journal: JCI Insight [Category] 임상, 진단, 치료기술, 치료제, [키워드] Acute cardiac injury Analysis antiplatelet association bioinformatics Biomarkers biomarkers of inflammation C-reactive protein cardiac injury Cardiology cardiovascular disease cause clinical factors Cohort conducted controls Corticosteroid corticosteroid treatment COVID-19 Critical enrichment erythrocyte sedimentation erythrocyte sedimentation rate etiology Extracellular matrix Features fibrinolysis fibroblast heart hearts identify In-hospital increased mortality Injury microthrombi Molecular pathology myocarditis Necrosis New York City pathophysiology Patient potential therapeutic target prevalent Prospective Study RNA-sequencing sedimentation rate Sequencing analysis Signaling tested therapeutic anticoagulation Therapies therapy transcriptomic were used [DOI] 10.1172/jci.insight.154633 PMC 바로가기 [Article Type] Clinical Trial
Case Report: COVID-19 Vaccination Associated Fulminant MyocarditisCardiovascular Medicine Published on 2022-01-242022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] administration cardiac Cell complication of COVID-19 COVID-19 COVID-19 vaccine discharged edema fibrosis first dose fulminant immunomodulatory immunomodulatory therapy inactivated infiltration Inflammatory interstitial intravenous knowledge Lymphocytes magnetic resonance imaging Myocardial myocarditis myocyte necrosis Necrosis Pathogenesis pathologic receiving reported SARS-CoV-2 vaccine Support the patient tissue treat treatment regimen two subject vaccination Vero Cell [DOI] 10.3389/fcvm.2021.769616 PMC 바로가기 [Article Type] Cardiovascular Medicine
Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection In Vitro , despite Eliciting a Prolonged Antiviral ResponseResearch Article Published on 2022-01-182022-10-29 Journal: mBio [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] absence Alpha Analysis Antiviral apical surface Apoptosis Atf3 basal cells Cell cell death cell type characterized contributing to COVID-19 COVID-19 patient DDIT3 disease Eliciting epithelia epithelial expression Factor gene signature host response Human Immune cell Immunocompromised patient infected NEC Infection interferon response investigated involved management nasal Nasal Epithelial cells NEC Necrosis Patient persistence persistent Postinfection Prolonged provide replicate Replication response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Signaling single-cell sequencing staining stress-related gene subset TNF-α transcriptome sequencing Transmission unique Viral antigen viral clearance Viral load viral persistence virus widespread [DOI] 10.1128/mbio.03436-21 PMC 바로가기 [Article Type] Research Article
Case Report: Associated Ocular Adverse Reactions With Inactivated COVID-19 Vaccine in ChinaMedicine Published on 2022-01-172022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] administration Adverse adverse event Adverse reaction age case sery China Community coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccine criterion Department diagnosed dose effective eye inactivated Inclusion keratitis Necrosis ocular ocular adverse event one patient ophthalmology Patient physician reaction receiving reported Seven Shandong University Symptom Uveitis Vaccine women [DOI] 10.3389/fmed.2021.823346 PMC 바로가기 [Article Type] Medicine
Inflammatory laboratory findings associated with severe illness among hospitalized individuals with COVID-19 in Medan, Indonesia: a cross-sectional studyResearch Article Published on 2022-01-142022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] 24 hour acute respiratory distress Admission Analysis Blood BMI body mass index C-reactive protein (CRP Characteristics comorbid Comorbidities Comorbidity Comparative conducted COVID-19 COVID-19 patient COVID-19 vaccination Critical Critically ill cross-sectional CRP cytokine Cytokine storm D-dimer diabete disease enzyme Factor good health groups Health higher risk Hospitalized ICU IFN-gamma IL-10 IL-6 increase indicated individuals with COVID-19 Inflammatory Inflammatory cytokine inflammatory markers inflammatory parameter Inflammatory response intensive care interferon Laboratory laboratory result Lipase Liver function MCP-1 men monocyte chemoattractant protein-1 Most patient Necrosis NLR obesity pancrea parameters peripheral renal function serum electrolyte severe COVID-19 severe COVID-19 patient severe pneumonia severity of COVID-19 Sex significant difference significantly higher subject syndrome the cytokine storm TNF-alpha vaccination Well-being were assessed [DOI] 10.12688/f1000research.74758.2 PMC 바로가기 [Article Type] Research Article
Humoral Immune Response in IBD Patients Three and Six Months after Vaccination with the SARS-CoV-2 mRNA Vaccines mRNA-1273 and BNT162b2Article Published on 2022-01-132022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] acute respiratory syndrome anti-TNF approach BNT162b2 booster coronavirus disease COVID-19 COVID-19 mRNA Vaccination domain Efficacy Evidence examined healthy control healthy subjects humoral IBD IBD patients IgG antibody Immunosuppressed Inflammatory bowel disease Month mRNA mRNA-1273 Necrosis neutralization neutralizing capacity not differ pandemic Patient patients patients treated Prospective Study response SARS-CoV-2 second vaccination Seroconversion seroconversion rate significant difference significantly lower spike-protein sVNT the SARS-CoV-2 therapy TNF two group vaccination Vaccine [DOI] 10.3390/biomedicines10010171 PMC 바로가기 [Article Type] Article